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11,312 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

The Geographical Variation of Colour Change in the Arabian Killifish (<i>Aphaniops dispar</i> Sensu Lato) From Freshwater and Marine Ecosystems.

Alfakih A, Nadeau NJ, Watt PJ · 2026 · Ecology and evolution

Widely distributed animals may exhibit substantial plastic physiological, morphological and behavioural responses to environmental changes. One such extraordinary form of plasticity is colour change, which varies substantially among most…

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Negative / Null Result ReportMedicine

Visual-Spatial Influences on Vocal Intensity: Effects of Speaker-to-Listener Distance and Room Size in Immersive Virtual Reality.

Daşdöğen Ü, Hitchcock J, Ahn S et al. · 2026 · Journal of speech, language, and hearing research : JSLHR

Objectives The aim of this study was to investigate the effects of speaker-to-listener distance versus room size on individuals' voice perception and production using immersive virtual reality (IVR). Method Fifteen vocally healthy…

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Negative / Null Result ReportOpen accessMedicine

Temporal shift in task factor influence across the stretch reflex.

Torell F, Rohlén R, Dimitriou M · 2026 · PloS one

Mechanical perturbations applied to the arm can elicit reflexive actions. These rapid corrective responses include the stretch reflex, which consists of different components: the short-latency reflex (SLR) and the early and late…

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Negative / Null Result ReportOpen accessMedicine

Up to 30 years of clinical performance of double-crown-retained removable dental prostheses with spark-eroded friction pins placed in a general dental practice.

Zierden K, Werdecker S, Wöstmann B et al. · 2026 · Clinical oral investigations

Purpose The purpose of this retrospective cohort study was to investigate the clinical performance and longevity of double-crown-retained removable-dental-prostheses (DCR-RDP) with spark-eroded friction pins inserted in a general dental…

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Negative / Null Result ReportOpen accessMedicine

Effects of maternal dental anxiety on the time of first dental visit and dental caries status of children.

Mohammadpour N, Shirdel M, Hekmatfar S · 2026 · Journal of education and health promotion

Background This study aimed to assess the effects of maternal dental anxiety on the time of first dental visit and dental caries status of children. Materials and methods This cross-sectional study was conducted on 220 children between 3…

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Negative / Null Result ReportMedicine

The effect of the liquid motion bubbler timer soothing sensory toy on children's fear and anxiety levels during blood sampling: a randomized clinical trial.

Sariali̇oğlu A, Oluç T · 2026 · BMC psychology

Background Blood sampling is one of the invasive procedures in a hospital setting that can cause fear, anxiety, and stress in children. Aim The study aimed to determine the effect of the Liquid Motion Bubbler Timer Soothing Sensory Toy on…

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Negative / Null Result ReportOpen accessMedicine

An improved translational approach to studying persistence-strengthening effects of differential reinforcement of alternative behavior.

Layton KL, Edwards TL, Foster TM · 2026 · Journal of the experimental analysis of behavior

Translational research investigating traditional differential reinforcement of alternative behavior (DRA) suggests that such procedures increase the persistence of target behavior relative to when the alternative behavior is first…

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Negative / Null Result ReportOpen accessMedicine

Relationship Between Pulmonary Thromboembolism, its Mortality and Seasonal, Meteorological Factors

Seda Beyhan Sağmen, Sevda Cömert, Nesrin Kıral et al. · 2019 · Southern Clinics of Istanbul Eurasia

INTRODUCTION[|]Seasonal and weather changes may affect the development of pulmonary embolism. The effects of seasonal and meteorological factors on mortality are controversial. We aimed to investigate the effects of seasons and meteorological data on patients with a low and high pulmonary embolism severity index and those with 30-day mortality. [¤]METHODS[|]Pulmonary embolism cases were included in our study. Daily pressure, humidity, temperature, and wind values were taken from the general online information by the Directorate of Meteorology. All cases were divided into the low-risk and high-

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Negative / Null Result ReportOpen accessMedicine

Low-dose oral pregabalin is not effective enough to control the acute post-thoracotomy pain

Swati Dogra , Altaf Hussain Mir , Suhail Sidiq et al. · 2025 · Asian Journal of Medical Sciences

Background: Acute post-thoracotomy pain (APTP) is severe and can lead to various respiratory complications if left untreated. Epidural (Ep) analgesia is the gold standard for APTP relief. Aims and Objectives: The aims and objectives of this study were to study the impact of low-dose oral pregabalin 75 mg on APTP. Materials and Methods: 100 patients were randomized into two groups (Group P and C). The Group P, study group received pregabalin 75 mg per oral preoperatively and for 2 days postoperatively. Group C received no medication. All the patients received thoracic Ep as a standard practice.

