e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

776 results for "aging" · page 11 of 26

Abandoned Hypothesis

Failed in aging? Queering in living with dementia

Valerie Keller · 2023 · Frontiers in Sociology

This article explored the ways in which living with dementia brings potentials to queer the concept of “successful aging” and associated notions of being human. Regarding the progressive development of dementia, it can be assumed that…

View details →DOI: 10.3389/fsoc.2023.1139271
Negative / Null Result ReportMedicine

The Influence of Os Acromiale on Patient Outcomes After Reverse Total Shoulder Arthroplasty: A Matched Cohort Study.

Schneider BS, Pfaehler CD, Hao KA et al. · 2026 · The Journal of the American Academy of Orthopaedic Surgeons

Background Although os acromiale is often noted on preoperative imaging in patients undergoing reverse total shoulder arthroplasty (rTSA), its clinical significance is ill-defined. The purpose of this study was to compare the clinical…

View details →DOI: 10.5435/jaaos-d-25-00614
Negative / Null Result ReportMedicine

Real-Time Perfusion Assessment with Hyperspectral Imaging After Revascularization in Peripheral Artery Disease.

Kluckner M, Hitzl W, Enzmann FK et al. · 2026 · Journal of clinical medicine

Background/Objectives : Hyperspectral imaging (HSI) facilitates noninvasive assessment of tissue perfusion in patients with peripheral arterial disease. However, available studies are either based on small cohorts and provide no comparison…

View details →DOI: 10.3390/jcm15041667
Negative / Null Result ReportMedicine

Comparison of neuromelanin-sensitive magnetic resonance imaging using different magnetic resonance protocols on the same patients with Parkinson's disease.

Hirose R, Matsuura K, Ii Y et al. · 2026 · Journal of neural transmission (Vienna, Austria : 1996)

In Parkinson's disease (PD), neuronal loss occurs in the substantia nigra (SN) and locus coeruleus (LC). Previous studies using neuromelanin-sensitive magnetic resonance imaging (NMI) at 3T MRI have described the measurement methods and…

View details →DOI: 10.1007/s00702-026-03179-z
Negative / Null Result ReportMedicine

Assessment of active fibrotic remodeling in patients with idiopathic pulmonary fibrosis (IPF)/progressive pulmonary fibrosis (PPF) using dual-time-point [<sup>68</sup>Ga]Ga-FAPI-46-PET/CT.

Grunert M, Horn V, Baudrexl JC et al. · 2026 · European journal of radiology

Background Progressive fibrosing interstitial lung diseases (ILD) continue to have a poor prognosis. To date, there is no imaging method that can reliably detect fibrotic remodeling processes or distinguish between active and dormant…

View details →DOI: 10.1016/j.ejrad.2026.113036
Negative / Null Result ReportMedicine

Reliability of Patellar Height Measurement in Children and Adolescents on MRI.

Jiang C, Cheng P, Liu Y et al. · 2025 · Journal of pediatric orthopedics

Introduction Imaging-based measurement indices of patellar height are essential for diagnosing patella alta in children and adolescents. The Patellotrochlear Index (PTI) measures the cartilaginous anatomy which is crucial for identifying…

View details →DOI: 10.1097/bpo.0000000000003057
Replication FailureMedicine

Imaging correlates of disease activity and patient-reported symptoms in primary Sjögren's disease: an ultrasonographic and scintigraphic study.

Vukšić J, Kustić D · 2026 · Rheumatology international

To examine whether salivary gland ultrasonography (SGUS) and scintigraphy (SGS) reflect systemic disease activity (ESSDAI) and patient-reported index (ESSPRI) in primary Sjögren's disease (PSD). We retrospectively enrolled 118 patients…

View details →DOI: 10.1007/s00296-026-06132-1
Negative / Null Result Report

Assessing the Effect of Subsidy Removal on Cost- Significant Material and Labour within Anambra State Construction Economy

Uchechi Vanessa Alintah-Abel, Francisca Nkachukwu Okeke, Eucharia Chika Enebe · 2025 · British Journal of Multidisciplinary and Advanced Studies

The goal of most countries is the desire to maintain a stable price level of goods and services. This however, appears to be an uphill task given the incidence of subsidy removal that is presently ravaging the developing economies of the…

View details →DOI: 10.37745/bjmas.2022.04253
Negative / Null Result ReportMedicine

An Occupation-Focused Intervention to Promote Functioning Among Adults Aging With Diabetes and Heart Disease.

