A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
713 results in Negative / Null Result Report for "aging" · page 10 of 24
Anna Prucnal · 2025 · International Journal of Business & Management Studies
This study examines the effectiveness of the monetary policy of the European Central Bank (ECB) in managing inflation in the Euro Area compared to the independent monetary policy of seven European Union Member States outside the Economic…
Sunwoong Yang, Ricardo Vinuesa, Namwoo Kang · 2024 · arXiv
This study addresses the critical challenge of error accumulation in spatio-temporal auto-regressive (AR) predictions within scientific machine learning models by exploring temporal integration schemes and adaptive multi-step rollout strategies. We introduce the first implementation of the two-step Adams-Bashforth method specifically tailored for data-driven AR prediction, leveraging historical derivative information to enhance numerical stability without additional computational overhead. To validate our approach, we systematically evaluate time integration schemes across canonical 2D PDEs be
Xu Ma, Jiajie Zhang, Fujing Xie et al. · 2025 · arXiv
Global localization is essential for autonomous robotics, especially in indoor environments where the GPS signal is denied. We propose a novel WiFi-based localization framework that leverages ubiquitous wireless infrastructure and the OpenStreetMap Area Graph (osmAG) for large-scale indoor environments. Our approach integrates signal propagation modeling with osmAG's geometric and topological priors. In the offline phase, an iterative optimization algorithm localizes WiFi Access Points (APs) by modeling wall attenuation, achieving a mean localization error of 3.79 m (35.3\% improvement over tr
Ciana Bowhay, Michael Nattrass · 2026 · NACTA Journal
Undergraduate students in agriculture often struggle to connect theoretical course concepts with real-world agricultural practices. Additionally, with expanding digitalization of professional markets, building a professional online…
· 2025 · International Journal of Medicine and Medical Research
Lifestyle-related disorders, particularly diabetes, pose a significant global health challenge. Diabetic macular oedema, a microvascular complication, highlights the importance of managing insulin resistance and hyperlipidaemia for optimal…
Hirose R, Matsuura K, Ii Y et al. · 2026 · Journal of neural transmission (Vienna, Austria : 1996)
In Parkinson's disease (PD), neuronal loss occurs in the substantia nigra (SN) and locus coeruleus (LC). Previous studies using neuromelanin-sensitive magnetic resonance imaging (NMI) at 3T MRI have described the measurement methods and…
· 2025 · European Journal of Clinical Pharmacy
Pediatric nephrolithiasis is an increasing concern and often requires complete stone clearance due to high recurrence risk. Managing large renal stones (>2 cm), lower calyceal stones (>1 cm), and stones refractory to Extracorporeal Shock…
Grunert M, Horn V, Baudrexl JC et al. · 2026 · European journal of radiology
Background Progressive fibrosing interstitial lung diseases (ILD) continue to have a poor prognosis. To date, there is no imaging method that can reliably detect fibrotic remodeling processes or distinguish between active and dormant…
Jiang C, Cheng P, Liu Y et al. · 2025 · Journal of pediatric orthopedics
Introduction Imaging-based measurement indices of patellar height are essential for diagnosing patella alta in children and adolescents. The Patellotrochlear Index (PTI) measures the cartilaginous anatomy which is crucial for identifying…
shoabjareh ME, Ansari-Astaneh M, Shoeibi N et al. · 2026 · Preprint
Abstract Background This study evaluated choroidal thickness in healthy Iranian individuals using enhanced depth imaging optical coherence tomography (EDI-OCT) and evaluated its correlation with demographic characteristics, laboratory test…
Uchechi Vanessa Alintah-Abel, Francisca Nkachukwu Okeke, Eucharia Chika Enebe · 2025 · British Journal of Multidisciplinary and Advanced Studies
The goal of most countries is the desire to maintain a stable price level of goods and services. This however, appears to be an uphill task given the incidence of subsidy removal that is presently ravaging the developing economies of the…
Soumboundou SM, Ndiaye ML, Ndiaye R et al. · 2026 · Cureus
Introduction The advent of 3D imaging has created a significant opportunity to enhance the accuracy of age estimation. By utilizing 3D segmentation, it is now possible to evaluate the three-dimensional pulp volume as an indicator of age.…
Vejdani-Jahromi M, Calle E, Ganem O et al. · 2026 · AJNR. American journal of neuroradiology
Background and purpose Alzheimer disease (AD) is a progressive neurodegenerative disorder that predominantly affects the aging population. Anti-amyloid β (anti-Aβ) therapies, such as lecanemab, have been developed to slow disease…
Tim Gould · 2012 · arXiv
The "ACFD-RPA" correlation energy functional has been widely applied to a variety of systems to successfully predict energy differences, and less successfully predict absolute correlation energies. Here we present a parameter-free exchange-correlation kernel that systematically improves absolute correlation energies, while maintaining most of the good numerical properties that make the ACFD-RPA numerically tractable. The "RXH" kernel is constructed to approximate the true exchange kernel via a carefully weighted, easily computable radial averaging. Correlation energy errors of atoms with two t
Chen JSC, Osborne JWA, Menz HB et al. · 2026 · Journal of foot and ankle research
Background Fatty infiltration, or fatty atrophy, of the abductor digiti minimi (ADM) muscle of the foot is proposed to be associated with entrapment of the first branch of the lateral plantar nerve (i.e., Baxter's neuropathy) as part of…
Zeng Y, Zhu Y, Liu W et al. · 2026 · Preprint
Abstract Background When the function of one kidney is impaired or lost, the contralateral kidney may exhibit varying degrees of compensatory response. However, the influencing factors and underlying mechanisms of renal compensation remain…
Bastian MB, Kyriakou I, Rosar F et al. · 2026 · The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...
