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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

697 results in Negative / Null Result Report for "aging" · page 18 of 24

Negative / Null Result ReportOpen accessPhysics

Results and forecasts on cosmic inflation from weak lensing

Agnès Ferté, Kevin Hong · 2023 · arXiv

We highlight the role of weak lensing measurements from current and upcoming stage-IV imaging surveys in the search for cosmic inflation, specifically in measuring the scalar spectral index $n_s$. To do so, we combine the Dark Energy Survey 3 years of observation weak lensing and clustering data with BICEP/Keck, Planck and Sloan Digital Sky Survey data in $rΛ$CDM where $r$ is the tensor-to-scalar ratio. While there is no significant improvement in constraining power, we obtain a 1$σ$ shift on $n_s$. Additionally, we forecast a weak lensing and clustering data vector from the 10-year Legacy Sur

Negative / Null Result ReportOpen accessComputer Science

Internal cumulants for femtoscopy with fixed charged multiplicity

H. C. Eggers, B. Buschbeck · 2013 · arXiv

A detailed understanding of all effects and influences on higher-order correlations is essential. At low charged multiplicity, the effect of a nonpoissonian multiplicity distribution can significantly distort correlations. Evidently, the reference samples with respect to which correlations are measured should yield a null result in the absence of correlations. We show how the careful specification of desired properties necessarily leads to an average-of-multinomials reference sample. The resulting internal cumulants and their averaging over several multiplicities fulfil all requirements of cor

Negative / Null Result ReportOpen accessPhysics

A Preliminary Observational Search for Circumbinary Disks Around Cataclysmic Variables

K. E. Belle, N. Sanghi, S. B. Howell et al. · 2004 · arXiv

Circumbinary (CB) disks have been proposed as a mechanism to extract orbital angular momentum from cataclysmic variables (CVs) during their evolution. As proposed by Taam & Spruit, these disks extend outwards to several a.u. and should be detected observationally via their infrared flux or by absorption lines in the ultraviolet spectra of the CV. We have made use of archival HST/STIS spectra as well as our own near-IR imaging to search for observational evidence of such CB disks in seven CVs. Based on the null result, we place an upper limit on the column density of the disk of N_H~10^17 cm^-2

Negative / Null Result ReportOpen accessPhysics

A New Brown Dwarf Desert? A Scarcity of Wide Ultracool Binaries

Peter R. Allen, David W. Koerner, Michael W. McElwain et al. · 2006 · arXiv

We present the results of a deep-imaging search for wide companions to low-mass stars and brown dwarfs using NSFCam on IRTF. We searched a sample of 132 M7-L8 dwarfs to magnitude limits of $J \sim 20.5$ and $K \sim 18.5$, corresponding to secondary-primary mass ratios of $\sim 0.5$. No companions were found with separations between $2{\arcsec}$ to $31{\arcsec}$ ($\sim$40 AU to $\sim$1000 AU). This null result implies a wide companion frequency below 2.3% at the 95% confidence level within the sensitivity limits of the survey. Preliminary modeling efforts indicate that we could have detected 85

Negative / Null Result ReportOpen accessPhysics

Limits on the cosmological abundance of supermassive compact objects from a search for multiple imaging in compact radio sources

P. N. Wilkinson, D. R. Henstock, I. W. A. Browne et al. · 2001 · arXiv

Using Very Long Baseline Interferometry we have searched a sample of 300 compact radio sources for examples of multiple imaging produced by gravitational lensing; no multiple images were found with separations in the angular range 1.5--50 milliarcsec. This null result allows us to place a limit on the cosmological abundance of intergalactic supermassive compact objects in the mass range $\sim 10^{6}$ to $\sim 10^{8}$M$_{\odot}$; such objects cannot make up more than $\sim 1%$ of the closure density (95% confidence). A uniformly distributed population of supermassive black holes forming soon af

Negative / Null Result ReportOpen accessPhysics

Friction of a slider on a granular layer: Non-monotonic thickness dependence and effect of boundary conditions

