Negative / Null Result ReportOpen accessMedicine
Schell C, Godinho A, Cunningham JA · 2026 · Substance abuse treatment, prevention, and policy
BACKGROUND: Invitation letters can be the first point of contact between research staff and potential participants and a number of modifiable variables have been studied to improve their effectiveness. The aim of this analysis was to…
View details →DOI: 10.1186/s13011-026-00704-x Negative / Null Result ReportOpen accessMedicine
Kipping R, Anne Simpson S, Hannam K et al. · 2026 · The Lancet regional health. Europe
Background Early childhood education and care (ECEC) provision is widespread. NAPSACC UK is an intervention in ECECs designed to improve nutrition and physical activity policies, practice and provision through ECEC staff workshops,…
View details →DOI: 10.1016/j.lanepe.2025.101550 Negative / Null Result ReportOpen accessMedicine
Singstock M, Abdul Khader AHS, Wayant C et al. · 2026 · The oncologist
Background Oncology clinical trials, regardless of success in meeting their primary endpoint, often suffer from spin-the misrepresentation of research findings. Despite dramatic improvements in myeloma outcomes, numerous recent myeloma…
View details →DOI: 10.1093/oncolo/oyag221 Negative / Null Result ReportOpen accessMedicine
Nakata Y, Watanabe Y, Ozaki A · 2026 · Cureus
Background The purpose of this study was to evaluate whether the workstyle reform, aimed at improving physician health and safety, achieved a secondary goal of enhancing surgical productivity by applying the Malmquist Index (MI) model. We…
View details →DOI: 10.7759/cureus.102095 Failed Experiment ReportOpen accessMedicine
Coker JA, Sun R, Polzer PM et al. · 2026 · ACS chemical biology
Point mutations in the exonuclease (ExoN) site of nonstructural protein 14 (NSP14) compromise the fitness of betacoronaviruses such as SARS-CoV-2, implicating NSP14 ExoN inhibition as an antiviral strategy. However, there are no advanced…
View details →DOI: 10.1021/acschembio.5c00930 Failed Experiment ReportOpen accessMedicine
Allard A, Clavien C · 2023 · PloS one
The recent replicability crisis in social and biomedical sciences has highlighted the need for improvement in the honest transmission of scientific content. We present the results of two studies investigating whether nudges and soft social…
View details →DOI: 10.1371/journal.pone.0290225 Negative / Null Result Report
Lantian A, Rose M · 2021 · Preprint
Introduction. Transhumanism is a movement that emphasizes the improvement of the human condition by developing technologies and making them widely available. Conspiracy theories regularly refer to the allegedly transhumanist agenda of…
View details →DOI: 10.31234/osf.io/pt8j7 Negative / Null Result Report
Williams EA, Ogden R, Stewart AJ et al. · 2021 · Preprint
Trains of auditory clicks increase subsequent judgements of stimulus duration by approximately 10%. Scalar timing theory suggests this is due to a 10% increase in pacemaker rate, a main component of the internal clock. The effect has been…
View details →DOI: 10.31234/osf.io/8hkmt Negative / Null Result ReportOpen accessMedicine
Schiff KJ, Schiff DS, Moy BJ et al. · 2025 · PNAS nexus
Does the implementation of external oversight in policing improve public perceptions of police legitimacy? Civilian review boards (CRBs) are frequently promoted as mechanisms to enhance the legitimacy of police agencies by providing…
View details →DOI: 10.1093/pnasnexus/pgaf267 Negative / Null Result ReportOpen accessMedicine
Li J, Jin T, Chi Y et al. · 2025 · Neuropsychiatric disease and treatment
Purpose Reducing electroconvulsive therapy (ECT)'s cognitive burden without compromising efficacy is critical. Although magnetic seizure therapy (MST) shows comparable symptom remission in schizophrenia, its neuroanatomical…
View details →DOI: 10.2147/ndt.s531892 Negative / Null Result ReportOpen accessMedicine
Fohrmann D, Schaffarczyk M, Menge C et al. · 2026 · Sports medicine - open
Background Advanced footwear technology (AFT) can enhance long-distance running performance by improving running economy (RE). However, the range of the individual improvements is large. Different intra-individual responses in running…
View details →DOI: 10.1186/s40798-026-01005-0 Negative / Null Result ReportOpen accessMedicine
Yoshikawa N, Masaki H · 2021 · Frontiers in psychology
Previous studies have shown that viewing cute pictures leads to performance improvement in a subsequent fine motor task. We examined the beneficial effects of viewing cute pictures in a more complex sporting skill (i.e., basketball free…
View details →DOI: 10.3389/fpsyg.2021.610817 Negative / Null Result ReportOpen accessMedicine
Diarra NH, Dicko Y, Roschnik N et al. · 2025 · Maternal & child nutrition
A cluster-randomised controlled trial was conducted in 60 communities in southern Mali to evaluate the impact of micronutrient powders (MNP) combined with seasonal malaria chemoprevention (SMC) on anaemia (primary endpoint), Plasmodium…
View details →DOI: 10.1111/mcn.70033 Negative / Null Result ReportOpen accessMedicine
Berks JW, Williams MN · 2026 · Europe's journal of psychology
According to creative writing experts, adding conflict to dialogue improves story quality and audience reaction to that story. This idea draws from the widely held theory that conflict is vital for dramatic stories. Yet despite conflict's…
View details →DOI: 10.5964/ejop.17499 Negative / Null Result ReportMedicine
Hu G, Woodman GF · 2024 · Visual cognition
Previous research suggests that applying anodal transcranial direct-current stimulation (tDCS) to the medial-frontal cortex can improve how quickly subjects learn to make simple discriminations (i.e., red from blue). Here, we tested the…
View details →DOI: 10.1080/13506285.2024.2402747 Negative / Null Result ReportOpen access
Radovich E, Karki S, Das S et al. · 2024 · Preprint
Background Understanding implementation fidelity, or adherence to the intervention-as-intended, is essential to interpreting the results of evaluations. In this paper, we propose a longitudinal, explanatory approach to implementation…
View details →DOI: 10.1101/2024.05.07.24306757 Negative / Null Result ReportOpen accessMedicine
Lara-Arevalo J, Corvalan C, Pemjean I et al. · 2025 · Advances in nutrition (Bethesda, Md.)
