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Failure-mode index

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A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

1934 results for "Mpro" · page 23 of 65

Negative / Null Result ReportOpen accessComputer Science

A wearable anti-gravity supplement to therapy does not improve arm function in chronic stroke: a randomized trial

Courtney Celian, Partha Ryali, Valentino Wilson et al. · 2024 · arXiv

Background: Gravity confounds arm movement ability in post-stroke hemiparesis. Reducing its influence allows effective practice leading to recovery. Yet, there is a scarcity of wearable devices suitable for personalized use across diverse therapeutic activities in the clinic. Objective: In this study, we investigated the safety, feasibility, and efficacy of anti-gravity therapy using the ExoNET device in post-stroke participants. Methods: Twenty chronic stroke survivors underwent six, 45-minute occupational therapy sessions while wearing the ExoNET, randomized into either the treatment (ExoNET

Negative / Null Result ReportOpen accessComputer Science

RLVR Training of LLMs Does Not Improve Thinking Ability for General QA: Evaluation Method and a Simple Solution

Kaiyuan Li, Jing-Cheng Pang, Yang Yu · 2026 · arXiv

Reinforcement learning from verifiable rewards (RLVR) stimulates the thinking processes of large language models (LLMs), substantially enhancing their reasoning abilities on verifiable tasks. It is often assumed that similar gains should transfer to general question answering (GQA), but this assumption has not been thoroughly validated. To assess whether RLVR automatically improves LLM performance on GQA, we propose a Cross-Generation evaluation framework that measures the quality of intermediate reasoning by feeding the generated thinking context into LLMs of varying capabilities. Our evaluat

Negative / Null Result ReportOpen accessComputer Science

I see artifacts: ICA-based EEG artifact removal does not improve deep network decoding across three BCI tasks

Taeho Kang, Yiyu Chen, Christian Wallraven · 2026 · arXiv

In this paper, we conduct a detailed investigation on the effect of independent component (IC)-based noise rejection methods in neural network classifier-based decoding of electroencephalography (EEG) data in different task datasets. We apply a pipeline matrix of two popular different independent component (IC) decomposition methods (Infomax and Adaptive Mixture Independent Component Analysis (AMICA)) with three different component rejection strategies (none, ICLabel, and multiple artifact rejection algorithm [MARA]) on three different EEG datasets (motor imagery, long-term memory formation, a

Negative / Null Result ReportOpen accessComputer Science

When Does Critique Improve AI-Assisted Theoretical Physics? SCALAR: Structured Critic--Actor Loop for Agentic Reasoning

Vasilis Niarchos, Constantinos Papageorgakis, Alexander G. Stapleton et al. · 2026 · arXiv

As large language models (LLMs) show increasing promise on research-level physics reasoning tasks and agentic AI becomes more common, a practical question emerges: How does the interaction between researchers and agents affect the results? We study this using SCALAR (Structured Critic--Actor Loop for AI Reasoning), an Actor--Critic--Judge pipeline applied to quantum field theory and string theory problems. The Actor proposes solutions, the Critic provides iterative feedback, and an independent Judge evaluates the transcript against reference solutions. We vary the Actor persona, the Critic fee

Negative / Null Result ReportOpen accessComputer Science

Penalizing Confident Predictions on Largely Perturbed Inputs Does Not Improve Out-of-Distribution Generalization in Question Answering

Kazutoshi Shinoda, Saku Sugawara, Akiko Aizawa · 2022 · arXiv

Question answering (QA) models are shown to be insensitive to large perturbations to inputs; that is, they make correct and confident predictions even when given largely perturbed inputs from which humans can not correctly derive answers. In addition, QA models fail to generalize to other domains and adversarial test sets, while humans maintain high accuracy. Based on these observations, we assume that QA models do not use intended features necessary for human reading but rely on spurious features, causing the lack of generalization ability. Therefore, we attempt to answer the question: If the

Negative / Null Result ReportOpen accessComputer Science

Discrimination of two channels by adaptive methods and its application to quantum system

Masahito Hayashi · 2008 · arXiv

The optimal exponential error rate for adaptive discrimination of two channels is discussed. In this problem, adaptive choice of input signal is allowed. This problem is discussed in various settings. It is proved that adaptive choice does not improve the exponential error rate in these settings. These results are applied to quantum state discrimination.