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Negative / Null Result ReportOpen accessMedicine

Clinical outcomes in low risk coronary artery disease patients treated with different limus-based drug-eluting stents--a nationwide retrospective cohort study using insurance claims database.

Chao-Lun Lai, Ching-Fen Wu, Raymond Nien-Chen Kuo et al. · 2015 · PLoS ONE

The clinical outcomes of different limus-based drug-eluting stents (DES) in a real-world setting have not been well defined. The aim of this study was to investigate the clinical outcomes of three different limus-based DES, namely sirolimus-eluting stent (SES), Endeavor zotarolimus-eluting stent (E-ZES) and everolimus-eluting stent (EES), using a national insurance claims database. We identified all patients who received implantation of single SES, E-ZES or EES between January 1, 2007 and December 31, 2009 from the National Health Insurance claims database, Taiwan. Follow-up was through Decemb

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Negative / Null Result ReportOpen accessMedicine

Obesity and Dyslipidemia

Feingold KR · 2000

Abnormalities in lipid metabolism are very commonly observed in patients who are obese. Approximately 60-70% of patients with obesity are dyslipidemic. The lipid abnormalities in patients who are obese include elevated serum TG, VLDL,…

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Negative / Null Result ReportOpen accessMedicine

Obturator or "lateral" bypass in the management of infected vascular prostheses at the groin

Davidović Lazar B., Kuzmanović Ilija B., Kostić Dušan M. et al. · 2002 · Srpski Arhiv za Celokupno Lekarstvo

The infection of the previously implanted vascular graft at the groin, is associated with great mortality and morbidity rate [1]. The authors present a retrospective study in which they analyzed management of infected vascular prostheses at the groin, using obturator bypass in 26 cases, and "lateral" bypass in 15 cases. The indications for obturator bypass reconstructions included: 20 infections of aorto-femoral grafts, two infected pse udoaneurysms in the groin after RTA of the superficial femoral artery, and 4 infections of iliac-femoral grafts. The indications for lateral bypass reconstruct

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Negative / Null Result ReportOpen accessMedicine

Association of outpatient use of renin–angiotensin–aldosterone system blockers on outcomes of acute respiratory illness during the COVID-19 pandemic: a cohort study

Molly Moore Jeffery, Lucas Oliveira J e Silva, Fernanda Bellolio et al. · 2022 · BMJ Open

Objectives Evaluate the associations between patients taking ACE inhibitors and angiotensin receptor blockers (ARBs) and their clinical outcomes after an acute viral respiratory illness (AVRI) due to COVID-19.Design Retrospective cohort.Setting The USA; 2017–2018 influenza season, 2018–2019 influenza season, and 2019–2020 influenza/COVID-19 season.Participants People with hypertension (HTN) taking an ACEi, ARB or other HTN medications, and experiencing AVRI.Main outcome measures Change in hospital admission, intensive care unit (ICU) or coronary care unit (CCU), acute respiratory distress (ARD

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Negative / Null Result ReportOpen accessMedicine

Allergic sensitization does not influence advancement or survival in oral cancer

Lara Kakabas, Krzysztof Piersiala, Aeneas Kolev et al. · 2023 · Scientific Reports

Abstract A history of allergies has been said to be associated with a lower risk of head and neck cancer compared to the general population. However, it is not known whether having an allergic sensitization influences the prognosis and advancement of cancer disease. Thus, the aim of the study was to investigate the relationship between allergic sensitization and oral cancer advancement and patient survival. Allergen-specific IgE antibodies were investigated by ImmunoCAP™ Rapid in consecutive 80 patients with oral cancer. ImmunoCAP Rapid system tests a mix of representative inhalant allergens s

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Negative / Null Result ReportOpen accessMedicine

RETROSPECTIVE OBSERVATIONAL STUDY ON THE INCIDENCE OF ORAL COMPLICATIONS IN PATIENTS WITH DIABETES MELLITUS

Alberta Simona Tinu, Doina Lucia Ghergic, Mirel Stoian et al. · 2018 · Romanian Journal of Stomatology

Objectives. We performed a retrospective observational analytical study to determine the incidence of complications in the oral cavity in a group of patients diagnosed with diabetes mellitus. Material and method. We have studied 68 diabetic patients, who have been referred to dental practices seeking specialized treatment. Patient data sheets were centralized, categorized, and statistically processed with IBM SPSS Statistics 22 and Microsoft Excel 2010 depending on: sex of patients, age, type of diabetes, time elapsed from diagnosis of diabetes, the environment of origin of the patients, the l

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Negative / Null Result ReportOpen accessMedicine

The Effectiveness of Immature Granulocyte Count for Predicting COVID-19 Severity and Poor Outcomes