Saloome Siavoshi, Ashish V. Orpe, Arshad Kudrolli · 2005 · arXiv

We investigate the effective friction encountered by a mass sliding on a granular layer as a function of bed thickness and boundary roughness conditions. The observed friction has minima for a small number of layers before it increases and saturates to a value which depends on the roughness of the sliding surface. We use an index-matched interstitial liquid to probe the internal motion of the grains with fluorescence imaging in a regime where the liquid has no significant effect on the measured friction. The shear profiles obtained as a function of depth show decrease in slip near the sliding

Negative / Null Result ReportOpen accessEngineering

Generative Style Transfer for MRI Image Segmentation: A Case of Glioma Segmentation in Sub-Saharan Africa

Rancy Chepchirchir, Jill Sunday, Raymond Confidence et al. · 2025 · arXiv

In Sub-Saharan Africa (SSA), the utilization of lower-quality Magnetic Resonance Imaging (MRI) technology raises questions about the applicability of machine learning methods for clinical tasks. This study aims to provide a robust deep learning-based brain tumor segmentation (BraTS) method tailored for the SSA population using a threefold approach. Firstly, the impact of domain shift from the SSA training data on model efficacy was examined, revealing no significant effect. Secondly, a comparative analysis of 3D and 2D full-resolution models using the nnU-Net framework indicates similar perfor

Negative / Null Result ReportOpen accessPhysics

Double Bars, Inner Disks, and Nuclear Rings in Early-Type Disk Galaxies

Peter Erwin, Linda S. Sparke · 2002 · arXiv

We present results from an imaging survey of an unbiased sample of thirty-eight early-type (S0--Sa), low-inclination, optically barred galaxies in the field. Our goal was to find and characterize central stellar and gaseous structures: secondary bars, inner disks, and nuclear rings. Bars inside bars are surprisingly common: at least one quarter of the sample galaxies (possibly as many as 40%) are double-barred, with no preference for Hubble type or the strength of the primary bar. A typical secondary bar is ~12% of the size of its primary bar and 240--750 pc in radius. We see no significant ef

Negative / Null Result ReportOpen accessPhysics

The Outer Cut-Off of the Giant Planet Population and the 6pc-Survey

D. Apai, M. R. Meyer, P. Hinz et al. · 2007 · arXiv

We present results from two high-contrast imaging surveys that exploit a novel technique, L-band angular differential imaging. Our first survey targeted 21 young stars in the Beta Pic and Tuc-Hor moving groups with VLT/NACO reaching typical sensitivities of 20 AU. The statistical analysis of the null result demonstrates that the giant planet population is truncated at 30 AU or less (90% confidence level). Our second, on-going MMT/Clio survey utilizes the unique sensitivity achieved in the L-band for old planets to probe all M-dwarf stars within 6 pc. The proximity of these targe

Negative / Null Result ReportOpen accessPlant culture

Quality and biochemical changes of sweet cherries cv. Regina stored in modified atmosphere packaging

J. Harb, A. A. Saquet, R. Bisharat et al. · 2012 · Journal of Applied Botany and Food Quality

Biochemical and quality changes of sweet cherries cv. Regina were assessed over three consecutive years after storage in different modified atmosphere packaging (MAP) liners, with or without hydrocooling, compared to regular atmosphere (RA) storage. All plastic liners used in the experiment resulted in CO2-enrichment and O2-reduction inside packages, with the following impact on fruit quality after five weeks of storage: improved retention of fruit firmness and red color of skin, no significant effect on acidity and total soluble solids, and minimal loss of fruit weight. Fruit decay was absent

