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Browse the failure-mode index

11,412 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Evaluation of multiple freeze-thaw cycles on growth factor and cytokine stability in canine platelet lysate: PDGF, TGF-<i>β</i>, and TNF-<i>α</i> preservation across cycles.

Sumner SM, Naskou MC · 2026 · Frontiers in veterinary science

Introduction Platelet-rich plasma (PRP) and platelet lysate (PL) are biologically active products used in regenerative medicine because of their high concentrations of growth factors, cytokines, and other bioactive molecules that promote…

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Negative / Null Result ReportMedicine

Observation on the clinical effects of four kinds of root canal filling materials in the treatment of chronic periapical periodontitis.

Wang K, Chen Y, Fu H et al. · 2026 · American journal of translational research

Objective To compare the clinical efficacy of four root canal filling materials for the treatment of chronic periapical periodontitis. Methods The clinical data of 200 patients with chronic periapical periodontitis from January 2023 to…

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Negative / Null Result ReportMedicine

Residual gastric content after holding of glucagon-like peptide-1 receptor agonists before elective surgery: a cross-sectional study - the RESIDUAL study.

Boudreau C, Couture M, Rousseau-Saine N et al. · 2026 · BMC anesthesiology

Introduction Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are now increasingly used for glycemic control in type 2 diabetes mellitus as well as for weight loss. Their effect on gastric emptying may increase the risk of aspiration…

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Negative / Null Result ReportMedicine

Desflurane versus sevoflurane and postoperative inflammatory biomarkers in older adults undergoing minor- to moderate-risk noncardiac surgery.

Adamowitsch N, Reiterer C, Fleischmann E et al. · 2026 · Scientific reports

Volatile anesthetics modulate inflammatory responses, but it remains unclear whether desflurane and sevoflurane differ in their effects on postoperative inflammation. We evaluated in this secondary analysis of a prospective randomized…

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Negative / Null Result ReportOpen accessMedicine

Medical students perceptions of spiritual care.

Prihanti GS, Firmansyah FH · 2026 · Frontiers in medicine

Introduction This study aimed to assess medical students' perceptions of spiritual care using a culturally adapted Muslim-context version of the Spirituality and Spiritual Care Rating Scale (SSCRS). Methods A cross-sectional study was…

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Negative / Null Result ReportMedicine

The Mediating Role of Eudaimonic Well-Being in the Effect of Perceived Poverty on Quality of Life in the Elderly.

Aydin MA, Aydoğdu NG, Kizilarslan V et al. · 2026 · Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

Background This study was conducted to examine the mediating role of eudaimonic well-being in the effect of perceived poverty on quality of life in the elderly. Methods This descriptive cross-sectional study was conducted with 523 elderly…

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Negative / Null Result ReportOpen accessMedicine

Arbuscular mycorrhizal symbiosis enhances the cadmium stress tolerance of Medicago sativa in association with regulation of the aminolevulinic acid pathway.

Li Y, Wang Z, Xu T et al. · 2026 · BMC plant biology

Arbuscular mycorrhizal (AM) fungi can effectively enhance the photosynthesis and antioxidant capacity of plants under cadmium stress; however, the underlying regulatory mechanisms remain poorly understood. This study focuses on the…

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Negative / Null Result ReportOpen accessMedicine

Methane mitigation, nutritional evaluation, and in vitro degradation kinetics of diets based on tropical grass haylage treated with xylanase.

Duarte ABA, Dias-Silva TP, Viana WCC et al. · 2026 · Tropical animal health and production

The aim of this study was to evaluate the effect of xylanase addition (1.8 g/kg dry matter [DM]) to tropical grass haylage used in total mixed rations (TMR) on in vitro organic matter degradability, ruminal fermentation kinetics, and…

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Negative / Null Result ReportOpen accessMedicine

Effects of acute HMB-FA supplementation on antioxidant status and muscle damage in Elite Judoka: a randomized pilot trial.

Tayebi SM, Mirzaei M, Stout JR · 2026 · Journal of the International Society of Sports Nutrition

Purpose High-intensity judo bouts induce oxidative stress and muscle damage, impairing recovery. This randomized, double-blind, placebo-controlled pilot trial examined whether acute β -hydroxy- β -methylbutyrate free acid (HMB-FA)…

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Negative / Null Result ReportOpen accessMedicine

CO<sub>2</sub>-Extract-Based Phytopreparation from <i>Arctium tomentosum</i> Mill. Root Exhibits No Acute and Subacute Toxicity and Suppresses Xylene-Induced Ear Edema and LPS-Induced Acute Inflammation in Mice.

Aitynova A, Dyusebaeva M, Issayeva D et al. · 2026 · Molecules (Basel, Switzerland)

A phytopreparation based on the CO 2 extract of Arctium tomentosum Mill. root (AT) was evaluated for its safety and anti-inflammatory potential in Swiss albino mice. Acute and 28-day subacute oral toxicity studies demonstrated that AT, at…

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Negative / Null Result ReportMedicine

Parameter Specific Modulation of Neuronal Firing and Extracellular Action Potential Dynamics by Transcranial Focused Ultrasound Stimulation in Rat Motor Cortex.

Huang H, Smets C, Chen L et al. · 2026 · Brain stimulation

Background Transcranial focused ultrasound stimulation (TUS) has emerged as a promising tool for noninvasive neuromodulation. However, the specific effects of stimulation parameters on neural activity remain incompletely understood.…

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Negative / Null Result ReportMedicine

Seems Like a Touch? Comparing Emotional Experience and Illusion of Touch of Visual and Haptic Presentations of Mediated Social Touch in VR.

Tietenberg J, Furtges T, Masuch M · 2026 · IEEE transactions on visualization and computer graphics

Social virtual reality (VR) applications enable users to experience highly immersive mediated interactions and social experiences. Especially embodied nonverbal communication, like mediated social touch, is mostly unique to social VR and…

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Negative / Null Result ReportMedicine

Exploring the impact of sleep apnea on renal transplant outcomes.

Satuluru S, Brower D, Mehta V et al. · 2026 · The American journal of the medical sciences

Background Sleep apnea (SA), a common diagnosis, has been shown to exhibit increased prevalence in patients with end-stage renal disease (ESRD). There is no clear consensus on the impact of SA on renal transplant outcomes. Methods We…

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Negative / Null Result ReportMedicine

Prewarming and thermal manipulation of long stored eggs: effect on embryonic development, hatching traits, body weight, rectal temperature, carcass, and organ traits at 3 days of age in broiler chickens.

Abdallah N, Baylan M, Kursun K et al. · 2026 · Journal of thermal biology

This study investigated the effect of prewarming (PD) and thermal manipulation (TM) of long-stored eggs on embryonic development, hatching traits, body weight (BW), rectal temperature (RT), carcass, and organ traits in broilers at 3 days…

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