Yunsur Çevik, Fatma Nur Karaarslan, Şeref Kerem Çorbacıoğlu et al. · 2022 · Eurasian Journal of Emergency Medicine

Aim:The aim of this study was to examine the relationship between immature granulocyte (IG) counts and the severity of the disease and to evaluate the effectiveness of IG in predicting the poor outcomes in polymerase chain reaction-confirmed Coronavirus disease-2019 (COVID-19) cases.Materials and Methods:The study was conducted prospectively and observationally at the emergency department. Patients were divided into three groups according to the clinical severity indicators such as mild, moderate and severe. The IG level was measured from the whole blood samples taken at the admission to the e

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Negative / Null Result ReportOpen accessMedicine

Associations between CYP2C8 rs10509681 and rs11572080 gene polymorphisms and age-related macular degeneration

Rasa Liutkevičienė, Ramunė Sungailienė, Alvita Vilkevičiūtė et al. · 2017 · Acta Medica Lituanica

Background. Age-related macular degeneration (AMD) is the most common cause of irreversible visual loss in industrialized countries. Early symptoms of AMD include drusen and changes in retinal pigment epithelium. However, the etiology of AMD and drusen formation is not fully understood. Recent studies suggest that CYP2C8-related metabolic processes might play an important role in the development of AMD. The aim of our study is to investigate CYP2C8 rs10509681 and CYP2C8 rs11572080 genotype frequencies in patients with early AMD and to compare them with healthy controls. Materials and Methods.

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Negative / Null Result ReportOpen accessMedicine

Origins of the obturator artery in Thai and Chinese

Damkoeng Purnindu · 2023 · Siriraj Medical Journal

Dissection of one-half of adult pelvis in 197 Thai and 44 Chinese cadavers disclosed that the obturator artery arose from the internal iliac and umbilical arteries in 34.9%, from the inferior gluteal artery in 10.4%, from the internal pudendal artery in 8.7%, from the superior gluteal - inferior gluteal trunk in 4.2%, from the inferior gluteal - internal pudendal trunk in 9.1%, from the inferior epigastric artery in 12.0%, from the external iliac artery in 1.2%, and from the superior gluteal and the inferior epigastric arteries in 0.4%. There were no statistically significant differences of fi

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Negative / Null Result ReportOpen accessMedicine

Correlation of body mass index and orthostatic hypotension in patients with hypertension on ACE inhibitor monotherapy

Tasić Danijela, Kovačević Zorana, Mitrović Miroslav et al. · 2021 · Scripta Medica

Background/Aim: Orthostatic hypotension (OH) is considered to be a drop in the systolic and diastolic blood pressure (> 20 mmHg; > 10 mmHg) 3 minutes from postural changes. The objective of this study was to analyse the correlation of body mass index (BMI) and OH during the treatment with trandolapril, as a single-drug treatment of hypertension. Methods: The study involved 255 patients (average age 54.3 ± 11.7; 54.1 % men) with poorly regulated hypertension, who were given trandolapril as a single-drug treatment. The patients were divided into two groups regarding stage of hypertension: first-

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Negative / Null Result ReportOpen accessMedicine

Impact of an Online Gastrointestinal Symptom History Taker on Physician Documentation and Charting Time: Pragmatic Controlled Trial

Hall, Natalie J, Berry, Sameer K, Aguilar, Jack et al. · 2021 · JMIR Formative Research

BackgroundA potential benefit of electronic health records (EHRs) is that they could potentially save clinician time and improve documentation by auto-generating the history of present illness (HPI) in partnership with patients prior to the clinic visit. We developed an online patient portal called AEGIS (Automated Evaluation of Gastrointestinal [GI] Symptoms) that systematically collects patient GI symptom information and then transforms the data into a narrative HPI that is available for physicians to review in the EHR prior to seeing the patient. ObjectiveThis study aimed to compare whether

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Negative / Null Result ReportOpen accessMedicine

Is pomegranate peels infusion effective for disinfection of toothbrushes?

Priscila Lima de Luna FREIRE, Priscila Hernández CAMPOS, Fabíola Galbiatti CARVALHO et al. · Revista de Odontologia da UNESP

Abstract Introduction Methods of decontamination or sanitization of toothbrushes have been questioned. Objective This study assessed the effectiveness of pomegranate peels infusion as a disinfectant of toothbrushes against Streptococcus mutans. Material and method A sample of 16 schoolchildren aged between 7 and 9 years performed brushing 5 days/week, with a careful brushing once a day. After each day of brushing, the toothbrushes were washed and sprayed with one disinfectant solution. This procedure was repeated for 4 weeks using one of the different solutions per week: distilled water (G1; n

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