Negative / Null Result ReportMedicine
Ageberg E, Donaldson A, Lucander K et al. · 2025 · Journal of science and medicine in sport
Objectives To compare the implementation of a co-created evidence-based injury prevention intervention with an existing program in youth team handball. Design Pragmatic two-armed cluster-randomized controlled trial, conducted…
View details →DOI: 10.1016/j.jsams.2025.06.011 Negative / Null Result ReportMedicine
Rocchetto S, Rondonotti E, Alicante S et al. · 2025 · Endoscopy
Both computer-aided detection (CADe) systems and mucosal exposure devices can enhance adenoma detection during colonoscopy. This research investigates whether combining a CADe system with a balloon-based mucosal exposure device increases…
View details →DOI: 10.1055/a-2652-8596 Negative / Null Result ReportOpen accessMedicine
El-Salam SA, Aboalnaga AA, Tawfik WA et al. · 2026 · BMC oral health
OBJECTIVE: To evaluate the effect of gradually increasing orthodontic force magnitude compared with a constant force magnitude on the rate of tooth movement during maxillary canine retraction. METHODS: This split-mouth randomized…
View details →DOI: 10.1186/s12903-026-08243-4 Negative / Null Result ReportMedicine
de Castro T, Viana LH, Botelho S et al. · 2026 · International urogynecology journal
Introduction and hypothesis Approximately 60% of women experience some degree of perineal laceration following vaginal delivery. Although there is evidence supporting the use of photobiomodulation (PBM) for pain relief and wound healing in…
View details →DOI: 10.1007/s00192-026-06686-5 Negative / Null Result ReportMedicine
Cowan C, Harmon EY, Melewski M et al. · 2026 · The American journal of occupational therapy : official publication of the American Occupational Therapy Association
Importance Understanding how upper extremity (UE) robotic therapy (RT) affects efficiency and effectiveness of inpatient rehabilitation is important to advancing poststroke treatment and recovery. Objective To determine whether UE RT…
View details →DOI: 10.5014/ajot.2026.051412 Negative / Null Result ReportMedicine
Kirkham MS, Carlson HB, Merrill E et al. · 2026 · Journal of shoulder and elbow surgery
Hypothesis Cutibacterium acnes is the most frequent cause of shoulder prosthetic joint infection with skin edges as a source of wound contamination. The primary purpose of this study was to determine if the use of a wound protector device…
View details →DOI: 10.1016/j.jse.2026.04.048 Negative / Null Result ReportMedicine
Bosqui T, Brown FL, Farah S et al. · 2026 · Journal of child psychology and psychiatry, and allied disciplines
Background There are no evaluated family-based mental health and psychosocial support (MHPSS) interventions for adolescents in Southwest Asia (known as the Middle East), and few whole-family interventions in low- and middle-income…
View details →DOI: 10.1111/jcpp.70174 Negative / Null Result ReportMedicine
Åberg S, Nordin E, Iversen KN et al. · 2026 · Clinical nutrition (Edinburgh, Scotland)
Background and aims Wholegrain rye foods have shown promising effects on metabolic regulation and weight-loss, which may be mediated via gut microbiota and derived metabolites. This study aimed to investigate effects of hypocaloric diets…
View details →DOI: 10.1016/j.clnu.2026.106618 Negative / Null Result ReportOpen accessMedicine
Kim B, Boustany C, Fethney J et al. · 2026 · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Purpose This study aimed to report the incidence, common reasons, and associated risk factors for unplanned hospital presentations during chemotherapy treatment. Methods A secondary analysis using data from a randomized controlled trial…
View details →DOI: 10.1007/s00520-026-10510-7 Negative / Null Result ReportMedicine
Türkiş NA, Taşdemir N · 2026 · Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses
Purpose Postoperative nausea and vomiting (PONV) is one of the most common complications in surgical patients during the first 24 hours after general anesthesia. This research aimed to evaluate the effect of cold application on early PONV…
