Negative / Null Result ReportOpen accessMedicine
Patel DM, Wilson RF, Gharibani T et al. · 2026 · Journal of patient-reported outcomes
BACKGROUND: Patient-reported outcomes (PROs) are key outcomes of importance for people with chronic kidney disease (CKD), and may be of even higher relevance for patients with concomitant anemia which can often be symptomatic. Thus, PROs…
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Advani H, Dixit A, Kumar S et al. · 2026 · Cureus
Background Gingival recession (GR) results in significant functional and cosmetic concerns and manifests as a disintegration of soft and hard tissues. Recently, clinical research has increasingly focused on the development of minimally…
View details →Negative / Null Result ReportOpen accessMedicine
Zhang Y, Guo M, Bian Q et al. · 2026 · BMC nephrology
Background Primary membranous nephropathy (pMN) is characterized by a prolonged course, frequent relapses, and variable treatment responses. While obinutuzumab (OBI) demonstrates promising efficacy in B-cell depletion, its direct…
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Sfulcini M, Trevisi E, Piccioli-Cappelli F et al. · 2026 · PloS one
Weaning represents a critical transition in dairy calves, involving simultaneous dietary, social, and environmental changes. This study investigated how the weaning affects immune-related gene expression in circulating leukocytes of…
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Mohamed HA, Azer A, AboElHassan RG · 2026 · International journal of dentistry
Background Advanced lithium disilicate glass ceramics offer excellent esthetics, but conservative crown preparations are not always the preferred choice. Various margin designs are available; however, more conservative vertical…
View details →Negative / Null Result ReportOpen accessMedicine
William Coley, Sree Rayavarapu, Jack H van der Meulen et al. · 2013 · PLoS ONE
BACKGROUND: Current treatments for idiopathic inflammatory myopathies (collectively called myositis) focus on the suppression of an autoimmune inflammatory response within the skeletal muscle. However, it has been observed that there is a poor correlation between the successful suppression of muscle inflammation and an improvement in muscle function. Some evidence in the literature suggests that metabolic abnormalities in the skeletal muscle underlie the weakness that continues despite successful immunosuppression. We have previously shown that decreased expression of a purine nucleotide cycle
View details →Negative / Null Result ReportOpen accessMedicine
James E Campbell, Michael Adam Meledeo, Andrew P Cap · 2014 · PLoS ONE
BACKGROUND: Acute traumatic coagulopathy (ATC) has been linked to an increase in activated protein C (aPC) from 40 pM in healthy individuals to 175 pM. aPC exerts its activity primarily through cleavage of active coagulation factor Va (fVa). Platelets reportedly possess fVa which is more resistant to aPC cleavage than plasma fVa; this work examines the hypothesis that normal platelets are sufficient to maintain coagulation in the presence of elevated aPC. METHODS: Coagulation responses of normal plasma, fV deficient plasma (fVdp), and isolated normal platelets in fVdp were conducted: prothromb
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Masoud Seifi, Shirin Farivar, Malihe Sadat Mirhosseini et al. · 2020 · Regeneration, Reconstruction & Restoration
Introduction: Stem cells have gained great attention in tissue engineering and curcumin is a natural phenolic product that had showed some positive effects on these cells. The aim of this study was to evaluate the effect of curcumin on the differentiation of human dental pulp stem cells (hDPSCs). Materials and Methods: In this experimental study, hDPSCs were isolated from human third molars and treated without and with different concentrations (5, 10 and 15 µM) of curcumin and dimethyl sulfoxide (DMSO) as solvent for curcumin. Proliferation of the cells was measured by methyl-thiazol-tetrazoli
View details →Negative / Null Result ReportOpen accessMedicine
Galiya Iskakova, Bauyrzhan Iztayev, Auyelbek Iztayev et al. · 2025 · Scientific Reports
Abstract The quality of food products and a balanced diet play a key role in maintaining health and improving the quality of life. Due to the high popularity of pasta, a promising direction is the development of recipes that include whole grain flour, carrot powder and ion-ozonated water, which increase the nutritional value of the product and improve its chemical composition. The aim of this study was to optimise the technological modes of production of durum wheat pasta using carrot powder and ion-ozonated water to minimise the loss of dry matter (DM) during cooking and increase the protein
