e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

42 results in Replication Failure for "Mpro" · page 2 of 2

Replication FailureOpen accessComputer Science

Not All Flips Are Conformity: Decomposing Stance Convergence in Multi-Agent LLM Debate

Xiqi Hao, Zengqing Wu, Yu-Xuan Qiu et al. · 2026 · arXiv

Multi-agent debate (MAD) is a promising strategy for improving LLM reasoning, but when agents converge on a shared answer, it is unclear whether that convergence reflects genuine deliberation or social compliance. We show that the conventional answer flip rate conflates three distinct mechanisms: spontaneous instability, stance-induced conformity, and reasoning-induced persuasion. Our three-source decomposition framework isolates each through controlled counterfactual conditions. In the primary MMLU-Pro setting, 37% of agent-question observations change under self-reflection alone, while robus

Replication FailureMedicine

Randomized, Double-Blind Phase III Study of Pazopanib Versus Placebo in Patients With Metastatic Renal Cell Carcinoma Who Have No Evidence of Disease After Metastasectomy: ECOG-ACRIN E2810.

Appleman LJ, Kim SE, Harris WB et al. · 2024 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Purpose Patients with no evidence of disease (NED) after metastasectomy for renal cell carcinoma are at high risk of recurrence. Pazopanib is an inhibitor of vascular endothelial growth factor receptor and other kinases that improves…

View details →DOI: 10.1200/jco.23.01544
Replication FailureOpen accessMedicine

The Effect of Milk Thistle Extract in the Treatment of Diabetic Nephropathy

Hassan Rezvanian, Ali Kachuei, Ali Mirzapour · 2011 · مجله دانشکده پزشکی اصفهان

Background: Milk thistle has antioxidative effects and may improve renal performance. Our study investigated whether Milk thistle improve renal performance in patients with type II diabetes mellitus nephropathy. Methods: In this clinical trial study, after ethics committee approval, 65 Patients with type II diabetes mellitus were enrolled into a randomized simple sampling, prospective, double-blinded study. In the case group, was gave Milk thistle and control group was given placebo. We measured urine albumin/cratinine (A/C) ratio and eGFR before and after intervention. The gathered data were

Replication FailureOpen accessComputer Science

Quantum Corrections to Baryon Properties in Chiral Soliton Models

Frank Meier, Hans Walliser · 1996 · arXiv

We present a procedure to calculate 1-loop graphs in the soliton sector of chiral Lagrangians and use it to calculate quantum corrections to certain baryon observables in Skyrme-type models. Results generally show an improvement over the values obtained in tree approximation except for the case of the axial coupling g_A.

Replication FailureMedicine

Implementation of a mentored scholarly project and corresponding research course at University of Maryland School of Medicine: 10 years of data showing improved scholarly productivity.

Silva SJ, Romero F, Magder LS et al. · 2026 · Academic medicine : journal of the Association of American Medical Colleges

Purpose Interest in research careers among medical graduates is decreasing, and fewer physicians report research as their primary work activity. This study examines the implementation of a required scholarly research course at the…

View details →DOI: 10.1093/acamed/wvag166
Replication FailureMedicine

Does Orthosis Improve Outcomes of Conservative Treatment in Trigger Fingers? A 3-Arm Prospective Randomized Controlled Trial.

Minkhorst K, Munn A, MacDermid J et al. · 2025 · Archives of physical medicine and rehabilitation

Objective To evaluate whether the addition of an orthosis improved the efficacy of cortisone injection for the nonoperative management of trigger finger. Design Block randomized controlled trial. Setting Outpatient hand clinic.…

View details →DOI: 10.1016/j.apmr.2025.05.015
Replication FailureMedicine

Comparative clinical effects of extraoral photobiomodulation using laser and LED on pain, swelling, and quality of life following impacted mandibular third molar surgery: a randomized split-mouth trial.

Albayrak D, Bulut E, Singer EA · 2026 · Lasers in medical science

This study aimed to compare the clinical effectiveness of extraoral photobiomodulation using laser and light-emitting diode (LED) in reducing postoperative pain, swelling, and improving oral health-related quality of life following…

View details →DOI: 10.1007/s10103-025-04796-y
Replication FailureMedicine

Targeted Temperature Management After Pediatric Cardiac Arrest: A Quality Improvement Program With Multidisciplinary Implementation in the PICU.

McMullin MP, Cadotte NB, Fuchs EM et al. · 2025 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives We aimed to implement a post-cardiac arrest targeted temperature management (TTM) bundle to reduce the percent of time with a fever from 7% to 3.5%. Design A prospective, quality improvement (QI) initiative utilizing the Method…

View details →DOI: 10.1097/pcc.0000000000003640
Replication FailureMedicine

Spinal Cord Stimulation Failed to Improve Parkinson's Disease Symptoms in Randomized Crossover Double-Blinded Evaluation.

Carra RB, Garcia LÁL, Menezes JR et al. · 2025 · Movement disorders : official journal of the Movement Disorder Society

Background Epidural electrical spinal cord stimulation has been studied for more than a decade for Parkinson's disease symptoms, but compelling evidence for its effectiveness is still lacking. Objective The aim of this study was to…

View details →DOI: 10.1002/mds.30187