459 results in Negative / Null Result Report for "randomized controlled trial" · page 12 of 16
Negative / Null Result ReportMedicine
Rajvanshi, Kumar, Goyal et al. · 2026 · Pediatric pulmonology
Flexible fibreoptic bronchoscopy (FFB) is widely used in pediatric pulmonology, though hypoxemia remains a primary concern during the procedure. High-flow nasal cannula (HFNC) has shown potential in reducing hypoxemia in adults undergoing…
View details →DOI: 10.1002/ppul.71683 Negative / Null Result ReportMedicine
Naoumova, Nawaia, Krekmanova · 2026 · European journal of orthodontics
Extraction of mandibular primary second molars in patients with congenitally missing second premolars may influence oral health-related quality of life (OHRQoL), yet this has not been previously investigated. To assess the impact of…
View details →DOI: 10.1093/ejo/cjag048 Negative / Null Result ReportMedicine
Mohammed, Naser, Abozaid · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]
Composite resin placement technique may influence marginal integrity, polymerization stress distribution, and long-term clinical performance of posterior restorations. This randomized controlled clinical trial evaluated the 24-month…
View details →DOI: 10.1111/jerd.70202 Negative / Null Result ReportMedicine
Niu, Bao, Zhao · 2026 · Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
This study aimed to systematically evaluate the efficacy and safety of different doses of domperidone (DOM) combined with esomeprazole (ESM) in the treatment of reflux esophagitis, providing a basis for precise clinical medication. This…
View details →DOI: 10.1093/dote/doag053 Negative / Null Result ReportMedicine
Chen, Song, Zang et al. · 2026 · BMC anesthesiology
Right lateral thoracotomy cardiac surgery induces postoperative atelectasis due to cardiopulmonary bypass (CPB), patient positioning, and mechanical ventilation. Fixed positive end-expiratory pressure (PEEP) may fail to meet pediatric…
View details →DOI: 10.1186/s12871-026-03947-0 Negative / Null Result ReportMedicine
Li, Zhang, Ni et al. · 2026 · Journal of pain research
The purpose of this study was to evaluate the analgesic effect of infraspinatus teres minor (ITM) block in scapular fracture (SFs) surgery. A prospective, randomized, controlled trial was carried out on patients undergoing SFs surgery.…
View details →DOI: 10.2147/jpr.s605358 Negative / Null Result ReportMedicine
Wang, Wang, Wu et al. · 2026 · BMC oral health
Anterior disc displacement with reduction (ADDwR) is a common temporomandibular joint disorder in adolescents. Conventional anterior repositioning splints (ARS) often lack anatomical adaptation, which may limit their therapeutic precision…
View details →DOI: 10.1186/s12903-026-08753-1 Negative / Null Result ReportMedicine
Ran, Wei, Huang et al. · 2025 · Frontiers in psychology
To investigate the effectiveness of a VR preoperative education program with sensory information support in reducing perioperative anxiety and improving the delivery experience among primiparas undergoing cesarean section (CS). A total of…
View details →DOI: 10.3389/fpsyg.2025.1648706 Negative / Null Result ReportMedicine
Shamsoddini, Cheraghifard · 2026 · European geriatric medicine
Balance issues and the fear of falling are among the primary factors contributing to falls in older people, leading to injury and a decline in quality of life. A single-blind, randomized, controlled trial was conducted involving 34 older…
View details →DOI: 10.1007/s41999-026-01493-z Negative / Null Result ReportMedicine
Tan, Feng, Wen et al. · 2026 · Medicine
To investigate the effect of expressive writing intervention on optimism and coping modes of newly diagnosed people with human immunodeficiency virus (HIV). A total of 84 newly diagnosed people with HIV in the care clinic of Public Health…
View details →DOI: 10.1097/md.0000000000048936 Negative / Null Result ReportMedicine
Reysner, Ciftci, Alver et al. · 2026 · Journal of clinical medicine
Background: The pericapsular nerve group block provides motor-sparing analgesia after total hip arthroplasty, but the optimal injectate volume and the role of dexamethasone remain unclear. Methods: In this prospective, randomized,…
View details →DOI: 10.3390/jcm15103676 Negative / Null Result ReportMedicine
Arslan, Tufekci, Acar et al. · 2026 · International urogynecology journal
This study aimed to examine the effects of tele-Pilates exercise on menopausal symptoms, quality of life, depression, and anxiety levels in postmenopausal women. Forty postmenopausal women were separated into two groups: as tele-Pilates…
View details →DOI: 10.1007/s00192-026-06713-5 Negative / Null Result ReportMedicine
