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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

741 results for "aging" · page 13 of 25

Negative / Null Result ReportMedicine

Waggle-dance-recruited honeybees expect landscape structures.

Wang Z, Mach J, Chen X et al. · 2025 · Current biology : CB

Honeybee foragers explore the environment before they start foraging, following dances, or performing dances. Foragers are therefore familiar with the landscape surrounding the hive during their foraging career. Here, we ask whether…

View details →DOI: 10.1016/j.cub.2025.08.055
Negative / Null Result ReportMedicine

Exploitation of Saccharomyces cerevisiae as an alternative microencapsulation strategy of thymol via β-glucan based matrix for the development of multilayer LDPE active packaging films - comparison with zeolite- and activated carbon-based carriers.

Giotopoulou I, Stamatis H, Barkoula NM · 2025 · International journal of biological macromolecules

In the current study Saccharomyces cerevisiae (S. cerevisiae) was exploited as an alternative carrier of thymol with the aim of developing multilayer low-density polyethylene (LDPE) films with advanced bioactivity over time. The results…

View details →DOI: 10.1016/j.ijbiomac.2025.146017
Negative / Null Result ReportOpen accessMedicine

A case-control neuroimaging investigation of chronic Zika virus-infected adults.

Jun S, Bido-Medina R, Oviedo J et al. · 2026 · Frontiers in human neuroscience

Background Systemic viral infections with neurotropic potential pose significant global health challenges. The Zika virus (ZIKV) is known for its pronounced neurotropism, with recent infectious clusters raising renewed public health…

View details →DOI: 10.3389/fnhum.2026.1710905
Negative / Null Result ReportOpen accessMedicine

Economic incentives contribute little to reducing agricultural damage from invasive non-native species: evidence from raccoon management in Hokkaido, Japan.

Mameno K, Suzuki T, Yamaguchi S et al. · 2026 · Pest management science

Background An economic incentive scheme is utilized to enhance citizens' support for managing invasive non-native species. However, the effectiveness of the incentive scheme in the outcomes of the management remains unclear. This study…

View details →DOI: 10.1002/ps.70397
Negative / Null Result ReportOpen accessMedicine

Effect of <i>Echinacea purpurea</i> on cytokine gene expression (IL10, IL1β, TNFα, IFNγ), telomere length, lipid peroxidation, and nitric oxide in broilers reared at high altitude.

Bahadoran S, Vaeznia S, Hassanpour H · 2026 · Veterinary and animal science

This study evaluated the effects of dietary Echinacea purpurea supplementation on immune regulation, oxidative stress, and cellular aging in broiler chickens reared at high altitude (2100 m). One hundred and eight day-old male Ross 308…

View details →DOI: 10.1016/j.vas.2026.100675
Negative / Null Result ReportOpen accessMedicine

Transcranial Magnetic Stimulation over the Left Inferior Parietal Lobule Facilitates Early-Stage Processing During Natural Chinese-English Bilingual Reading.

Wu J, Hang R, Xin P et al. · 2026 · Brain sciences

Background: Proficient second language (L2) reading relies on complex neurocognitive processes. Neuroimaging studies have identified key brain regions recruited during L2 reading, including the left inferior parietal lobule (LIPL) and the…

View details →DOI: 10.3390/brainsci16050530
Negative / Null Result ReportMedicine

Telomere length in individuals with and without major depression and adverse childhood experiences.

Kuehl LK, de Punder K, Deuter CE et al. · 2022 · Psychoneuroendocrinology

Major depressive disorder (MDD) and adverse childhood experiences (ACE) are associated with poor physical and mental health in adulthood. One underlying mechanism might be accelerated cellular aging. For example, both conditions, MDD and…

View details →DOI: 10.1016/j.psyneuen.2022.105762
Negative / Null Result ReportOpen accessMedicine

No evidence that averaging voices influences attractiveness.

Ostrega J, Shiramizu V, Lee AJ et al. · 2024 · Scientific reports

Vocal attractiveness influences important social outcomes. While most research on the acoustic parameters that influence vocal attractiveness has focused on the possible roles of sexually dimorphic characteristics of voices, such as…

View details →DOI: 10.1038/s41598-024-61064-9
Negative / Null Result ReportOpen accessMedicine

The relationship between aging out of the special supplemental nutrition program for women, infants, and children assistance and weight status in kindergarten.

