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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

1759 results in Negative / Null Result Report for "Mpro" · page 30 of 59

Negative / Null Result ReportMedicine

Selective PI3Kγ inhibition attenuates chemotherapy-induced intestinal mucositis without compromising the anticancer properties of irinotecan.

Cajado AG, Lopes MH, Rangel GFP et al. · 2025 · European journal of pharmacology

Irinotecan-based anticancer therapy induces intestinal mucositis, increasing the risk of sepsis and patient death. The phosphoinositide 3-kinases (PI3K) are involved in cancer and inflammatory diseases, but their role in intestinal…

View details →DOI: 10.1016/j.ejphar.2025.178165
Negative / Null Result ReportOpen accessMedicine

Diverticular perforation with exclusive local invasion in cytomegalovirus infection during ganciclovir treatment: an autopsy case report.

Ishiguro Y, Kuriyama A, Ishiguro S · 2025 · Annals of medicine and surgery (2012)

Introduction and importance Cytomegalovirus (CMV) can cause severe colitis in immunocompromised patients. While its morphological manifestations vary, diverticular perforation is rare, with most lesions remaining intact. We report a rare…

View details →DOI: 10.1097/ms9.0000000000003573
Negative / Null Result ReportMedicine

Time-restricted feeding does not improve daily rhythms in locomotion and drinking disrupted by artificial light at night.

Rumanova VS, Foppen E, Okuliarova M et al. · 2025 · Physiology & behavior

Exposure to artificial light at night (ALAN) disrupts natural darkness and desynchronizes daily rhythms in physiological processes and behavior. Previously, in rats, we have shown that dim ALAN disturbed the central circadian control and…

View details →DOI: 10.1016/j.physbeh.2024.114780
Negative / Null Result ReportOpen accessMedicine

Observation on the Efficacy of Hyperbaric Oxygen as Adjuvant Therapy for Breast Cancer-Related Wounds: A Case Report.

Tang F, Zhang L, Lu S et al. · 2026 · Cancer reports (Hoboken, N.J.)

Background Hyperbaric oxygen therapy (HBOT) is widely used as a therapeutic intervention for various types of wounds. Studies have shown that in addition to improving local oxygen supply to the wound site, HBOT can also influence cytokine…

View details →DOI: 10.1002/cnr2.70563
Negative / Null Result ReportMedicine

Randomized controlled trial of Understanding Social Situations versus problem-solving training in improving social function in people with psychosis.

Fiszdon JM, Wang K, Fulford D et al. · 2026 · Journal of the International Neuropsychological Society : JINS

Objectives Poor social function in people with psychosis has been linked to impairments in social cognition and neurocognition, which in turn have been identified as promising treatment targets. We developed a novel social cognitive…

View details →DOI: 10.1017/s1355617726102070
Negative / Null Result ReportOpen accessMedicine

Physical activity and glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1) plasma levels in different age cohorts.

Raza GS, Jokelainen J, Stenbäck V et al. · 2026 · PloS one

Physical activity (PA) has numerous positive health effects, including improvements in cognitive function. PA stimulates the release of glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1) from the liver, resulting in hippocampal…

View details →DOI: 10.1371/journal.pone.0349883
Negative / Null Result ReportMedicine

More graminoids in community breaks the trade-off between forage production and quality to improve forage quality storage in alpine grasslands

Wu S, Liu Q, Li L et al. · 2025 · Agriculture, Ecosystems and Environment.

Forage production and quality, two crucial ecosystem functions of grasslands, often demonstrate a trade-off and are significantly affected by both grassland community characteristics and environmental factors. However, whether and how…

Negative / Null Result ReportMedicine

The Utility of Comprehensive Sampling in Cervical Lymph Node Dissection for Head and Neck Squamous Cell Carcinoma: Is More Better?

Ould Ismail AA, Pettus JR, Tafe LJ et al. · 2026 · Head & neck

Purpose To evaluate whether comprehensive sampling of cervical lymphadenectomy tissue increases lymph node yield (LNY) and improves staging adequacy beyond standard grossing practice. Methods At a single academic center, a comprehensive…

View details →DOI: 10.1002/hed.70288
Negative / Null Result ReportMedicine

Testosterone treatment and respiratory medications and exacerbations in people prescribed inhaled corticosteroids: a nationwide cohort study.