Mirza M, Fischer H, Arias D · 2026 · OTJR : occupation, participation and health

Background Aging adults with chronic diseases are at risk of functional decline. Objectives This pilot randomized control trial examined the feasibility, acceptability, and preliminary efficacy of an occupational therapy intervention to…

View details →DOI: 10.1177/15394492261446563
Negative / Null Result ReportOpen accessMedicine

Assessment of Pulp-Tooth Ratio Based on 3D Segmentation for Age Estimation for Forensic Purposes in a Senegalese Population.

Soumboundou SM, Ndiaye ML, Ndiaye R et al. · 2026 · Cureus

Introduction The advent of 3D imaging has created a significant opportunity to enhance the accuracy of age estimation. By utilizing 3D segmentation, it is now possible to evaluate the three-dimensional pulp volume as an indicator of age.…

View details →DOI: 10.7759/cureus.109325
Negative / Null Result ReportMedicine

Clinical Characteristics and Long-Term Outcomes of Atypical Choroid Plexus Papillomas: A Single-Center Experience of 40 Cases.

Zuo P, Jiang K, Zou W et al. · 2026 · Neurosurgery

Background and objectives Atypical choroid plexus papillomas (ACPPs) are exceedingly uncommon. The treatment strategies for managing this condition remain a topic of debate. The main aim of this study was to elucidate the clinical features…

View details →DOI: 10.1227/neu.0000000000004026
Negative / Null Result ReportMedicine

Is postoperative routine thoracic imaging necessary to detect thoracic complications in patients undergoing supracostal mini percutaneous nephrolithotomy (m-PCNL) surgery?

Esmeray A, Yazili HB, Gelmis M et al. · 2026 · The Canadian journal of urology

Objectives Supracostal access during percutaneous nephrolithotomy (PCNL) increases the risk of pulmonary complications. Although routine postoperative thoracic imaging is commonly performed to detect these events, its clinical necessity…

View details →DOI: 10.32604/cju.2025.069657
Negative / Null Result ReportMedicine

Evaluating the Impact of Ursodeoxycholic Acid on Hepatic Clearance of [<sup>99m</sup>Tc]Tc-Sestamibi: A Randomized Controlled Trial to Improve Myocardial Perfusion Imaging.

Hosseinzadeh E, Arefnia M, Bayat M et al. · 2026 · Cancer biotherapy & radiopharmaceuticals

Background Intense hepatobiliary uptake of [ 99m Tc]Tc-sestamibi in myocardial perfusion scintigraphy (MPS) often degrades image quality by obscuring the inferior myocardial wall, leading to equivocal studies. While nonpharmacological…

View details →DOI: 10.1177/10849785251376736
Negative / Null Result ReportMedicine

Relationship between <i>APOE</i> Genotype Status and Imaging Features in Patients with Alzheimer Disease Being Considered for Antiamyloid β Therapy.

Vejdani-Jahromi M, Calle E, Ganem O et al. · 2026 · AJNR. American journal of neuroradiology

Background and purpose Alzheimer disease (AD) is a progressive neurodegenerative disorder that predominantly affects the aging population. Anti-amyloid β (anti-Aβ) therapies, such as lecanemab, have been developed to slow disease…

View details →DOI: 10.3174/ajnr.a9056
Negative / Null Result ReportOpen accessPhysics

Beyond the RPA on the cheap: improved correlation energies with the efficient "Radial Exchange Hole" kernel

Tim Gould · 2012 · arXiv

The "ACFD-RPA" correlation energy functional has been widely applied to a variety of systems to successfully predict energy differences, and less successfully predict absolute correlation energies. Here we present a parameter-free exchange-correlation kernel that systematically improves absolute correlation energies, while maintaining most of the good numerical properties that make the ACFD-RPA numerically tractable. The "RXH" kernel is constructed to approximate the true exchange kernel via a carefully weighted, easily computable radial averaging. Correlation energy errors of atoms with two t

Negative / Null Result ReportMedicine

Outcomes from a structured conflict management programme implemented at three paediatric healthcare sites: a mixed-methods evaluation.