Lazic A, Thomsen MR, Brown CC et al. · 2025 · Preventive medicine reports

Objective The Supplemental Nutrition Program for Women, Infants, and Children (WIC) provides access to nutritional resources to low-income children starting at birth through enrollment in kindergarten or turning five years old. The…

View details →DOI: 10.1016/j.pmedr.2025.103125
Negative / Null Result ReportOpen accessMedicine

Association of cardiovascular risk scores with coronary plaque and its progression among individuals with family history of coronary artery disease.

Soh CH, Nerlekar N, Whitmore K et al. · 2026 · American journal of preventive cardiology

Background Multiple cardiovascular (CV) risk assessment scores can predict CV events. The current trend towards assessing atheroma has led to these scores being used to identify patients who might benefit from coronary plaque imaging.…

View details →DOI: 10.1016/j.ajpc.2026.101423
Negative / Null Result ReportOpen accessMedicine

No Support for White Matter Alterations in Adults With Dyslexia: A Fixel-Based Diffusion MRI Study.

Verhelst H, Gerrits R, Karlsson EM · 2025 · Neurobiology of language (Cambridge, Mass.)

Developmental dyslexia is a common learning disability marked by reading and spelling difficulties. While previous imaging studies aiming to elucidate the neurobiological mechanisms of this disorder have reported white matter alterations,…

View details →DOI: 10.1162/nol.a.17
Failed Experiment ReportMedicine

Is exergaming a viable exercise option for obese black women?

Hicks J, Dash C, Smith D et al. · 2025 · Contemporary clinical trials

Background Physical inactivity and obesity, which are disproportionately higher in Black women, are known risk factors of breast cancer. Novel methods to address this public health concern involve leveraging screen-viewing activities to…

View details →DOI: 10.1016/j.cct.2025.107846
Abandoned HypothesisOpen accessMedicine

Why doesn't neuroimaging work in psychiatry?

McCutcheon RA, Jauhar S, Pillinger T · 2026 · The British journal of psychiatry : the journal of mental science

Half a century of neuroimaging has transformed our understanding of psychiatric disorders but not our clinical practice. This piece examines why that promise remains unfulfilled and argues that the future lies not in ever newer tools but…

View details →DOI: 10.1192/bjp.2025.10517
Negative / Null Result ReportOpen accessMedicine

Effects of one avocado a day for six months on cognitive performance in overweight adults: A randomized controlled trial.

Lee GJ, Morrell HER, Adams M et al. · 2026 · The journal of nutrition, health & aging

Background With the rising incidence of neurodegenerative diseases and aging of the global population, it is important to investigate foods that may preserve cognitive function with advancing years. Avocados are rich in fiber, carotenoids,…

View details →DOI: 10.1016/j.jnha.2026.100847
Negative / Null Result ReportOpen accessMedicine

The role of household composition in social isolation and anxiety: evidence from adults in South Africa during the COVID-19 pandemic.

Jennings EA, Roberts-Toler C, Harriman NW et al. · 2026 · The journals of gerontology. Series B, Psychological sciences and social sciences

Objectives Social isolation is a concern among aging populations, and household composition may play an important role in its impact on mental health. We use data from an aging cohort in rural South Africa to investigate the moderating…

View details →DOI: 10.1093/geronb/gbag076
Negative / Null Result ReportOpen accessMedicine

Redefining Ischemic Core, Penumbra, and Target Mismatch on Perfusion Imaging in Acute Anterior Distal Medium Vessel Occlusion.

Cai LY, Hoseinyazdi M, Lakhani DA et al. · 2025 · Stroke (Hoboken, N.J.)

Background Recent trials of endovascular thrombectomy (EVT) for acute distal medium vessel occlusions (DMVOs) were negative but also used inconsistent imaging-based inclusion criteria, whereas many successful large vessel occlusion (LVO)…

View details →DOI: 10.1161/svin.125.001900
Negative / Null Result ReportMedicine

Performance of the Healthy Aging Brain Care Monitor Self Report in Monitoring Post-Intensive Care Syndrome Among Acute Respiratory Failure Survivors.