Kacar, Ayaz-Alkaya · 2026 · Journal of pediatric nursing
Internet addiction is a growing problem among children and adolescents. Pathological internet use may lead to psychological and social issues. More effective and innovative interventions are needed to promote the mental health of children.…
View details →DOI: 10.1016/j.pedn.2026.02.035 Negative / Null Result ReportMedicine
Elgayar · 2026 · Scientific reports
This trial aimed to explore the effect of supervised breathing exercises (BEs) on depression, sexual function, and exercise capacity in postmenopausal women. Sixty-four depressed postmenopausal women with associated sexual dysfunction were…
View details →DOI: 10.1038/s41598-026-41198-8 Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Yan-Tao Ma, Yu-Lin Dong, Bo Wang et al. · 2023 · BMC Musculoskeletal Disorders
Abstract Background Latent and active myofascial trigger points (MTrPs) in knee-associated muscles may play a key role in pain management among patients with knee osteoarthritis (KOA). The aim of this study was to investigate the effect of dry needling treatment on pain intensity, disability, and range of motion (ROM) in patients with KOA. Methods This randomized, single-blinded, clinical trial was carried out for 6 weeks of treatment and 6-month follow-up. A total of 98 patients met the entry criteria and were randomly assigned to the dry needling latent and active myofascial trigger point (M
View details →DOI: 10.1186/s12891-022-06116-9 Negative / Null Result ReportOpen accessSurgery
Mohamed Nasr, Moustafa AH El-Nawasany, Haytham E Ali et al. · 2025 · JPRAS Open
Background: Diabetic foot ulcers (DFUs) are a serious complication of diabetes that can lead to significant morbidity. Autologous platelet-rich plasma (PRP), rich in growth factors and cytokines, has emerged as a promising treatment to enhance ulcer healing. This study aimed to compare the clinical and histological efficacy of injected PRP versus topically applied PRP and traditional wound care in the management of DFUs. Methods: Sixty patients with DFUs were randomly assigned to three equal groups (n = 20 each). Group A received locally injected autologous PRP; Group B received topically appl
View details →DOI: 10.1016/j.jpra.2025.08.008 Negative / Null Result ReportOpen accessSports medicine
Xianfu Song, Dan Wang, Dexin Wang et al. · 2026 · BMC Sports Science, Medicine and Rehabilitation
Abstract Objective This study investigated the effects of an 8-week Taekwondo program on the attention of children aged 7–8 years, exploring its potential as a motor intervention during a critical developmental period. Methods Forty children were randomly assigned to either an experimental group (EG, n = 20), which participated in a structured Taekwondo program (three 45-minute sessions/week at ≥ 60% HRmax), or a control group (CG, n = 20), which attended regular physical education classes. Attention was assessed pre- and post-intervention using tasks measuring stability, allocation, shifting,
View details →DOI: 10.1186/s13102-026-01570-7 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Pankaj Puar, Nikhil Mistry, Kim A. Connelly et al. · 2023 · ESC Heart Failure
Abstract Aims Given recent suggestions that serum levels of insulin‐like growth factor‐binding protein 7 (IGFBP7) may identify patients who derive greater cardiorenal benefits from treatment with sodium‐glucose transport 2 inhibitors (SGLT2i), this exploratory sub‐analysis of the EMPA‐HEART CardioLink‐6 randomized controlled trial evaluated the association between serum levels of IGFBP7 and empagliflozin‐mediated left ventricular mass regression. Methods and results The EMPA‐HEART CardioLink‐6 trial used gold‐standard cardiac magnetic resonance imaging to detect change in left ventricular mass
View details →DOI: 10.1002/ehf2.14335 Negative / Null Result ReportMedicine
N. Segal, Lauren N. Neuman, Maria C Hochstedler et al. · 2018 · The Foot
INTRODUCTION Anthropometric changes to the feet with pregnancy may increase risk for musculoskeletal disease. Customized arch-supportive orthoses to prevent anthropometric changes could potentially provide an inexpensive means to prevent…
View details →DOI: 10.1016/j.foot.2018.07.007 Negative / Null Result ReportOpen accessMedicine
Xin Yuan, Kai Chen, Jing Yuan et al. · 2023 · International Journal of Antimicrobial Agents
BACKGROUND Inappropriate antimicrobial use is common for patients undergoing surgery. Whether a multifaceted computerized antimicrobial stewardship program is effective and safe in reducing inappropriate antimicrobial use in surgical…
View details →DOI: 10.1016/j.ijantimicag.2023.106787 Negative / Null Result ReportOpen accessMedicine
