466 results in Negative / Null Result Report for "randomized controlled trial" · page 3 of 16
Negative / Null Result ReportOpen accessMedicine
Junichi Kitagawa, Ryo Kobayashi, Yasuyuki Nagata et al. · 2020 · International Journal of Cancer
Oral mucositis is a common and distressing complication in patients receiving high-dose chemotherapy followed by hematopoietic stem cell transplantation (HSCT). We reported previously in a single-center retrospective analysis that…
View details →DOI: 10.1002/ijc.33316Cited by 15 Negative / Null Result Report
Heather M. Wasser, Amanda L. Thompson, Chirayath M. Suchindran et al. · 2020 · BMC Pediatrics
Abstract Background Non-Hispanic black (NHB) infants are twice as likely as non-Hispanic white infants to experience rapid weight gain in the first 6 months, yet few trials have targeted this population. The current study tests the…
View details →DOI: 10.1186/s12887-020-02273-9Cited by 15 Negative / Null Result ReportMedicine
Geri R. Donenberg, Jessica Fitts, Charles Ingabire et al. · 2022 · JAIDS Journal of Acquired Immune Deficiency Syndromes
Background: Adolescents living with HIV have elevated mental distress and suboptimal antiretroviral therapy (ART) adherence. Setting: Two urban clinics in Kigali, Rwanda. Methods: A 2-arm individual randomized controlled trial compared…
View details →DOI: 10.1097/qai.0000000000002911Cited by 15 Negative / Null Result ReportOpen accessPsychology
Yvonne Stikkelbroek, Gerko Vink, Maaike H. Nauta et al. · 2020 · Scientific Reports
We examined if manualized cognitive behavioral therapy (CBT) was more effective than Treatment As Usual (TAU) for clinically depressed adolescents within routine care. This multisite Randomized controlled trail included 88 clinically depressed adolescents (aged 12-21 years) randomly assigned to CBT or TAU. Multiple assessments (pre-, post treatment and six-month follow-up) were done using semi-structured interviews, questionnaires and ratings and multiple informants. The primary outcome was depressive or dysthymic disorder based on the KSADS. Completers, CBT (n = 19) and TAU (n = 26), showed a
View details →DOI: 10.1038/s41598-020-71160-1Cited by 14 Negative / Null Result ReportOpen accessMedicine
Ryota Nishio, Tomotaka Dohi, Miho Yokoyama et al. · 2025 · JMIR mhealth and uhealth
Background: Cardiac rehabilitation (CR) is effective in preventing cardiovascular diseases; however, participation in CR programs remains limited due to the associated challenges. The integration of wearable devices and real-time monitoring offers a potential solution to enhance adherence to remote CR programs and their outcomes. Objective: This study aimed to evaluate the efficacy of a remote CR program using wearable devices and real-time monitoring with or without online coaching (OLC) in improving exercise capacity in patients with coronary artery disease (CAD). Methods: We enrolled 50 pat
View details →DOI: 10.2196/63797Cited by 13 Negative / Null Result Report
Martin S. Davey, Eoghan T. Hurley, Tom R. Doyle et al. · 2022 · The American Journal of Sports Medicine
Background: Debate centering on the management of anterior shoulder instability (ASI) in recent years has led to many randomized controlled trials (RCTs) being published on the topic. The fragility index (FI) has subsequently emerged as a…
View details →DOI: 10.1177/03635465221077268Cited by 13 Negative / Null Result ReportOpen accessSocial Sciences
Kate Ambler, Kelly Jones, Michael O’Sullivan · 2025 · Journal of Development Economics
We conduct a randomized controlled trial to test a novel intervention for increasing women’s empowerment in Uganda. The intervention includes a within-household transfer of a productive asset, which has a lower cost than an external…
View details →DOI: 10.1016/j.jdeveco.2025.103575Cited by 13 Negative / Null Result ReportOpen accessPsychology
Amy D. Herschell, David J. Kolko, Ashley T. Scudder et al. · 2021 · Journal of Clinical Child & Adolescent Psychology
OBJECTIVE: This study (NIMH RO1 MH095750; ClinicalTrials.gov Identifier: NCT02543359) evaluated the effectiveness of three training models to implement a well-established evidence-based treatment, Parent-Child Interaction Therapy (PCIT).…
View details →DOI: 10.1080/15374416.2021.2001745Cited by 13 Negative / Null Result ReportMedicine
Andrew Goudie, Douglas H.J. Elder, Harshal Deshmukh et al. · 2014 · European Journal of Heart Failure
BACKGROUND: The use of oral anticoagulation in patients with heart failure in sinus rhythm remains controversial as previous large randomized controlled trials (RCTs) have not shown a survival benefit. However, heterogeneity exists among…
View details →DOI: 10.1002/ejhf.199Cited by 10 Negative / Null Result ReportOpen accessImmunology and Microbiology
Shih-Hong Chen, Wing-Sum Chan, Chih‐Min Liu et al. · 2020 · Annals of Intensive Care
Abstract Background Endotoxins can induce an excessive inflammatory response and result in microcirculatory dysfunction. Polymyxin-B hemoperfusion (PMX-HP) has been recognized to effectively remove endotoxins in patients with sepsis and…
