A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
730 results in Negative / Null Result Report for "aging" · page 12 of 25
Straub D, Englert T, Beller A et al. · 2026 · Sports medicine - open
Background The gut microbiome plays a critical role in metabolism, immunity, and aging. While endurance training has been shown to beneficially modulate the microbiome, the effects of resistance training remain less clear, with some…
Xu Ma, Jiajie Zhang, Fujing Xie et al. · 2025 · arXiv
Global localization is essential for autonomous robotics, especially in indoor environments where the GPS signal is denied. We propose a novel WiFi-based localization framework that leverages ubiquitous wireless infrastructure and the OpenStreetMap Area Graph (osmAG) for large-scale indoor environments. Our approach integrates signal propagation modeling with osmAG's geometric and topological priors. In the offline phase, an iterative optimization algorithm localizes WiFi Access Points (APs) by modeling wall attenuation, achieving a mean localization error of 3.79 m (35.3\% improvement over tr
Abassi W, Ouerghi N, Feki O et al. · 2026 · Clinics (Sao Paulo, Brazil)
Objective Obesity is a major independent risk factor for chronic kidney disease. High-Intensity Interval Training (HIIT) is recognized as an interesting therapeutic strategy in managing obesity and related disorders. However, there is…
Domin M, Liew SL, Hordacre B et al. · 2025 · NeuroImage
Indirect structural disconnection-symptom mapping allows white matter impairment to be determined without the need for multi-directional diffusion (MDDW) imaging for each individual. Although widely used this method has not been validated.…
Rodriguez-Belenguer P, Beser-Robles M, Marfil-Trujillo M et al. · 2026 · Computer methods and programs in biomedicine
Background and objectives Radiomics-based machine learning models are increasingly used for clinical decision-making, yet their reliability is often constrained by limited sample sizes and class imbalance in imaging datasets. While prior…
Phillipson J, Menson E, Barclay S et al. · 2026 · Archives of disease in childhood
Objective Evaluation of the Medical Mediation Foundation's Conflict Management Programme (CMP)-a structured process for managing conflict. Design Mixed-methods evaluation using Kirkpatrick's framework, a four-level model for evaluating…
Baek CH, Lim C, Kim JG et al. · 2026 · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
Background Cystic changes within interpositional grafts used for arthroscopy-assisted lower trapezius tendon transfer (aLTT) are occasionally detected on postoperative magnetic resonance imaging (MRI); however, their clinical significance…
Van Dyken PC, Yang K, Faria AV et al. · 2025 · Biological psychiatry global open science
Background White matter alterations observed using diffusion weighted imaging have become a hallmark of chronic schizophrenia, but it is unclear when these changes arise over the course of the disease. Nearly all studies reported to date…
Vang K, Panich J, Folz C et al. · 2025 · Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
IntroductionImmune checkpoint inhibitors (CPIs) work by engaging the patient's immune system against tumor cells and have demonstrated a significant benefit in the treatment of cancers. Activation of the patient's immune system can lead to…
Hosseinzadeh E, Arefnia M, Bayat M et al. · 2026 · Cancer biotherapy & radiopharmaceuticals
Background Intense hepatobiliary uptake of [ 99m Tc]Tc-sestamibi in myocardial perfusion scintigraphy (MPS) often degrades image quality by obscuring the inferior myocardial wall, leading to equivocal studies. While nonpharmacological…
Esmeray A, Yazili HB, Gelmis M et al. · 2026 · The Canadian journal of urology
Objectives Supracostal access during percutaneous nephrolithotomy (PCNL) increases the risk of pulmonary complications. Although routine postoperative thoracic imaging is commonly performed to detect these events, its clinical necessity…
Matziorinis AM, Gaser C, Koelsch S · 2022 · Preprint
Music-making and engagement in music-related activities have shown procognitive benefits for healthy and pathological populations, suggesting reductions in brain aging. A previous brain aging study, using Brain Age Gap Estimation…
Zuo P, Jiang K, Zou W et al. · 2026 · Neurosurgery
Background and objectives Atypical choroid plexus papillomas (ACPPs) are exceedingly uncommon. The treatment strategies for managing this condition remain a topic of debate. The main aim of this study was to elucidate the clinical features…
Ciana Bowhay, Michael Nattrass · 2026 · NACTA Journal
Undergraduate students in agriculture often struggle to connect theoretical course concepts with real-world agricultural practices. Additionally, with expanding digitalization of professional markets, building a professional online…
· 2025 · International Journal of Medicine and Medical Research
