11,412 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Nechemya Y, Shames J · 2026 · Harefuah
Introduction Background: Chronic pain syndrome is a common disease with major economic costs. The aim of this study is to examine the effect of outpatient multidisciplinary pain rehabilitation on the utilization of medical services in…
View details →Nemes A, Ambrus N, Szili-Török T et al. · 2026 · Journal of clinical medicine
Introduction : The left ventricular (LV) function can be characterized by the spatial displacement of the aortic valve annulus (AVA), represented by the AVA plane systolic excursion (AAPSE). AAPSE, measured using 3DSTE, has been shown to…
View details →Ozden H · 2026 · Open life sciences
Perfluorooctanoic acid (PFOA) is widely utilized perfluoroalkyl substance (PFAS) in various industrial and household applications, known for its persistence in the environment. Due to the limited toxicity data for PFOA in edible vegetable…
View details →Kathpalia A, Vlachos I, Hlinka J et al. · 2026 · Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Objective Finding indicators of early response to antidepressant treatment in EEG signals recorded from patients suffering from major depressive disorder. Methods Functional brain connectivity networks based on weighted imaginary coherence…
View details →Putos J, Atkinson HF, Walton DM · 2026 · Osteoarthritis and cartilage open
Objectives The acute response of lumbar intervertebral discs (IVD) to spinal rotation mobilization (SRM) is poorly understood. We evaluated sustained morphological changes in lumbar IVDs following a rotation mobilization commonly used to…
View details →Ajiki H, Tanaka M · 2026 · Journal of imaging
Even when an object's color is accurately reproduced in a colorimetrically reproduced image (CRI), the perceived material appearance does not necessarily match that of the original object. This mismatch remains a challenge for faithfully…
View details →Uysal A, Soslu R, Soslu R · 2026 · Journal of strength and conditioning research
Abstract Uysal, A and Soslu, R. Acute and long-term effects of spinning-based high-intensity interval training on inducible nitric oxide synthase: a randomized controlled trial. J Strength Cond Res XX(X): 000-000, 2026-This study…
View details →Ravenda S, Gerra MC, Barbetti M et al. · 2026 · Psychoneuroendocrinology
MicroRNAs (miRNAs) have attracted great interest as potential biomarkers in several research domains, including acute and chronic stress conditions. While most of these studies focused on circulating blood miRNA levels, the investigation…
View details →Guo C, Geng A, Wang Q et al. · 2026 · Journal of integrative neuroscience
Background The cortex and cerebellum have a closely connected closed-loop circuit. Intermittent theta burst stimulation (iTBS) targeting the cerebellum has shown promise in improving balance function and inducing neuroplasticity. This…
View details →Salimi Y, Namdarzadeh B, Aarani FD et al. · 2026 · Behavioural brain research
The gut-brain axis plays a key role in the bidirectional communication between the gastrointestinal system and the brain, with gut microbiota significantly influencing cognitive function. While synbiotic and probiotic interventions have…
View details →Sudhakar S, Mishra VK, Harikrishna S et al. · 2026 · Physical chemistry chemical physics : PCCP
Human PrimPol (hPrimPol) is the primase and polymerase enzyme involved in reinitiating DNA replication at stalled replication forks. The hPrimPol mutants are linked to multiple ophthalmoplegic conditions and mitochondriopathies. The WFYY…
View details →Sanmartino F, Rashid-López R, López-Sosa F et al. · 2026 · International journal of neural systems
Resting-state eye conditions modulate cortical oscillations, but their impact on subthalamic nucleus (STN) and cortico-STN dynamics in Parkinson's disease (PD) remains poorly understood. Here, we characterized electrophysiological changes…
View details →Mabkhot BA, Taha SEE, Kamel MH et al. · 2026 · BMC oral health
BACKGROUND: Subgingival crown margins have been linked to chronic gingival inflammation in pediatric patients. This clinical trial evaluated periodontal outcomes in first permanent molars that had undergone root canal therapy and were…
View details →Koper M, Jaworska K, Kopacz W et al. · 2026 · Kidney & blood pressure research
Hypertension contributes to renal dysfunction, partly through dysregulation of the renin-angiotensin system (RAS). Betaine, an osmolyte that helps maintain medullary osmotic gradients, has demonstrated renoprotective effects in models of…
View details →Wiel É, Menu H, Roger F et al. · 2026 · Anaesthesia, critical care & pain medicine
Background Endotracheal Intubation (ETI) inserts an endotracheal tube (ETT) inside the human trachea to allow a proper mechanical ventilation of the lungs. Practitioners insert the ETT through the human vocal cords following a…