Hansen ESH, Håkansson KEJ, Brustad N et al. · 2026 · Respiratory medicine

Background After puberty asthma is more common and often more severe in females, indicating a potential role of sex steroids. Observational and genetic studies suggest that higher testosterone levels are associated with improved lung…

View details →DOI: 10.1016/j.rmed.2026.108910
Negative / Null Result ReportMedicine

Post-AI uterine lavage and PRP infusion reduce some uterine inflammation parameters but do not improve fertility in jennies inseminated with frozen semen.

Sancler-Silva YFR, Albino MV, Freitas MS et al. · 2026 · Journal of equine veterinary science

Background The use of cryopreserved semen in donkey jennies induces an exacerbated post-insemination uterine inflammatory response, resulting in low fertility rates. Aims/objectives This study aimed to investigate the effects of different…

View details →DOI: 10.1016/j.jevs.2026.106061
Negative / Null Result ReportMedicine

Passive heat therapy is feasible but does not affect cardiometabolic health outcomes in persons with spinal cord injury - a pilot study.

Hoekstra SP, Leicht CA, Kellogg D Jr et al. · 2026 · Experimental physiology

Passive heat therapy can improve cardiometabolic health outcomes in some clinical populations, making it a potential therapeutic tool for individuals with spinal cord injury (SCI), who exhibit elevated cardiometabolic disease risk and face…

View details →DOI: 10.1113/ep093636
Negative / Null Result ReportMedicine

Low-frequency transient-evoked otoacoustic emission characteristics as potential indicators of hearing improvement in acute Ménière's disease: an exploratory analysis.

Yin TK, Sengar N, Fang TY et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

PURPOSE: Fluctuating hearing loss in Ménière’s disease (MD) presents a key clinical challenge due to lack of reliable prognostic markers. The clinical value of transient-evoked otoacoustic emissions (TEOAEs) low-frequency components…

View details →DOI: 10.1007/s00405-026-10152-9
Negative / Null Result ReportMedicine

Repeated Melatonin Implant Improves Testicular Volume, Testicular Blood Flow, Estradiol, Antioxidant Capacity, and Nitric Oxide Levels in Post-Pubertal Camels Under Heat Stress Conditions.

Abdelnaby EA, Alhaider AK, Emam IA · 2026 · Reproduction in domestic animals = Zuchthygiene

This current work aimed to determine the impacts of melatonin implants on testicular artery blood flow and Doppler indices, in relation to hormonal profile in post-pubertal camels (Camelus dromedaries) under heat stress and non-breeding…

View details →DOI: 10.1111/rda.70180
Negative / Null Result ReportMedicine

Effect of Vericiguat on Pulmonary Artery Pressures in Patients With Heart Failure: Real-World Insights From Pressure Sensor Monitoring.

Elad B, Lotan D, Richter I et al. · 2026 · Journal of cardiovascular pharmacology

Abstract Vericiguat improves outcomes in heart failure (HF) by promoting vasodilation of the systemic and pulmonary arterial beds. Little is known about its impact on pulmonary artery pressure (PAP). We aimed to study this effect using…

View details →DOI: 10.1097/fjc.0000000000001761
Negative / Null Result ReportMedicine

Combined anterior cruciate ligament and anterolateral ligament reconstruction using an adjustable-loop device provides similar short-term clinical outcomes compared with isolated reconstruction.

Jaramillo Quiceno GA, Sarmiento Riveros PA, Arias Perez RD et al. · 2026 · Journal of ISAKOS : joint disorders & orthopaedic sports medicine

Introduction/objectives Residual rotational laxity remains a relevant clinical concern after anterior cruciate ligament (ACL) reconstruction. Combined ACL and anterolateral ligament (ALL) reconstruction has been proposed to improve control…

View details →DOI: 10.1016/j.jisako.2026.101073
Negative / Null Result ReportMedicine

Robot-assisted versus conventional unicompartmental knee arthroplasty: a retrospective comparative study of postoperative complications.

Gonzalez W, Riquelme JP, Arellano J et al. · 2026 · BMC musculoskeletal disorders

Background Unicompartmental knee arthroplasty (UKA) is an established procedure for selected patients with unicompartmental osteoarthritis. Robotic-assisted UKA (RA-UKA) has been introduced to improve accuracy of implant positioning.…

View details →DOI: 10.1186/s12891-026-09928-1
Negative / Null Result ReportMedicine

Efficacy of Watercress (<i>Nasturtium officinale</i> R.Br.) Consumption on Blood Pressure, Oxidative Stress Biomarkers, and Estimated Cardiovascular Risk in Thai Middle-Aged Adults: A Randomized Placebo-Controlled Pilot Study.