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Mengting Chen, Eng Wah Teo, Sau Cheong Loh · 2026 · Scientific Reports
Abstract Cyberbullying and cybervictimization have become widespread phenomena on social media platforms, particularly in emotionally charged environments such as sports fandom. While prior research has emphasized the role of individual personality traits, the influence of social identification—specifically, fan identity—on these behaviors remains underexplored, especially within Chinese digital communities, such as Sina Weibo. Grounding the study in the Social Identity Model of Deindividuation Effects, we theorize that platform affordances, such as anonymity and group salience, amplify identi
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Dong Chengtung · 1987 · 针刺研究
Somatosensory evoked potentials(SEPs)were recorded simultaneously from the cervical spine and scalp in 10 normal subjects and 22 patients with cerebrovascular attack(9)and syringomelia(13)using median nerve stimulation.Patients were considered as having abnormal studies,if either N_(18) were absent or if their peak latencies were prolonged more than 21.1 msec,or if the difference of (N_(13)-N_(18))conduction time was more than 7.53 msec.In addition,side-to-side value for(N_(13)-N_(18))were compared, these normally differ by less than 1.38 msec. The results may be summarized as followings: Acup
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Manisha Kalpesh Gohel, Jashbhai B. Prajapati, Sreeja V. Mudgal et al. · 2016 · Journal of Clinical and Diagnostic Research
Introduction: Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. Sufficient calcium intake has been reported to support bone growth and prevent bone loss during the ageing process. Aim: To determine the effect of Lactobacillus helveticus MTCC 5463 probiotic dietary intervention on serum calcium & haematological parameters in geriatric population. Materials and Methods: Healthy volunteers with age ranging from 64-74 years were recruited from the nearby residential areas in and around Anand, Gujarat. Study duration was from 2012 to
View details →Negative / Null Result ReportOpen accessMedicine
Viktoriia V. Yevsieieva, Volodimyr I. Cherniy, Kateryna V. Kharchenko et al. · 2023 · Клінічна та профілактична медицина
Introduction. One of the main factors affecting postoperative outcomes in patients with advanced ovarian cancer is the cardiopulmonary status. Several studies have reported that preoperative multifactorial rehabilitation and physical fitness can lead to reduced postoperative morbidity, mortality, shorter length of stay, and improved quality of life in cancer patients. The issue of adaptability to physical activity of overweight and obese patients who undergoing debulking surgery is insufficiently studied. The study of compensatory changes that occur in physically inactive obese patients remain
View details →Negative / Null Result ReportOpen accessMedicine
Björkman AS, Malusek A, Persson A et al. · 2026 · European radiology experimental
Objective The aim was to compare the image quality of photon-counting detector CT (PCD-CT) and energy-integrating detector CT (EID-CT) in patients with tibial plateau fractures treated with metallic osteosynthesis material, and to identify…
View details →Negative / Null Result ReportOpen accessMedicine
P.F. Wong, M.P.L. Cheung, O WS et al. · 2014 · Asian Pacific Journal of Reproduction
Objective: To study the effect of inter medin(IMD) on smooth muscle of rat seminal vesicles including the specific receptors and the signal pathways involved. Methods: The contraction of the seminal vesicle in response to norepinephrine (NE) and ADM2/IMD was studied by the organ bath method. The effects of antagonists for calcitonin gene related peptide (CGRP), adrenomedullin (ADM) and IMD receptors, and inhibitors of nitric oxide synthase, [L-NG-Nitroarginine Methyl Ester, L-NAME) and cAMP-dependent protein kinase (PKA), KT5720] were also investigated. The first overshoot, amplitude, frequenc
View details →Negative / Null Result ReportMedicine
Dang M, Bishop Z, Schick KD et al. · 2026 · Child abuse & neglect
Background In child maltreatment investigations, forensic interviewers must elicit accurate narratives while prioritizing children's wellbeing in a safe environment that minimizes distress. While note-taking may help reduce suggestive…
View details →Negative / Null Result ReportOpen accessMedicine
Kristiina Aalto, Hannu Kautiainen, Anders Fasth et al. · 2025 · RMD Open
Introduction The age at the onset of juvenile idiopathic arthritis (JIA) can influence the trajectory of the disease. We aimed to clarify how age at the visit 6 months after the onset as a continuous variable affects long-term remission of JIA.Methods This study investigated 358 patients from the Nordic JIA cohort study. Age at diagnosis was analysed continuously. Three age groups were studied: under 3 years, 3–5 years and over 6 years of age. JIA was categorised as oligoarthritis, seronegative polyarthritis and others (enthesitis-related, psoriatic and undifferentiated arthritis). Clinical da
