Negative / Null Result ReportOpen accessGeriatrics
Veronika Keppner, Sebastian Krumpoch, Robert Kob et al. · 2023 · BMC Geriatrics
Abstract Background The risk of older adults being injured or killed in a bicycle accident increases significantly due to the age-related decline of physical function. Therefore, targeted interventions for older adults to improve safe cycling competence (CC) are urgently needed. Methods The “Safer Cycling in Older Age” (SiFAr) randomized controlled trial investigated if a progressive multi-component training program related to cycling improves CC of older adults. Between June 2020 and May 2022, 127 community-dwelling persons living in the area Nürnberg-Fürth-Erlangen, Germany aged 65 years and
View details →DOI: 10.1186/s12877-023-03816-2 Negative / Null Result ReportOpen accessEducation (General)
Rahmah Johar, Rahmah Johar, M. Ikhsan et al. · 2025 · Frontiers in Education
Mathematical communication skills are essential for helping students grasp mathematical concepts. Fostering students’ knowledge of Islamic values can also encourage them to relate mathematical topics to real-world situations, particularly in worship, enhancing their mathematical communication. Therefore, an innovative teaching approach is crucial to improving students’ mathematical communication and understanding of Islamic values. This study investigates the integration of these concepts within mathematics through the contextualized framework of Qurban. The study explores how an interactive w
View details →DOI: 10.3389/feduc.2025.1633056 Negative / Null Result Report
Mary Cushman, Suzanne E Judd, Virginia J Howard et al. · 2011 · Circulation
Background. The AHA 2020 Goal includes improving cardiovascular health, defined using a metric consisting of 7 health factors, Life's Simple 7. A central concept of the goal is that small improvements in behavior / lifestyle factors at the…
View details →DOI: 10.1161/circ.124.suppl_21.a17917 Negative / Null Result ReportOpen accessComputer Science
Niek Beckers, Edwin van Asseldonk, Herman van der Kooij · 2020 · arXiv
Haptic interaction between two humans, for example, a physiotherapist assisting a patient regaining the ability to grasp a cup, likely facilitates motor skill acquisition. Haptic human-human interaction has been shown to enhance individual performance improvement in a tracking task with a visuomotor rotation perturbation. These results are remarkable given that haptically assisting or guiding an individual rarely benefits their individual improvement when the assistance is removed. We, therefore, replicated a study that reported that haptic interaction between humans was beneficial for individ
Negative / Null Result ReportOpen accessComputer Science
Runtian Zhai, Chen Dan, Zico Kolter et al. · 2022 · arXiv
Empirical risk minimization (ERM) is known in practice to be non-robust to distributional shift where the training and the test distributions are different. A suite of approaches, such as importance weighting, and variants of distributionally robust optimization (DRO), have been proposed to solve this problem. But a line of recent work has empirically shown that these approaches do not significantly improve over ERM in real applications with distribution shift. The goal of this work is to obtain a comprehensive theoretical understanding of this intriguing phenomenon. We first posit the class o
Negative / Null Result ReportOpen accessMedicine
Lin C, Mei YM, Yan Y et al. · 2026 · Head & face medicine
AIM: To evaluate the adjunctive clinical efficacy of manual root planing following ultrasonic subgingival debridement (SD) in the treatment of generalized severe periodontitis. MATERIAL AND METHODS: Twenty-nine patients diagnosed with…
View details →DOI: 10.1186/s13005-026-00622-0 Negative / Null Result Report
Ainun Oktavia Sari, Rahayu Sulistyowati, Ita Prihantika · 2020 · Administrativa: Jurnal Birokrasi, Kebijakan dan Pelayanan Publik
The Conditional Cash Transfer (CCT) is a conditional social cash transfer program that provides assistance to Very Poor Households (RTSM) appointed as participants in the Conditional Cash Transfer program which is related to improving the…
View details →DOI: 10.23960/administrativa.v2i3.51 Negative / Null Result ReportOpen accessDiseases of the blood and blood-forming organs
Edvan de Queiroz Crusoe, Fabiana Higashi, Maria Paula Nalesso Camargo Padilha et al. · 2014 · Revista Brasileira de Hematologia e Hemoterapia
Background: Induction therapy followed by high-dose chemotherapy and autologous transplantation is the standard treatment for suitable patients with multiple myeloma. Objective: The aim of this study was to assess whether induction therapy with thalidomidecontaining regimens was associated with improved results compared to vincristine, doxorubicin, and dexamethasone, and whether cyclophosphamide, thalidomide, and dexamethasone were associated with better results than thalidomide and dexamethasone. Methods: The records of 152 patients who underwent autologous transplantation at this institution
