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11,412 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Blue®m gel vs hyaluronic acid gel in wound healing and pain control following functional crown lengthening: a randomized controlled trial

Riddhi Vyas, Santhosh Kumar, C M Manasa · 2026 · Saudi Dental Journal

Abstract Periodontal wound dressings have advanced from passive protectants to bioactive agents. This study compared the efficacy of Blue®m gel and a hyaluronic acid (HA) gel in promoting wound healing and controlling postoperative pain after functional crown lengthening surgery. A prospective, randomized, patient and outcome assessor-blinded study was conducted on 40 systemically healthy patients (aged 20–60 years) requiring crown lengthening of posterior teeth. Participants were divided into two groups: Blue®m gel (Group A) and custom-formulated HA gel (Group B). Both gels were applied to th

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Negative / Null Result ReportOpen accessMedicine

The influence of Hydroxyzine Premedication on Preoperative Hemodynamics in Pediatric Patients

gehad Abd algaliel, Amani Abo alhassein, Sarah Omar · 2024 · Minia Journal of Medical Research

BACKGROUND: Hydroxyzine is an antihistamine that belongs to the first generation of H1 Antihistamines and used in medicine for a variety of purposes. It was introduced into the field of anesthesia for a variety of reasons, including its sedative, antiemetic and anti-allergic properties. Therefore, it's critical to understand how hydroxyzine premedication affects hemodynamic changes in individuals, particularly in younger ones undergoing surgery OBJECTIVES: The objective of this study was to identify the impact of administering hydroxyzine orally before surgery on hemodynamics prior to inductio

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Negative / Null Result ReportOpen accessMedicine

Postoperative complications of laparoscopic cholecystectomy among women in Permam hospital

Pola farhad hassan, Hamdia Mirkhan Ahmed · 2019 · Diyala Journal of Medicine

Background: Benefits of minimally invasive or laparoscopic procedures include less post operative discomfort. Objective: This study aimed to identify the early postoperative complications of laparscopic cholecystectomy and their association with age, occupation and previous laparatomy. Patients and Methods: 60 female patients diagnosed with having symptomatic gallstone underwent laparscopic cholecystectomy in Pirmam General Hospital, during the period from Jan 2015 to Jul 2015. Surgery done by researchers and after 10 days, the patient interviewed and examined for finding the complications, th

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Negative / Null Result ReportOpen accessMedicine

Clinical outcomes of fenestration discectomy and iLESSYS-Delta interlaminar endoscopic system for treatment of LDH: a single-center retrospective cohort study

Xuetao Zhu, Yixiang Zhao, Kaiwen Liu et al. · 2024 · Scientific Reports

Abstract To compare the clinical efficacy of interlaminar endoscopic surgical system delta (iLESSYS-Delta) discectomy with that of classical fenestration discectomy for treating lumbar disc herniation. Patients who underwent iLESSYS-Delta or fenestration discectomy were enrolled in this study. Baseline information and clinical indicators were collected. The baseline data were matched using propensity score matching. Fifty-two patients were in each group. In the iLESSYS-Delta cohort, the volume of intraoperative bleeding was 18.17 ± 4.20 ml, the length of postoperative hospital stay was 4.16 ±

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Negative / Null Result ReportOpen accessMedicine

Impact of Cross-Sectoral Video Consultation on Perceived Care Coordination and Information Satisfaction in Cancer Care: Randomized Controlled Trial

Fereshteh Baygi, Theis Bitz Trabjerg, Lars Henrik Jensen et al. · 2025 · JMIR Formative Research

BackgroundEnhancing care coordination and sharing information in cancer care improves patient experiences by promoting clarity and satisfaction. ObjectiveThis study aims to assess the impact of cross-sectoral video consultation on patient perceptions of care coordination and satisfaction with received information compared to usual care. MethodsThis study presents secondary outcomes on patient perceptions of care coordination and satisfaction with received information from a 7-month follow-up of the Partnership Project. In this randomized controlled trial, patients with cancer were allocated to

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Negative / Null Result ReportOpen accessMedicine

Association between Chewing Side Preference and Dental Caries among Deciduous, Mixed and Permanent Dentition

Ullal Anand Nayak, Reena Sharma, Nilotpol Kashyap et al. · 2016 · Journal of Clinical and Diagnostic Research

Introduction: Chewing Side Preference (CSP) is said to occur when mastication is recognized exclusively/consistently or predominantly on the same side of the jaw. It can be assessed by using the direct method - visual observation and indirect methods by electric programs, such as cinematography, kinetography and computerized electromyography. Aim: The present study was aimed at evaluating the prevalence of CSP in deciduous, mixed and permanent dentitions and relating its association with dental caries. Materials and Methods: In a cross-sectional observational study, 240 school going children a