View details →DOI: 10.1016/j.jopan.2025.06.003 Negative / Null Result ReportMedicine
Janssen JC, Schurink AW, Verhoef C et al. · 2026 · European journal of cancer (Oxford, England : 1990)
Background Adjuvant systemic therapy for resected stage III melanoma was introduced in clinical practice following the improved recurrence free survival in randomized controlled trials. However, after ten years of follow-up, adjuvant…
View details →DOI: 10.1016/j.ejca.2025.116202 Negative / Null Result ReportMedicine
Santaularia N, Arnau A, Torà N et al. · 2026 · Journal of cardiopulmonary rehabilitation and prevention
Purpose Our purpose was to assess the efficacy of a phase III cardiac rehabilitation (CR) program, based on counseling in the maintenance of physical exercise, on the time spent on physical exercise per week in patients with ischemic heart…
View details →DOI: 10.1097/hcr.0000000000000993 Negative / Null Result ReportMedicine
Pohl V, Haas R, Rosen R et al. · 2025 · Clinical implant dentistry and related research
Objective This randomized controlled trial aimed to evaluate the impact of early versus delayed change of abutment on bone levels, soft tissue, and patient satisfaction with single-tooth immediate implants. Material and methods In 26…
View details →DOI: 10.1111/cid.70088 Negative / Null Result ReportMedicine
Bodensohn R, Kaempfel AL, Boulesteix AL et al. · 2023 · Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Background and purpose There is no randomized evidence comparing whole-brain radiotherapy (WBRT) and stereotactic radiosurgery (SRS) in the treatment of multiple brain metastases. This prospective nonrandomized controlled single arm trial…
View details →DOI: 10.1016/j.radonc.2023.109744 Negative / Null Result ReportOpen accessMedicine
Lee JH, Hwang K, Jeong WK · 2026 · Clinics in orthopedic surgery
Background Arthroscopic rotator cuff repair is widely performed; yet tendon healing failure still occurs in some cases and remains a challenge. To address this issue, several studies have investigated intraoperative injection or patch…
View details →DOI: 10.4055/cios25235 Negative / Null Result ReportMedicine
Pirracchio R, Fong N, Legrand M · 2025 · Intensive care medicine
Background The best blood pressure target in sepsis is a matter of debate. SEPSIS-PAM, a large multicenter pragmatic randomized controlled trial, compared two mean arterial pressure targets (65-70 mmHg vs 80-85 mmHg) in septic shock and…
View details →DOI: 10.1007/s00134-025-08104-8 Negative / Null Result Report
Chowdhury R, Maiti U, Devi S et al. · 2025 · Preprint
Background Early-life interventions targeting maternal and child health, nutrition, and psychosocial care may influence infant growth and immune development by modulating systemic inflammation and growth factor pathways. However, causal…
View details →DOI: 10.1101/2025.08.10.25333400 Negative / Null Result ReportMedicine
Taylor LM, Parsons J, Moyes SA et al. · 2024 · Journal of the American Medical Directors Association
Objectives To investigate the effect of an exercise program on falls in intermediate and high-level long-term care (LTC) residents and to determine whether adherence, physical capacity, and cognition modified outcomes. Design Randomized…
View details →DOI: 10.1016/j.jamda.2023.10.022 Negative / Null Result ReportOpen accessMedicine
Chen J, Chen Z, Yan Q et al. · 2025 · BMC oral health
Objectives To evaluate patient-reported outcome measures (PROMs) of povidone-iodine rinse and chlorhexidine rinse for patients undergoing dental implant treatments, as well as their bacteriostatic efficacy. Materials and methods Patients…
View details →DOI: 10.1186/s12903-025-06560-8 Negative / Null Result ReportOpen accessMedicine
Sasidharan S, Philips CA, Philips CA et al. · 2026 · Hepatology communications
Background Fatigue affects 60%-80% of patients with cirrhosis, yet no universally effective pharmacologic therapy exists. Taurine, an amino sulfonic acid with antioxidant and membrane-stabilizing properties, may address metabolic…
