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Browse the failure-mode index

11,312 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Face-To-Face Vs. Online Behavioral Parent Training for Young Children with ADHD: Child and Parent Outcomes.

DuPaul GJ, Kern L, Dever BV et al. · 2026 · Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53

Objective Behavioral parent training is a first-line psychosocial intervention for young children with Attention-Deficit/Hyperactivity Disorder. Traditional face-to-face delivery is limited by access to therapists, feasibility, and/or…

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Negative / Null Result ReportOpen accessMedicine

The rise and fall of glucocorticoids and immunosuppressants in idiopathic pulmonary fibrosis: a historical paradigm shift driven by mechanistic understanding.

Wen B, Wu X, Ma X et al. · 2026 · Frontiers in immunology

The therapeutic strategy for Idiopathic Pulmonary Fibrosis (IPF) has undergone a fundamental transformation over recent decades. Combination therapy with glucocorticoids and immunosuppressants, particularly the "triple therapy" regimen…

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Negative / Null Result ReportMedicine

PD-L1 subpopulations of metastatic urothelial carcinoma demonstrate heterogeneity to chemotherapy: an integrated analysis of digitized trial results.

Zhou J, Jiang X, Liu Q et al. · 2026 · Cancer metastasis reviews

Efforts to translate advances in immunology into anti-cancer immunotherapies have progressed rapidly in recent years. Six antibodies acting on programmed death ligand 1 or programmed death 1 pathways were approved in 75 cancer indications…

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Negative / Null Result ReportMedicine

Optimal endoscopic treatment for rectal neuroendocrine tumors, confirmed after forceps biopsy: a Korean Association for the Study of Intestinal Diseases multicenter, randomized noninferiority trial.

Gweon TG, Kim SJ, Myung DS et al. · 2026 · Gastrointestinal endoscopy

Background and aims Insufficient submucosal lifting because of pretreatment with forceps biopsy frequently complicates endoscopic treatment of rectal neuroendocrine tumors (NETs) and potentially affects procedural outcomes. Despite…

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Negative / Null Result ReportMedicine

Anti-inflammatory agents for the management of COPD - Quo Vadis?

Bakakos A, Sotiropoulou Z, Anagnostopoulos N et al. · 2025 · Respiratory medicine

Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality around the globe. Its main characteristics are persistent respiratory symptoms and progressive airflow limitation, both of which are driven by…

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Negative / Null Result ReportOpen accessMedicine

A Retrospective Study of a Postoperative Inflammation-Based Score for Predicting Disease-Free Survival in Locally Advanced Rectal Cancer After Neoadjuvant Chemoradiotherapy.

Yang Q, Li J, Ding L et al. · 2026 · Cancer management and research

Background Growing research findings highlight the potential of inflammatory markers measured after surgery as prognostic indicators for survival outcomes in rectal carcinoma patients. However, their precise clinical significance remains…

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Negative / Null Result ReportOpen accessMedicine

The fluid paradox: dissociation between clinical and ultrasound parameters of fluid overload - results of the INCIVEX exploratory study.

Wong A, Cheah K, Papathanakos G et al. · 2026 · Anaesthesiology intensive therapy

Introduction Fluid management in critically ill patients relies on clinical assessment, fluid balance calculations and, increasingly, point-of-care ultrasound. However, the rela-tionships between these assessment modalities remain poorly…

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Negative / Null Result ReportMedicine

Survival outcomes of the use of adjuvant chemotherapy in resected esophagus cancer after neoadjuvant chemoradiotherapy.

Ke TM, Lin T, Chow WH et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Introduction Neoadjuvant chemoradiotherapy (nCRT) followed by surgery is the standard treatment for esophageal cancer, but the role of adjuvant chemotherapy remains unclear. This study investigates the survival benefits of adjuvant…

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Negative / Null Result ReportMedicine

Does the Timing of Lysis of Adhesions After Anterior Cruciate Ligament Reconstruction Affect Final Range of Motion?

