A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
1896 results for "Mpro" · page 33 of 64
Lu X, Han Y, Song J et al. · 2025 · Frontiers in endocrinology
Background Recent studies have focused on investigating the role of cellular senescence in ovarian aging. Targeting cellular senescence has been proposed as a potential strategy to improve ovarian aging. p16 and p21 are classical molecules…
Hoe B, Heimbürger SMN, Gasbjerg LS et al. · 2026 · Diabetes, obesity & metabolism
Aims In type 1 diabetes, glucose-dependent insulinotropic polypeptide (GIP) increases glucagon secretion during low plasma glucose and improves time in the glycaemic range during daytime. To explore the glucose-stabilising potential of GIP…
Drumeva GO, Plane AF, Petrenyov DR et al. · 2026 · Cardio-oncology (London, England)
BACKGROUND: Ivabradine (IVAB) is an effective drug in patients with heart failure (HF). However, data in the context of chemotherapy-induced cardiomyopathy are limited. This study investigated the cardioprotective potential of IVAB in a…
Vercalsteren E, Karampatsi D, Buizza C et al. · 2025 · Nutrients
Background/objectives : Being overweight increases the predisposition to obesity and type 2 diabetes (T2D), which significantly elevate stroke risk and the likelihood of severe post-stroke disability. Dietary nitrate (NO 3 - )…
Paulsson M, Ekholm C, Rolfson O et al. · 2024 · Geriatric orthopaedic surgery & rehabilitation
Introduction Surgical treatment of distal femoral fractures (DFFs) in osteoporotic bone is challenging despite improvements in hardware and surgical techniques. The occurrence and degree of secondary displacement during healing after…
Cajado AG, Lopes MH, Rangel GFP et al. · 2025 · European journal of pharmacology
Irinotecan-based anticancer therapy induces intestinal mucositis, increasing the risk of sepsis and patient death. The phosphoinositide 3-kinases (PI3K) are involved in cancer and inflammatory diseases, but their role in intestinal…
Ishiguro Y, Kuriyama A, Ishiguro S · 2025 · Annals of medicine and surgery (2012)
Introduction and importance Cytomegalovirus (CMV) can cause severe colitis in immunocompromised patients. While its morphological manifestations vary, diverticular perforation is rare, with most lesions remaining intact. We report a rare…
Dragan E, Ghinea M, Haba D et al. · 2025 · Dentistry journal
Background: Maxillary sinus floor augmentation (MSFA) is frequently required for implant placement in the atrophic posterior maxilla. However, limited bone quality and volume can compromise long-term success. Strontium ranelate (SrR), a…
Rumanova VS, Foppen E, Okuliarova M et al. · 2025 · Physiology & behavior
Exposure to artificial light at night (ALAN) disrupts natural darkness and desynchronizes daily rhythms in physiological processes and behavior. Previously, in rats, we have shown that dim ALAN disturbed the central circadian control and…
Tang F, Zhang L, Lu S et al. · 2026 · Cancer reports (Hoboken, N.J.)
Background Hyperbaric oxygen therapy (HBOT) is widely used as a therapeutic intervention for various types of wounds. Studies have shown that in addition to improving local oxygen supply to the wound site, HBOT can also influence cytokine…
Sadighi T, Dudley A, Churaman B et al. · 2026 · Nursing education perspectives
This study explored the impact of an interprofessional mass casualty simulation on undergraduate nursing students' disaster preparedness. A total of 127 students participated; 50 completed pre- and postsurveys using a validated 14-item…
Fiszdon JM, Wang K, Fulford D et al. · 2026 · Journal of the International Neuropsychological Society : JINS
Objectives Poor social function in people with psychosis has been linked to impairments in social cognition and neurocognition, which in turn have been identified as promising treatment targets. We developed a novel social cognitive…
Raza GS, Jokelainen J, Stenbäck V et al. · 2026 · PloS one
Physical activity (PA) has numerous positive health effects, including improvements in cognitive function. PA stimulates the release of glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1) from the liver, resulting in hippocampal…
Wu S, Liu Q, Li L et al. · 2025 · Agriculture, Ecosystems and Environment.
