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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

1934 results for "Mpro" · page 34 of 65

Negative / Null Result ReportMedicine

Evaluating the need for omentectomy during laparoscopic placement of tunneled peritoneal dialysis catheters in pediatrics: a multicenter comparative study.

Shehata MA, Khirallah MG, Al Nafesa A et al. · 2026 · Pediatric surgery international

Purpose To evaluate whether routine omentectomy improves outcomes during laparoscopic placement of peritoneal dialysis (PD) catheters in children. Methods This multicenter retrospective study included children ≤ 5 years who underwent…

View details →DOI: 10.1007/s00383-026-06464-w
Negative / Null Result ReportMedicine

Rigorous Donor Selection for Fecal Microbiota Transplantation in Active Ulcerative Colitis: Key Lessons From a Randomized Controlled Trial Halted for Futility.

Caenepeel C, Deleu S, Vazquez Castellanos JF et al. · 2025 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Background & aims Rigorous donor preselection on microbiota level, strict anaerobic processing, and repeated fecal microbiota transplantation (FMT) administration were hypothesized to improve FMT induction of remission in ulcerative…

View details →DOI: 10.1016/j.cgh.2024.05.017
Negative / Null Result ReportMedicine

Effect of dietary phosphorus and calcium depletion-repletion on pig performance and bone quality.

Palacios-Duchicela R, Létourneau-Montminy MP, Lizardo R et al. · 2026 · Animal : an international journal of animal bioscience

Feeding strategies such as P and Ca depletion and repletion have been proposed to reduce the use of phosphate or improve P utilisation efficiency in pig diets, thereby contributing to the sustainability of the sector. A total of 48 entire…

View details →DOI: 10.1016/j.animal.2026.101865
Negative / Null Result ReportMedicine

How does prescribed burning in grasslands of coastal southern Texas, USA, impact butterfly populations?

Zerlin RR, Elissetche JC, Avila-Sanchez JS et al. · 2025 · Journal of environmental management

Butterflies are important pollinators worldwide and are often sensitive indicators of ecosystem health. Prescribed fire is used in grassland to mimic historic wildfires, improve forage nutritional value, and increased forb production and…

View details →DOI: 10.1016/j.jenvman.2025.128034
Negative / Null Result ReportMedicine

Cynandione A improves white adipose tissue homeostasis in high-fat diet-fed mice.

Sawamoto A, Shiba M, Okuyama S et al. · 2026 · The Journal of pharmacy and pharmacology

Objectives Cynandione A (CA), a major bioactive compound isolated from Cynanchum wilfordii Radix, is a crude drug traditionally used in East Asia. We have previously demonstrated that CA induces a beige adipocyte-like phenotype in vitro.…

View details →DOI: 10.1093/jpp/rgag038
Negative / Null Result ReportMedicine

Co-administration of digoxin and trans-2-decenoic acid ethyl ester improves motor learning performance in mice.

Fujita E, Hadano J, Hashimoto J et al. · 2026 · Behavioural brain research

Neural circuit formation through synaptogenesis plays a crucial role in learning, memory, and the recovery of neural function following brain dysfunction. We previously reported that administering the low-dose cardiac glycoside digoxin,…

View details →DOI: 10.1016/j.bbr.2026.116225
Negative / Null Result ReportMedicine

Exposure to a high-fat diet compromises gut health, behavior, and HPA axis function, with partial reversal when limited to adolescence.

Ott A, Gül AZ, Löber U et al. · 2026 · Brain research bulletin

High-fat diet (HFD) consumption contributes to obesity, yet its impact on females of (pre)reproductive age and the effects of dietary modification after adolescence remain underexplored. This study examined how continuous HFD exposure or…

View details →DOI: 10.1016/j.brainresbull.2026.111883
Negative / Null Result ReportMedicine

Magnesium supplements, sleep quality, and nocturnal leg cramps: a combination of cross-sectional and prospective studies.

Stadie N, Heinzer R, Marques-Vidal P · 2026 · European journal of nutrition

PURPOSE: Many individuals turn to supplements like magnesium, believing them to offer a natural way to improve sleep quality. Yet, research on magnesium’s effects has produced inconsistent results. We assessed the relationships between…

View details →DOI: 10.1007/s00394-026-03910-2
Negative / Null Result ReportMedicine

Glucose-dependent insulinotropic polypeptide reduces postprandial glucose excursions but does not protect from hypoglycaemia in persons with type 1 diabetes-A randomised placebo-controlled study.