View details →DOI: 10.1186/s13613-020-00699-zCited by 10 Negative / Null Result ReportOpen accessMedicine
Jack W. O’Sullivan, Anil Palepu, Khaled Saab et al. · 2026 · Nature Medicine
The scarcity of subspecialist medical expertise poses a considerable challenge for healthcare delivery. This issue is particularly acute in cardiology, where timely, accurate management determines outcomes. We explored the potential of Articulate Medical Intelligence Explorer (AMIE), a large language model-based experimental medical artificial intelligence system, to augment clinical decision-making in this challenging context. We conducted a randomized controlled trial comparing large language model-assisted care with the usual care of complex patients suspected of having a genetic cardiomyop
View details →DOI: 10.1038/s41591-025-04190-9Cited by 10 Negative / Null Result ReportOpen accessMedicine
Geri R. Donenberg, Jessica Fitts, Charles Ingabire et al. · 2022 · PubMed
BACKGROUND: Adolescents living with HIV have elevated mental distress and suboptimal antiretroviral therapy (ART) adherence. SETTING: Two urban clinics in Kigali, Rwanda. METHODS: A 2-arm individual randomized controlled trial compared…
View details →DOI: 10.1097/qai.0000000000002911Cited by 10 Negative / Null Result ReportOpen accessMedicine
Mahima Chillakanti, Elaine Young, April Hopcroft et al. · 2024 · touchREVIEWS in Endocrinology
AID systems can achieve near-desired glycaemic targets with minimal hypoglycaemia in pregnant women with T1D. Randomized controlled trials are needed to confirm these findings and to win FDA indications in pregnancy.
View details →DOI: 10.17925/ee.2024.20.2.14Cited by 10 Negative / Null Result Report
Wei Tang, Yuwei Qiu, Huijie Lu et al. · 2021 · Frontiers in Surgery
Study Objective: This study aimed to investigate whether stroke volume variation (SVV)-guided goal-directed therapy (GDT) can improve postoperative outcomes in elderly patients undergoing minimally invasive esophagectomy (MIE) compared…
View details →DOI: 10.3389/fsurg.2021.794272Cited by 9 Negative / Null Result ReportOpen accessMedicine
Corey A. Lester, Brigid Rowell, Yifan Zheng et al. · 2025 · JMIR Medical Informatics
Background: Artificial intelligence (AI)-based clinical decision support systems are increasingly used in health care. Uncertainty-aware AI presents the model's confidence in its decision alongside its prediction, whereas black-box AI only provides a prediction. Little is known about how this type of AI affects health care providers' work performance and reaction time. Objective: This study aimed to determine the effects of black-box and uncertainty-aware AI advice on pharmacist decision-making and reaction time. Methods: Recruitment emails were sent to pharmacists through professional listser
View details →DOI: 10.2196/64902Cited by 9 Negative / Null Result ReportOpen accessMedicine
Maria Dalamaga, Rodopi Emfietzoglou, Dimitra Petropoulou et al. · 2026 · Current Nutrition Reports
PURPOSE OF REVIEW: Vitamin D is a pleiotropic hormone with an established role in skeletal integrity and broader actions in immune regulation, inflammation, cellular proliferation, and energy homeostasis. Despite decades of research, its extra-skeletal effects remain controversial, largely due to discordant findings across observational studies, Mendelian randomization studies (MRS), and randomized controlled trials (RCTs). Unlike many prior reviews, this state-of-the-art review synthesizes triangulated evidence across these study designs to clarify outcome-specific causal relationships and on
View details →DOI: 10.1007/s13668-026-00748-2Cited by 9 Negative / Null Result ReportOpen accessComputer Science
Michael Vaccaro, Mikayla Friday, Arash E. Zaghi · 2025 · Applied Sciences
Multi-agent large language models promise flexible, modular architectures for delivering personalized educational content. Drawing on a pilot randomized controlled trial with middle school students (n = 23), we introduce a two-agent GPT-4 framework in which a Profiler agent infers learner-specific preferences and a Rewrite agent dynamically adapts science passages via an explicit message-passing protocol. We implement structured system and user prompts as inter-agent communication schemas to enable real-time content adaptation. The results of an ordinal logistic regression analysis hinted that
View details →DOI: 10.3390/app15137579Cited by 9 Negative / Null Result ReportOpen accessPsychology
Pim Cuijpers, Mathias Harrer, Clara Miguel et al. · 2026 · Journal of Affective Disorders
It is not yet clear whether baseline severity is associated with the effects of psychotherapies. We examined baseline severity at the study level in a large sample of randomized controlled trials comparing psychotherapies against a control condition for the treatment of depression. We used an existing large database of randomized trials comparing psychotherapies for depression with control groups ( www.metapsy.org ). We converted baseline severity scores across different depression measures into a common metric. We ran bivariable and multivariable meta-regression analyses to examine the associ