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Ting-Ting Xu, Rui Cao, Yan-Ling Dong et al. · 2022 · PLoS ONE
This study aimed to analyze the factors of rapid attenuation of graft endothelium in the early stage after penetrating keratoplasty (PKP), with a view to guiding patients with PKP to better long-term outcomes. This study included 226 patients who underwent PKP with follow-up time >1 year at the Qingdao Eye Hospital of Shandong First Medical University from January 2018 to June 2020. Medical records were retrospectively studied, and donor factors, patient factors, and surgical factors were comparatively analyzed to clarify those affecting the rapid decay of graft endothelium after PKP. The medi
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Zerrin Tuncer, Turhan Soylu · 2012 · Türk Oftalmoloji Dergisi
Pur po se: To evaluate the long-term results of rigid gas permeable (RGP) contact lenses in severe keratoconic eyes. Ma te ri al and Met hod: Severe keratoconic eyes with RGP contact lenses were evaluated retrospectively. Re sults: Long-term follow-up results of RGP contact lenses applied to 59 eyes of 42 patients (25 women, 17 men) with a diagnosis of severe keratoconus were analyzed. Follow-up period was 3 to 12 years (mean: 6.57±3.60). The mean age at first exam was 25.88±9.10 years, the mean corneal curve K1 was 6.49±0.40 mm and K2 was 5.91±0.40 mm. Mean visual acuities with spectacles and
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Tomoharu Takeuchi, Risa Nakamura, Megumi Hamasaki et al. · 2023 · BMC Research Notes
Abstract Objective Galectins are sugar-binding proteins that participate in many biological processes, such as immunity, by regulating host immune cells and their direct interaction with pathogens. They are involved in mediating infection by Schistosoma mansoni, a parasitic trematode that causes schistosomiasis. However, their direct effects on schistosomes have not been investigated. Results We found that galectin-2 recognizes S. mansoni glycoconjugates and investigated whether galectin-1, 2, and 3 can directly affect S. mansoni in vitro. Adult S. mansoni were treated with recombinant galecti
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Anna Keodara, Lukas Jeker, Lars Straub et al. · 2024 · Scientific Reports
Abstract Bees are often exposed to pesticides affecting physiological functions and molecular mechanisms. Studies showed a potential link between altered expression of energy metabolism related transcripts and increased homing flight time of foragers exposed to pesticides. In this study, we investigated the effects of thiamethoxam and pyraclostrobin on longevity, flight behavior, and expression of transcripts involved in endocrine regulation (hbg-3, buffy, vitellogenin) and energy metabolism (cox5a, cox5b, cox17) using radio frequency identification (RFID) technology and quantitative polymeras
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Jerzy A Zoladz, Joanna Majerczak, Bruno Grassi et al. · 2016 · PLoS ONE
In this study we have examined the effect of prolonged endurance training program on the pulmonary oxygen uptake (V'O2) kinetics during heavy-intensity cycling-exercise and its impact on maximal cycling and running performance. Twelve healthy, physically active men (mean±SD: age 22.33±1.44 years, V'O2peak 3198±458 mL ∙ min-1) performed an endurance training composed mainly of moderate-intensity cycling, lasting 20 weeks. Training resulted in a decrease (by ~5%, P = 0.027) in V'O2 during prior low-intensity exercise (20 W) and in shortening of τp of the V'O2 on-kinetics (30.1±5.9 s vs. 25.4±1.5
View details →Negative / Null Result ReportOpen accessMedicine
Hassan Nakisa, Fatemeh Ayoobi, Vahid Ehsani et al. · 2015 · مجله دانشگاه علوم پزشکی بیرجند
Background and Aim: Oxidative stresses are involved in neuronal degeneration of substantia nigra and thereby induction of Parkinson's disease. It is reported that Foeniculum Vulgare L. can affect lactating and modulating dopaminergic system activity and antioxidant activity as well. In the present study, the effects of methanolic extract of Foeniculum Vulgare seeds on a Parkinson’s disease model induced by ICV injection of 6-hydroxydopamin (6-OHDA) in female rats were investigated. Materials and Methods: In this experimental study, 60 female rats were randomly divided into 6 equal groups inclu
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Mohsen Dalband, Mona Isapour, Pantea Nazeman · 2016 · Regeneration, Reconstruction & Restoration
