A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
1934 results for "Mpro" · page 31 of 65
Jegarl AM, Martin M, Cormier NR et al. · 2026 · Anesthesiology
Background Whether adding a bilateral superficial cervical plexus block to a thyroidectomy enhanced recovery pathway improves postoperative quality of recovery remains uncertain. Methods In a single-center prospective, randomized,…
Peretz-Kahlon M, Wood K, Harris A et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
BACKGROUND: Branch retinal vein occlusion (BRVO) frequently results in macular edema (ME), impairing visual acuity (VA). Intravitreal anti-vascular endothelial growth factor (VEGF) injections are standard first-line therapy but the benefit…
Bliesner RK, Stevens AA, Holling L et al. · 2026 · Cureus
Background Being in the large majority, right-handed people are not required to use their nondominant hands throughout their daily lives, resulting in a loss of motor dexterity. As technology continues to advance, improving motor dexterity…
Sobel Misieczko M, Barber SJ · 2026 · Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition
Affective forecasting, the process of predicting future feelings, is key for decision-making, but prone to errors. Prior research suggests that age differences in forecasting accuracy vary by event valence such that older adults tend to be…
Vargas Ribera PR, Nogales A, Calvet C et al. · 2026 · Applied Soil Ecology.
Crop rotation enhances agroecosystem sustainability by reducing nutrient loss, improving soil fertility, and decreasing crop evapotranspiration. Arbuscular mycorrhizal fungi (AMF) inoculation further supports enhanced nutrient and water…
Hayashi T, Go M, Kawasumi K et al. · 2026 · Preprint
Abstract Introduction Maintaining dose intensity is essential for the efficacy of adjuvant S-1 chemotherapy in gastric cancer. Although pharmacist interventions can reduce toxicity and improve adherence, multicenter evidence regarding…
Saloojee H, Gramanie MC, Mwale R et al. · 2026 · Medical teacher
Background Generative artificial intelligence (AI) tools are entering clinical training faster than curricula and assessments can adapt. It is currently unknown whether point-of-care access to large language models (LLMs) improves…
An DW, Wang Y, Cheng YB et al. · 2026 · Hypertension (Dallas, Tex. : 1979)
Background Whether central systolic blood pressure (cSBP) compared with brachial systolic blood pressure (bSBP) improves risk stratification remains debated. This study investigated whether cSBP is more closely associated with total and…
Forville H, Coppla FM, Naupari-Villasante R et al. · 2026 · Journal of dentistry
Objective To evaluate whether dentin airborne-particle abrasion (APA) with aluminum oxide affects the retention and clinical performance of composite resin restorations in non-carious cervical lesions (NCCLs). Methods This prospective,…
Chau IJ, Dixon PR, Lin V et al. · 2026 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Objective To identify patient characteristics associated with improvements in speech recognition scores (SRS) and Cochlear Implant Quality of Life (CIQOL-35) scores following cochlear implantation. Study design Multi-institutional…
Yoshida M, Urabe Y, Kadota T et al. · 2026 · Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
Objectives To investigate whether considering the B2 vessel area (B2VA) size and macroscopic type improves diagnostic performance. Methods In total, 136 esophageal squamous cell carcinoma (ESCCs) with B2 but not B3 vessels were…
Acar C, Şahin G, Yüksel HÇ et al. · 2026 · Immunotherapy
Background Malnutrition is common in metastatic cancer and may compromise outcomes. We evaluated whether oral nutritional supplementation (ONS) improves survival and compared the performance of nutritional risk scores in immune checkpoint…
Bansaghi S, Klein J · 2026 · Preprint
Background Cruise ships are relatively small, crowded spaces where many people travel in a new environment, making infection control especially important. Proper hand hygiene is the first line of defense against the spread of infection.…
Kuula L, Pesonen AK · 2026 · The Journal of adolescent health : official publication of the Society for Adolescent Medicine
Purpose Many adolescents develop very late circadian rhythms, indicating delayed sleep phase. Interventions are sparse, and the stability of any improvements is rarely reported. To evaluate how late sleep patterns can be improved, we…
Hoyle JD Jr, Ekblad G, Dunwoody S et al. · 2026 · Prehospital emergency care
Objectives We sought to decrease pediatric prehospital dosing errors by implementing a bundled drug dosing safety system (DDSS). Multiple studies have demonstrated that pediatric prehospital drug-dosing errors occur at rates of > 30% for…
Allotey J, Junaid F, Peréz T et al. · 2026 · BMJ neurology open
Background Serum lamotrigine concentrations fall during pregnancy, and therapeutic drug monitoring is often used to guide dose adjustment. We do not know whether serial antenatal measurements improve prediction of seizure risk in pregnant…
Li JL, Wu JH, Zhao X et al. · 2026 · Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing
BACKGROUND: The role of prophylactic cavotricuspid isthmus (CTI) ablation remains controversial in atrial fibrillation (AF) patients without atrial flutter (AFL). Given the strong association between AF, AFL, and age, this study aimed to…
Hertig D, Furian M, Müller J et al. · 2026 · ERJ open research
Background Little is known about the effects of portable supplemental oxygen therapy (SOT) to improve exercise performance in highlanders at risk for high-altitude pulmonary hypertension (HAPH). We aimed to investigate whether SOT improves…
Jeon SH, Song C, Jeon JH et al. · 2026 · Cancer research and treatment
Purpose The aim of this study was to identify subgroups of patients with pathologic N2 (pN2) non-small cell lung cancer (NSCLC) who may benefit from postoperative radiotherapy (PORT). Particular attention was given to evaluating whether…
Andriotti NM, Paris W, Maia FJ et al. · 2026 · Animal Feed Science and Technology.
