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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

1896 results for "Mpro" · page 24 of 64

Negative / Null Result Report

Modified string test to improve and confirm by molecular characterization for bacterial identification

Muhammad Dawood Mian, Saadullah Jan Khan, Rehana Rani et al. · 2026 · Access Microbiology

Rapid and reliable identification of bacteria is essential in clinical and environmental microbiology. Gram staining remains a widely used method for preliminary classification; however, it may require additional steps and can be difficult…

View details →DOI: 10.1099/acmi.0.000965.v3
Negative / Null Result ReportOpen accessComputer Science

CroCo: Cross-Lingual Contrastive Preference Tuning on Self-Generations

Mike Zhang, Ali Basirat, Desmond Elliott · 2026 · arXiv

Prior work establishes that controlled contrastiveness between self-generated responses from large language models, set via reward scores, improves downstream preference tuning in English. We extend this method to multiple languages and evaluate two models across a total of 14 high and low-resource languages on a diverse set of tasks. Our central finding is that cross-lingual contrastive preference tuning on self-generations (CroCo) transfers without language-specific preference annotation. A reward model trained on English preferences (atop a multilingual base) produces useful within-language

Negative / Null Result ReportOpen accessComputer Science

Improving Policy Optimization with Generalist-Specialist Learning

Zhiwei Jia, Xuanlin Li, Zhan Ling et al. · 2022 · arXiv

Generalization in deep reinforcement learning over unseen environment variations usually requires policy learning over a large set of diverse training variations. We empirically observe that an agent trained on many variations (a generalist) tends to learn faster at the beginning, yet its performance plateaus at a less optimal level for a long time. In contrast, an agent trained only on a few variations (a specialist) can often achieve high returns under a limited computational budget. To have the best of both worlds, we propose a novel generalist-specialist training framework. Specifically, w

Negative / Null Result ReportOpen accessComputer Science

Robustness to Spurious Correlations Improves Semantic Out-of-Distribution Detection

Lily H. Zhang, Rajesh Ranganath · 2023 · arXiv

Methods which utilize the outputs or feature representations of predictive models have emerged as promising approaches for out-of-distribution (OOD) detection of image inputs. However, these methods struggle to detect OOD inputs that share nuisance values (e.g. background) with in-distribution inputs. The detection of shared-nuisance out-of-distribution (SN-OOD) inputs is particularly relevant in real-world applications, as anomalies and in-distribution inputs tend to be captured in the same settings during deployment. In this work, we provide a possible explanation for SN-OOD detection failur

Negative / Null Result Report

Abstract 17917: Is Small Change Significant? Association of Small Differences in Life's Simple 7 and Mortality: the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Cohort

Mary Cushman, Suzanne E Judd, Virginia J Howard et al. · 2011 · Circulation

Background. The AHA 2020 Goal includes improving cardiovascular health, defined using a metric consisting of 7 health factors, Life's Simple 7. A central concept of the goal is that small improvements in behavior / lifestyle factors at the…

View details →DOI: 10.1161/circ.124.suppl_21.a17917
Negative / Null Result ReportOpen accessMathematics

Forecasting Multivariate Time Series under Predictive Heterogeneity: A Validation-Driven Clustering Framework

Ziling Ma, Ángel López Oriona, Hernando Ombao et al. · 2026 · arXiv

We study adaptive pooling under predictive heterogeneity in high-dimensional multivariate time series forecasting, where global models improve statistical efficiency but may fail to capture heterogeneous predictive structure, while naive specialization can induce negative transfer. We formulate adaptive pooling as a statistical decision problem and propose a validation-driven framework that determines when and how specialization should be applied. Rather than grouping series based on representation similarity, we define partitions through out-of-sample predictive performance, thereby aligning

Negative / Null Result ReportOpen accessComputer Science

Haptic human-human interaction does not improve individual visuomotor adaptation

Niek Beckers, Edwin van Asseldonk, Herman van der Kooij · 2020 · arXiv

Haptic interaction between two humans, for example, a physiotherapist assisting a patient regaining the ability to grasp a cup, likely facilitates motor skill acquisition. Haptic human-human interaction has been shown to enhance individual performance improvement in a tracking task with a visuomotor rotation perturbation. These results are remarkable given that haptically assisting or guiding an individual rarely benefits their individual improvement when the assistance is removed. We, therefore, replicated a study that reported that haptic interaction between humans was beneficial for individ

Negative / Null Result ReportOpen accessComputer Science

Reinforcement Learning vs. Distillation: Understanding Accuracy and Capability in LLM Reasoning

Minwu Kim, Anubhav Shrestha, Safal Shrestha et al. · 2025 · arXiv

Recent studies have shown that reinforcement learning with verifiable rewards (RLVR) enhances overall accuracy (pass@1) but often fails to improve capability (pass@k) of LLMs in reasoning tasks, while distillation can improve both. In this paper, we investigate the mechanisms behind these phenomena. First, we demonstrate that RLVR struggles to improve capability as it focuses on improving the accuracy of the easier questions to the detriment of the accuracy of the most difficult questions. Second, we show that RLVR does not merely increase the success probability for the easier questions, but

