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Browse the failure-mode index

11,412 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Instructing participants about the random assignment of patients to treated and non-treated conditions does not diminish causal illusions.

Barreiro A, Rodríguez-Ferreiro J, Barberia I · 2025 · Royal Society open science

People sometimes perceive causal relationships between non-contingent events. When having to assess the contingency between a putative cause and an outcome, it is vital to ensure that all other causal forces are held constant whether the…

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Negative / Null Result ReportOpen accessMedicine

Risk Factors for Endoscopic Gastric Mucosal Lesions: Analysis of Lifestyle, Dietary, and Clinical Determinants in 361 Patients.

Chiciudean PL, Filip AM, Munteanu SN et al. · 2025 · Life (Basel, Switzerland)

Background/objectives Gastric mucosal lesions represent a significant health burden, with Helicobacter pylori infection being the primary cause of chronic gastritis worldwide. However, the role of modifiable lifestyle factors in modulating…

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Negative / Null Result ReportOpen accessMedicine

Tipping the scale: Effects of physical activity and body composition on cardiac parameters in postmenopausal females.

Fischer M, Tamariz-Ellemann A, Egelund J et al. · 2024 · Physiological reports

The risk of cardiovascular disease increases significantly after menopause. We sought to assess the impact of different activity levels on cardiac structure and function in postmenopausal women. We grouped age-similar, postmenopausal women…

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Negative / Null Result ReportOpen accessMedicine

Parental political engagement and self-efficacy: An exploratory study.

Randolph C, Needlman R, Hutchinson E · 2024 · American journal of community psychology

Political engagement (PE) is associated with a sense of empowerment. PE by parents affects children's lives. This study explored parents' attitudes about inclusion of political engagement discussion in well-child care. Because voting is an…

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Negative / Null Result ReportMedicine

Patterns of Symptom Change in Behaviors and Cognitions During 10-Session Cognitive Behavioral Therapy (CBT-T) for Non-Underweight Eating Disorders.

Kambanis PE, Graver H, Palmer LP et al. · 2025 · The International journal of eating disorders

Objective Little is known about the timing of behavioral versus cognitive change in 10-session cognitive-behavioral therapy for non-underweight eating disorders (CBT-T). We aimed to: (a) evaluate the magnitude of behavioral and cognitive…

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Negative / Null Result ReportOpen accessMedicine

Exosome enriched serum enhances engineered ligament mechanics and collagen content with no additional benefit of resistance exercise.

Paulussen KJM, Hayden CMT, Griffin T et al. · 2025 · Matrix biology plus

Following resistance exercise, systemic changes foster improved functionality of tendons and ligaments. Post-exercise, muscle tissue releases exosomes that are thought to facilitate inter-tissue communication. To determine the potential…

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Negative / Null Result ReportOpen accessMedicine

Comparison of Medial Meniscus Root Repair with Two Surgical Techniques Using Medial and Lateral Tunnels: A Prospective Cohort Study.

Shahsavari Pour A, Hosseini A, Ghomashi I et al. · 2026 · The archives of bone and joint surgery

Objectives This study aimed to compare the clinical outcomes of trans-tibial pullout repair of the medial meniscus posterior root using the lateral tibial tunnel versus the conventional medial tibial tunnel. Methods In this prospective…

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Negative / Null Result ReportOpen accessMedicine

Does the change between the native and the prosthetic posterior tibial slope influence the clinical outcomes after posterior stabilized TKA? A review of 793 knees at a minimum of 5 years follow-up.

Alhamdi H, Deroche E, Shatrov J et al. · 2025 · SICOT-J

Introduction The understanding of the influence of posterior tibial slope (PTS) on knee kinematics has increased. However, the PTS influence on clinical outcomes remains unclear. The study aimed to evaluate whether a significant change…

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Negative / Null Result ReportOpen accessMedicine

Omega-3 fatty acid supplementation does not attenuate declines in skeletal muscle mitochondrial area in young, healthy females during immobilization.

Lo MM, Black MN, McGlory C et al. · 2026 · Physiological reports

Mitochondrial subcellular area influences function. Muscle disuse reduces mitochondrial content; however, its effect on mitochondrial subcellular location is unclear. Omega-3 fatty acid (n-3) attenuates declines in muscle mass and…

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Negative / Null Result ReportOpen accessMedicine

Do Surrogate Markers of Cardiorespiratory Fitness Predict Individual Changes in VO<sub>2peak</sub>? A Randomized Controlled Trial.