View details →DOI: 10.1016/j.jad.2025.121106Cited by 9 Negative / Null Result ReportOpen accessMathematics
Ezequiel Mauro, Tiago de Castro, Marcus Zeitlhoefler et al. · 2025 · Journal of Hepatology
BACKGROUND & AIMS: Non-proportional hazards (NPH) can lead to discrepancies between interim (IA) and final analyses (FA) in randomized controlled trials (RCTs) of hepatocellular carcinoma (HCC). We assessed the impact of NPH in pivotal HCC…
View details →DOI: 10.1016/j.jhep.2025.08.042Cited by 9 Negative / Null Result ReportOpen accessMedicine
Dinh Van Trung, Bui Thi Huong Giang, Đang Quoc Tuan et al. · 2025 · Scientific Reports
Electrical impedance tomography (EIT)-guided positive end-expiratory pressure (PEEP) titration may optimize ventilation and reduce ventilator-induced lung injury in acute respiratory distress syndrome (ARDS). We compared EIT-guided PEEP…
View details →DOI: 10.1038/s41598-025-29787-5Cited by 9 Negative / Null Result Report
Trent Cross, Lynne Bartlett, Chrispen Mushaya et al. · 2012 · International Surgery
Abstract Medications, including topical 0.2% glyceryl trinitrate (GTN), can reduce anal spasm and pain after excisional hemorrhoidectomy. GTN after stapled hemorrhoidopexy was compared with routine postoperative management. Patients with…
View details →DOI: 10.9738/cc92.1Cited by 8 Negative / Null Result Report
Hyunjae Jeon, Sean Krysak, Steven J. Pfeiffer et al. · 2022 · International Journal of Athletic Therapy and Training
Second anterior cruciate ligament (ACL) injury has similar biomechanical risk factors as primary injury. Standard of care rehabilitation does not adequately mitigate these biomechanical risks. This study examined the effectiveness of a…
View details →DOI: 10.1123/ijatt.2020-0072Cited by 5 Negative / Null Result Report
Hammad Sadiq, Sanjeev Rampam, Jay Patel et al. · 2022 · Medicine
Objectives: To assess the impact of a preoperative walking intervention on improving postoperative recovery in at-risk frail older adult patients. Study Type: Unblinded, randomized controlled trial which assigned patients to intervention…
View details →DOI: 10.1097/md.0000000000030689Cited by 3 Negative / Null Result Report
Yoshihiko Saito, Sadanori Okada, Hisao Ogawa et al. · 2016 · Circulation
Introduction: It takes long time to conclude efficacy and safety of an intervention on primary prevention of cardiovascular events. Up to date, there is no study to investigate the effect of the low-dose aspirin therapy on primary…
View details →DOI: 10.1161/circ.134.suppl_1.13428 Negative / Null Result Report
Daniel I. Rhon, Tina A. Greenlee, Rachel Mayhew et al. · 2022 · Journal of the American Academy of Orthopaedic Surgeons
Introduction: After elective orthopaedic surgery, many individuals go on to become long-term opioid users. Mitigating this risk has become a priority for surgeons, other members of the medical care team, and healthcare systems. The purpose…
View details →DOI: 10.5435/jaaos-d-21-00603 Negative / Null Result Report
Claire M. Douglas, Marnie Newell, Susan Goruk et al. · 2025 · PLOS One
Supplementation of omega-3 (n-3) polyunsaturated fatty acids has been associated with reduced side effects and improved quality of life (QoL) in breast cancer patients receiving chemotherapy. The current study reports secondary outcomes…
View details →DOI: 10.1371/journal.pone.0322178 Negative / Null Result ReportMedicine
Erdoğan, Ayaz-Alkaya · 2026 · Nurse education in practice
To evaluate the effect of crossword puzzle activities on nursing students' willingness to work with older adults and their competence in gerontological nursing. Although crossword puzzles are widely used learning tools, their effects in…
View details →DOI: 10.1016/j.nepr.2026.104844 Negative / Null Result ReportMedicine
Wang, Li, Zhang et al. · 2026 · Child development
This study examines how center-based parenting interventions aimed at improving early child development in rural China affect the mental health of caregivers. Data from an analytic sample of 615 caregiver-child dyads (children aged 6 to 24…
View details →DOI: 10.1093/chidev/aacag099 Negative / Null Result ReportMedicine
van Keulen, Voogt, Kleinjan et al. · 2026 · JMIR mHealth and uHealth
Excessive alcohol consumption among adolescents and young adults is a serious health problem. Dynamically tailored interventions could reduce their excessive drinking. We therefore developed "What Do You Drink" (WDYD), a 17-week…
View details →DOI: 10.2196/68468 Negative / Null Result ReportMedicine
Le, Chotikkakamthorn, Kasetsuwan et al. · 2026 · Clinical ophthalmology (Auckland, N.Z.)
This study aims to compare the effect of meibomian gland expression (MGX) combined with lid hygiene versus lid hygiene alone on the meibomian gland's morphology and function for obstructive meibomian gland dysfunction (oMGD). In this…
View details →DOI: 10.2147/opth.s607078 