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Browse the failure-mode index

11,312 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

The temporal interplay between physical activity, emotional well-being, and health-related quality of life in individuals with recently diagnosed type 2 diabetes mellitus: a cross-lagged panel analysis.

Kristoffersen SF, Domazet SL, Pouwer F et al. · 2026 · Diabetes research and clinical practice

Aims We investigated longitudinal, bidirectional associations between objectively measured moderate to vigorous physical activity (MVPA), health-related quality of life (HRQoL), and emotional well-being (EWB) in individuals recently…

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Negative / Null Result ReportOpen accessMedicine

Differences in umbilical cord blood gas parameters between women with and without gestational diabetes: a single-center prospective-retrospective cohort study.

Szablewska AW, Zając B · 2026 · Scientific reports

Gestational diabetes mellitus (GDM) is associated with various perinatal complications and may affect neonatal acid-base status. Umbilical cord arterial blood gas (ABG) analysis provides an objective measure of fetal well-being at birth,…

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Negative / Null Result ReportMedicine

Integrating ankle weights into Nordic walking to improve muscle strength and functional outcomes in community-dwelling older adults: A randomized controlled trial.

Soenarti S, Sitorus S, Nugroho MB et al. · 2026 · Rehabilitacion

Sarcopenia represents a leading cause of functional decline in older adults. This randomized controlled trial examined whether the addition of ankle weights to a Nordic walking protocol yields superior outcomes compared with standard…

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Negative / Null Result ReportOpen accessMedicine

Cerebral glycerol during haemorrhagic shock in normal and raised intracranial pressure resuscitated with total REBOA: an experimental porcine study.

Bader S, Magnuson A, Brorsson C et al. · 2026 · European journal of trauma and emergency surgery : official publication of the European Trauma Society

Background Haemorrhagic shock (HS) is frequently associated with secondary cerebral injury due to compromised cerebral perfusion. Resuscitative endovascular balloon occlusion of the aorta (REBOA) is an effective haemorrhage control…

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Negative / Null Result ReportMedicine

2019 Marathon of Rome: Relationship Between Resilience and Coping Strategies in 682 Runners.

Longo UG, Mazzola A, Stelitano G et al. · 2026 · Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine

Objective The aim of this study was to evaluate, in runners participating in the 2019 Rome Marathon, the interaction between resilience and coping and how they are influenced by sex, age, body weight, height, number of weekly training…

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Negative / Null Result ReportOpen accessMedicine

Simultaneous bispectral index and near-infrared spectroscopy monitoring to evaluate two induction protocols in elective cardiovascular surgery.

Eke H, Toprak B, Bozkurt ED · 2026 · Journal of cardiothoracic surgery

BACKGROUND: Laryngoscopy and intubation provoke strong sympathetic activation and may cause hemodynamic instability in cardiovascular surgery patients. Maintaining adequate hypnotic depth and cerebral oxygenation during induction is…

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Negative / Null Result ReportMedicine

Decreased evertor strength following peroneus longus tendon harvest for anterior cruciate ligament reconstruction : an isokinetic muscle strength testing study.

Kotian RN, Ajoy SM, Panduranga R et al. · 2026 · The bone & joint journal

Aims There are conflicting results in the literature regarding the safety of the peroneus longus tendon (PLT) as a potential graft for anterior cruciate ligament (ACL) reconstruction, and no long-term studies with objective assessment…

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Negative / Null Result ReportOpen accessMedicine

Predictive Factors of Functional Prognosis in Patients with Rhegmatogenous Retinal Detachment Treated by Pars Plana Vitrectomy-A Retrospective Study.

Chereji G, Chelaru VF, Nicoară SD · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives : Rhegmatogenous retinal detachment (RRD) is a surgical emergency that causes vision loss if not properly treated. Pars plana vitrectomy (PPV) is the preferred procedure for most complex RRD cases, with a high success…

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Negative / Null Result ReportOpen accessMedicine

Genetically predicted TTK inhibition and its association with reduced breast cancer risk: a two-step Mendelian randomization study of potential gut microbiome mediation.

Liu J, Liu M, Xu Y et al. · 2026 · Clinics (Sao Paulo, Brazil)

Background BOS172722, a selective TTK inhibitor, shows promise for Breast Cancer (BC) treatment. The role of gut microbiota as a potential mediator in this process has not been established. This Mendelian Randomization (MR) study…

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Negative / Null Result ReportMedicine

Effects of different hyrax maxillary expansion protocols compared with novel magnetic expansion on the pharyngeal airway and maxillary sinus spaces: A retrospective CBCT-based observational study.

Algahefi AL, Alhammadi MS, Li Z et al. · 2026 · American journal of otolaryngology

Purpose To evaluate three-dimensional changes in the maxillary sinus (MS) and pharyngeal airway space (PAS) following rapid (RME), slow (SME), and magnetic maxillary expansion (MME) using cone-beam computed tomography (CBCT). Methods This…

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Negative / Null Result ReportOpen accessMedicine

Comparison of Lower Limb Muscle Strength Imbalances and Gait Performance in Postmenopausal Women with Healthy and Low Bone Mineral Density.

Svobodová L, Kasović M, Vodicka T et al. · 2026 · International journal of women's health

Introduction Osteoporosis and osteopenia increase the risk of fractures, impair physical function, and may lead to loss of independence in postmenopausal women. This study examined differences in muscle strength imbalances and gait…

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Negative / Null Result ReportOpen accessMedicine

Effect of Two Post-Curing Units on the Physico-Mechanical Properties of 3D-Printed Resins for Permanent Crown Fabrication.

Mujayridi M, Matinlinna J, Silikas N · 2026 · Materials (Basel, Switzerland)

Three-dimensional (3D) printing is increasingly used for the fabrication of definitive crowns; however, whether specific post-curing hardware is mandatory for clinical success remains a practical concern. This study provided a practical…

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Negative / Null Result ReportMedicine

Effect of oral health education by audio aids, braille, tactile models on the oral health status of visually impaired adults: a 6-month follow-up study.

Yıldırım D, Zorluoğlu SL, Navruz ES et al. · 2026 · BMC oral health

Background Oral and dental health education is typically delivered using visual methods on jaw models. However, these methods are insufficient for individuals with visual impairments. This study aims to contribute to the oral and dental…

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Negative / Null Result ReportOpen accessMedicine

Focus on comfort: the effect of focus language on postoperative hospital stay compared to the Numeric Rating Scale in children receiving postoperative care-a pre-post study.

Angenent A, Maaskant JM, Nieland L et al. · 2026 · European journal of pediatrics

This study evaluates the effect of a comfort assessment using focus language compared with pain assessment using the Numeric Rating Scale (NRS) on postoperative length of stay (LOS), analgesic use and patient and parental satisfaction.…

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Negative / Null Result ReportOpen accessMedicine

Early outcomes of transverse perineal support in obstructed defecation syndrome with pathological perineal descent; a prospective cohort study.

Azmy Basiouny HM, Shafik AA, Elbarmelgi MY et al. · 2026 · BMC surgery

Background While current surgical approaches for obstructed defecation syndrome (ODS) primarily target rectocele and rectal intussusception, excessive perineal descent (PD) may contribute to persistent symptoms and suboptimal surgical…

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