Negative / Null Result ReportOpen accessMedicine (General)
Thuy Thi-Thanh Tran, Huy Phuong Tran, Loc Thai Ly et al. · 2024 · Middle East Fertility Society Journal
Abstract Background Endometrial preparation significantly influences the success of embryo transfer procedures. Although both oral and transdermal estradiol are common methods for endometrial priming, their efficacy and potential side effects remain uncertain. This randomized controlled trial aims to compare the effectiveness of oral and transdermal estradiol in endometrial preparation, while also evaluating their respective side effects in patients undergoing assisted reproduction treatments. Method This randomized clinical trial (ISRCTN15301227) was conducted at Hung Vuong Hospital between J
View details →DOI: 10.1186/s43043-024-00204-7 Negative / Null Result ReportOpen access
Manuel Carlos Martins Castro (5255606) · 2022
ABSTRACT Online hemodiafiltration is potentially a superior mode of dialysis compared to conventional hemodialysis. However, prospective randomized controlled trials have failed to demonstrate such superiority. Post-hoc analyses of these…
View details →DOI: 10.6084/m9.figshare.19964391.v1 Negative / Null Result ReportMedicine
Makkar RR, Chakravarty T, Gupta A et al. · 2025 · Journal of the American College of Cardiology
Background In the ACURATE IDE (Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement) randomized controlled trial, ACURATE neo2 failed to show noninferiority to commercially available balloon-expandable…
View details →DOI: 10.1016/j.jacc.2025.05.011 Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Sung Hye Kong · 2026 · Endocrinology and Metabolism
For decades, vitamin D has been a cornerstone of preventive medicine. However, recent large-scale randomized controlled trials have failed to replicate the broad benefits previously observed in epidemiological studies, particularly with respect to fracture and fall prevention in vitamin D-replete populations. Moreover, growing evidence suggesting an increased fall risk associated with high-dose bolus administration has necessitated a re-evaluation of safety assumptions. This review synthesizes these discordant findings to propose a framework grounded in precision medicine. We explore the ‘dive
View details →DOI: 10.3803/enm.2026.2938 Negative / Null Result ReportMedicine
Yang G, Milne GL, Nogueira MS et al. · 2026 · International journal of cancer
Despite widespread interest, large randomized controlled trials have failed to demonstrate chemopreventive benefits of antioxidant supplementation, raising concerns about its efficacy and safety. Building on our prior observation of a…
View details →DOI: 10.1002/ijc.70585 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Oh Young Bang, Mi Ji Lee, Sookyung Ryoo et al. · 2015 · Journal of Stroke
Patent foramen ovale (PFO) is growing in clinical interest because of a renewed focus on embolic stroke of undetermined source (ESUS), the PFO attributable fraction (the 10-point Risk of Paradoxical Embolism score), technical advances in PFO diagnosis, and the emergence of endovascular device closure as a treatment option. However, recent randomized controlled trials of the management of patients with ESUS and PFO failed to demonstrate the superiority of closure over medical treatment. The mechanisms of stroke other than paradoxical embolism may be important in patients with ESUS and PFO. This
View details →DOI: 10.5853/jos.2015.17.3.229 Failed Experiment ReportOpen accessMedicine
Wallon S, Williamsson C, Karlsson V et al. · 2026 · Trials
Background Routine use of surgical drains after abdominal operations has largely been abandoned over the past decades. Studies have failed to demonstrate benefits of routine drainage following liver, gallbladder, gastric, and colorectal…
View details →DOI: 10.1186/s13063-026-09762-9 Negative / Null Result ReportMedicine
Schreiner M, Thien H, Braasch T et al. · 2025 · Abdominal radiology (New York)
Background Many patients are instructed to fast before abdominal ultrasound examinations in order to obtain better image quality. However, the few available studies on this topic have so far failed to demonstrate an advantage of several…
View details →DOI: 10.1007/s00261-025-04947-3 Negative / Null Result ReportOpen accessMedicine
Liu S, Chen B, Zhu Y et al. · 2025 · The oncologist
Background Previous results of our trial demonstrated that the addition of induction chemotherapy (IC) prior to definitive chemoradiotherapy (CRT) failed to significantly improve the response rate or 3-year survival in patients with…
View details →DOI: 10.1093/oncolo/oyae295 Negative / Null Result ReportOpen accessMedicine
Murillo-Olaizola A, Rodrigo-Gisbert M, Requena M et al. · 2026 · Stroke (Hoboken, N.J.)