View details →DOI: 10.5581/1516-8484.20140008 Negative / Null Result ReportOpen accessSurgery
Eiji Nomura, Takatoshi Seki, Kentaro Yatabe et al. · 2024 · World Journal of Surgical Oncology
Abstract Background Elderly gastric cancer patients (EGCPs) require treatment according to not just the stage of their cancer, but also to their general condition and organ function, and rather than full treatment, the appropriate amount of treatment is necessary. Methods A total of 425 patients who underwent gastrectomy for primary gastric cancer in our institution between April 2013 and March 2020 were classified by age into two groups: elderly patients (EP, age ≥ 80 years, n = 89); and younger patients (YP, age < 80 years, n = 336). The preoperative, intraoperative, and postoperative condit
View details →DOI: 10.1186/s12957-024-03488-1 Negative / Null Result ReportOpen accessDiseases of the digestive system. Gastroenterology
Olga Maria Nardone, Giulio Calabrese, Alessia La Mantia et al. · 2025 · Therapeutic Advances in Gastroenterology
Background: Managing extraintestinal manifestations (EIMs) in inflammatory bowel disease (IBD) patients remains challenging due to considerable heterogeneity in diagnostic criteria and the lack of a standardised definition and validated diagnostic pathways. Delays in recognising and treating EIMs can lead to significant disease progression. Therefore, early detection and treatment are crucial. Objectives: We aimed to assess the effectiveness of a dedicated immune-mediated inflammatory diseases (IMIDs) clinic in reducing EIM diagnostic delays and improving patients’ outcomes. Design: A single-c
View details →DOI: 10.1177/17562848251323529 Negative / Null Result ReportOpen accessMathematics
Mark Rubin · 2020 · arXiv
Preregistration entails researchers registering their planned research hypotheses, methods, and analyses in a time-stamped document before they undertake their data collection and analyses. This document is then made available with the published research report to allow readers to identify discrepancies between what the researchers originally planned to do and what they actually ended up doing. This historical transparency is supposed to facilitate judgments about the credibility of the research findings. The present article provides a critical review of 17 of the reasons behind this argument.
Negative / Null Result ReportOpen accessOrthopedic surgery
Michał Maciejewski, Piotr Janusz, Michalina Dudkiewicz et al. · 2023 · Chirurgia Narządów Ruchu i Ortopedia Polska
Introduction. Radial neck fractures in children are rare and account for 1-3% of all childhood trauma. Severe displacement of the fracture can lead to a higher incidence of complications, such as limited range of motion (ROM), pain, instability, neurovascular trauma, premature physeal closure, cubitus valgus, radial head overgrowth, avascular necrosis and improper ossification. The treatment outcome depends on the injury type, treatment method and presence of complications.Aim. The purpose of the study was to assess the outcome of patients treated with elastic-stable intramedullary nailing (ES
View details →DOI: 10.31139/chnriop.2023.88.3.4 Negative / Null Result ReportOpen accessComputer Science
Alex Ayoub, Samuel Robertson, Dawen Liang et al. · 2025 · arXiv
Matrix factorization is a widely used approach for top-N recommendation and collaborative filtering. When implemented on implicit feedback data (such as clicks), a common heuristic is to upweight the observed interactions. This strategy has been shown to improve performance for certain algorithms. In this paper, we conduct a systematic study of various weighting schemes and matrix factorization algorithms. Somewhat surprisingly, we find that training with unweighted data can perform comparably to, and sometimes outperform, training with weighted data, especially for large models. This observat
Negative / Null Result ReportOpen accessSurgery
Samah Abdelfatah Eshiaty, Shimaa Abdelsattar, Dina Sweed et al. · 2023 · Egyptian Liver Journal
Abstract Background Early detection of biliary atresia (BA) is a great challenge providing the main useful way to improve its clinical consequence. Promising metabolomics provides an effective method for determining innovative biomarkers and biochemical ways for improving early diagnosis. This study aimed to determine the benefit of serum and urinary potential bile acid metabolites in the differentiation of BA from non-biliary atresia (non-BA) cases using tandem mass spectrometry (MS/MS). Fourteen bile acids metabolites were measured quantitively by MS/MS in serum and urine samples from 102 ch
View details →DOI: 10.1186/s43066-023-00244-0 Negative / Null Result ReportOpen accessMathematics
Andrea Schioppa · 2015 · arXiv
For each $β>1$ we construct a family $F_β$ of metric measure spaces which is closed under the operation of taking weak-tangents (i.e.~blow-ups), and such that each element of $F_β$ admits a $(1,P)$-Poincaré inequality if and only if $P>β$.