Healthy food voucher programs (HFVPs) provide lower-income participants with benefits to purchase healthy, nutrient-dense foods and are a promising strategy for improving dietary and nutritional outcomes. HFVPs can complement policies…
View details →DOI: 10.1016/j.advnut.2025.100530 Negative / Null Result Report
Castellano Bueno J, Paraskevopoulou A, Miller CW et al. · 2025 · Preprint
Fluid control protocols are widely used in neuroscience to motivate laboratory macaques to engage with behavioural tasks. Despite strong evidence that the physiology of the animals is not compromised by such protocols, fluid control…
View details →DOI: 10.1101/2025.10.10.681594 Negative / Null Result Report
Hornsby G, Pu C, Badamikar A et al. · 2025 · Preprint
ABSTRACT Introduction While improving water, sanitation, and hygiene (WASH) service delivery in schools supports the Sustainable Development Goals, rigorous trials have recently reported inconsistent effects of WASH in schools (WinS)…
View details →DOI: 10.1101/2025.10.23.25338677 Negative / Null Result ReportMedicine
Newton JD, Ellis T, Ruther M et al. · 2026 · Environmental research
Living near green areas with high vegetation may contribute to an active lifestyle, stress reduction, and enhance social cohesion, and consequently may be associated with improved cancer survival. Epidemiologic studies focused on greenness…
View details →DOI: 10.1016/j.envres.2025.123574 Negative / Null Result ReportOpen accessMedicine
Hiredesai AN, Martinez CJ, Hinckley NB et al. · 2026 · Cureus
Purpose Shear wave elastography (SWE) is a non-invasive technique for assessing median nerve (MN) stiffness in carpal tunnel syndrome (CTS). This study evaluated whether SWE measurements of the MN improve after corticosteroid injection…
View details →DOI: 10.7759/cureus.102587 Negative / Null Result ReportOpen accessMedicine
Pater WJ, Buller LT, Ziemba-Davis M et al. · 2026 · Arthroplasty today
Background Tourniquet use in revision total knee arthroplasty (rTKA) enhances visualization and improves cement penetration. However, concerns exist about muscle injury, pain, wound complications, and venous thromboembolism (VTE). This…
View details →DOI: 10.1016/j.artd.2026.102028 Negative / Null Result ReportOpen accessMedicine
Dragan KL · 2026 · Journal of policy analysis and management : [the journal of the Association for Public Policy Analysis and Management]
Low-income housing is often of substandard quality. Health care payers like Medicaid and Medicare are piloting reimbursement for housing quality improvement with the rationale of reducing expenses from acute care use, but little is known…
View details →DOI: 10.1002/pam.70074 Negative / Null Result ReportOpen accessMedicine
Liu J, Long Y, Yang Z · 2026 · Nutrients
Background Growing evidence suggests that vitamin D plays a role in the pathophysiology of childhood asthma. However, its effectiveness in reducing asthma exacerbations and improving asthma-related outcomes remains controversial. Methods…
View details →DOI: 10.3390/nu18101560 Negative / Null Result ReportMedicine
Fertig A, Hartman A, Iyer L et al. · 2026 · The journal of politics
Can financial incentives lead households to register land in women's names, thereby providing them with formal property rights? Can formal property ownership improve women's economic outcomes and change decision-making dynamics within the…
View details →DOI: 10.1086/734236 Replication FailureMedicine
Gass JC, Tonkin S, Maguin E et al. · 2024 · Translational behavioral medicine
Ecological Momentary Assessment (EMA) methods are increasingly used by translational scientists to study real-world behavior and experience. The ability to draw meaningful conclusions from EMA research depends upon participant compliance…
View details →DOI: 10.1093/tbm/ibad066 Negative / Null Result ReportMedicine
Kumar AR, Sanford NN · 2025 · Seminars in radiation oncology
Based on available Level 1 evidence, standard dose conventional chemoradiation does not improve survival in patients with locally advanced pancreas cancer (LAPC), thus chemotherapy remains the only widely accepted therapy. Yet prognosis…
View details →DOI: 10.1016/j.semradonc.2025.07.002 Negative / Null Result ReportOpen accessMedicine
Van der Helm-van Mil AHM · 2023 · Joint bone spine
During the last decade, the outlook for patients with rheumatoid arthritis (RA) has improved greatly, especially for patients with autoantibody-positive RA. To further improve long-term disease outcomes, the field has turned to…
View details →DOI: 10.1016/j.jbspin.2023.105543 Negative / Null Result ReportOpen accessMedicine
Gatto L, Di Nunno V, Tosoni A et al. · 2023 · Cancers
The lack of significant improvement in the prognosis of patients with GB over the last decades highlights the need for innovative treatments aimed at fighting this malignancy and increasing survival outcomes. The results of the phase III…
View details →DOI: 10.3390/cancers15123251 Negative / Null Result ReportMedicine
Janeway KA, Chou AJ, Buxton A et al. · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose Mouse models demonstrate a role for RANK and its ligand, RANKL, in osteosarcoma. The primary objective of this single-arm, open-label phase 2 trial was to determine whether denosumab, a RANKL mAb, improved disease control in…
View details →DOI: 10.1158/1078-0432.ccr-24-2885 