A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
741 results for "aging" · page 11 of 25
Zeng Y, Zhu Y, Liu W et al. · 2026 · Preprint
Abstract Background When the function of one kidney is impaired or lost, the contralateral kidney may exhibit varying degrees of compensatory response. However, the influencing factors and underlying mechanisms of renal compensation remain…
Chen JSC, Osborne JWA, Menz HB et al. · 2026 · Journal of foot and ankle research
Background Fatty infiltration, or fatty atrophy, of the abductor digiti minimi (ADM) muscle of the foot is proposed to be associated with entrapment of the first branch of the lateral plantar nerve (i.e., Baxter's neuropathy) as part of…
Felix Krejca, Tobias Kietreiber, Alexander Buchelt et al. · 2025 · arXiv
The increasing volume of online discussions requires advanced automatic content moderation to maintain responsible discourse. While hate speech detection on social media is well-studied, research on German-language newspaper forums remains limited. Existing studies often neglect platform-specific context, such as user history and article themes. This paper addresses this gap by developing and evaluating binary classification models for automatic content moderation in German newspaper forums, incorporating contextual information. Using LSTM, CNN, and ChatGPT-3.5 Turbo, and leveraging the One Mi
Weronika Ormaniec, Michael Vollenweider, Elisa Hoskovec · 2025 · arXiv
In this paper, we explore the idea of combining GCNs into one model. To that end, we align the weights of different models layer-wise using optimal transport (OT). We present and evaluate three types of transportation costs and show that the studied fusion method consistently outperforms the performance of vanilla averaging. Finally, we present results suggesting that model fusion using OT is harder in the case of GCNs than MLPs and that incorporating the graph structure into the process does not improve the performance of the method.
Mohamad A. Alanbari, Mohamad A. Alanbari, Hebah M. Hamdan et al. · 2024 · Frontiers in Pediatrics
Background/AimManaging young children with negative behaviors can be challenging in dental settings. Moderate sedation (MS) is often used as a treatment option for such children. However, children's behavior during MS may vary depending on several variables. These variables include parental factors, such as parental anxiety, coping strategies, and pain catastrophizing. However, this area, particularly in Saudi Arabia, remains underexplored. Therefore, this study aimed to assess the association among parental anxiety, coping style, pain catastrophizing, and children's behavior during MS among S
Brandtzäg AA, Eiberg JP, Taudorf M et al. · 2026 · EJVES vascular forum
Introduction To evaluate intra-arterial pressure measurement (IAPM) in relation to pre- and intra-operative diagnostic methods for assessing superior mesenteric artery (SMA) stenosis in patients with a diagnosis of chronic mesenteric…
Deng, Zhu, Cao et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
The clinical evaluation of lumbar degenerative disease (LDD) severity relies on symptoms and imaging, lacking biologically specific diagnostic markers. This study investigated the role of serum complements in LDD to assess their potential…
Vukšić J, Kustić D · 2026 · Rheumatology international
To examine whether salivary gland ultrasonography (SGUS) and scintigraphy (SGS) reflect systemic disease activity (ESSDAI) and patient-reported index (ESSPRI) in primary Sjögren's disease (PSD). We retrospectively enrolled 118 patients…
Denis Boyer, Peter D. Walsh · 2010 · arXiv
Thanks to recent technological advances, it is now possible to track with an unprecedented precision and for long periods of time the movement patterns of many living organisms in their habitat. The increasing amount of data available on single trajectories offers the possibility of understanding how animals move and of testing basic movement models. Random walks have long represented the main description for micro-organisms and have also been useful to understand the foraging behaviour of large animals. Nevertheless, most vertebrates, in particular humans and other primates, rely on sophistic
Grunert M, Horn V, Baudrexl JC et al. · 2026 · European journal of radiology
Background Progressive fibrosing interstitial lung diseases (ILD) continue to have a poor prognosis. To date, there is no imaging method that can reliably detect fibrotic remodeling processes or distinguish between active and dormant…
Comeau MO, Gascon F, Corbeil M et al. · 2025 · Acta neurochirurgica
Purpose Meningioma resection remains partial in over 25% of cases, with few known predictors of residual disease progression. This study aims to assess if dural attachment, identified on postoperative imaging, influences meningioma…
Toyama Y, Taniguchi Y, Morisue M et al. · 2026 · European heart journal. Case reports