Negative / Null Result ReportOpen accessScience
Hans IJzerman, Jaap J. A. Denissen · 2019 · Royal Society Open Science
We report a replication and extension of a finding from Studies 1 and 2 of Van Lange et al.'s influential paper (Van Lange et al. 1997 J. Pers. Soc. Psychol. 73, 733–746. (doi:10.1037/0022-3514.73.4.733)), which showed an association between Social Value Orientation (SVO) and attachment security. We report a close replication but with measures of attachment that are considered superior in comparison to measures used by Van Lange et al., due to subsequent psychometric improvements. Psychometric analyses indeed showed that our attachment measures were reliable and valid, demonstrating theoretica
View details →DOI: 10.1098/rsos.181575 Negative / Null Result ReportOpen accessMedicine (General)
Martins MJ, Martins CPMO, Castro-Alves LJ et al. · 2018 · Journal of Pain Research
Marcelo J Martins,1 Caroline Paiva Matos Oliveira Martins,2 Lucas J Castro-Alves,3 Gabriel Nascimento Jesus,4 Guilherme Oliveira Campos,5 Breno Barbosa Cerqueira Sacramento,4 Leonardo Ferrari Borges,6 Carlos Augusto Bastos Mello,6 Rodrigo Leal Alves,5 Norma Sueli Pinheiro Módolo7 1Department of Anesthesiology, São Paulo State University (UNESP), São Paulo, Brazil; 2Department of Anesthesiology at Federal University of Bahia, Bahia, Brazil; 3Department of Anesthesiology, Santo Antonio Hospital, Salvador, Bahia, Brazil; 4Department of Anesthesia, Bahia University of Medicine
Negative / Null Result ReportOpen accessMedicine (General)
Madeleine M. Southey, Trent Rees, Margaret Rolfe et al. · 2019 · Addiction Science & Clinical Practice
Abstract Background Residential opioid rehabilitation aims to improve the mental health and quality of life of opioid users through abstinence and residential program participation. This study aimed to determine the depression, anxiety, stress and quality of life amongst maintenance to abstinence (MTA) program residents. Secondary study aims were to assess the personal characteristics of MTA clients, addiction and risk taking behaviours, factors associated with program completion, as well as to assess the reliable change in participants’ mental health and quality of life on exit. Methods Retro
View details →DOI: 10.1186/s13722-019-0132-x Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Ian Crawford, Carl-Emil Pless · 2026 · arXiv
We study the associations between everyday economic decision-making quality and people's emotional states. Using high-frequency, highly disaggregated consumer "scanner" data, we show that the cost of poor decision-making is substantial, on average equal to around half of day-to-day consumption budgets. While material circumstances help explain decision-making quality, how people feel about those circumstances is equally important. Contrary to evidence that stress and worry impair performance in settings where distraction is costly, we find these same feelings are associated with improved decis
Abandoned Hypothesis
Julia Casañas Cast · 2020 · Royal Conservatoire Research Portal
Many classical musicians can suffer from tension and nervousness during solo performance. This research looks at how practicing improvisation and creative body movement, as well as creating one’s own performance together with a dancer, can…
View details →DOI: 10.22501/koncon.792184 Negative / Null Result Report
Bahadır Kartal, Mehmet Berksun Tutan, Fatih Şahin et al. · 2024 · Hitit Medical Journal
Objective: Gastric cancer surgery, including curative and palliative procedures, is crucial for managing gastric cancer. Accurate assessment of nutritional status is essential for risk stratification and improving patient outcomes. This…
View details →DOI: 10.52827/hititmedj.1516777 Negative / Null Result ReportOpen accessVeterinary medicine
ali kargarirezapour, somayye ghobadi, afshin zakeri · 2013 · Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī
Glucans derived from yeast cell wall are promising alternatives to antibiotics, as they have been shown to improve growth performance and stimulate the immune system of immature broilers. In this study we evaluated the effect of different levels of yeast beta-glucan (YBG) on some blood parametrs of broiler chickens. In a factorial experiment based on completely randomized design (the first factor: YBG levels: 0, 0.04 and 0.08% of basal diet and sex as a second factor) 144 day old chicks (72 male and 72 female) were selected and allocated to different treatments (three replicates of each treatm
Negative / Null Result ReportOpen accessComputer Science
Paul K. Mandal · 2025 · arXiv
In this paper, I investigate the effectiveness of dataset cartography for extractive question answering on the SQuAD dataset. I begin by analyzing annotation artifacts in SQuAD and evaluate the impact of two adversarial datasets, AddSent and AddOneSent, on an ELECTRA-small model. Using training dynamics, I partition SQuAD into easy-to-learn, ambiguous, and hard-to-learn subsets. I then compare the performance of models trained on these subsets to those trained on randomly selected samples of equal size. Results show that training on cartography-based subsets does not improve generalization to