Negative / Null Result ReportOpen accessComputer Science

AFP Algorithm and a Canonical Normal Form for Horn Formulas

Ruhollah Majdoddin · 2014 · arXiv

AFP Algorithm is a learning algorithm for Horn formulas. We show that it does not improve the complexity of AFP Algorithm, if after each negative counterexample more that just one refinements are performed. Moreover, a canonical normal form for Horn formulas is presented, and it is proved that the output formula of AFP Algorithm is in this normal form.

Negative / Null Result ReportMedicine

ClassPass Memberships to Improve Well-Being Among Psychiatry Residents: A Pilot Randomized Controlled Trial.

Yang, Mueller, D'Andrea et al. · 2026 · Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry

Resident physicians experience high rates of depression, anxiety, burnout, and loneliness, yet few evidence-based interventions have been evaluated in this population. This randomized controlled pilot trial examined the feasibility,…

View details →DOI: 10.1007/s40596-026-02384-y
Negative / Null Result ReportOpen accessEngineering

Failing Forward: Improving Generative Error Correction for ASR with Synthetic Data and Retrieval Augmentation

Sreyan Ghosh, Mohammad Sadegh Rasooli, Michael Levit et al. · 2024 · arXiv

Generative Error Correction (GEC) has emerged as a powerful post-processing method to enhance the performance of Automatic Speech Recognition (ASR) systems. However, we show that GEC models struggle to generalize beyond the specific types of errors encountered during training, limiting their ability to correct new, unseen errors at test time, particularly in out-of-domain (OOD) scenarios. This phenomenon amplifies with named entities (NEs), where, in addition to insufficient contextual information or knowledge about the NEs, novel NEs keep emerging. To address these issues, we propose DARAG (D

Negative / Null Result ReportOpen accessComputer Science

SRA-Seg: Synthetic to Real Alignment for Semi-Supervised Medical Image Segmentation

OFM Riaz Rahman Aranya, Kevin Desai · 2026 · arXiv

Synthetic data, an appealing alternative to extensive expert-annotated data for medical image segmentation, consistently fails to improve segmentation performance despite its visual realism. The reason being that synthetic and real medical images exist in different semantic feature spaces, creating a domain gap that current semi-supervised learning methods cannot bridge. We propose SRA-Seg, a framework explicitly designed to align synthetic and real feature distributions for medical image segmentation. SRA-Seg introduces a similarity-alignment (SA) loss using frozen DINOv2 embeddings to pull s

Failed Experiment ReportOpen accessComputer Science

On bound entanglement assisted distillation

V. Vedral · 1999 · arXiv

We investigate asymptotic distillation of entanglement in the presence of an unlimited amount of bound entanglement for bi-partite systems. We show that the distillability is still bounded by the relative entropy of entanglement. This offers a strong support to the fact that bound entanglement does not improve distillation of entanglement.

Negative / Null Result ReportOpen accessComputer Science

People readily follow personal advice from AI but it does not improve their well-being

Lennart Luettgau, Vanessa Cheung, Magda Dubois et al. · 2025 · arXiv

People increasingly seek personal advice from large language models (LLMs), yet whether humans follow their advice, and its consequences for their well-being, remains unknown. In a longitudinal randomised controlled trial with a representative UK sample (N = 6,474), we found that up to 79% of participants who had a 20-minute discussion with one of three AI chatbots (GPT-4o, LLama-3.3-70B, Gemini 3 Pro) about health, careers or relationships subsequently reported following its advice. Advice-following remained above 60% even for high-stakes recommendations, suggesting that users only weakly cal

Negative / Null Result ReportOpen accessComputer Science

A New Method for Employing Feedback to Improve Coding Performance

Aaron B. Wagner, Nirmal V. Shende, Yücel Altuğ · 2019 · arXiv

We introduce a novel mechanism, called timid/bold coding, by which feedback can be used to improve coding performance. For a certain class of DMCs, called compound-dispersion channels, we show that timid/bold coding allows for an improved second-order coding rate compared with coding without feedback. For DMCs that are not compound dispersion, we show that feedback does not improve the second-order coding rate. Thus we completely determine the class of DMCs for which feedback improves the second-order coding rate. An upper bound on the second-order coding rate is provided for compound-dispersi

