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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

697 results in Negative / Null Result Report for "aging" · page 13 of 24

Negative / Null Result ReportOpen accessMedicine

Microultrasound imaging for accuracy of diagnosis in prostate cancer: a single‑center observational study.

Grynkiewicz M, Buffi NM, Fasulo V et al. · 2025 · Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques

Introduction Research results suggest that high-resolution ultrasonography (microUS) can be used to estimate the risk of prostate cancer (PCa) and identify suspicious areas, enabling precise biopsy during examination. Aim The aim of the…

View details →DOI: 10.20452/wiitm.2025.17978
Negative / Null Result ReportOpen accessMedicine

Effect of Nonsteroidal Anti-Inflammatory Drugs on Sacroiliac Joint Inflammation, as Seen on Magnetic Resonance Imaging, in Axial Spondyloarthritis.

Jones GT, Bennett AN, Sengupta R et al. · 2025 · Arthritis care & research

Objective Imaging evidence of active sacroiliitis is important for diagnosis, classification, and monitoring of axial spondyloarthritis (axSpA). However, there is no consistent guidance on whether patients should temporarily stop…

View details →DOI: 10.1002/acr.25581
Negative / Null Result Report

Sensitivity and Predictors of False-Negative SPECT Myocardial Perfusion Imaging in a High-Burden Coronary Artery Disease Population: A Retrospective Analysis Using Revascularization as the Reference Standard

Wright L, Hamze J, Nagrani TR et al. · 2026 · Preprint

Abstract Background Coronary artery disease (CAD) places a disproportionate burden on rural Appalachian communities. Scioto County, Ohio has among the highest rates of CAD-related hospitalizations in the state, approaching double the…

View details →DOI: 10.21203/rs.3.rs-9246863/v1
Negative / Null Result ReportMedicine

Diagnostic performance of somatostatin receptor positron emission tomography in preoperative evaluation of pancreatic neuroendocrine tumor lymph node metastases.

Gudmundsdottir H, Hernandez-Delima FJ, McDowell BC et al. · 2026 · Surgery

Background Regional lymph node involvement impacts prognosis for patients with pancreatic neuroendocrine tumors and may influence management decisions for small tumors. Conventional cross-sectional imaging modalities have low sensitivity…

View details →DOI: 10.1016/j.surg.2026.110136
Negative / Null Result ReportOpen accessMedicine

False-negative results of combined endobronchial and endoscopic ultrasound in mediastinal staging of lung cancer.

Gambuś K, Moszczyński K, Popovchenko S et al. · 2026 · Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery

Introduction Accurate assessment of mediastinal lymph node involvement is crucial for treatment planning in lung cancer. Combined endobronchial and endoscopic ultrasound (CUS) offers high sensitivity and negative predictive value (NPV),…

View details →DOI: 10.5114/kitp.2026.160677
Negative / Null Result Report

Anterior middle cingulate cortex gamma-aminobutyric acid level is elevated in children with both familial and prenatal alcohol exposure-associated attention deficit hyperactivity disorder

Alger JR, Gupta I, Farkouh L et al. · 2026 · Preprint

Background Prior neuroimaging suggests brain differences between children with attention deficit hyperactivity disorder due to prenatal alcohol exposure (ADHD+PAE) and non-exposed children with ADHD due to other, e.g., familial, causes…

View details →DOI: 10.64898/2026.05.25.26354065
Negative / Null Result Report

Diagnostic Accuracy of Magnetic Resonance Imaging versus Computed Tomography for Lumbar Spondylolysis in Patients with Chronic Low Back Pain: A Single-Center Retrospective Study

TEZCE A, DURMUŞ E · 2026 · Preprint

Abstract Purpose The objective of this study is to compare the diagnostic efficacy of Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) in detecting lumbar spondylolysis among patients presenting with chronic low back pain, and…

View details →DOI: 10.21203/rs.3.rs-9247900/v1
Negative / Null Result ReportOpen accessMedicine

Diagnostic performance and clinical limitations of sentinel lymph node biopsy in head and neck melanoma: a 20-year retrospective cohort study.

Lükewille L, Wiegand S, Fazel A et al. · 2026 · Journal of cancer research and clinical oncology

Purpose Sentinel lymph node biopsy (SLNB) is a standard procedure for nodal staging in cutaneous melanoma. However, its diagnostic performance in the head and neck region remains limited due to complex lymphatic drainage patterns. This…

View details →DOI: 10.1007/s00432-026-06499-5
Negative / Null Result Report

Designing and making an in-house real-time RT qPCR kit for the detection of SARS-CoV- 2 infection at high sensitivity and low cost

AL-Saeedi A, Abdulamir AS, Aufi IM et al. · 2025 · Preprint

Abstract Background The widespread use of accurate real-time RT-PCR tests for community individuals is a critical approach to managing the disease and reducing COVID-19 transmission effectively. In addition, serological ELISA assays are…

View details →DOI: 10.21203/rs.3.rs-8233598/v1
Negative / Null Result ReportMedicine

Managing demand for the direct antiglobulin test with a big data-derived predictive equation.

