A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
697 results in Negative / Null Result Report for "aging" · page 15 of 24
Xu C, Annapureddy H, Carson L et al. · 2026 · JCI insight
Antiretroviral therapy (ART) has prolonged the life expectancy of persons living with HIV, the majority of whom are now older than 50 years. Aging people with HIV are at increased risk for cardiovascular events driven by HIV-related…
Dalla Via J, Radavelli-Bagatini S, Sim M et al. · 2026 · Aging clinical and experimental research
Background Provision of vascular imaging results has been investigated to prompt changes towards healthy lifestyle behaviours, but effects on body composition and muscle health are unknown. Aim This secondary analysis of a 12-week…
Kim TE, Bae JW, Hong S et al. · 2025 · The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
Donepezil, an acetylcholinesterase inhibitor, is widely used for managing the symptoms of Alzheimer's disease (AD), yet its clinical response varies widely among individuals. This study aims to investigate the influence of CYP2D6 genetic…
Myhre MG, Azeem A, Barrett M · 2024 · New Zealand veterinary journal
Case history Medical records from 2009 to 2021 from a private equine referral hospital in Rochester, NH, USA were analysed for cases that underwent general anaesthesia for low-field MRI of the distal limb. These were used to determine…
Ehinger BV, Bonasch H · 2023 · Preprint
Abstract 1 Some participants consistently show large, and others small activations in Electroencephalography (EEG) and other neuroimaging studies. Similarly, decoding accuracies in Brain-Computer-Interface (BCI) vary between subjects, in…
López-de la Rosa A, Díez-Montero C, Martínez-Plaza E et al. · 2024 · Ophthalmology and therapy
Introduction Characterizing lens thickness (LT) in patients with cataracts is important for better understanding the lens aging process and for designing new intraocular lens power formulas. This study aimed to analyze the influence of…
Turton S, Hawkins PCT, Muller-Pollard C et al. · 2025 · Psychopharmacology
Rationale It is hypothesised that modulation of striatal dopaminergic signalling plays a key role in the rewarding effects of opioids. The monetary incentive delay (MID) task is a functional magnetic resonance imaging (fMRI) paradigm used…
Farhat MR, Jacobson KR · 2024 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Active case finding leveraging new molecular diagnostics and chest X-rays with automated interpretation algorithms is increasingly being developed for high-risk populations to drive down tuberculosis incidence. We consider why such an…
Galante H, Czaczkes TJ · 2022 · Preprint
Nectar-feeding insects are often the victims of psychoactive manipulation, with plants lacing their nectar with secondary metabolites such as alkaloids and non-protein amino acids which often boost learning, foraging, or recruitment.…
Mommers I, Mubarik S, van Boven JFM et al. · 2025 · BMJ open respiratory research
Background Antibiotics are widely used to manage acute asthma exacerbations, despite little evidence for their effectiveness. This study assesses the added value of antibiotics alongside oral corticosteroids (OCSs) in treating asthma…
Zhiping N, Yuanyuan Y, Qichun Z et al. · 2025 · Journal of applied gerontology : the official journal of the Southern Gerontological Society
With the acceleration of China's aging society, how to enhance the subjective well-being of older adults has become a core issue of concern. This study aims to explore the influence mechanisms of socioeconomic status, health, recreation,…
Cohen L, Laferrère A · 2025 · Preprint
Palliative care (PC) is a multidimensional approach to end-of-life care aimed at alleviating suffering and enhancing the quality of life for individuals and their families. A key aspect of PC is managing symptoms such as pain, dyspnea, and…
Noël A, Picard L · 2025 · Emotion (Washington, D.C.)