Negative / Null Result ReportOpen accessPhysics

Internal Cumulants for Femtoscopy with Fixed Charged Multiplicity

H. C. Eggers, B. Buschbeck · 2013 · Advances in High Energy Physics

A detailed understanding of all effects and influences on higher-order correlations is essential. At low charged multiplicity, the effect of a non-Poissonian multiplicity distribution can significantly distort correlations. Evidently, the reference samples with respect to which correlations are measured should yield a null result in the absence of correlations. We show how the careful specification of desired properties necessarily leads to an average-of-multinomials reference sample. The resulting internal cumulants and their averaging over several multiplicities fulfill all requirements of c

View details →DOI: 10.1155/2013/230515
Negative / Null Result ReportOpen accessMedicine

Delayed neurological sequelae of carbon monoxide intoxication initially treated as infectious meningo encephalitis

Xavier Jannot, Alpha Oumar Diallo, Judicaelle Didierjean et al. · 2025 · European Journal of Case Reports in Internal Medicine

We report the case of a 75-year-old woman admitted to the emergency department for confusion, gait disturbances and mutism associated with an inflammatory syndrome occurring 3 weeks after acute carbon monoxide intoxication. The main hypothesis upon arrival was infectious meningoencephalitis, and the patient was put on acyclovir and antibiotics in meningeal doses. After a short stay in intensive care, the patient’s condition did not improve, and the revaluation of her case history and imaging studies led to the diagnosis of post-interval syndrome secondary to carbon monoxide intoxication after

View details →DOI: 10.12890/2025_005235
Negative / Null Result ReportMedicine

Where does cryoprecipitate fit into balanced resuscitation? An evaluation of 2,117 hemorrhaging patients using viscoelastic-based resuscitation.

Van Gent JM, Clements TW, Gurney JM et al. · 2025 · The journal of trauma and acute care surgery

Background Empiric cryoprecipitate administration has recently failed to show survival benefit in hemorrhaging trauma patients. However, a recent Trauma Quality Improvement Program query suggested a survival benefit in massive transfusions…

View details →DOI: 10.1097/ta.0000000000004643
Negative / Null Result Report

Phonological decoding ability is associated with fiber density of the left arcuate fasciculus longitudinally across reading development

Perdue MV, Geeraert BL, Manning KY et al. · 2024 · Preprint

Numerous studies have linked reading ability to white matter microstructure using diffusion tensor imaging, but recent large studies have failed to show consistency. Fiber-specific diffusion-weighted magnetic resonance imaging (dMRI)…

View details →DOI: 10.1101/2024.09.24.614799
Negative / Null Result ReportMedicine

Widespread Skeletal Metastases in Medullary Thyroid Carcinoma: Diagnostic Superiority of 68Ga-FAPI PET/CT Over Somatostatin Receptor-Targeted Imaging.

Taheri F, Tanha AS, Aboutorabi RB et al. · 2026 · Clinical nuclear medicine

A 78-year-old woman with medullary thyroid carcinoma (MTC) demonstrated persistently elevated serum calcitonin despite prior surgery and radiotherapy. 99mTc-octreotide imaging failed to detect skeletal metastases, while 68Ga-FAPI PET/CT…

View details →DOI: 10.1097/rlu.0000000000006450
Negative / Null Result ReportMedicine

Romosozumab does not improve volumetric bone mineral density at distal radius but is associated with early changes in bone strength: a prospective study.

Diz-Lopes M, Rovetta CF, Pollastri F et al. · 2026 · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

We evaluated how romosozumab affects bone structure, density, and strength at the wrist over 12 months. Volumetric bone mineral density did not increase, but high-resolution quantitative computed tomography imaging showed modest…

View details →DOI: 10.1007/s00198-026-08113-3
Negative / Null Result ReportMedicine

Bi-allelic pathogenic variants in <i>NR2E3</i> may be associated with a subtle enhanced S-cone syndrome phenotype.