Introduction: Antibiotics are routinely administered in clinical setting for prevention of infections in surgeries and as a routine supplement to the culture medium. The nobility of the present study was to evaluate the effect of two commonly used antibiotics, clindamycin and cefazolin, in dental treatments, on osteogenic capability of periodontal ligament stem cells (PDLSCs). Materials and Methods: PDLSCs were isolated from periodontal ligament (PDL) of the root section out of four healthy extracted teeth. The cells were incubated in the following medium for 28 days: (1) Osteogenic medium (OM
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Amin Ebneshahidi, Mojtaba Akbari, Masood Mohseni · 2013 · Advanced Biomedical Research
Introduction: Haloperidol has an established role in nausea and vomiting prophylaxis and possible effects on multiple aspects of postoperative recovery including pain and sedation. The purpose of this study was to evaluate the effects of low-dose intraoperative intravenous haloperidol on quality of recovery (QoR) and pain control after general anesthesia and surgery. Methods: Ninety eight American Society of Anesthesiologists (ASA) physical status I-II patients undergoing elective general, gynecologic or orthopedic surgery under general anesthesia were enrolled. Participants were randomly allo
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Sayed Reza Eshaghi, Armindokht Shahsanai, Maryam Mellat Ardakani · 2011 · مجله دانشکده پزشکی اصفهان
Background: Improvement of medical care and decreasing of mortality, have lead to an increase in ageing in Iranian population. The main goal of Active ageing is improving the quality of life. Physical activity is one of the factors that is important to achieve a good quality of life. The aim of this study was to evaluate the physical activity of the elderly in Isfahan. Methods: This cross sectional study was carried out on 350 old residents of Isfahan, Iran between the years 2009-2010. Multi stage cluster sampling technique was used to collect the sample population. Rapid assessment of physica
View details →Negative / Null Result ReportMedicine
Wu S, Yang L, Cai Y et al. · 2026 · Eye (London, England)
Objective This study aimed to compare the diagnostic performance of Dixon T2-weighted imaging (Dixon-T2WI), T2 mapping, and T1 mapping in evaluating orbital activity in Graves' orbitopathy (GO). Methods Seventy-three GO patients were…
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Samira Ghorbani, Seyyedeh Solmaz Talebi · 2025 · Journal of Mazandaran University of Medical Sciences
Background and purpose: Declining fertility rates and decreasing population growth are major challenges for the country. Numerous studies have been conducted to identify factors influencing this issue. One such factor is the childbirth experience. This research examines the relationship between previous childbirth experiences and fertility decisions in women with one child. Materials and methods: This cross-sectional study was conducted in 2023-2024 on 400 women with one child covered by health centers in Shahrud. Health centers were selected from various city areas (northern, southern, easter
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Shokrollah Assar, Ali Darehkordi, Mohammad Moradi et al. · 2019 · Journal of Clinical and Diagnostic Research
Introduction: Fluoroquinolones are a form of antibiotics capable of influencing DNA Gyrase of bacteria. Any alteration in the structure of current fluoroquinolone antibacterials may provide a better effect on the growth inhibition of bacteria. Aim: To assess the probable anti-bacterial activity of two fluoroquinolone derivatives on Staphylococcus aureus (S.aureus) and Enterococcus faecalis (E. faecalis). Materials and Methods: The inhibitory effect of two synthetic derivatives of fluoroquinolones, N-4-methyl (phenyl) -2,2,2- trifluoroacetimidoyl ciprofloxacin (C1), and N-4-methyl (phenyl) -2,2
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Mohammad Haddadi, Javad Ganjloo, Hamid Reza Hashemifard et al. · 2019 · Complementary Medicine Journal of Faculty of Nursing and Midwifery
Objective Cancer disease and its treatment methods affect the quality of life of those suffering from breast cancer. Nausea and vomiting are frequent side-effects of chemotherapy. Nowadays, complementary therapies are used along with routine treatments to control this disease. This study aimed to evaluate the effect of sucking ice bits with plain water on nausea and vomiting during chemotherapy in patients with breast cancer. Methods In this clinical trial, participants were 60 breast cancer patients undergoing chemotherapy. They were randomly divided into two groups of control and ice. The ic
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