Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

All Replication Failure Negative / Null Result Report Failed Experiment Report Abandoned Hypothesis Methods Dead-End Short Note Null Dataset Protocol

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

By fieldMedicine 12,218 Computer Science 744 Biochemistry, Genetics and Molecular Biology 414 Social Sciences 302 Psychology 299 Physics 280 Neuroscience 244 Economics, Econometrics and Finance 196 Environmental Science 172 Mathematics 155 Agricultural and Biological Sciences 138 Engineering 135

34 results in Replication Failure for "Mpro" · page 2 of 2

Replication FailureOpen accessMedicine

The Effect of Milk Thistle Extract in the Treatment of Diabetic Nephropathy

Hassan Rezvanian, Ali Kachuei, Ali Mirzapour · 2011 · مجله دانشکده پزشکی اصفهان

Background: Milk thistle has antioxidative effects and may improve renal performance. Our study investigated whether Milk thistle improve renal performance in patients with type II diabetes mellitus nephropathy. Methods: In this clinical trial study, after ethics committee approval, 65 Patients with type II diabetes mellitus were enrolled into a randomized simple sampling, prospective, double-blinded study. In the case group, was gave Milk thistle and control group was given placebo. We measured urine albumin/cratinine (A/C) ratio and eGFR before and after intervention. The gathered data were

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Replication FailureMedicine

Does Orthosis Improve Outcomes of Conservative Treatment in Trigger Fingers? A 3-Arm Prospective Randomized Controlled Trial.

Minkhorst K, Munn A, MacDermid J et al. · 2025 · Archives of physical medicine and rehabilitation

Objective To evaluate whether the addition of an orthosis improved the efficacy of cortisone injection for the nonoperative management of trigger finger. Design Block randomized controlled trial. Setting Outpatient hand clinic.…

View details →DOI: 10.1016/j.apmr.2025.05.015

Replication FailureMedicine

Implementation of a mentored scholarly project and corresponding research course at University of Maryland School of Medicine: 10 years of data showing improved scholarly productivity.

Silva SJ, Romero F, Magder LS et al. · 2026 · Academic medicine : journal of the Association of American Medical Colleges

Purpose Interest in research careers among medical graduates is decreasing, and fewer physicians report research as their primary work activity. This study examines the implementation of a required scholarly research course at the…

View details →DOI: 10.1093/acamed/wvag166

Replication FailureMedicine

Comparative clinical effects of extraoral photobiomodulation using laser and LED on pain, swelling, and quality of life following impacted mandibular third molar surgery: a randomized split-mouth trial.

Albayrak D, Bulut E, Singer EA · 2026 · Lasers in medical science

This study aimed to compare the clinical effectiveness of extraoral photobiomodulation using laser and light-emitting diode (LED) in reducing postoperative pain, swelling, and improving oral health-related quality of life following…

View details →DOI: 10.1007/s10103-025-04796-y