Hoe B, Heimbürger SMN, Gasbjerg LS et al. · 2026 · Diabetes, obesity & metabolism

Aims In type 1 diabetes, glucose-dependent insulinotropic polypeptide (GIP) increases glucagon secretion during low plasma glucose and improves time in the glycaemic range during daytime. To explore the glucose-stabilising potential of GIP…

View details →DOI: 10.1111/dom.70373
Negative / Null Result ReportOpen accessMedicine

Improvement of cardiac function by Ivabradine in a doxorubicin-induced cardiomyopathy murine model is associated with a normal renal angiotensin II type I receptor expression but not with a reduction in fibrosis.

Drumeva GO, Plane AF, Petrenyov DR et al. · 2026 · Cardio-oncology (London, England)

BACKGROUND: Ivabradine (IVAB) is an effective drug in patients with heart failure (HF). However, data in the context of chemotherapy-induced cardiomyopathy are limited. This study investigated the cardioprotective potential of IVAB in a…

View details →DOI: 10.1186/s40959-026-00469-z
Negative / Null Result ReportOpen accessMedicine

Secondary Displacement was Common in Healing Distal Femur Fractures in a Cohort of Elderly Patients.

Paulsson M, Ekholm C, Rolfson O et al. · 2024 · Geriatric orthopaedic surgery & rehabilitation

Introduction Surgical treatment of distal femoral fractures (DFFs) in osteoporotic bone is challenging despite improvements in hardware and surgical techniques. The occurrence and degree of secondary displacement during healing after…

View details →DOI: 10.1177/21514593241280914
Negative / Null Result ReportMedicine

Selective PI3Kγ inhibition attenuates chemotherapy-induced intestinal mucositis without compromising the anticancer properties of irinotecan.

Cajado AG, Lopes MH, Rangel GFP et al. · 2025 · European journal of pharmacology

Irinotecan-based anticancer therapy induces intestinal mucositis, increasing the risk of sepsis and patient death. The phosphoinositide 3-kinases (PI3K) are involved in cancer and inflammatory diseases, but their role in intestinal…

View details →DOI: 10.1016/j.ejphar.2025.178165
Negative / Null Result ReportOpen accessMedicine

Diverticular perforation with exclusive local invasion in cytomegalovirus infection during ganciclovir treatment: an autopsy case report.

Ishiguro Y, Kuriyama A, Ishiguro S · 2025 · Annals of medicine and surgery (2012)

Introduction and importance Cytomegalovirus (CMV) can cause severe colitis in immunocompromised patients. While its morphological manifestations vary, diverticular perforation is rare, with most lesions remaining intact. We report a rare…

View details →DOI: 10.1097/ms9.0000000000003573
Failed Experiment ReportOpen accessMedicine

A 10-Year Follow-Up Study on the Success Rate of Maxillary Sinus Floor Augmentation and Implant Placement in Relation to Strontium Ranelate.

Dragan E, Ghinea M, Haba D et al. · 2025 · Dentistry journal

Background: Maxillary sinus floor augmentation (MSFA) is frequently required for implant placement in the atrophic posterior maxilla. However, limited bone quality and volume can compromise long-term success. Strontium ranelate (SrR), a…

View details →DOI: 10.3390/dj13120565
Negative / Null Result ReportMedicine

Time-restricted feeding does not improve daily rhythms in locomotion and drinking disrupted by artificial light at night.

Rumanova VS, Foppen E, Okuliarova M et al. · 2025 · Physiology & behavior

Exposure to artificial light at night (ALAN) disrupts natural darkness and desynchronizes daily rhythms in physiological processes and behavior. Previously, in rats, we have shown that dim ALAN disturbed the central circadian control and…

View details →DOI: 10.1016/j.physbeh.2024.114780
Negative / Null Result ReportOpen accessMedicine

Observation on the Efficacy of Hyperbaric Oxygen as Adjuvant Therapy for Breast Cancer-Related Wounds: A Case Report.

Tang F, Zhang L, Lu S et al. · 2026 · Cancer reports (Hoboken, N.J.)

Background Hyperbaric oxygen therapy (HBOT) is widely used as a therapeutic intervention for various types of wounds. Studies have shown that in addition to improving local oxygen supply to the wound site, HBOT can also influence cytokine…

View details →DOI: 10.1002/cnr2.70563
Negative / Null Result ReportMedicine

Randomized controlled trial of Understanding Social Situations versus problem-solving training in improving social function in people with psychosis.