Background Recent randomized controlled trials of endovascular treatment (EVT) for distal and medium vessel occlusion (DMVO) stroke did not demonstrate clinical benefit over best medical therapy and suggested potential safety concerns. We…
View details →DOI: 10.1161/svin.125.002137 Negative / Null Result ReportMedicine
Peker Y, Saygin M, Celik Y et al. · 2026 · Annals of the American Thoracic Society
Rationale Recent randomized controlled trials failed to show cardiovascular benefits of treating obstructive sleep apnea (OSA) in intention-to-treat analyses which has been a matter of debate since publication of the results. Objectives To…
View details →DOI: 10.1093/annalsats/aaoag072 Negative / Null Result ReportMedicine
Gaub M, Shaffer KV, Patel P et al. · 2026 · Clinical neurology and neurosurgery
Objective EC-IC bypass for symptomatic atherosclerotic internal carotid and middle cerebral artery chronic occlusion (AIMCAO) failed to show benefit over medical management in previous randomized controlled trials. We explored how a…
View details →DOI: 10.1016/j.clineuro.2026.109417 Replication FailureMedicine
Pieracci FM, Doben A, Eriksson E et al. · 2026 · The journal of trauma and acute care surgery
Abstract The use of surgical stabilization of rib fractures (SSRF) for non-flail fracture patterns continues to rise. However, multiple, recent randomized controlled trials in this patient population have failed to show a clear benefit to…
View details →DOI: 10.1097/ta.0000000000004723 Methods Dead-EndMedicine
Iatropoulos S, Dandrieux PE, Navarro L et al. · 2024 · Scandinavian journal of medicine & science in sports
Despite exercise-based injury prevention programs (EIPPs) being widely researched and used, several randomized controlled trials (RCTs) have failed to show their protective effect on injury risk. This is potentially due to…
View details →DOI: 10.1111/sms.14720 Negative / Null Result ReportMedicine
Morimoto J, Satogami K, Naraoka T et al. · 2024 · International heart journal
Deficiency of vitamin B 1 (VB1), an essential micronutrient, causes heart failure (HF). A recent randomized controlled trial failed to show any improvement in HF prognosis after short-term VB1 supplementation. In the current study, we…
View details →DOI: 10.1536/ihj.23-550 Negative / Null Result ReportMedicine
Chevalley S, Wängberg V, Åhlén M et al. · 2024 · The Journal of hand surgery
Purpose There is no consensus on the optimal postoperative rehabilitation program following flexor tendon repair. Some studies suggest a faster recovery after active mobilization, whereas other studies have failed to find any differences…
View details →DOI: 10.1016/j.jhsa.2024.08.011 Negative / Null Result ReportMedicine
Kong SH · 2026 · Endocrinology and metabolism (Seoul, Korea)
For decades, vitamin D has been a cornerstone of preventive medicine. However, recent large-scale randomized controlled trials have failed to replicate the broad benefits previously observed in epidemiological studies, particularly with…
View details →DOI: 10.3803/enm.2029.2938 Negative / Null Result ReportMedicine
Ledesma V, Vanbaelen T, Gestels Z et al. · 2024 · FEMS microbiology letters
The ResistAZM randomized controlled trial found that the receipt of ceftriaxone/azithromycin, compared to ceftriaxone was not associated with an increase in the proportion of oral commensal Neisseria spp. and streptococci with azithromycin…
View details →DOI: 10.1093/femsle/fnae104 Negative / Null Result ReportMedicine
Gordon EJ, Gacki-Smith J, Smith JD et al. · 2026 · Clinical journal of the American Society of Nephrology : CJASN
Key points Apolipoprotein L1 genetic testing did not reduce potential living donors' willingness to donate, supporting integration of testing into practice. The Apolipoprotein L1 Testing and Counseling Program did not reduce potential…
View details →DOI: 10.2215/cjn.0000001064 Negative / Null Result ReportMedicine
Kant N, Garssen SH, Vernooij CA et al. · 2024 · Studies in health technology and informatics
Adding continuous monitoring to usual care at an acute admission ward did not have an effect on the proportion of patients safely discharged. Implementation challenges of continuous monitoring may have contributed to the lack of effect…