Negative / Null Result ReportOpen accessComputer Science

Depth Adaptive Efficient Visual Autoregressive Modeling

Chunliang Li, Tianze Cao, Sanyuan Zhao · 2026 · arXiv

Visual Autoregressive (VAR) modeling inefficiently applies a fixed computational depth to each position when generating high-resolution images. While existing methods accelerate inference by pruning tokens using frequency maps, their binary hard-pruning approach is fundamentally limited and fails to improve quality even with better frequency estimation. Observing that VAR models possess significant depth redundancy, we propose a paradigm shift from pruning entire tokens to adaptively allocating per-token computational depth. To this end, we introduce DepthVAR, a training-free framework that dy

Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Modeling the mobility of living organisms in heterogeneous landscapes: Does memory improve foraging success?

Denis Boyer, Peter D. Walsh · 2010 · arXiv

Thanks to recent technological advances, it is now possible to track with an unprecedented precision and for long periods of time the movement patterns of many living organisms in their habitat. The increasing amount of data available on single trajectories offers the possibility of understanding how animals move and of testing basic movement models. Random walks have long represented the main description for micro-organisms and have also been useful to understand the foraging behaviour of large animals. Nevertheless, most vertebrates, in particular humans and other primates, rely on sophistic

Negative / Null Result ReportOpen accessComputer Science

Self-Consistency Falls Short! The Adverse Effects of Positional Bias on Long-Context Problems

Adam Byerly, Daniel Khashabi · 2024 · arXiv

Self-consistency (SC) improves the performance of large language models (LLMs) across various tasks and domains that involve short content. However, does this support its effectiveness for long-context problems? We challenge the assumption that SC's benefits generalize to long-context settings, where LLMs often struggle with position bias, the systematic over-reliance on specific context regions-which hinders their ability to utilize information effectively from all parts of their context. Through comprehensive experimentation with varying state-of-the-art models, tasks, and SC formulations, w

Negative / Null Result ReportOpen accessComputer Science

Adaptation Odyssey in LLMs: Why Does Additional Pretraining Sometimes Fail to Improve?

Fırat Öncel, Matthias Bethge, Beyza Ermis et al. · 2024 · arXiv

In the last decade, the generalization and adaptation abilities of deep learning models were typically evaluated on fixed training and test distributions. Contrary to traditional deep learning, large language models (LLMs) are (i) even more overparameterized, (ii) trained on unlabeled text corpora curated from the Internet with minimal human intervention, and (iii) trained in an online fashion. These stark contrasts prevent researchers from transferring lessons learned on model generalization and adaptation in deep learning contexts to LLMs. To this end, our short paper introduces empirical ob

Negative / Null Result ReportOpen accessComputer Science

Towards Geo-Culturally Grounded LLM Generations

Piyawat Lertvittayakumjorn, David Kinney, Vinodkumar Prabhakaran et al. · 2025 · arXiv

Generative large language models (LLMs) have demonstrated gaps in diverse cultural awareness across the globe. We investigate the effect of retrieval augmented generation and search-grounding techniques on LLMs' ability to display familiarity with various national cultures. Specifically, we compare the performance of standard LLMs, LLMs augmented with retrievals from a bespoke knowledge base (i.e., KB grounding), and LLMs augmented with retrievals from a web search (i.e., search grounding) on multiple cultural awareness benchmarks. We find that search grounding significantly improves the LLM p

Failed Experiment ReportOpen accessComputer Science

How to Fine-Tune a Reasoning Model? A Teacher-Student Cooperation Framework to Synthesize Student-Consistent SFT Data

Zixian Huang, Kaichen Yang, Xu Huang et al. · 2026 · arXiv

A widely adopted strategy for model enhancement is to use synthetic data generated by a stronger model for supervised fine-tuning (SFT). However, for emerging reasoning models like Qwen3-8B, this approach often fails to improve reasoning capabilities and can even lead to a substantial drop in performance. In this work, we identify substantial stylistic divergence between teacher generated data and the distribution of student as a major factor impacting SFT. To bridge this gap, we propose a Teacher-Student Cooperation Data Synthesis framework (TESSY), which interleaves teacher and student model