Forage production and quality, two crucial ecosystem functions of grasslands, often demonstrate a trade-off and are significantly affected by both grassland community characteristics and environmental factors. However, whether and how…
Kapellas N, Alkhalil S, Senkal M · 2026 · Obesity surgery
INTRODUCTION: Accreditation systems are designed to standardize surgical care and improve outcomes in bariatric surgery, yet evidence on the effects of accreditation transitions within a single center is scarce. This study evaluated…
Saito M, Tanaka H, Matsui M et al. · 2026 · Preprint
Abstract Background Intradialytic exercise is recommended to improve exercise capacity, physical function, and quality of life in patients undergoing maintenance hemodialysis (HD). However, objective and practical physiological indicators…
Ould Ismail AA, Pettus JR, Tafe LJ et al. · 2026 · Head & neck
Purpose To evaluate whether comprehensive sampling of cervical lymphadenectomy tissue increases lymph node yield (LNY) and improves staging adequacy beyond standard grossing practice. Methods At a single academic center, a comprehensive…
Hansen ESH, Håkansson KEJ, Brustad N et al. · 2026 · Respiratory medicine
Background After puberty asthma is more common and often more severe in females, indicating a potential role of sex steroids. Observational and genetic studies suggest that higher testosterone levels are associated with improved lung…
Sancler-Silva YFR, Albino MV, Freitas MS et al. · 2026 · Journal of equine veterinary science
Background The use of cryopreserved semen in donkey jennies induces an exacerbated post-insemination uterine inflammatory response, resulting in low fertility rates. Aims/objectives This study aimed to investigate the effects of different…
Hoekstra SP, Leicht CA, Kellogg D Jr et al. · 2026 · Experimental physiology
Passive heat therapy can improve cardiometabolic health outcomes in some clinical populations, making it a potential therapeutic tool for individuals with spinal cord injury (SCI), who exhibit elevated cardiometabolic disease risk and face…
Yin TK, Sengar N, Fang TY et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
PURPOSE: Fluctuating hearing loss in Ménière’s disease (MD) presents a key clinical challenge due to lack of reliable prognostic markers. The clinical value of transient-evoked otoacoustic emissions (TEOAEs) low-frequency components…
Zampino S, Hosler R, Brown K et al. · 2026 · The Journal of cardiovascular nursing
Background Reiki plus manual therapy are utilized to improve relaxation, sleep, emotional state, and pain. Evidence within hospital settings was limited, and previous studies had weak designs. Objective The purpose of this study was to…
McNamara ME, Becker MS, Nota JA et al. · 2026 · Journal of anxiety disorders
While rumination has been recognized in clinical settings as prevalent and problematic for individuals with obsessive compulsive disorder (OCD), its relationship to OCD symptom trajectories has been understudied. In a large sample of N =…
Abdelnaby EA, Alhaider AK, Emam IA · 2026 · Reproduction in domestic animals = Zuchthygiene
This current work aimed to determine the impacts of melatonin implants on testicular artery blood flow and Doppler indices, in relation to hormonal profile in post-pubertal camels (Camelus dromedaries) under heat stress and non-breeding…
Elad B, Lotan D, Richter I et al. · 2026 · Journal of cardiovascular pharmacology
Abstract Vericiguat improves outcomes in heart failure (HF) by promoting vasodilation of the systemic and pulmonary arterial beds. Little is known about its impact on pulmonary artery pressure (PAP). We aimed to study this effect using…
Ritter C, Hausman H, Gaschler R et al. · 2025 · Preprint
Making judgments of learning (JOLs) can directly affect learning outcomes. The present study investigated whether providing JOLs during inductive learning tasks improves learning of new material (forward effect) and whether feedback…
Jaramillo Quiceno GA, Sarmiento Riveros PA, Arias Perez RD et al. · 2026 · Journal of ISAKOS : joint disorders & orthopaedic sports medicine
Introduction/objectives Residual rotational laxity remains a relevant clinical concern after anterior cruciate ligament (ACL) reconstruction. Combined ACL and anterolateral ligament (ALL) reconstruction has been proposed to improve control…
Gonzalez W, Riquelme JP, Arellano J et al. · 2026 · BMC musculoskeletal disorders
Background Unicompartmental knee arthroplasty (UKA) is an established procedure for selected patients with unicompartmental osteoarthritis. Robotic-assisted UKA (RA-UKA) has been introduced to improve accuracy of implant positioning.…
Kijkuokool P, Rerkasem K, Fakfum P et al. · 2026 · Antioxidants (Basel, Switzerland)
Watercress ( Nasturtium officinale R.Br.) is a cruciferous vegetable rich in bioactive compounds that may improve cardiovascular disease (CVD) risk factors. However, clinical evidence regarding its direct impact on CVD risk remains…
Goyal A, Konieczny K, Plombon S et al. · 2026 · Journal of general internal medicine
Background Diagnostic errors (DEs) are a major threat to hospital patient safety. Identifying admission-based predictors associated with harmful DEs may help improve diagnostic safety in high-risk populations. Objective To assess the…