Negative / Null Result ReportOpen accessNeuroscience
Nic Glewwe, Evan M. Dastin-van Rijn, Cathy S. Chen et al. · 2026 · Neuropsychopharmacology
Cognitive flexibility can be defined as the ability to adaptively shift between choices or strategies based on environmental feedback. Flexibility is disrupted in numerous neuropsychiatric conditions. Individual differences in the computations supporting cognitive flexibility may reveal mechanisms of neuropsychiatric risk and resilience. One critical variable well known to influence individual differences in neuropsychiatric risk is sex. While previous research has identified sex differences in value based decision making in mice, whether sex reflects a major source of variation in cognitive f
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Ryan J. Farrell, S. Thomas Hennigan, Kirsten G. Bredvik et al. · 2026 · The Journal of General Physiology
The ER is an important regulator of Ca2+ in cells and dysregulation of ER Ca2+ homeostasis can lead to numerous pathologies. Understanding how various pharmacological and genetic perturbations of ER Ca2+ homeostasis impact cellular…
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Valdemar Brimnes Ingemann Johansen, Anna Katrina Jógvansdóttir Gradel, Stephanie Kjærulff Holm et al. · 2025 · Cell Reports Medicine
Liver-expressed antimicrobial peptide 2 (LEAP2) is an endogenous antagonist and inverse agonist of the ghrelin receptor, countering ghrelin's effects on cell signaling and feeding. However, despite an emerging interest in LEAP2's…
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Sabine Willems, Vasily Morozov, Julian A. Marschner et al. · 2025 · Journal of Medicinal Chemistry
The ligand-activated transcription factors of the NR4A family are implicated as promising drug targets with neuroprotective and anticancer potential and attract strong attention in drug discovery. Several NR4A modulators have been…
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Amanda Zieselman, Jonathan Fisher, Ting Hu et al. · 2014 · BioData Mining
BACKGROUND: Alzheimer's disease is the most common form of progressive dementia and there is currently no known cure. The cause of onset is not fully understood but genetic factors are expected to play a significant role. We present here a bioinformatics approach to the genetic analysis of grey matter density as an endophenotype for late onset Alzheimer's disease. Our approach combines machine learning analysis of gene-gene interactions with large-scale functional genomics data for assessing biological relationships. RESULTS: We found a statistically significant synergistic interaction among t
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Dawn Finzi, Eshed Margalit, Kendrick Kay et al. · 2026 · Nature Communications
Human visual cortex is organized into dorsal, lateral, and ventral streams. A long-standing hypothesis is that the functional organization into streams emerged to support distinct visual behaviors. Here, we compare neural network-based…
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