Negative / Null Result ReportOpen accessComputer Science

Does Editing Improve Answer Quality on Stack Overflow? A Data-Driven Investigation

Saikat Mondal, Chanchal K. Roy · 2025 · arXiv

High-quality answers in technical Q&A platforms like Stack Overflow (SO) are crucial as they directly influence software development practices. Poor-quality answers can introduce inefficiencies, bugs, and security vulnerabilities, and thus increase maintenance costs and technical debt in production software. To improve content quality, SO allows collaborative editing, where users revise answers to enhance clarity, correctness, and formatting. Several studies have examined rejected edits and identified the causes of rejection. However, prior research has not systematically assessed whether acce

Negative / Null Result ReportOpen accessComputer Science

Does Multimodality Improve Recommender Systems as Expected? A Critical Analysis and Future Directions

Hongyu Zhou, Yinan Zhang, Aixin Sun et al. · 2025 · arXiv

Multimodal recommendation systems are increasingly popular for their potential to improve performance by integrating diverse data types. However, the actual benefits of this integration remain unclear, raising questions about when and how it truly enhances recommendations. In this paper, we propose a structured evaluation framework to systematically assess multimodal recommendations across four dimensions: Comparative Efficiency, Recommendation Tasks, Recommendation Stages, and Multimodal Data Integration. We benchmark a set of reproducible multimodal models against strong traditional baseline

Negative / Null Result ReportOpen accessEngineering

From KAN to GR-KAN: Advancing Speech Enhancement with KAN-Based Methodology

Haoyang Li, Yuchen Hu, Chen Chen et al. · 2024 · arXiv

Deep neural network (DNN)-based speech enhancement (SE) usually uses conventional activation functions, which lack the expressiveness to capture complex multiscale structures needed for high-fidelity SE. Group-Rational KAN (GR-KAN), a variant of Kolmogorov-Arnold Networks (KAN), retains KAN's expressiveness while improving scalability on complex tasks. We adapt GR-KAN to existing DNN-based SE by replacing dense layers with GR-KAN layers in the time-frequency (T-F) domain MP-SENet and adapting GR-KAN's activations into the 1D CNN layers in the time-domain Demucs. Results on Voicebank-DEMAND sho

Negative / Null Result ReportOpen accessComputer Science

The Adverse Effects of Omitting Records in Differential Privacy: How Sampling and Suppression Degrade the Privacy--Utility Tradeoff (Long Version)

Àlex Miranda-Pascual, Javier Parra-Arnau, Thorsten Strufe · 2026 · arXiv

Sampling is renowned for its privacy amplification in differential privacy (DP), and is often assumed to improve the utility of a DP mechanism by allowing a noise reduction. In this paper, we further show that this last assumption is flawed: When measuring utility at equal privacy levels, sampling as preprocessing consistently yields penalties due to utility loss from omitting records over all canonical DP mechanisms -- Laplace, Gaussian, exponential, and report noisy max -- , as well as recent applications of sampling, such as clustering. Extending this analysis, we investigate suppression as

Negative / Null Result ReportOpen accessComputer Science

SciRepEval: A Multi-Format Benchmark for Scientific Document Representations

Amanpreet Singh, Mike D'Arcy, Arman Cohan et al. · 2022 · arXiv

Learned representations of scientific documents can serve as valuable input features for downstream tasks without further fine-tuning. However, existing benchmarks for evaluating these representations fail to capture the diversity of relevant tasks. In response, we introduce SciRepEval, the first comprehensive benchmark for training and evaluating scientific document representations. It includes 24 challenging and realistic tasks, 8 of which are new, across four formats: classification, regression, ranking and search. We then use this benchmark to study and improve the generalization ability o

Negative / Null Result ReportOpen accessComputer Science

The Persuasion Paradox: When LLM Explanations Fail to Improve Human-AI Team Performance

