e-ISSN: Pending

Browse the failure-mode index

11,312 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Impact of pulsed stimulation on objective and subjective visual acuity measurements in nystagmus.

Quanz EV, Al-Nosairy KO, Stolle FH et al. · 2026 · Documenta ophthalmologica. Advances in ophthalmology

Purpose Quanz et al. (Sci Rep 14:16797, 2024) reported that participants with nystagmus had higher objective visual evoked potential visual acuity estimates (VA VEP ) by 0.12 logMAR relative compared to standard psychophysical VA (VA…

View details →
Negative / Null Result ReportOpen accessMedicine

Comparison of effectiveness of common targeting heuristics in repetitive transcranial magnetic stimulation treatment of depression.

Sakreida K, Trapp NT, Kreuzer S et al. · 2025 · BMJ mental health

Background Repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) is an effective non-pharmacological, non-invasive intervention for depression. However, the optimal strategy for localising…

View details →
Negative / Null Result ReportOpen accessMedicine

Corneal biomechanics are not exclusively compromised in high myopia.

Yii F, Strang N, Bernabeu MO et al. · 2024 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

Introduction Research assuming linearity has concluded that corneal biomechanics are compromised in high myopia. We investigated whether this assumption was appropriate and re-examined these associations across different levels of myopia.…

View details →
Negative / Null Result ReportMedicine

Is variability in working memory capacity related to differences in the reactivation of memory traces? A test based on the time-based resource sharing (TBRS) model.

Gonthier C, Gavornikova-Baligand Z · 2023 · Attention, perception & psychophysics

Working memory performance depends on reactivating memory traces, by rapidly switching between refreshing item representations and performing concurrent cognitive processing (time-based resource sharing (TBRS) account). Prior research has…

View details →
Negative / Null Result ReportOpen accessMedicine

Does the airway circulation influence airflow obstruction in asthma?

Wanner A · 2025 · BMJ open respiratory research

The airway wall is thickened in asthma and the airway microvasculature participates in the remodelling. It has been assumed but not convincingly demonstrated that the remodelled airway vasculature has a mechanical role in asthma-associated…

View details →
Negative / Null Result ReportOpen accessMedicine

The Impact of GLP-1 Receptor Agonists on Esophagogastroduodenoscopy Outcomes: A Retrospective Cohort Study in a Predominantly African American Population.

El Sabagh A, Abdulraheem A, Jimenez A et al. · 2026 · JGH open : an open access journal of gastroenterology and hepatology

Background Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) improve glycemic control and promote weight loss but may increase gastric residue, raising concerns during esophagogastroduodenoscopy (EGD). African American patients remain…

View details →
Negative / Null Result ReportOpen accessMedicine

Impact of a Mindfulness-Based Intervention on Symptoms and Emotion Regulation Strategies in Young Adolescents From the General Population: A Randomized Controlled Trial.

Piguet C, Celen Z, Meuleman B et al. · 2025 · Depression and anxiety

Adolescence is marked by major puberty-induced changes including increased reactivity to stress and a peak incidence of mental disorders. The implementation of early interventions during this developmental period is essential to prevent…

View details →
Negative / Null Result ReportOpen accessMedicine

Lack of effect of cyclic adenosine monophosphate modulation during prematuration in vitro on development to the blastocyst stage and expression of specific genes associated with lineage commitment.

Desenzi R, Cuellar CJ, Hoorn QA et al. · 2025 · JDS communications

Pharmacological elevation of cyclic AMP (cAMP) of cultured cumulus-oocyte complexes (COC) before or coincident with initiation of maturation has been reported to improve outcomes for various systems for in vitro production of embryos. Here…

View details →
Negative / Null Result ReportOpen accessMedicine

Assessing the Impact of PCSK9 and HMGCR Inhibition on Liver Function: Drug-Target Mendelian Randomization Analyses in Four Ancestries.

Rosoff DB, Bell AS, Wagner J et al. · 2024 · Cellular and molecular gastroenterology and hepatology

Background & aims Observational studies have linked lipid-lowering drug targets pro-protein convertase subtilisin/kexin 9 (PCSK9) and HMG-CoA reductase (HMGCR) with adverse liver outcomes; however, liver disease incidence varies across…

View details →
Negative / Null Result ReportOpen accessMedicine

Establishing validity and measurement invariance of the Claremont Purpose Scale among adolescents from diverse racial-ethnic backgrounds.

Xie H, Ratner K, Estevez M et al. · 2026 · Journal of research on adolescence : the official journal of the Society for Research on Adolescence

The Claremont Purpose Scale (CPS) was designed to assess youth purpose, but the English version has not yet undergone rigorous psychometric evaluation among adolescents. Prior validation efforts have also mostly relied on white-majority…

View details →
Negative / Null Result ReportMedicine

Yield of Sleep Deprivation EEG in Suspected Epilepsy. A Retrospective Study.

Guerrero-Aranda A, Enríquez-Zaragoza A, López-Jiménez K et al. · 2024 · Clinical EEG and neuroscience

Background. Sleep is an activation procedure and is considered the most potent and best-documented modulator of seizures and interictal epileptiform discharges (IEDs) on electroencephalogram (EEG). The precise role of sleep deprivation in…

View details →