Hüther A, Sherman CL, Sumaroka A et al. · 2026 · Ophthalmic genetics

Purpose To describe the phenotype of a patient with bi-allelic pathogenic variants in NR2E3 that did not result in an overt enhanced S-cone syndrome (ESCS) phenotype. Methods The patient underwent a comprehensive ophthalmic exam, imaging…

View details →DOI: 10.1080/13816810.2026.2635611
Negative / Null Result ReportOpen accessMedicine

Histomorphometric bone assessment in patients with fracture of the proximal end of the femur

Caio Gonçalves de Souza, Márcio Passini Gonçalves de Souza, Vanda Jorgetti et al. · 2015 · Acta Ortopédica Brasileira

OBJECTIVE: To determine whether there is a difference on the bone architecture in patients with femoral neck fracture compared to patients with intertrochanteric fractures and assess the importance of aging on bone microarchitecture in patients with proximal femoral fracture.METHODS: Biopsy of the iliac crest was made in seventeen patients between 55 and 90 years old who were admitted to the emergency room with fractures of the proximal end of the femur. After a small fragment was removed, we made a histomorphometric analysis of it.RESULTS: There was no significant difference between patients

View details →DOI: 10.1590/1413-78522015230201056
Negative / Null Result ReportMedicine

Outcome of segmentectomy vs. lobectomy in patients with cT1a-b N0 lung cancer and postoperative N1 upstaging.

Kaman, Stork, Okumus et al. · 2026 · Langenbeck's archives of surgery

Segmentectomy is offered in selected patients with clinical T1a-b N0 M0 lung cancer. In case of positive N1 lymph node at fresh frozen section, conversion to lobectomy is recommended. Indication for redo surgery and completion lobectomy in…

View details →DOI: 10.1007/s00423-026-04089-0
Negative / Null Result Report

Radiologist Approval for CTPA in the ED : A Single‐Centre Pilot Study Did Not Demonstrate a Statistically Significant Difference in Diagnostic Yield

Hwang Tan, Pramod Chandru · 2026 · Emergency Medicine Australasia

ABSTRACT Objective Overuse of CT Pulmonary Angiography (CTPA) remains a challenge in emergency medicine. Some institutions resort to radiologist vetting to reduce unnecessary imaging. This is a pilot study that aims to investigate the…

View details →DOI: 10.1111/1742-6723.70237
Negative / Null Result Report

This is Going to Sound Crazy, But What If We Used Large Language Models to Boost Automatic Database Tuning Algorithms By Leveraging Prior History? We Will Find Better Configurations More Quickly Than Retraining From Scratch!

William Zhang, Wan Shen Lim, Andrew Pavlo · 2026 · Proceedings of the ACM on Management of Data

Tuning database management systems (DBMSs) is challenging due to trillions of possible configurations and evolving workloads. Recent advances in tuning have led to breakthroughs in optimizing over the possible configurations. However, due…

View details →DOI: 10.1145/3786704
Negative / Null Result Report

Inflation Management In The Eu: Does The Eurozone Outperform Non-Euro States?

Anna Prucnal · 2025 · International Journal of Business &amp; Management Studies

This study examines the effectiveness of the monetary policy of the European Central Bank (ECB) in managing inflation in the Euro Area compared to the independent monetary policy of seven European Union Member States outside the Economic…

View details →DOI: 10.56734/ijbms.v6n1a7
Negative / Null Result Report

Engaging Education About Risks of Opioid Use With Patients Before Elective Surgery of the Lower Extremity Did Not Reduce Postoperative Opioid Utilization: A Randomized Controlled Trial

Daniel I. Rhon, Tina A. Greenlee, Rachel Mayhew et al. · 2022 · Journal of the American Academy of Orthopaedic Surgeons

Introduction: After elective orthopaedic surgery, many individuals go on to become long-term opioid users. Mitigating this risk has become a priority for surgeons, other members of the medical care team, and healthcare systems. The purpose…

View details →DOI: 10.5435/jaaos-d-21-00603
Negative / Null Result Report

“Football Did Not Make Me a World Champion, but It Did Help My Wellbeing”: A Qualitative Study of Study-sport Balance Based on Fung Ka Ki