Ruth Cohen, Lu Feng, Ayala Bloch et al. · 2026 · arXiv

While natural-language explanations from large language models (LLMs) are widely adopted to improve transparency and trust, their impact on objective human-AI team performance remains poorly understood. We identify a Persuasion Paradox: fluent explanations systematically increase user confidence and reliance on AI without reliably improving, and in some cases undermining, task accuracy. Across three controlled human-subject studies spanning abstract visual reasoning (RAVEN matrices) and deductive logical reasoning (LSAT problems), we disentangle the effects of AI predictions and explanations u

Negative / Null Result ReportOpen accessComputer Science

On-Policy Self-Distillation with Sampled Demonstrations Reduces Output Diversity

Andrei Liviu Nicolicioiu, Mohammad Pezeshki, Aaron Courville · 2026 · arXiv

On-policy self-distillation achieves strong pass@1 accuracy by using a single model as both teacher and student, with the teacher conditioned on a correct demonstration to provide dense token-level feedback. We show that this could come at a hidden cost: rollout diversity decreases and pass@k curves flatten (i.e., generating more rollouts fails to improve accuracy). We trace this to compounding biases in the design of self-distillation with sampled demonstrations. The teacher scores each student rollout while conditioned on a sampled correct rollout, channeling its feedback through the model's

Negative / Null Result ReportOpen accessComputer Science

Uncovering the Impact of Chain-of-Thought Reasoning for Direct Preference Optimization: Lessons from Text-to-SQL

Hanbing Liu, Haoyang Li, Xiaokang Zhang et al. · 2025 · arXiv

Direct Preference Optimization (DPO) has proven effective in complex reasoning tasks like math word problems and code generation. However, when applied to Text-to-SQL datasets, it often fails to improve performance and can even degrade it. Our investigation reveals the root cause: unlike math and code tasks, which naturally integrate Chain-of-Thought (CoT) reasoning with DPO, Text-to-SQL datasets typically include only final answers (gold SQL queries) without detailed CoT solutions. By augmenting Text-to-SQL datasets with synthetic CoT solutions, we achieve, for the first time, consistent and

Negative / Null Result ReportOpen accessMathematics

ScoreStop: Gradient-based early stopping using functional score tests

Oliver J. Hines, Christian L. Hines · 2026 · arXiv

Gradient boosted decision trees require a stopping rule to avoid overfitting. The standard rule monitors a validation loss and stops if the loss fails to improve for a fixed patience period. However, the patience parameter has no interpretable scale and validation losses can be noisy or implicitly defined by a user-specified gradient. We propose ScoreStop, a gradient-based early-stopping rule that casts the stopping decision at each iteration as a test of the null hypothesis that the current predictor is the population risk minimizer. We use a functional score test, computed on validation data

Negative / Null Result ReportOpen accessPhysics

Does H2O improve the catalytic activity of Au1-4/MgO towards CO oxidation?

Martin Amft, Natalia V. Skorodumova · 2011 · arXiv

The present density functional theory study addresses the question whether the presence of H2O influences the catalytic activity of small gold clusters, Au1-4/MgO(100), towards the oxidation of carbon monoxide. To this end, we studied the (co-)adsorption of H2O and CO/O2 on these gold clusters. The ground state structures in the presence of all three molecular species, that we found, are Au1O2/MgO and Au2-4CO/MgO with H2O adsorbed on the surface in the proximity of the clusters-molecule complex. In this configuration the catalytic activity of Au1-4/MgO is indifferent to the presence of H2O. We

Negative / Null Result ReportOpen accessComputer Science

InsCLR: Improving Instance Retrieval with Self-Supervision

Zelu Deng, Yujie Zhong, Sheng Guo et al. · 2021 · arXiv

This work aims at improving instance retrieval with self-supervision. We find that fine-tuning using the recently developed self-supervised (SSL) learning methods, such as SimCLR and MoCo, fails to improve the performance of instance retrieval. In this work, we identify that the learnt representations for instance retrieval should be invariant to large variations in viewpoint and background etc., whereas self-augmented positives applied by the current SSL methods can not provide strong enough signals for learning robust instance-level representations. To overcome this problem, we propose InsCL