Feed additives that improve energy metabolism efficiency can enhance cattle performance and nitrogen use. This study evaluated the effects of guanidinoacetic acid (GAA) and methionine (MET) supplementation, alone or combined, on…
Perton FT, Pouw JN, Spierings J et al. · 2026 · Arthritis research & therapy
Background To investigate the associations of circulating immune cell biomarkers with clinical manifestations and treatment response in Psoriatic Arthritis (PsA), and to evaluate whether these biomarkers improve prediction of individual…
Avsar FN, Erinc O, Sahutoglu T · 2026 · Hemodialysis international. International Symposium on Home Hemodialysis
Introduction Depression is prevalent in maintenance hemodialysis patients and is influenced by the interplay of physical and mental health. Rather than a direct antidepressant effect of dialyzer membrane type, improved clearance of middle…
Iurchenkov A, Danilova A, Shilo P et al. · 2026 · Cancers
Background : Immune checkpoint inhibitors have significantly improved survival in metastatic melanoma. Combination nivolumab plus ipilimumab demonstrated superior efficacy in randomized trials, including CheckMate 067, but data beyond the…
Guan X, Li X, Yue M et al. · 2026 · Scientific reports
Pressure injury (PI) prevention requires sustained nursing behaviors from patients, caregivers, and nurses. This single-center quasi-experimental, non-randomized, non-equivalent control group study enrolled 60 inpatients with PI or high PI…
Chen Z, Wang S, Palus S et al. · 2026 · Journal of cachexia, sarcopenia and muscle
Background Cancer cachexia is associated with rapid body wasting and cardiac dysfunction. Bisoprolol (BIS) and megestrol acetate (MA) improve selected cachexia phenotypes in the Yoshida AH-130 model, but their combined effects are not…
Miyauchi K, Narita T, Morishita S et al. · 2026 · Preprint
Abstract Background Whether initial dose reduction of apalutamide compromises clinical outcomes in patients with androgen pathway modulation–naïve metastatic prostate cancer remains uncertain. In routine practice, reduced dosing is often…
Hegde P, Acharya SR, Mayya A et al. · 2026 · International journal of dentistry
Background White spot lesions (WSLs) represent the earliest clinical manifestations of enamel demineralization. Resin infiltration (RI) is a minimally invasive method used to mask WSLs for esthetic improvement; however, infiltrated enamel…
Bleckwedel J, Nieva RE, González V et al. · 2026 · Preprint
Soybean ( Glycine max [L.] Merr.) productivity is frequently compromised by soil-borne pathogens. Macrophomina phaseolina (Mp), the causal agent of charcoal rot, can produce important soybean yield losses especially when hot and dry…
Akdag A, Aktas E, Kutlu A et al. · 2026 · Preprint
Abstract Purpose: Residual fragments after retrograde intrarenal surgery (RIRS) may compromise delayed stone-free (SF) status and increase the likelihood of secondary intervention. This study evaluated the association between postoperative…
Ho CB, Tran TT, Ngo LT · 2026 · Preprint
Background: /Objectives: Glass-hybrid and high-viscosity glass-ionomer systems aim to improve conventional glass-ionomer performance. This in vitro study compared Vickers hardness and microleakage of a coated glass-hybrid system and a…