Lifestyle-related disorders, particularly diabetes, pose a significant global health challenge. Diabetic macular oedema, a microvascular complication, highlights the importance of managing insulin resistance and hyperlipidaemia for optimal…
Liu J, Catanzariti MJ, Nguyen-Hao HT et al. · 2026 · Journal of neuropathology and experimental neurology
Alcohol use disorder (AUD) is characterized by an inability to stop consuming alcohol. Neuroimaging studies of patients with AUD show mild grey and white matter atrophy, while pathological studies suggest that atrophy is restricted to the…
Schneider BS, Pfaehler CD, Hao KA et al. · 2026 · The Journal of the American Academy of Orthopaedic Surgeons
Background Although os acromiale is often noted on preoperative imaging in patients undergoing reverse total shoulder arthroplasty (rTSA), its clinical significance is ill-defined. The purpose of this study was to compare the clinical…
Mirza M, Fischer H, Arias D · 2026 · OTJR : occupation, participation and health
Background Aging adults with chronic diseases are at risk of functional decline. Objectives This pilot randomized control trial examined the feasibility, acceptability, and preliminary efficacy of an occupational therapy intervention to…
Kluckner M, Hitzl W, Enzmann FK et al. · 2026 · Journal of clinical medicine
Background/Objectives : Hyperspectral imaging (HSI) facilitates noninvasive assessment of tissue perfusion in patients with peripheral arterial disease. However, available studies are either based on small cohorts and provide no comparison…
Hashimoto R, Otsuki Y, Nakamura T · 2026 · Cureus
Pulmonary metastases from papillary thyroid carcinoma (PTC) are usually detectable by computed tomography (CT) or radioactive iodine (RAI) scanning. Pathologically proven pulmonary micrometastases that are completely undetectable by…
Hirose R, Matsuura K, Ii Y et al. · 2026 · Journal of neural transmission (Vienna, Austria : 1996)
In Parkinson's disease (PD), neuronal loss occurs in the substantia nigra (SN) and locus coeruleus (LC). Previous studies using neuromelanin-sensitive magnetic resonance imaging (NMI) at 3T MRI have described the measurement methods and…
· 2025 · European Journal of Clinical Pharmacy
Pediatric nephrolithiasis is an increasing concern and often requires complete stone clearance due to high recurrence risk. Managing large renal stones (>2 cm), lower calyceal stones (>1 cm), and stones refractory to Extracorporeal Shock…
Samal DR, Mendiratta P · 2026 · Preprint
Abstract The CoViD situation globally tested the efficacy of health infrastructure as well as the administrative management of urban areas. This study focuses on the impact of the CoViD-19 pandemic across the nine municipal corporations in…
Wilk B, Lim H, Hicks J et al. · 2025 · JACC. Clinical electrophysiology
Background Atrial fibrillation is associated with abnormal synchronization of left atrial electrical activity and substantially increased risk of myocardial infarction, stroke and heart failure. Objectives This study sought to investigate,…
Grunert M, Horn V, Baudrexl JC et al. · 2026 · European journal of radiology
Background Progressive fibrosing interstitial lung diseases (ILD) continue to have a poor prognosis. To date, there is no imaging method that can reliably detect fibrotic remodeling processes or distinguish between active and dormant…
Jiang C, Cheng P, Liu Y et al. · 2025 · Journal of pediatric orthopedics
Introduction Imaging-based measurement indices of patellar height are essential for diagnosing patella alta in children and adolescents. The Patellotrochlear Index (PTI) measures the cartilaginous anatomy which is crucial for identifying…
shoabjareh ME, Ansari-Astaneh M, Shoeibi N et al. · 2026 · Preprint
Abstract Background This study evaluated choroidal thickness in healthy Iranian individuals using enhanced depth imaging optical coherence tomography (EDI-OCT) and evaluated its correlation with demographic characteristics, laboratory test…
Miao J, Xu Y, Qiao F et al. · 2026 · Oncology letters
The present prospective study aimed to investigate whether gallium-68-labeled fibroblast activation protein inhibitor-04 ( 68 Ga-FAPI-04) positron emission tomography (PET)/magnetic resonance imaging (MRI) could provide notably increased…
Uchechi Vanessa Alintah-Abel, Francisca Nkachukwu Okeke, Eucharia Chika Enebe · 2025 · British Journal of Multidisciplinary and Advanced Studies
The goal of most countries is the desire to maintain a stable price level of goods and services. This however, appears to be an uphill task given the incidence of subsidy removal that is presently ravaging the developing economies of the…
Brandtzäg AA, Eiberg JP, Taudorf M et al. · 2026 · EJVES vascular forum
Introduction To evaluate intra-arterial pressure measurement (IAPM) in relation to pre- and intra-operative diagnostic methods for assessing superior mesenteric artery (SMA) stenosis in patients with a diagnosis of chronic mesenteric…