Negative / Null Result ReportOpen accessComputer Science

Understanding Why Generalized Reweighting Does Not Improve Over ERM

Runtian Zhai, Chen Dan, Zico Kolter et al. · 2022 · arXiv

Empirical risk minimization (ERM) is known in practice to be non-robust to distributional shift where the training and the test distributions are different. A suite of approaches, such as importance weighting, and variants of distributionally robust optimization (DRO), have been proposed to solve this problem. But a line of recent work has empirically shown that these approaches do not significantly improve over ERM in real applications with distribution shift. The goal of this work is to obtain a comprehensive theoretical understanding of this intriguing phenomenon. We first posit the class o

Negative / Null Result ReportOpen accessEngineering

A Unified Approach to Enforce Non-Negativity Constraint in Neural Network Approximation for Optimal Voltage Regulation

Jiaqi Wu, Jingyi Yuan, Yang Weng et al. · 2025 · arXiv

Power system voltage regulation is crucial to maintain power quality while integrating intermittent renewable resources in distribution grids. However, the system model on the grid edge is often unknown, making it difficult to model physical equations for optimal control. Therefore, previous work proposes structured data-driven methods like input convex neural networks (ICNN) for "optimal" control without relying on a physical model. While ICNNs offer theoretical guarantees based on restrictive assumptions of non-negative neural network parameters, can one improve the approximation power with

Negative / Null Result ReportOpen accessEngineering

Learning-based Axial Video Motion Magnification

Kwon Byung-Ki, Oh Hyun-Bin, Kim Jun-Seong et al. · 2023 · arXiv

Video motion magnification amplifies invisible small motions to be perceptible, which provides humans with a spatially dense and holistic understanding of small motions in the scene of interest. This is based on the premise that magnifying small motions enhances the legibility of motions. In the real world, however, vibrating objects often possess convoluted systems that have complex natural frequencies, modes, and directions. Existing motion magnification often fails to improve legibility since the intricate motions still retain complex characteristics even after being magnified, which may di

Negative / Null Result Report

Dampak Sosial Ekonomi pada Keluaga Penerima Manfaat (KPM) Program Keluarga Harapan (PKH) Exit Mandiri di Kecamatan Pagelaran Kabuoaten Pringsewu dalam Perspektif The Most Significant Change Technique (MSCt)

Ainun Oktavia Sari, Rahayu Sulistyowati, Ita Prihantika · 2020 · Administrativa: Jurnal Birokrasi, Kebijakan dan Pelayanan Publik

The Conditional Cash Transfer (CCT) is a conditional social cash transfer program that provides assistance to Very Poor Households (RTSM) appointed as participants in the Conditional Cash Transfer program which is related to improving the…

View details →DOI: 10.23960/administrativa.v2i3.51
Negative / Null Result ReportOpen accessMathematics

Does preregistration improve the credibility of research findings?

Mark Rubin · 2020 · arXiv

Preregistration entails researchers registering their planned research hypotheses, methods, and analyses in a time-stamped document before they undertake their data collection and analyses. This document is then made available with the published research report to allow readers to identify discrepancies between what the researchers originally planned to do and what they actually ended up doing. This historical transparency is supposed to facilitate judgments about the credibility of the research findings. The present article provides a critical review of 17 of the reasons behind this argument.

Negative / Null Result ReportOpen accessComputer Science

Does Weighting Improve Matrix Factorization for Recommender Systems?

Alex Ayoub, Samuel Robertson, Dawen Liang et al. · 2025 · arXiv

Matrix factorization is a widely used approach for top-N recommendation and collaborative filtering. When implemented on implicit feedback data (such as clicks), a common heuristic is to upweight the observed interactions. This strategy has been shown to improve performance for certain algorithms. In this paper, we conduct a systematic study of various weighting schemes and matrix factorization algorithms. Somewhat surprisingly, we find that training with unweighted data can perform comparably to, and sometimes outperform, training with weighted data, especially for large models. This observat

Negative / Null Result ReportOpen accessMathematics

The Poincaré Inequality does not improve with blow-up

Andrea Schioppa · 2015 · arXiv

For each $β>1$ we construct a family $F_β$ of metric measure spaces which is closed under the operation of taking weak-tangents (i.e.~blow-ups), and such that each element of $F_β$ admits a $(1,P)$-Poincaré inequality if and only if $P>β$.

Negative / Null Result ReportMedicine

Alveolar socket preservation with human umbilical cord mesenchymal stem cell-seeded hydroxyapatite-chitosan scaffolds: An in vivo assessment of osteoprotegerin and receptor activator of nuclear factor-κB expression.

Alshaibani, Kamadjaja, Sitalaksmi et al. · 2026 · Journal of molecular histology

Tooth extraction is a common procedure often followed by alveolar bone resorption, which may compromise future implant placement, prosthetic rehabilitation, esthetics, and periodontal support. Hydroxyapatite-chitosan (HA-Chi) scaffolds…

View details →DOI: 10.1007/s10735-026-10874-4
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Does Anxiety Improve Economic Decision-Making?