Negative / Null Result ReportOpen accessSports medicine
Alison Bulow, Judith E Anderson, Jeff R S Leiter et al. · 2021 · International Journal of Sports Physical Therapy
# Background Adolescent females are at much greater risk for ACL injury than their male counterparts when participating in the same sports. Preventative and pre-operative rehabilitation neuromuscular (NM) exercise programs are often recommended to improve knee function and reduce injury rates. The effectiveness of perturbation-based NM training program has been established in an adult population but has yet to be investigated in the at-risk adolescent female population. # Purpose To determine the effectiveness of a perturbation-based NM exercise program in a group of physically active adolesce
View details →DOI: 10.26603/001c.25685 Negative / Null Result ReportOpen accessMathematics
Mark Rubin · 2024 · arXiv
One justification for preregistering research hypotheses, methods, and analyses is that it improves the transparent evaluation of the severity of hypothesis tests. In this article, I consider two cases in which preregistration does not improve this evaluation. First, I argue that, although preregistration may facilitate the transparent evaluation of severity in Mayo's error statistical philosophy of science, it does not facilitate this evaluation in Popper's theory-centric approach. To illustrate, I show that associated concerns about Type I error rate inflation are only relevant in the error
Negative / Null Result ReportOpen accessSurgery
Eric R. Bain, Bistees George, Syed H. Jafri et al. · 2024 · Journal of Cardiothoracic Surgery
Abstract Background Patients with severe aortic stenosis (AS) and left ventricular (LV) dysfunction demonstrate improvement in left ventricular injection fraction (LVEF) after aortic valve replacement (AVR). The timing and magnitude of recovery in patients with very low LVEF (≤ 25%) in surgical or transcatheter AVR is not well studied. Objective Determine clinical outcomes following transcatheter aortic valve replacement (TAVR) and surgical aortic valve repair (SAVR) in the subset of patients with severely reduced EF ≤ 25%. Methods Single-center, retrospective study with primary endpoint of LV
View details →DOI: 10.1186/s13019-024-02724-9 Negative / Null Result ReportOpen accessComputer Science
Ab Mosca, Alvitta Ottley, Remco Chang · 2021 · arXiv
Interaction enables users to navigate large amounts of data effectively, supports cognitive processing, and increases data representation methods. However, there have been few attempts to empirically demonstrate whether adding interaction to a static visualization improves its function beyond popular beliefs. In this paper, we address this gap. We use a classic Bayesian reasoning task as a testbed for evaluating whether allowing users to interact with a static visualization can improve their reasoning. Through two crowdsourced studies, we show that adding interaction to a static Bayesian reaso
Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Yea Eun Kang, Sorim Choung, Ju Hee Lee et al. · 2017 · Endocrinology and Metabolism
BackgroundSlit2 is a new secreted protein from adipose tissue that improves glucose hemostasis in mice; however, there is no study about the serum levels and precise role of Slit2 in human. The aim of this study is to explore the serum level of Slit2 in human, and to identify the role of Slit2 in diabetes mellitus (DM).MethodsThe participants of this study consist of 38 subjects with newly diagnosed DM, and 75 healthy subjects as a control group. Serum Slit2 levels were measured using an enzyme-linked immunosorbent assay. Relationship between circulating Slit2 and diabetic related factors was
View details →DOI: 10.3803/enm.2017.32.3.383 Negative / Null Result ReportOpen accessComputer Science
Joris Dannemann, Gero Junike · 2025 · arXiv
Batch normalization is one of the most important regularization techniques for neural networks, significantly improving training by centering the layers of the neural network. There have been several attempts to provide a theoretical justification for batch ormalization. Santurkar and Tsipras (2018) [How does batch normalization help optimization? Advances in neural information rocessing systems, 31] claim that batch normalization improves initialization. We provide a counterexample showing that this claim s not true, i.e., batch normalization does not improve initialization.
Negative / Null Result ReportOpen accessComputer Science
Cheng Tang, Andrew Arnold · 2020 · arXiv
Recently, Nogueira et al. [2019] proposed a new approach to document expansion based on a neural Seq2Seq model, showing significant improvement on short text retrieval task. However, this approach needs a large amount of in-domain training data. In this paper, we show that this neural document expansion approach can be effectively adapted to standard IR tasks, where labels are scarce and many long documents are present.