Renwick JRM, Preobrazenski N, Giudice MD et al. · 2024 · International journal of exercise science

The purpose of the current study was to test the hypothesis that individual response classification for surrogate markers of cardiorespiratory fitness (CRF) will agree with response classification for VO 2peak . Surrogate markers of CRF…

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Negative / Null Result ReportOpen accessMedicine

Relationship between the stiffness of the medial gastrocnemius and spatiotemporal variables during 100-m sprint running in collegiate sprinters.

Fujii N, Takahashi K, Kawama R et al. · 2026 · PloS one

Higher stiffness of the medial gastrocnemius (MG) has been reported to be associated with faster race time in 100-m sprint running. However, the association of muscle stiffness with spatiotemporal variables (i.e., step frequency, step…

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Negative / Null Result ReportOpen accessMedicine

Effect of wild yeast inoculation on the nutritive value, fermentation profile, and aerobic stability of rehydrated corn grain silage.

Pupo MR, Diepersloot EC, Wenzel MPR et al. · 2026 · JDS communications

Feeding spoiled silage with high yeast activity is commonly related to impaired lactation performance by dairy cows. However, rehydrated corn grain silage (RCGS) may be more prone to yeast proliferation and be greatly affected by high…

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Negative / Null Result ReportOpen accessMedicine

Comparison of Jaw Function and Mental Health Between Patients With Anterior Disc Displacement With and Without Reduction.

Yao Y, Liu SS, Jin L et al. · 2025 · Clinical and experimental dental research

Objectives Anterior disc displacement with reduction (ADDWR) and without reduction (ADDWOR) are two common clinical types of temporomandibular disorders. This study compared the levels of anxiety, depression, somatization, and jaw function…

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Negative / Null Result ReportOpen accessMedicine

Effects of Supervised Exercise during Neoadjuvant Chemotherapy on Tumor Response in Patients with Breast Cancer (Neo-train): A Randomized Controlled Trial.

Kjeldsted E, Ammitzbøll G, Lænkholm AV et al. · 2025 · Clinical cancer research : an official journal of the American Association for Cancer Research

Purpose Preclinical studies have indicated that physical exercise may enhance chemotherapy efficacy. However, clinical trials are needed to investigate these findings. We hypothesized that an exercise program during neoadjuvant…

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Negative / Null Result ReportOpen accessMedicine

Long-Term Impact of the COVID-19 Pandemic on Diet Quality Among Adults in the Province of Quebec: Longitudinal Analyses of the NutriQuébec Project

Lancup-Gauthier A, Brassard D, Côté M et al. · 2022 · Current developments in nutrition

Objectives While there is evidence that the early lockdown due to COVID-19 pandemic may have had small positive impacts on several populations’ dietary habits, the longer term effects remain largely unknown. The aim of this study was to…

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Negative / Null Result ReportMedicine

Out-of-home care placement and mortality rate in early adulthood: identifying vulnerable subgroups in a nationwide cohort study.

Sørensen TT, Rod NH, Nguyen TL et al. · 2023 · European journal of epidemiology

Out-of-home care has been linked to excess mortality across the lifespan. We examined whether this association is modified by the age at first out-of-home care placement and the number of placements. In this population-based cohort study,…

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Negative / Null Result ReportOpen accessMedicine

Directional deficits in reactive postural control during perturbations among groups of chronic ankle instability, ankle sprain coper, and healthy control.

Kim MJ, Kim S, Kim J et al. · 2025 · Scientific reports

Unanticipated postural control measures may better identify mechanisms of ankle sprains in real-life situations. The purpose of this study was to identify directional deficits in reactive postural control during unanticipated horizontal…

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Negative / Null Result ReportOpen accessMedicine

Visual Perception and Fixation Patterns in an Individual with Ventral Simultanagnosia, Integrative Agnosia and Bilateral Visual Field Loss.

Williams I, Phillipou A, Storey E et al. · 2025 · Neurology international

Background/objectives As high-acuity vision is limited to a very small visual angle, examination of a scene requires multiple fixations. Simultanagnosia, a disorder wherein elements of a scene can be perceived correctly but cannot be…

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