View details →DOI: 10.3233/shti240764 Negative / Null Result ReportMedicine
Sanders JF, de Boer SE, Jonker J et al. · 2026 · Journal of the American Society of Nephrology : JASN
Key points Low-dose tacrolimus, everolimus, and prednisolone did not result in a higher rate of successful transplantation in older kidney transplant recipients. Low-dose tacrolimus, everolimus, and prednisolone did not result in better…
View details →DOI: 10.1681/asn.0000000924 Negative / Null Result ReportMedicine
Finkelstein A, Cantor JC, Gubb J et al. · 2024 · Health affairs (Project Hope)
When a randomized evaluation finds null results, it is important to understand why. We investigated two very different explanations for the finding from a randomized evaluation that the Camden Coalition's influential care management…
View details →DOI: 10.1377/hlthaff.2023.01151 Negative / Null Result ReportMedicine
Eulenburg C, Celik Y, Redline S et al. · 2023 · Annals of the American Thoracic Society
Rationale: Recent randomized controlled trials did not show cardiovascular benefits of continuous positive airway pressure (CPAP) in adults with coronary artery disease (CAD) and obstructive sleep apnea (OSA) in intention-to-treat…
View details →DOI: 10.1513/annalsats.202208-676oc Negative / Null Result ReportMedicine
Ryser MD, Holloway ST, Morsomme R et al. · 2025 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Background The UK Collaborative Trial of Ovarian Cancer Screening did not detect a reduction in ovarian cancer mortality with either multimodal screening (MMS) or transvaginal ultrasound screening (USS) compared with no screening. The…
View details →DOI: 10.1158/1055-9965.epi-25-0498 Methods Dead-EndMedicine
Starch-Jensen, Giordano, Alsadi et al. · 2026 · Journal of oral & maxillofacial research
The aim of this single-blinded randomized controlled trial was to test the hypothesis of no difference in long-term oral health-related quality of life following surgical removal of an impacted mandibular third molar with advanced…
View details →DOI: 10.5037/jomr.2026.17101 Negative / Null Result Report
Ron Skorochod, Yoav Gronovich · 2024 · Plastic and Reconstructive Surgery - Global Open
Background: The fragility index (FI) was conceived as an adjunct to the P value, signifying the strength of statistically significant results. The index states the minimal number of patients whose outcome must be changed from “event” to…
View details →DOI: 10.1097/gox.0000000000005916 Negative / Null Result Report
Claire M. Douglas, Marnie Newell, Susan Goruk et al. · 2025 · PLOS One
Supplementation of omega-3 (n-3) polyunsaturated fatty acids has been associated with reduced side effects and improved quality of life (QoL) in breast cancer patients receiving chemotherapy. The current study reports secondary outcomes…
View details →DOI: 10.1371/journal.pone.0322178 Negative / Null Result Report
Daniel I. Rhon, Tina A. Greenlee, Rachel Mayhew et al. · 2022 · Journal of the American Academy of Orthopaedic Surgeons
Introduction: After elective orthopaedic surgery, many individuals go on to become long-term opioid users. Mitigating this risk has become a priority for surgeons, other members of the medical care team, and healthcare systems. The purpose…
View details →DOI: 10.5435/jaaos-d-21-00603 Negative / Null Result Report
Yoshihiko Saito, Sadanori Okada, Hisao Ogawa et al. · 2016 · Circulation
Introduction: It takes long time to conclude efficacy and safety of an intervention on primary prevention of cardiovascular events. Up to date, there is no study to investigate the effect of the low-dose aspirin therapy on primary…
View details →DOI: 10.1161/circ.134.suppl_1.13428 Negative / Null Result Report
L Rose · 2011 · Focus on Alternative and Complementary Therapies
Andersen D, Løssl K, Andersen AN, Fürbringer J, Bach H, Simonsen J, Larsen EC. Acupuncture on the day of embryo transfer: a randomized controlled trial of 635 patients. Reprod Biomed Online 2010; 21: 366–372.
View details →DOI: 10.1111/j.2042-7166.2011.01091_6.x 