Ceacero-Marín D, Puig-Pey Comas I, Nieto-Moragas J et al. · 2026 · Scandinavian journal of clinical and laboratory investigation

Background The direct antiglobulin test (DAT) is a key diagnostic tool in evaluating autoimmune haemolytic anaemia. However, indiscriminately ordering this test, together with certain methodological limitations, can compromise the…

View details →DOI: 10.1080/00365513.2025.2605640
Negative / Null Result ReportMedicine

Early Endoscopic Retrograde Cholangiopancreatography is Associated With Improved Health Care Resource Utilization in Acute Biliary Pancreatitis Without Cholangitis.

Chu BK, Abdelbaki A, Nikahd M et al. · 2026 · Journal of clinical gastroenterology

Background The optimal timing for endoscopic retrograde cholangiopancreatography (ERCP) in managing uncomplicated acute biliary pancreatitis (ABP) remains unclear. This population-based study assessed the impact of ERCP timing on outcomes…

View details →DOI: 10.1097/mcg.0000000000002341
Negative / Null Result Report

Elevated HbA1c is associated with advanced brain age in severe obesity

Juhasz J, DeFeis B, Britton MK et al. · 2026 · Preprint

ABSTRACT Introduction Brain-predicted age, estimated from structural MRI data, is a machine learning biomarker of biological brain aging. Greater brain age gap (BAG) indicates advanced brain aging and is associated with cognitive decline…

View details →DOI: 10.64898/2026.06.04.26354935
Negative / Null Result ReportMedicine

Long Term Growth and Rupture Risk, and Associated Factors of Splenic Artery Aneurysms in a Large Observational Cohort.

Larkio J, Söderström M, Holmström J et al. · 2026 · European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

Objective The aim of this retrospective observational study was to analyse imaging and patient related parameters of splenic artery aneurysms (SAAs) and their impact on SAA growth and rupture. Methods The term "aneurysm" was systematically…

View details →DOI: 10.1016/j.ejvs.2026.06.019
Negative / Null Result ReportMedicine

Predictors of Ageism among Social Work Students and Practitioners in Greece: The Role of Aging Anxiety and Experiential Factors.

Micheli K, Koutra K, Markakis G · 2026 · International journal of aging & human development

This study examines whether aging anxiety (based on terror management theory) or demographic and experiential factors better explain attitudes toward older adults among social work students and professionals. Cross-sectional data were…

View details →DOI: 10.1177/00914150261456748
Negative / Null Result ReportOpen accessMedicine

Mesial temporal shape asymmetry as a neuro-imaging correlate of epilepsy in mild cognitive impairment and dementia.

Zawar I, Zhu S, Quigg M et al. · 2026 · Brain communications

Epilepsy is a common comorbidity of Alzheimer's disease (AD) and related dementias (ADRD). Both epilepsy and ADRD affect the mesial temporal structures in volume and morphology. Nonetheless, mesial temporal shape and volume asymmetry…

View details →DOI: 10.1093/braincomms/fcag179
Negative / Null Result ReportMedicine

Managing auditory hallucination symptoms in patients with schizophrenia in China: a best practice implementation project.

Jin X, Shen T, Wang Y et al. · 2026 · JBI evidence implementation

Introduction Auditory hallucinations, persistent and distressing symptoms in patients with schizophrenia, are often poorly controlled by antipsychotics. Structured non-pharmacological interventions remain limited in routine clinical…

View details →DOI: 10.1097/xeb.0000000000000595
Negative / Null Result ReportMedicine

Blue versus white light for transurethral resection of non-muscle invasive bladder cancer.

Maisch P, Hamidi Madani M, Koziarz A et al. · 2026 · The Cochrane database of systematic reviews

Rationale Disease recurrence and progression remain major challenges in the treatment of non-muscle invasive bladder cancer (NMIBC). Blue light-enhanced transurethral resection of bladder cancer (TURBT) is an approach to improve staging…

View details →DOI: 10.1002/14651858.cd013776.pub3
Negative / Null Result ReportOpen accessMedicine

Sound-induced visual motion perception in older adults: aging enhances audiovisual motion integration.

Harada S, Teraoka R, Kuroda N et al. · 2026 · Experimental brain research

This study investigated audiovisual integration in visual motion perception among both younger and older adults. Participants were asked to discriminate the visual motion direction of a random dot kinematogram in two experiments. The…

View details →DOI: 10.1007/s00221-026-07286-x
Negative / Null Result ReportMedicine

Dual-Energy X-Ray Absorptiometry Does Not Confirm Validity of the Craig's Test.

Clark KA, Nielsen S, Heywood T et al. · 2024 · Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry

The Craig's test is a clinical assessment used to quantify femoral version. The validity of the Craig's test has been called into question due to instances where the test exhibits relatively poor correlation with three-dimensional imaging.…

View details →DOI: 10.1016/j.jocd.2024.101466