Phillipson J, Menson E, Barclay S et al. · 2026 · Archives of disease in childhood

Objective Evaluation of the Medical Mediation Foundation's Conflict Management Programme (CMP)-a structured process for managing conflict. Design Mixed-methods evaluation using Kirkpatrick's framework, a four-level model for evaluating…

View details →DOI: 10.1136/archdischild-2025-329335
Negative / Null Result ReportOpen accessComputer Science

On the Effectiveness of Mode Exploration in Bayesian Model Averaging for Neural Networks

John T. Holodnak, Allan B. Wollaber · 2021 · arXiv

Multiple techniques for producing calibrated predictive probabilities using deep neural networks in supervised learning settings have emerged that leverage approaches to ensemble diverse solutions discovered during cyclic training or training from multiple random starting points (deep ensembles). However, only a limited amount of work has investigated the utility of exploring the local region around each diverse solution (posterior mode). Using three well-known deep architectures on the CIFAR-10 dataset, we evaluate several simple methods for exploring local regions of the weight space with re

Negative / Null Result ReportOpen accessMedicine

Plantar Heel Pain Is Not Associated With Fatty Infiltration of the Abductor Digiti Minimi Muscle on Magnetic Resonance Imaging: A Cross-Sectional Observational Study.

Chen JSC, Osborne JWA, Menz HB et al. · 2026 · Journal of foot and ankle research

Background Fatty infiltration, or fatty atrophy, of the abductor digiti minimi (ADM) muscle of the foot is proposed to be associated with entrapment of the first branch of the lateral plantar nerve (i.e., Baxter's neuropathy) as part of…

View details →DOI: 10.1002/jfa2.70155
Negative / Null Result Report

Differential Effects of Cultural Performing Arts on Anti-Aging Biomarkers and Well-Being: A Non- Randomized Pre–Post Comparative Study of Traditional Noh/Kyogen and Comedy

Tomisawa T, Nanashima N, In N et al. · 2026 · Preprint

Abstract This study examined how cultural performing arts affect psychological well-being and stress-related biomarkers, comparing traditional Japanese Noh and Kyogen (TNKP) with live comedy (CLP). Participants aged 18–64 years were…

View details →DOI: 10.21203/rs.3.rs-9490822/v1
Negative / Null Result ReportOpen accessComputer Science

MedNet-PVS: A MedNeXt-Based Deep Learning Model for Automated Segmentation of Perivascular Spaces

Zhen Xuen Brandon Low, Rory Zhang, Hang Min et al. · 2025 · arXiv

Enlarged perivascular spaces (PVS) are increasingly recognized as biomarkers of cerebral small vessel disease, Alzheimer's disease, stroke, and aging-related neurodegeneration. However, manual segmentation of PVS is time-consuming and subject to moderate inter-rater reliability, while existing automated deep learning models have moderate performance and typically fail to generalize across diverse clinical and research MRI datasets. We adapted MedNeXt-L-k5, a Transformer-inspired 3D encoder-decoder convolutional network, for automated PVS segmentation. Two models were trained: one using a homog

Negative / Null Result ReportMedicine

FDG PET/CT imaging in recurrent papillary thyroid cancer: does BRAF mutation status matter?

Bastian MB, Kyriakou I, Rosar F et al. · 2026 · The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...

Background Papillary thyroid carcinoma (PTC) with a BRAFV600E mutation is linked to more aggressive tumor characteristics, as well as a higher likelihood of recurrence and disease-specific mortality. This study aimed to investigate the…

View details →DOI: 10.23736/s1824-4785.26.03686-1
Negative / Null Result ReportMedicine

Magnetic resonance imaging-derived anterior tibial translation after anterior cruciate ligament reconstruction and its association with postoperative adverse events: A retrospective cohort study.

Gonzalez W, Isla J, Barba D et al. · 2026 · Journal of ISAKOS : joint disorders & orthopaedic sports medicine

Background Anterior tibial translation (ATT) measured on magnetic resonance imaging (MRI) is a reproducible marker of anterior cruciate ligament (ACL) deficiency. However, its longitudinal evolution after ACL reconstruction (ACLR) and its…

View details →DOI: 10.1016/j.jisako.2026.101134
Negative / Null Result ReportOpen accessEngineering

The International Workshop on Osteoarthritis Imaging Knee MRI Segmentation Challenge: A Multi-Institute Evaluation and Analysis Framework on a Standardized Dataset

Arjun D. Desai, Francesco Caliva, Claudia Iriondo et al. · 2020 · arXiv

Purpose: To organize a knee MRI segmentation challenge for characterizing the semantic and clinical efficacy of automatic segmentation methods relevant for monitoring osteoarthritis progression. Methods: A dataset partition consisting of 3D knee MRI from 88 subjects at two timepoints with ground-truth articular (femoral, tibial, patellar) cartilage and meniscus segmentations was standardized. Challenge submissions and a majority-vote ensemble were evaluated using Dice score, average symmetric surface distance, volumetric overlap error, and coefficient of variation on a hold-out test set. Simil