Ian Crawford, Carl-Emil Pless · 2026 · arXiv

We study the associations between everyday economic decision-making quality and people's emotional states. Using high-frequency, highly disaggregated consumer "scanner" data, we show that the cost of poor decision-making is substantial, on average equal to around half of day-to-day consumption budgets. While material circumstances help explain decision-making quality, how people feel about those circumstances is equally important. Contrary to evidence that stress and worry impair performance in settings where distraction is costly, we find these same feelings are associated with improved decis

Abandoned Hypothesis

How can I find my own voice through my instrument

Julia Casañas Cast · 2020 · Royal Conservatoire Research Portal

Many classical musicians can suffer from tension and nervousness during solo performance. This research looks at how practicing improvisation and creative body movement, as well as creating one’s own performance together with a dancer, can…

View details →DOI: 10.22501/koncon.792184
Negative / Null Result ReportOpen accessComputer Science

When is dataset cartography ineffective? Using training dynamics does not improve robustness against Adversarial SQuAD

Paul K. Mandal · 2025 · arXiv

In this paper, I investigate the effectiveness of dataset cartography for extractive question answering on the SQuAD dataset. I begin by analyzing annotation artifacts in SQuAD and evaluate the impact of two adversarial datasets, AddSent and AddOneSent, on an ELECTRA-small model. Using training dynamics, I partition SQuAD into easy-to-learn, ambiguous, and hard-to-learn subsets. I then compare the performance of models trained on these subsets to those trained on randomly selected samples of equal size. Results show that training on cartography-based subsets does not improve generalization to

Negative / Null Result ReportMedicine

Investigating the Association between the Presence of Pulp Stone and Anesthesia Failure in Upper and Lower Molar Teeth.

Parirokh, Manochehrifar, Nakahee et al. · 2026 · Iranian endodontic journal

The close relationship between pulp stones in the pulp chamber and pulp neurovascular tissues suggests that the presence of pulp stones may compromise successful anesthesia. The present study assessed the effect of pulp stone presence on…

View details →DOI: 10.22037/iej.v21i1.46586
Negative / Null Result ReportOpen accessMathematics

Preregistration does not improve the transparent evaluation of severity in Popper's philosophy of science or when deviations are allowed

Mark Rubin · 2024 · arXiv

One justification for preregistering research hypotheses, methods, and analyses is that it improves the transparent evaluation of the severity of hypothesis tests. In this article, I consider two cases in which preregistration does not improve this evaluation. First, I argue that, although preregistration may facilitate the transparent evaluation of severity in Mayo's error statistical philosophy of science, it does not facilitate this evaluation in Popper's theory-centric approach. To illustrate, I show that associated concerns about Type I error rate inflation are only relevant in the error

Negative / Null Result ReportOpen accessComputer Science

Does Interaction Improve Bayesian Reasoning with Visualization?

Ab Mosca, Alvitta Ottley, Remco Chang · 2021 · arXiv

Interaction enables users to navigate large amounts of data effectively, supports cognitive processing, and increases data representation methods. However, there have been few attempts to empirically demonstrate whether adding interaction to a static visualization improves its function beyond popular beliefs. In this paper, we address this gap. We use a classic Bayesian reasoning task as a testbed for evaluating whether allowing users to interact with a static visualization can improve their reasoning. Through two crowdsourced studies, we show that adding interaction to a static Bayesian reaso

Negative / Null Result ReportMedicine

Improving ricotta cheese shelf life using saffron petal extract double nanoemulsions stabilized by plant proteins and Lepidium sativum L. gum.

Bakhshalipoor, Bolandi, Nahidi et al. · 2026 · Scientific reports

This study evaluated the effects of double nanoemulsions of saffron petal extract (DN-SPE), stabilized with soybean (SPI) and pea protein isolates (PPI), alone or combined with Lepidium sativum L. seed gum (LSG) (SL or PL), on the quality…

View details →DOI: 10.1038/s41598-026-52693-3
Negative / Null Result ReportOpen accessComputer Science

Batch normalization does not improve initialization

Joris Dannemann, Gero Junike · 2025 · arXiv

Batch normalization is one of the most important regularization techniques for neural networks, significantly improving training by centering the layers of the neural network. There have been several attempts to provide a theoretical justification for batch ormalization. Santurkar and Tsipras (2018) [How does batch normalization help optimization? Advances in neural information rocessing systems, 31] claim that batch normalization improves initialization. We provide a counterexample showing that this claim s not true, i.e., batch normalization does not improve initialization.

Negative / Null Result ReportOpen accessComputer Science

Neural document expansion for ad-hoc information retrieval

Cheng Tang, Andrew Arnold · 2020 · arXiv

Recently, Nogueira et al. [2019] proposed a new approach to document expansion based on a neural Seq2Seq model, showing significant improvement on short text retrieval task. However, this approach needs a large amount of in-domain training data. In this paper, we show that this neural document expansion approach can be effectively adapted to standard IR tasks, where labels are scarce and many long documents are present.