Background Magnetic resonance imaging (MRI) is increasingly performed in patients with cardiac implantable electronic devices. Although generally considered safe under specific protocols, electromagnetic interference may still lead to…
Nima Akhlaghi, Ananya Dhawan, Amir A. Khan et al. · 2018 · arXiv
Objective: The objectives of this paper are to determine the optimal location for ultrasound transducer placement on the anterior forearm for imaging maximum muscle deformations during different hand motions and to investigate the effect of using a sparse set of ultrasound scanlines for motion classification for ultrasound-based muscle computer interfaces (MCIs). Methods: The optimal placement of the ultrasound transducer along the forearm is identified using freehand 3D reconstructions of the muscle thickness during rest and motion completion. From the ultrasound images acquired from the opti
Mirza M, Fischer H, Arias D · 2026 · OTJR : occupation, participation and health
Background Aging adults with chronic diseases are at risk of functional decline. Objectives This pilot randomized control trial examined the feasibility, acceptability, and preliminary efficacy of an occupational therapy intervention to…
Chen CD, Aguero C, Melloni A et al. · 2026 · Alzheimer's & dementia : the journal of the Alzheimer's Association
Introduction Alzheimer's disease (AD) biomarkers are assessed on their ability to detect AD pathophysiology in vivo, with confirmation of AD neuropathology only at autopsy. Methods Positron emission tomography (PET), plasma, and cognitive…
Zuo P, Jiang K, Zou W et al. · 2026 · Neurosurgery
Background and objectives Atypical choroid plexus papillomas (ACPPs) are exceedingly uncommon. The treatment strategies for managing this condition remain a topic of debate. The main aim of this study was to elucidate the clinical features…
Esmeray A, Yazili HB, Gelmis M et al. · 2026 · The Canadian journal of urology
Objectives Supracostal access during percutaneous nephrolithotomy (PCNL) increases the risk of pulmonary complications. Although routine postoperative thoracic imaging is commonly performed to detect these events, its clinical necessity…
Hosseinzadeh E, Arefnia M, Bayat M et al. · 2026 · Cancer biotherapy & radiopharmaceuticals
Background Intense hepatobiliary uptake of [ 99m Tc]Tc-sestamibi in myocardial perfusion scintigraphy (MPS) often degrades image quality by obscuring the inferior myocardial wall, leading to equivocal studies. While nonpharmacological…
Fery Mai Rafanan, Eduard Alfanta, Romulus Roberto Peter Instrella · 2024 · Philippine Journal of Otolaryngology Head and Neck Surgery
Objective: To investigate the association between the time intervals of key clinical time points and tumor progression (increase in clinical staging) in head and neck cancer patients before and during the pandemic. Methods: Design: Retrospective Cohort Study Setting: Tertiary Government Training Hospital Participants: A total of 81 head and neck cancer patients who consulted at the OPD and underwent elective surgery between January 1, 2018, and December 31, 2022, under the Department of Otorhinolaryngology – Head and Neck Surgery of East Avenue Medical Center were included in the study; 40 pat
Kollipara Sumanth, Uma Sinharoy, Anindita Joardar et al. · 2026 · Annals of Indian Academy of Neurology
Background and Objectives: Epilepsy, with its complex interplay of neurobiological, genetic, and pharmacological factors, continues to challenge neurologists worldwide—particularly in managing drug resistance. This study aimed to evaluate the frequency of the SCN1A and SCN2A gene polymorphisms among patients with epilepsy (PWE) from Eastern India to assess their relationship with clinical profiles, electroencephalography (EEG) findings, and response to antiseizure medication. Methods: In this case–control genetic association study, a total of 110 PWE were assessed for demographic and clinical
Barrak Alahmad, Taofik Oyekunle, Claire Strohmeyer et al. · 2025 · Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Arrhythmia, particularly atrial fibrillation, is on the rise globally. While increased surveillance, aging populations, and other risk factors partially explain this rise, emerging risks such as extreme heat from climate change are underexplored. Methods We used Product Surveillance Registry by Medtronic (2016–2023) in the United States to examine patients with implantable cardioverter‐defibrillator or cardiac resynchronization therapy defibrillator devices. We identified first arrhythmic episodes (atrial tachycardia/fibrillation [AT/AF] or ventricular tachycardia/fibrillation) reco
Phillipson J, Menson E, Barclay S et al. · 2026 · Archives of disease in childhood
Objective Evaluation of the Medical Mediation Foundation's Conflict Management Programme (CMP)-a structured process for managing conflict. Design Mixed-methods evaluation using Kirkpatrick's framework, a four-level model for evaluating…