View details →Yuan Y, Gao Y, Moen H et al. · 2026 · NPJ digital medicine
Digital phenotyping leverages continuous data from smartphones and wearable devices for real-time mental health monitoring, offering opportunities for early detection and personalized care in mood disorders by enabling clinicians to…
View details →Montasser ZM, Montasser MA · 2026 · BMC oral health
Objective To review the available evidence on temporomandibular joint morphological changes after orthodontic treatment with clear aligners, as assessed using CBCT scans. Materials and methods This review sought randomized clinical trials,…
View details →Singh Y, Lei Q, Dixit M et al. · 2026 · Medical care research and review : MCRR
Corporate employment of primary care physicians by hospitals and private equity-backed organizations has increased in recent years, raising concerns that the financial incentives of corporate employment will incentivize provision of…
View details →Karacaer C, Kaya G, Ergenc H et al. · 2026 · Pakistan journal of medical sciences
Objectives This study aimed to evaluate the prognostic significance of Cluster of Differentiation 4 (CD4+) and Cluster of Differentiation 8 (CD8+) T cell dynamics and cytokine profiles during the early stage of Coronavirus Disease 2019…
View details →Chowdhury M, Bustamante AV · 2026 · Health affairs (Project Hope)
Lawfully present noncitizen immigrants face persistent coverage gaps due to federal restrictions on Medicaid eligibility, including the five-year bar under the 1996 Personal Responsibility and Work Opportunity Reconciliation Act, and…
View details →Yakasai AM, Maharaj SS, Danazumi MS · 2026 · American journal of physical medicine & rehabilitation
Objective This study evaluated the efficacy of endurance exercise on balance impairment and gait disturbance among individuals living with Human Immunodeficiency Virus (HIV)-related distal symmetrical polyneuropathy (DSPN). Design This was…
View details →Srinivasan VV, Ravikumar A, Ostrin LA · 2026 · Eye & contact lens
Purpose To determine the effects of contact lens-induced full-field and peripheral-field myopic defocus on choroid thickness and variation with time of day in young adults. Methods In this prospective, randomized, crossover study, 16…
View details →Echizen T, Yusu S, Chiba U et al. · 2026 · Physical therapy research
Objectives This study aimed to compare the effects of repetitive peripheral magnetic stimulation (rPMS) and neuromuscular electrical stimulation (NMES) on hemodynamics and obtain basic data to verify the safety of rPMS in healthy adults.…
View details →Esen Baris M, Guclu A, Guven S et al. · 2026 · BMC ophthalmology
Background Phenylephrine is widely used for pharmacological mydriasis in routine ophthalmic practice. While its vascular and pupillary effects are well established, its influence on anterior segment structures and intraocular inflammatory…
View details →Dobsikova R, Marsalek P, Velisek J et al. · 2026 · Veterinarni medicina
This study assessed the effect of a 24-hour bath with praziquantel (2 and 4 mg/l) on grass carp ( Ctenopharyngodon idella ) by monitoring the haematological parameters, plasma biochemical profile, and oxidative stress indices. Fish were…
View details →Di̇ncer M, Canturk N, Dagalp R et al. · 2026 · Forensic science international
A signature is writing and/or signs that contain the signatory's personal characteristics and are used to indicate that people accept the authenticity of the formal and private transactions made by themselves in their daily lives and…
View details →Koyama K, Hosono S · 2026 · Journal of strength and conditioning research
Abstract Koyama, K and Hosono, S. Comparison of the effects of barefoot and shod training on foot structure, muscle strength, and sensory function. J Strength Cond Res 40(5): 566-575, 2026-The aim of this study was to compare the effects…
View details →Biguino B, Haigh ID, Dias JM et al. · 2025 · Scientific reports
Marine Heat Waves (MHWs) have been the focus of numerous studies due to the dramatic consequences they can have on coastal systems. However, Marine Cold Spells (MCSs) can also have harmful effects on the environment while play an important…
View details →Cesna S, Bielinis A, Zvirblis T et al. · 2026 · Cardiology in the young
Objectives Despite the effectiveness of the surgical or percutaneous treatment of coarctation of the aorta, the presence of hypertension in these patients remains a common and concerning issue. This study was undertaken to explore the…
View details →Andrés AI, Martín-Mateos MJ, D'Arrigo M et al. · 2026 · Food chemistry
This study evaluated the effects of high hydrostatic pressure (HHP)-treated white (WGP) and red grape pomace (RGP) on oxidative stability, volatile compounds, and polycyclic aromatic hydrocarbons (PAHs) in barbecued Frankfurter sausages.…
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