Fiszdon JM, Wang K, Fulford D et al. · 2026 · Journal of the International Neuropsychological Society : JINS

Objectives Poor social function in people with psychosis has been linked to impairments in social cognition and neurocognition, which in turn have been identified as promising treatment targets. We developed a novel social cognitive…

View details →DOI: 10.1017/s1355617726102070
Negative / Null Result ReportOpen accessMedicine

Physical activity and glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1) plasma levels in different age cohorts.

Raza GS, Jokelainen J, Stenbäck V et al. · 2026 · PloS one

Physical activity (PA) has numerous positive health effects, including improvements in cognitive function. PA stimulates the release of glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1) from the liver, resulting in hippocampal…

View details →DOI: 10.1371/journal.pone.0349883
Negative / Null Result ReportMedicine

More graminoids in community breaks the trade-off between forage production and quality to improve forage quality storage in alpine grasslands

Wu S, Liu Q, Li L et al. · 2025 · Agriculture, Ecosystems and Environment.

Forage production and quality, two crucial ecosystem functions of grasslands, often demonstrate a trade-off and are significantly affected by both grassland community characteristics and environmental factors. However, whether and how…

Negative / Null Result ReportMedicine

The Utility of Comprehensive Sampling in Cervical Lymph Node Dissection for Head and Neck Squamous Cell Carcinoma: Is More Better?

Ould Ismail AA, Pettus JR, Tafe LJ et al. · 2026 · Head & neck

Purpose To evaluate whether comprehensive sampling of cervical lymphadenectomy tissue increases lymph node yield (LNY) and improves staging adequacy beyond standard grossing practice. Methods At a single academic center, a comprehensive…

View details →DOI: 10.1002/hed.70288
Negative / Null Result ReportMedicine

Testosterone treatment and respiratory medications and exacerbations in people prescribed inhaled corticosteroids: a nationwide cohort study.

Hansen ESH, Håkansson KEJ, Brustad N et al. · 2026 · Respiratory medicine

Background After puberty asthma is more common and often more severe in females, indicating a potential role of sex steroids. Observational and genetic studies suggest that higher testosterone levels are associated with improved lung…

View details →DOI: 10.1016/j.rmed.2026.108910
Negative / Null Result ReportMedicine

Post-AI uterine lavage and PRP infusion reduce some uterine inflammation parameters but do not improve fertility in jennies inseminated with frozen semen.

Sancler-Silva YFR, Albino MV, Freitas MS et al. · 2026 · Journal of equine veterinary science

Background The use of cryopreserved semen in donkey jennies induces an exacerbated post-insemination uterine inflammatory response, resulting in low fertility rates. Aims/objectives This study aimed to investigate the effects of different…

View details →DOI: 10.1016/j.jevs.2026.106061
Negative / Null Result ReportMedicine

Passive heat therapy is feasible but does not affect cardiometabolic health outcomes in persons with spinal cord injury - a pilot study.

Hoekstra SP, Leicht CA, Kellogg D Jr et al. · 2026 · Experimental physiology

Passive heat therapy can improve cardiometabolic health outcomes in some clinical populations, making it a potential therapeutic tool for individuals with spinal cord injury (SCI), who exhibit elevated cardiometabolic disease risk and face…

View details →DOI: 10.1113/ep093636
Negative / Null Result ReportMedicine

Low-frequency transient-evoked otoacoustic emission characteristics as potential indicators of hearing improvement in acute Ménière's disease: an exploratory analysis.

Yin TK, Sengar N, Fang TY et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

PURPOSE: Fluctuating hearing loss in Ménière’s disease (MD) presents a key clinical challenge due to lack of reliable prognostic markers. The clinical value of transient-evoked otoacoustic emissions (TEOAEs) low-frequency components…

View details →DOI: 10.1007/s00405-026-10152-9
Failed Experiment ReportMedicine

Randomized Controlled Trial of the Psychological and Clinical Outcomes of Reiki Plus Manual Therapy After Open Heart Surgery.

Zampino S, Hosler R, Brown K et al. · 2026 · The Journal of cardiovascular nursing

Background Reiki plus manual therapy are utilized to improve relaxation, sleep, emotional state, and pain. Evidence within hospital settings was limited, and previous studies had weak designs. Objective The purpose of this study was to…

View details →DOI: 10.1097/jcn.0000000000001334