S. Possmark, F. Sellberg, A. Ghaderi et al. · 2021 · PLoS ONE
Background The majority of Roux-en-Y gastric bypass (RYGB) patients are not sufficiently physically active post-surgery, yet little support from the Swedish healthcare system is offered. We investigated if a dissonance-based group…
View details →DOI: 10.1371/journal.pone.0255556 Negative / Null Result ReportOpen accessMedicine
Fabio La Porta, S. Caselli, G. Lullini et al. · 2022 · medRxiv
Background: The fall risk in the elderly is a major public health issue due to the immediate injury-related consequences and the risk of associated long-term disability. However, the delivery of effective interventions for fall prevention…
View details →DOI: 10.1101/2022.03.26.22272987 Negative / Null Result ReportMedicine
K. Mattern-Baxter, J. Looper, Chuan Zhou et al. · 2020 · Archives of Physical Medicine and Rehabilitation
OBJECTIVE To compare the effect of low-intensity (LI) versus high-intensity (HI) TT on walking attainment and overall walking activity in children with cerebral palsy (CP). DESIGN Prospective, multi-site, randomized controlled trial…
View details →DOI: 10.1016/j.apmr.2019.09.015 Negative / Null Result ReportOpen accessMedicine
Danni Qu, Yuan Li · 2020 · Journal of International Medical Research
Objective To evaluate the efficacy and safety of multiple- versus single-dose gonadotropin-releasing hormone agonist (GnRH-a) addition to luteal phase support (LPS), in patients with a first in vitro fertilization (IVF) failure associated…
View details →DOI: 10.1177/0300060520926026 Negative / Null Result ReportOpen accessMedicine
Chen C, Zhang J, Hua K et al. · 2026 · Orthopaedic surgery
Purposes Open elbow arthrolysis (OEA) is a common method for treating post-traumatic elbow stiffness, which may lead to severe bleeding when resecting heterotopic ossification (HO) and fibrous scar tissue. The purpose of this study is to…
View details →DOI: 10.1111/os.70311 Negative / Null Result ReportOpen accessMedicine
Friederich M, Brunner J, Kirsch E et al. · 2026 · BMC musculoskeletal disorders
Background Distal radius fractures (DRF) are often immobilized using a conventional plaster cast although orthoses offer a time- and resource-saving alternative. This prospective randomized study compared the conservative DRF treatment…
View details →DOI: 10.1186/s12891-026-09585-4 Negative / Null Result ReportOpen accessMedicine
Shi S, Liang Y, Liu T et al. · 2026 · Drug design, development and therapy
Background Colorectal cancer remains a leading cause of cancer-related mortality worldwide. Postoperative pain can impair recovery. Thoracic paravertebral block (TPVB) and erector spinae plane block (ESPB) are regional analgesic techniques…
View details →DOI: 10.2147/dddt.s581084 Negative / Null Result ReportMedicine
Xie YJ, Song MS, Ma XD et al. · 2026 · Gait & posture
Objective This study seeks to compare the impacts of various robotic gait training (RAGT) modes on lower limb motor function recovery in stroke patients while exploring the corresponding neural mechanisms. Design A single-blind, randomized…
View details →DOI: 10.1016/j.gaitpost.2026.110249 Negative / Null Result ReportOpen accessMedicine (General)
Dalia M. Kamel, Nashwa S. Hamed, Neveen A. Abdel Raoof et al. · 2017 · Journal of Advanced Research
The aim of this study was to compare the effects of pulsed electromagnetic field versus pulsed ultrasound in treating patients with postnatal carpal tunnel syndrome. The study was a randomized, double-blinded trial. Forty postnatal female patients with idiopathic carpal tunnel syndrome were divided randomly into two equal groups. One group received pulsed electromagnetic field, with nerve and tendon gliding exercises for the wrist, three times per week for four weeks. The other group received pulsed ultrasound and the same wrist exercises. Pain level, sensory and motor distal latencies and con
View details →DOI: 10.1016/j.jare.2016.11.001 Negative / Null Result ReportOpen accessAnesthesiology
Christian Rothe, Jørgen Lund, Morten Troels Jenstrup et al. · 2020 · BMC Anesthesiology
Abstract Background The sensory innervation of the shoulder is complex and there are variations in the branching patterns of the sensory fibres. Articular branches from the axillary nerve to the subacromial bursa are described in more than 50% of investigated shoulders but the isolated contribution of sensory input from the axillary nerve has never been investigated clinically. We hypothesized that a selective block of the axillary nerve would reduce morphine consumption and pain after arthroscopic subacromial decompression. Methods We included 60 patients in a randomized, blinded, placebo-con
View details →DOI: 10.1186/s12871-020-0952-y 