Bill Cheuk Long Chan, Billy Lee · 2024 · Studia sportiva

Managing the balance of academic and athletic responsibilities at university is a serious challenge for student athletes. This phenomenological case study illuminates how one individual successfully managed his study-sport balance at…

View details →DOI: 10.5817/sts2023-2-6
Negative / Null Result ReportOpen accessComputer Science

Turning Waste into Wealth: Leveraging Low-Quality Samples for Enhancing Continuous Conditional Generative Adversarial Networks

Xin Ding, Yongwei Wang, Zuheng Xu · 2023 · arXiv

Continuous Conditional Generative Adversarial Networks (CcGANs) enable generative modeling conditional on continuous scalar variables (termed regression labels). However, they can produce subpar fake images due to limited training data. Although Negative Data Augmentation (NDA) effectively enhances unconditional and class-conditional GANs by introducing anomalies into real training images, guiding the GANs away from low-quality outputs, its impact on CcGANs is limited, as it fails to replicate negative samples that may occur during the CcGAN sampling. We present a novel NDA approach called Dua

Negative / Null Result ReportOpen accessComputer Science

AnxietyFaceTrack: A Smartphone-Based Non-Intrusive Approach for Detecting Social Anxiety Using Facial Features

Nilesh Kumar Sahu, Snehil Gupta, Haroon R Lone · 2025 · arXiv

Social Anxiety Disorder (SAD) is a widespread mental health condition, yet its lack of objective markers hinders timely detection and intervention. While previous research has focused on behavioral and non-verbal markers of SAD in structured activities (e.g., speeches or interviews), these settings fail to replicate real-world, unstructured social interactions fully. Identifying non-verbal markers in naturalistic, unstaged environments is essential for developing ubiquitous and non-intrusive monitoring solutions. To address this gap, we present AnxietyFaceTrack, a study leveraging facial video

Negative / Null Result ReportOpen accessPhysics

Significant improvement in planetary system simulations from statistical averaging

David M. Hernandez, Eric Agol, Matthew J. Holman et al. · 2021 · arXiv

Symplectic integrators are widely used for the study of planetary dynamics and other $N$-body problems. In a study of the outer Solar system, we demonstrate that individual symplectic integrations can yield biased errors in the semi-major axes and possibly other orbital elements. The bias is resolved by studying an ensemble of initial conditions of the outer Solar system. Such statistical sampling could significantly improve measurement of planetary system properties like their secular frequencies. We also compared the distributions of action-like variables between high and low accuracy integr

Negative / Null Result ReportOpen accessComputer Science

An Eye on Clinical BERT: Investigating Language Model Generalization for Diabetic Eye Disease Phenotyping

Keith Harrigian, Tina Tang, Anthony Gonzales et al. · 2023 · arXiv

Diabetic eye disease is a major cause of blindness worldwide. The ability to monitor relevant clinical trajectories and detect lapses in care is critical to managing the disease and preventing blindness. Alas, much of the information necessary to support these goals is found only in the free text of the electronic medical record. To fill this information gap, we introduce a system for extracting evidence from clinical text of 19 clinical concepts related to diabetic eye disease and inferring relevant attributes for each. In developing this ophthalmology phenotyping system, we are also afforded

Negative / Null Result ReportOpen accessPhysics

Refraction efficiency of Huygens' and bianisotropic terahertz metasurfaces

Michael A. Cole, Aristeidis Lamprianidis, Ilya V. Shadrivov et al. · 2018 · arXiv

Metasurfaces are an enabling technology for complex wave manipulation functions, including in the terahertz frequency range, where they are expected to advance security, imaging, sensing, and communications technology. For operation in transmission, Huygens' metasurfaces are commonly used, since their good impedance match to the surrounding media minimizes reflections and maximizes transmission. Recent theoretical work has shown that Huygens' metasurfaces are non-optimal, particularly for large angles of refraction, and that to eliminate reflections and spurious diffracted beams it is necessar