Numerous studies have highlighted the beneficial effect of humor on memory in younger adults. While older adults are known to preferentially process positive information and appreciate humor, no study has investigated whether the effect of…
Pérez Serena A, Martínez Betancourt DP · 2026 · Neurocirugia
We report the case of a 56-year-old female patient with controlled Human Immunodeficiency Virus (HIV) who presented with binocular diplopia and a known sixth cranial nerve palsy. Imaging revealed a lesion centered in the right cavernous…
Di Noia D, Maiorano MFP, Sanasi A et al. · 2026 · Journal of gynecology obstetrics and human reproduction
Radiation necrosis is a rare but serious complication of pelvic chemoradiotherapy that may closely mimic tumor recurrence on both imaging and clinical examination. We describe the case of a 43-year-old woman with FIGO stage II vaginal…
Carrillo Lizarazo JL, Cecchin D, Camozzi V et al. · 2025 · BJS open
Background Accurate preoperative localization is essential for successful, focused, minimally invasive surgery in primary hyperparathyroidism (PHPT). New imaging techniques have recently been proposed. This study evaluated the impact of…
D’Amario A, Ambrosini R, Gullino A et al. · 2025 · Preprint
Background: Ovarian cancer is a leading gynecological malignancy with high global mortality. Early and accurate diagnosis is essential for effective management, yet many ovarian masses remain indeterminate after initial assessment.…
Shiba Y, Aoki K, Ohka F et al. · 2025 · AJNR. American journal of neuroradiology
Background and purpose Differentiating between a brain tumor and a nontumorous lesion remains a diagnostic challenge, particularly when conventional imaging modalities such as CT and MRI provide inconclusive results. While 11 C-methionine…
Kaseb A, Benider H, Treglia G et al. · 2025 · European journal of clinical investigation
Background 4D-CT has garnered attention as complementary imaging for patients with primary hyperparathyroidism (pHPT). Herein we evaluated a diagnostic strategy using [ 18 F]Fluorocholine Positron Emission Tomography/Computed Tomography…
Saber Tanha A, Hosseini S, Soltani E et al. · 2025 · Clinical nuclear medicine
Abstract A 47-year-old woman, recently diagnosed with breast cancer, underwent staging. A whole-body bone scan revealed an unexpected focal 99m Tc-MDP uptake in her right ovary. Extensive literature review suggested various malignant…
Abdo M, Kunisaki KM, Morris A et al. · 2026 · AIDS research and human retroviruses
People aging with HIV (PAWH) experience greater impairment in physical and pulmonary function than individuals aging without HIV. We examined whether baseline physical function was associated with subsequent pulmonary impairments.…
Rodrigo C, Gnanathasan A · 2024 · Transactions of the Royal Society of Tropical Medicine and Hygiene
Globally, snakebites cause an estimated 80 000-140 000 deaths annually. While there are evidence-based recommendations for managing snakebite victims, recommendations on the prevention of snakebites are limited to expert opinions. We…
Paisant A, Faroche E, Fouche A et al. · 2024 · Abdominal radiology (New York)
Purpose Preoperative imaging is now recommended in patients with suspected acute appendicitis (AA) by the World Society of Emergency Surgery. Our aims were (i) to describe our local practice and (ii) to evaluate the efficiency of…
Gobishangar S, Abiharan P, Jenil A et al. · 2026 · Cureus
Background The appendix is a vermiform structure with a variable position, length, and thickness. Imaging plays a critical role in diagnosing an inflamed appendix, with non-contrast computed tomography (NCCT) being an effective modality…
Kennedy J, Cooley SA, Roman Fox J et al. · 2026 · The Journal of infectious diseases
Background As persons with human immunodeficiency virus (PWH) live longer, interactions between human immunodeficiency virus (HIV), aging, and structural brain integrity become increasingly vital for understanding cognitive disorders. This…
Willems R, Cappelletti M, Schüre JR et al. · 2026 · Scientific reports
Messenger ribonucleic acid (mRNA)-based vaccines delivered via lipid nanoparticles (LNP) were pivotal in managing the severe acute respiratory syndrome coronavirus (SARS-CoV-2) pandemic. While mild systemic reactions are common after…
Iribarren A, Obrutu O, Maughan J et al. · 2026 · American heart journal plus : cardiology research and practice
Background Caffeine, a nonselective adenosine A2 receptor antagonist, blunts adenosine-induced coronary hyperemia. Despite recommended abstinence before adenosine stress cardiac magnetic resonance imaging (CMRi), residual caffeine may…
Pisani M, Marcheschi P, Clemente A et al. · 2026 · Preprint
Aortic calcification represents a key marker of cardiovascular disease, detectable through medical imaging. This research investigates the use of artificial intelligence (AI) to assist radiologists in identifying aortic calcification in…
Ware A, LaMountain J, White RC et al. · 2026 · Nature communications
The electromagnetic response of materials serves as the foundation for a broad range of vital applications, from imaging, to sensing, to classical and quantum communications. Here we demonstrate, theoretically and experimentally, a…
Vockert KL, Winter N, Kirschmann FS et al. · 2026 · Neurological research and practice
Background and aims Hereditary polyneuropathies are rare heterogeneous neurological disorders that cause progressive muscle weakness and disability. As new therapies emerge, sensitive imaging biomarkers to monitor disease progression are…