Amir Yunus, Peng Rend Gay, Oon Teng Lee · 2025 · arXiv
This study examines the development and deployment of a Generative AI proof-of-concept (POC) designed to support lecturers in a vocational education setting in Singapore. Employing a user-centred, mixed-methods design process, we co-developed an AI chatbot with lecturers to address recurring instructional challenges during exam preparation, specifically managing repetitive questions and scaling feedback delivery. The POC achieved its primary operational goals: lecturers reported streamlined workflows, reduced cognitive load, and observed improved student confidence in navigating course content
Tristan Piater, Niklas Penzel, Gideon Stein et al. · 2024 · arXiv
A substantial body of research has focused on developing systems that assist medical professionals during labor-intensive early screening processes, many based on convolutional deep-learning architectures. Recently, multiple studies explored the application of so-called self-attention mechanisms in the vision domain. These studies often report empirical improvements over fully convolutional approaches on various datasets and tasks. To evaluate this trend for medical imaging, we extend two widely adopted convolutional architectures with different self-attention variants on two different medical
Han SB · 2017 · Clinical Interventions in Aging
Sang Beom HanDepartment of Ophthalmology, Kangwon National University Hospital, Kangwon National University Graduate School of Medicine, Chuncheon, Republic of KoreaI read with great interest the article by Ahn et al1 entitled “Sex differences in the effect of aging on dry eye disease”, in which the authors revealed the sex differences in the effect of aging on dry eye disease (DED) in Korean adult population. They also showed the differences in patterns of DED following ocular surgery according to sex.1 The large population-based cross-sectional study was undoubtfully well designe
Tomisawa T, Nanashima N, In N et al. · 2026 · Preprint
Abstract This study examined how cultural performing arts affect psychological well-being and stress-related biomarkers, comparing traditional Japanese Noh and Kyogen (TNKP) with live comedy (CLP). Participants aged 18–64 years were…
Kiho Sung, Junsol Kim, Yeong-Ran Park et al. · 2026 · Scientific Reports
Abstract Cardiovascular disease (CVD) is prevalent among older adults, but studies often focus on individual spouses rather than couple dynamics. This study examines how interplay between spouses—specifically discordance in gender role attitudes—relates to CVD risk biomarkers, using couple-matched data from the Korean Social Life, Health, and Aging Project (KSHAP) on 308 older married couples (616 individuals). Actor-partner interdependence models (APIM) reveal that discordant gender role attitudes are significantly associated with higher CVD risk markers—higher systolic blood pressure, higher
Michael A. Cole, Aristeidis Lamprianidis, Ilya V. Shadrivov et al. · 2018 · arXiv
Metasurfaces are an enabling technology for complex wave manipulation functions, including in the terahertz frequency range, where they are expected to advance security, imaging, sensing, and communications technology. For operation in transmission, Huygens' metasurfaces are commonly used, since their good impedance match to the surrounding media minimizes reflections and maximizes transmission. Recent theoretical work has shown that Huygens' metasurfaces are non-optimal, particularly for large angles of refraction, and that to eliminate reflections and spurious diffracted beams it is necessar
Anjali B Susan, Uttam B George, Jeyaraj D Pandian · 2022 · Journal of Clinical and Diagnostic Research
Introduction: Arterial Spin Labeling-Perfusion Weighted Imaging (ASL-PWI) assesses cerebral blood flow using magnetically labeled inflowing arterial blood water protons as freely diffusible tracer without exogenous contrast agent. Seizures are one of the sequelae of stroke with its mechanism not well studied. Aim: Qualitative assessment of cerebral perfusion in post stroke seizure patients using ASL-PWI and comparison of perfusion patterns in post stroke seizure patients and stroke patients. Materials and Methods: This was a case-control study among 100 stroke patients who underwent Magnetic R
Yiyi Chen, Yiyi Chen, Yiyi Chen et al. · 2021 · Frontiers in Neurology
Background: High plasma levels of trimethylamine N-oxide (TMAO) and its precursor choline have been linked to stroke; however, their association with cerebral small vessel disease remains unclear. Here we evaluated the association of plasma levels of TMAO and choline with imaging markers of cerebral small vessel disease, including white matter hyperintensities, lacunes, and cerebral microbleeds.Methods: We performed a baseline cross-sectional analysis of a multicenter hospital-based cohort study from 2015 to 2018. The data were collected from 30 hospitals in China and included 1,098 patients w