Background Papillary thyroid carcinoma (PTC) with a BRAFV600E mutation is linked to more aggressive tumor characteristics, as well as a higher likelihood of recurrence and disease-specific mortality. This study aimed to investigate the…
Gonzalez W, Isla J, Barba D et al. · 2026 · Journal of ISAKOS : joint disorders & orthopaedic sports medicine
Background Anterior tibial translation (ATT) measured on magnetic resonance imaging (MRI) is a reproducible marker of anterior cruciate ligament (ACL) deficiency. However, its longitudinal evolution after ACL reconstruction (ACLR) and its…
John T. Holodnak, Allan B. Wollaber · 2021 · arXiv
Multiple techniques for producing calibrated predictive probabilities using deep neural networks in supervised learning settings have emerged that leverage approaches to ensemble diverse solutions discovered during cyclic training or training from multiple random starting points (deep ensembles). However, only a limited amount of work has investigated the utility of exploring the local region around each diverse solution (posterior mode). Using three well-known deep architectures on the CIFAR-10 dataset, we evaluate several simple methods for exploring local regions of the weight space with re
Zhen Xuen Brandon Low, Rory Zhang, Hang Min et al. · 2025 · arXiv
Enlarged perivascular spaces (PVS) are increasingly recognized as biomarkers of cerebral small vessel disease, Alzheimer's disease, stroke, and aging-related neurodegeneration. However, manual segmentation of PVS is time-consuming and subject to moderate inter-rater reliability, while existing automated deep learning models have moderate performance and typically fail to generalize across diverse clinical and research MRI datasets. We adapted MedNeXt-L-k5, a Transformer-inspired 3D encoder-decoder convolutional network, for automated PVS segmentation. Two models were trained: one using a homog
Arjun D. Desai, Francesco Caliva, Claudia Iriondo et al. · 2020 · arXiv
Purpose: To organize a knee MRI segmentation challenge for characterizing the semantic and clinical efficacy of automatic segmentation methods relevant for monitoring osteoarthritis progression. Methods: A dataset partition consisting of 3D knee MRI from 88 subjects at two timepoints with ground-truth articular (femoral, tibial, patellar) cartilage and meniscus segmentations was standardized. Challenge submissions and a majority-vote ensemble were evaluated using Dice score, average symmetric surface distance, volumetric overlap error, and coefficient of variation on a hold-out test set. Simil
Benmoussa H, Barkani ME, Khodriss C et al. · 2026 · Preprint
Abstract Background: Dry eye disease is the most common ophthalmological manifestation in patients with rheumatoid arthritis (RA). Its diagnosis relies on clinical parameters and non-invasive imaging techniques. The aim of this study was…
Sabri H, Baniameri S, Kataria P et al. · 2026 · Journal of periodontology
Background Periodontitis, a chronic inflammatory disease, is linked to systemic conditions such as cardiovascular and kidney disease. Serum α-Klotho, an anti-aging protein with anti-inflammatory properties, has been associated with…
Brandtzäg AA, Eiberg JP, Taudorf M et al. · 2026 · EJVES vascular forum
Introduction To evaluate intra-arterial pressure measurement (IAPM) in relation to pre- and intra-operative diagnostic methods for assessing superior mesenteric artery (SMA) stenosis in patients with a diagnosis of chronic mesenteric…
Bayar E, Cengiz T, Erdoğan F et al. · 2026 · BMC geriatrics
BACKGROUND: Hip fractures represent a major public health concern due to their increasing incidence in the aging population and their association with significant morbidity and mortality. Comorbidities are known to complicate both the…
Jan Tiemann, Matthew McGinity, Ulrik Günther · 2026 · arXiv
In contemporary biology and medicine, 3D microscopy is one of the most widely-used techniques for imaging and manipulation of various kinds of samples. Navigating such a micrometer-sized, 3-dimensional sample under the microscope -- e.g. to find relevant imaging regions -- can pose a tedious challenge for the experimenter. In this paper, we examine whether 2D desktop, 3D desktop, or Virtual Reality (VR) interfaces provide the best user experience and performance for the exploration of 3D samples. We invited 12 skilled microscope operators to perform two different exploration tasks in 2D, 3D an
Karlin NJ · 2026 · Psychological reports
Given the unique challenges faced by frontier aging older adults, such as limited access to healthcare and social services, the potential for different functional disabilities as compared to rural older adults exists. By comparing frontier…
Samal DR, Mendiratta P · 2026 · Preprint
Abstract The CoViD situation globally tested the efficacy of health infrastructure as well as the administrative management of urban areas. This study focuses on the impact of the CoViD-19 pandemic across the nine municipal corporations in…
Ozden Sertcelik U, Turker M, Sertcelik A et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Perspectives : Obstructive sleep apnea (OSA) is a prevalent condition associated with increased perioperative risks. Endobronchial ultrasound (EBUS), a diagnostic and staging procedure requiring deep sedation, may pose…
Jose A. Rivera, Carmen E. Gonzalez, Tonita Bates · 2024 · JCO Oncology Practice
327 Background: Delayed assessment of diagnostic imaging (DI) significant actionable findings (AFs) at an oncological center prompted the creation of a safety net system which used technological advancements to improve communication…