Kijkuokool P, Rerkasem K, Fakfum P et al. · 2026 · Antioxidants (Basel, Switzerland)

Watercress ( Nasturtium officinale R.Br.) is a cruciferous vegetable rich in bioactive compounds that may improve cardiovascular disease (CVD) risk factors. However, clinical evidence regarding its direct impact on CVD risk remains…

View details →DOI: 10.3390/antiox15060766
Negative / Null Result ReportMedicine

Frequent Ambulatory Care Visits Predict Harmful Diagnostic Errors in High-Risk Hospitalized Patients: a Retrospective Cohort Study.

Goyal A, Konieczny K, Plombon S et al. · 2026 · Journal of general internal medicine

Background Diagnostic errors (DEs) are a major threat to hospital patient safety. Identifying admission-based predictors associated with harmful DEs may help improve diagnostic safety in high-risk populations. Objective To assess the…

View details →DOI: 10.1007/s11606-026-10527-y
Negative / Null Result ReportMedicine

Real-World Outcomes of Total Neoadjuvant Therapy Versus Standard Neoadjuvant Chemoradiotherapy in Stage II-III Locally Advanced Rectal Cancer: A Comparative Cohort Study.

Erken AA, Dincer ST · 2026 · Asia-Pacific journal of clinical oncology

Aim Total neoadjuvant therapy has been adopted to improve systemic disease control in locally advanced rectal cancer, yet long-term real-world outcomes, particularly in non-Western populations, remain incompletely defined. We compared…

View details →DOI: 10.1111/ajco.70118
Negative / Null Result ReportMedicine

Changes in female sexual function during the retirement transition.

Virkkunen V, Kero K, Stenholm S et al. · 2026 · Menopause (New York, N.Y.)

Objectives For many women, retirement represents a significant transition in late adulthood, which may result in many alterations in lifestyle habits and behavioral patterns. Several factors known to improve during the retirement…

View details →DOI: 10.1097/gme.0000000000002778
Negative / Null Result ReportMedicine

Preoperative computed tomography findings of chest wall or mediastinal invasion in pulmonary metastases among children, adolescents, and young adults.

Shirane K, Kitagawa N, Morishima R et al. · 2026 · Journal of pediatric surgery

Background Pulmonary metastasectomy can improve the survival of children with pulmonary metastases from solid tumors. However, preoperative imaging often suggests chest wall and/or mediastinal invasion, raising concerns about…

View details →DOI: 10.1016/j.jpedsurg.2026.163183
Negative / Null Result ReportMedicine

Clinical outcomes and prognostic factors in hematologic malignancy patients with probable CMV pneumonia.

Aydın Güçlü Ö, Demirdöğen E, Hunutlu FÇ et al. · 2026 · BMC infectious diseases

Background Cytomegalovirus (CMV) infection is an important cause of morbidity and mortality among immunocompromised patients, particularly those with hematologic malignancies. The present study aims to evaluate the clinical features,…

View details →DOI: 10.1186/s12879-026-13708-6
Negative / Null Result ReportMedicine

Methylprednisolone Taper After Total Knee Arthroplasty: A Prospective Single-Blinded Randomized Trial.

Premkumar A, Arellano E, Heo KY et al. · 2026 · The Journal of arthroplasty

Background The use of short-term postoperative corticosteroid regimens has been reported to improve pain control and decrease opioid consumption following total knee arthroplasty (TKA). The purpose of this study was to evaluate the effect…

View details →DOI: 10.1016/j.arth.2026.04.076
Negative / Null Result ReportMedicine

Enhanced biomechanical outcomes of split-thickness skin grafts with a three-dimensional collagen-elastin matrix in deep second-degree burns: A 12-month comparative study.

Nicklas A, Bienger K, Rudari M et al. · 2026 · Burns : journal of the International Society for Burn Injuries

Background Split-thickness skin grafting (STSG) remains the standard for deep second-degree burns, but grafted skin often shows suboptimal biomechanical properties. The dermal substitute MatriDerm® may improve elasticity, structural…

View details →DOI: 10.1016/j.burns.2026.107977
Negative / Null Result ReportMedicine

Robot-Assisted TKA for Varus Knees: Post Hoc Exploratory Analysis of Alignment Strategy and Deformity Severity.

Lychagin AV, Gritsyuk AA, Elizarov MP et al. · 2026 · Journal of clinical medicine

Background: Robot-assisted total knee arthroplasty (raTKA) improves the precision of component positioning and coronal alignment restoration, but it remains uncertain whether that technical accuracy modifies the clinical effect of…

View details →DOI: 10.3390/jcm15124515