Savsani PK, Khan SH, Perkins AJ et al. · 2025 · Critical care medicine

Objectives To describe the performance of the Healthy Aging Brain Care Monitor Self Report (HABC-M SR) in assessment of post-intensive care syndrome (PICS) among Acute Respiratory Failure ICU survivors. Design Secondary data analysis of a…

View details →DOI: 10.1097/ccm.0000000000006522
Negative / Null Result ReportOpen accessMedicine

Triple Therapy: A Safe, Cost-Effective Regimen of Heparin, Aspirin and Clopidogrel for Managing Intracranial Vessel Occlusions in Patients With Acute Ischemic Stroke Who Are Ineligible for Intravenous Thrombolytics and Endovascular Thrombectomy.

Chaudhari A, Almajali M, Khan N et al. · 2026 · Stroke (Hoboken, N.J.)

Background Endovascular thrombectomy (EVT) has transformed the management of acute ischemic stroke, but remains inaccessible to many patients due to anatomic, clinical, or logistical limitations. Treatment strategies for patients with…

View details →DOI: 10.1161/svin.125.002175
Negative / Null Result ReportOpen accessMedicine

Conventional versus advanced imaging selection for endovascular treatment of basilar artery occlusion strokes.

Chen H, Colasurdo M, Matsukawa H et al. · 2026 · European stroke journal

Introduction Endovascular thrombectomy (EVT) is an effective treatment for basilar artery occlusion (BAO) stroke in select patients. While there is a growing body of literature suggesting that advanced imaging modalities such as computed…

View details →DOI: 10.1093/esj/23969873251364973
Failed Experiment ReportOpen accessMedicine

Conventional versus advanced imaging selection for endovascular treatment of basilar artery occlusion strokes.

Chen H, Colasurdo M, Matsukawa H et al. · 2025 · European stroke journal

Introduction Endovascular thrombectomy (EVT) is an effective treatment for basilar artery occlusion (BAO) stroke in select patients. While there is a growing body of literature suggesting that advanced imaging modalities such as computed…

View details →DOI: 10.1177/23969873251364973
Negative / Null Result ReportMedicine

Quantitative Analysis of Serial Positron Emission Tomography Imaging in Men with Metastatic Castration-resistant Prostate Cancer Treated with Enzalutamide.

Gandhy SU, Karzai FH, Bilusic M et al. · 2024 · European urology oncology

Background The emergence of positron emission tomography (PET) in prostate cancer is impacting clinical practice, but little is known about PET imaging as a tool to determine treatment failure in metastatic castration-resistant prostate…

View details →DOI: 10.1016/j.euo.2023.09.010
Negative / Null Result ReportOpen accessMedicine

Fluorescence-Guided Laparoscopy after Oral Hypericin Administration for Staging of Locally Advanced Gastric Cancer-A Pilot Study.

Yurttas C, Horvath P, Fischer I et al. · 2024 · Journal of clinical medicine

(1) Background: Laparoscopic staging is essential in gastric cancer (GC) to rule out peritoneal metastasis (PM). Hypericin, a plant-derived fluorescent compound, has been suggested to improve laparoscopic visualization of PM from GC. This…

View details →DOI: 10.3390/jcm13082422
Failed Experiment ReportMedicine

Diagnostic utility and limitations of CT-guided transthoracic fine-needle aspiration biopsy in Lung-RADS 4 pulmonary nodules ≤2 cm.

Cengiz SK, Demirer E, Baysal T et al. · 2026 · Annals of Saudi medicine

Background Managing small Lung-RADS 4 pulmonary nodules is clinically challenging. While CT-guided TTFNAB is standard, its efficacy and safety for lesions ≤2 cm require further evaluation to optimize outcomes and reduce unnecessary…

View details →DOI: 10.5144/0256-4947.2026.225
Negative / Null Result ReportOpen accessMedicine

Concordance Analysis of ALEX-2, ImmunoCAP, and Prick Test for Respiratory Allergies in Lima, Peru.

Galván CA, Durán R, Larco JI et al. · 2026 · Immunity, inflammation and disease

Background Accurate identification of respiratory allergen sensitization is essential for managing asthma and allergic rhinitis (AR). While Skin Prick Test (SPT) and ImmunoCAP are standard diagnostic tools, exploratory comparative data for…

View details →DOI: 10.1002/iid3.70325