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12 real negative results, null findings, and replication failures in Medicine · Short Note. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

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Oxidative stress and heart failure

Camelia C. Diaconu · 2019 · Archives of the Balkan Medical Union

Oxidative stress is involved in the pathophysiology of many chronic diseases, including heart failure. Oxidative stress is an imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense. The overproduction of ROS can lead to cellular damage and eventually cellular death. This applies also in patients with chronic heart failure, who present a dramatic increase of oxidative stress associated with a pronounced decrease of the antioxidant defense mechanisms. The components of the antioxidant defense mechanism of myocardial cells are superoxide dismutase (SOD), cat

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Magnetic resonance imaging-induced artefact mimicking torsade de pointes in a patient with an implantable cardiac monitor: a case report.

Toyama Y, Taniguchi Y, Morisue M et al. · 2026 · European heart journal. Case reports

Background Magnetic resonance imaging (MRI) is increasingly performed in patients with cardiac implantable electronic devices. Although generally considered safe under specific protocols, electromagnetic interference may still lead to…

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Short NoteMedicine

DNA repair-associated nucleases induce double-strand breaks following sequential exposure to UVA1 and UVB.

Narimichi, Komaki, Suzuki et al. · 2026 · Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

Solar UV comprises UVA and UVB; each exerts distinct biological effects, while their combined impact is not yet fully understood. We previously reported that human keratinocytes exposed to UVA1 followed by UVB irradiation exhibited severe…

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Building a Science-Driven Business: How National Institutes of Health Funding Enabled an Evidence-Based Approach to Maternal Mental Health Innovation

Jennifer Huberty, Lara Baez, Kelsey McAlister et al. · 2026 · JMIR Formative Research

AbstractThe digital mental health (DMH) industry has grown drastically over the last decade; yet, many DMH products have failed to demonstrate meaningful clinical outcomes, in large part due to lack of scientific evidence. This viewpoint paper highlights an example of how early-stage DMH companies can prioritize science as a strategic advantage. We discuss Moment for Parents, an artificial intelligence–driven maternal mental health app built entirely with support from the National Institutes of Health (NIH) Small Business Innovation Research (SBIR) program. We illustrate the advantages and cha

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