View details →DOI: 10.1097/hc9.0000000000000938 Replication FailureOpen accessMedicine
Vander Zwalmen Y, Vrijsen JN, Meuleman B et al. · 2026 · Internet interventions
Background Late-life depression (LLD) is a prevalent and debilitating condition associated with a poor long-term prognosis and high rates of chronicity. Cognitive control impairments are common in LLD and contribute to symptom persistence,…
View details →DOI: 10.1016/j.invent.2026.100951 Replication FailureOpen accessMedicine
Grischott T, Rachamin Y, Senn O et al. · 2023 · Journal of general internal medicine
Background Medication safety in patients with polypharmacy at transitions of care is a focus of the current Third WHO Global Patient Safety Challenge. Medication review and communication between health care professionals are key targets to…
View details →DOI: 10.1007/s11606-022-07728-6 Replication FailureOpen accessMedicine
Yi K, Zhan Y, Wei A et al. · 2026 · Drug design, development and therapy
Background The optimal analgesia regimen for patients undergoing laparoscopic gastrectomy is still unclear. This study evaluated the efficacy of ultrasound-guided rectus sheath block (RSB) with liposomal bupivacaine in providing sustained…
View details →DOI: 10.2147/dddt.s574724 Negative / Null Result ReportMedicine
Martineau AR · 2026 · Current opinion in infectious diseases
Purpose of review This review summarizes findings of recent Phase 3 randomized controlled trials (RCTs) and meta-analyses investigating effectiveness of vitamin D supplementation for prevention and treatment of tuberculosis or acute…
View details →DOI: 10.1097/qco.0000000000001181 Negative / Null Result ReportMedicine
Wang Y, Sha S, Gwenzi T et al. · 2026 · Clinical nutrition (Edinburgh, Scotland)
Background & aims Vitamin D insufficiency and deficiency are common worldwide and linked to adverse health outcomes, including higher all-cause mortality. Two large randomized controlled trials (VITAL and D-Health), conducted in mostly…
View details →DOI: 10.1016/j.clnu.2026.106597 Negative / Null Result ReportMedicine
Vinceti M, Vicentini M, Ottone M et al. · 2026 · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
Background Consistent evidence from randomized controlled trials has shown that overexposure to selenium induces type 2 diabetes. However, uncertainties remain about the specific species and doses of selenium that trigger such diabetogenic…
View details →DOI: 10.1016/j.jtemb.2026.127838 Negative / Null Result Report
Hornsby G, Pu C, Badamikar A et al. · 2025 · Preprint
ABSTRACT Introduction While improving water, sanitation, and hygiene (WASH) service delivery in schools supports the Sustainable Development Goals, rigorous trials have recently reported inconsistent effects of WASH in schools (WinS)…
View details →DOI: 10.1101/2025.10.23.25338677 Negative / Null Result ReportMedicine
Harding JF, Walzer J, Piatt R et al. · 2025 · Contraception
Objectives It is important to identify programs that can work in multiple contexts to support adolescent parents in achieving their reproductive health goals. A randomized controlled trial in Ohio in 2012 found that the Teen Options to…
View details →DOI: 10.1016/j.contraception.2025.111200 Negative / Null Result ReportOpen accessMedicine
Suberry A, Okun S, Ayalon L · 2026 · The Gerontologist
Background and objectives Ageism often emerges in childhood, yet rigorously evaluated school-based interventions-especially in multicultural settings-are scarce. The study evaluated the efficacy of a 90-min educational intervention to…
View details →DOI: 10.1093/geront/gnaf274 Negative / Null Result ReportOpen accessMedicine
Watkins K, Ladabaum U, Olsen E et al. · 2024 · iGIE : innovation, investigation and insights
Background and aims The progress of artificial intelligence (AI) in endoscopy is at a crossroads. The positive results of randomized controlled trials of computer-aided detection (CADe) have not been replicated in multiple pragmatic CADe…
View details →DOI: 10.1016/j.igie.2024.04.016 