Schneble CA, Miltenberg B, Jurgensmeier K et al. · 2025 · The American journal of sports medicine

Background Arthrofibrosis is seen in 1.7% to 38% of patients after anterior cruciate ligament reconstruction (ACLR) and has been associated with worse postoperative patient-reported outcomes. There are limited data regarding the optimal…

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Negative / Null Result ReportMedicine

Collaborative Navigation Improves Spatial Learning Across Symmetric and Asymmetric Locomotion in Virtual Reality.

Chakraborty S, Gagnon H, McNamara TP et al. · 2026 · IEEE transactions on visualization and computer graphics

Multi-user virtual reality (VR) systems support multiple locomotion methods, but coordination may be challenging when partners use different methods. We studied dyads navigating a shared virtual maze using symmetric (same) or asymmetric…

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Negative / Null Result ReportMedicine

Family satisfaction with intensive care and preexisting family and patient characteristics: equivalence analysis of cross-sectional surveys.

Riguzzi M, Verweij L, Naef R · 2025 · Intensive & critical care nursing

Objectives This study aims to demonstrate that family satisfaction with intensive care and decision-making is independent of sociodemographic family member and patient characteristics and the patient outcomes of mortality and length of…

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Negative / Null Result ReportMedicine

Effect of an educational antimicrobial stewardship programme on antibiotic prescriptions' appropriateness in three medical units of a large university hospital: an interrupted time series analysis.

Giovannenze F, Del Vecchio P, Frondizi F et al. · 2025 · The Journal of hospital infection

Background Antimicrobial stewardship (AMS) programmes aim to enhance antibiotic prescription quality, reduce antibiotic use, and combat multi-drug-resistant pathogens. However, the optimal AMS intervention for different clinical settings…

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Negative / Null Result ReportOpen accessMedicine

Tremor Recurrence in MR-Guided Focused Ultrasound Thalamotomy for Essential Tremor: DBS vs. Re-lesion.

Walker-Pizarro N, Chan JL, Yu J et al. · 2026 · Tremor and other hyperkinetic movements (New York, N.Y.)

Clinical vignette A 59-year-old man with essential tremor (ET) and bilateral symptoms initially underwent left thalamic MRI-guided focused ultrasound (MRgFUS) at an outside institution to address tremor in the right upper extremity.…

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Negative / Null Result ReportOpen accessMedicine

Effect of Ultrasound-Guided Lateral Infraclavicular Brachial Plexus Block With Lidocaine or Ropivacaine for Closed Reduction of Distal Radius Fractures: A Randomized Controlled Noninferiority Trial.

Steensbæk MT, Yousef S, Bahuet AR et al. · 2026 · Acta anaesthesiologica Scandinavica

Background Closed reduction of distal radius fractures is painful, and current analgesic strategies may be inadequate. Ultrasound-guided lateral infraclavicular brachial plexus block may offer complete analgesia and muscle relaxation,…

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Negative / Null Result ReportMedicine

Hypofractionated Versus Single-Session Radiosurgery to Preserve Hearing in Patients Affected by Sporadic Vestibular Schwannoma: The ACOUNEU Randomized Clinical Trial.

Marchetti M, Pinzi V, Gemma M et al. · 2025 · International journal of radiation oncology, biology, physics

Purpose During the last decades, in addition to tumor control, hearing preservation has become an important priority in the treatment of vestibular schwannoma (VS). Given that the potential advantages of hypofractionated radiosurgery (hRS)…

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Negative / Null Result ReportMedicine

Can visual acceleration evoke a sensation of tilt?

Harris LR, Jörges B, Bury N et al. · 2025 · Experimental brain research

Under the microgravity of the International Space Station, many of the normal processes that determine the perceptual upright on Earth are disrupted. For example, somatosensory cues are absent and an applied physical linear acceleration…

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Negative / Null Result ReportOpen accessMedicine

External cold and vibration with BUZZY versus topical anesthetic gel for pain and anxiety associated with infiltrative anesthesia in pediatric dentistry: a double-blinded, split-mouth, randomized, controlled trial.

Faghihian R, Tofighi MM, Ziaei S et al. · 2025 · European oral research

Purpose A way to reduce the pain of injection is applying of external cold or vibrations with BUZZY, along with spinal cord gate control systems. We aimed to evaluate the effectiveness of this method in reducing children's pain and anxiety…

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