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Negative / Null Result ReportOpen accessMedicine

Comparison of the Urodynamic Patterns of the Disorders Frequently Encountered in the Field of Pediatric Urology

Hasan Demirkan, Mehmet Ozgur Kuzdan · 2022 · Haseki Tıp Bülteni

Aim:There is still a lack of sufficient evidence-based data on the standardized urodynamic patterns of urological disorders worldwide, particularly in the childhood age group. With this study, we sought to investigate the outcomes of urodynamic studies of common disorders frequently encountered in pediatric urology practice.Methods:Children who underwent urodynamic studies in a pediatric urology unit between March 2019 and September 2020 were included in the study. A retrospective review of data on demographic characteristics and cystometrogram findings of 266 children from the urodynamic labo

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Negative / Null Result ReportOpen accessMedicine

Analysis of polymorphisms, promoter methylation, and mRNA expression profile of maternal and placental P53 and P21 genes in preeclamptic and normotensive pregnant women

Mahdiyeh Harati-Sadegh, Leila Kohan, Batool Teimoori et al. · 2019 · Journal of Biomedical Science

Abstract Background Preeclampsia (PE), as a multisystem disorder, is associated with maternal hypertension and proteinuria. Apoptosis seems to be involved in the pathophysiology of PE, although its precise pathogenic mechanisms are not well established. In this study, we aimed to identify the association between maternal TP53-rs1042522, P21-rs1801270, and P21-rs1059234 polymorphisms and PE. In addition, we examined the effects of promoter methylation and TP53 and P21 polymorphisms on placental mRNA expression in PE women. Methods The blood of 226 PE women and 228 normotensive pregnant women wa

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Negative / Null Result ReportOpen accessMedicine

Effect of secukinumab dose escalation on MRI-detected inflammation and structural damage in axial spondyloarthritis: a clinical, investigator-initiated, treat-to-target study (TRACE)

Oliver Hendricks, Mikkel Østergaard, Susanne Juhl Pedersen et al. · 2026 · RMD Open

Introduction Evidence of treat-to-target strategies including secukinumab dose escalation in patients with axial spondyloarthritis (axSpA) remains limited. We investigated the effect of a treat-to-target approach aiming for Axial Spondyloarthritis Disease Activity Score (ASDAS) remission, assessed by clinical and MRI outcomes over 24 weeks.Methods TRACE was a multicentre study including biologic-naïve patients with active axSpA. Sixteen weeks after secukinumab 150 mg initiation, patients in ASDAS remission (<1.3)(week 16 remitters) continued the same dose, while non-remitters (week 16 non-remi

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Negative / Null Result ReportOpen accessMedicine

Comparative Evaluation of Buffy Coat-Derived and Apheresis Platelet-Rich Plasma in the Treatment of Androgenetic Alopecia: Laboratory and Clinical Insights.

Huang C, Wu M, Li Y et al. · 2026 · Clinical, cosmetic and investigational dermatology

Background Androgenetic alopecia (AGA) is the most common type of hair loss, and platelet-rich plasma (PRP) has emerged as a promising therapy. However, preparation methods may influence clinical outcomes. Objective To compare buffy coat…

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Negative / Null Result ReportOpen accessMedicine

Enhancing Port Performance through Digital Transformation: The Role of Networking Capability and Organizational transformation in Indonesian Container Ports.

Pramitra B, Al Musadieq M, Afrianty TW et al. · 2026 · F1000Research

Although digital transformation in port management has been widely discussed, previous studies have not extensively examined how organizational capabilities translate into performance through digital adoption at ports. This study addresses…

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Negative / Null Result ReportMedicine

Investigating farmers' preferences for rapeseed sales contracts in Iran.

Mehrabi A, Mohamadi-Nejad A, Ghorbani M et al. · 2026 · Brazilian journal of biology = Revista brasleira de biologia

Contract farming has gained popularity in recent years. Understanding farmers' preferences for contracts can help make contracts more sustainable and profitable. Therefore, the present study aimed to investigate farmers' preferences for…

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Negative / Null Result ReportMedicine

A comparison of the effects of cognitive rehabilitation and binaural beats on creativity, psychological well-being, and academic performance in university students.

Bayrami M, Dadashi Mazraeh S · 2026 · Acta psychologica

This study compared the effects of cognitive rehabilitation and binaural beats on creativity, psychological well-being, and academic performance in 45 undergraduate students using a quasi-experimental pretest-posttest design with a control…

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Negative / Null Result ReportMedicine

The tipping point: Friction and thigh length influence imminent falls from a tilting ski lift chair.

Talhelm J, Srivastava S, Ostrander J et al. · 2026 · Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine

Falls by subjects riding a ski lift while in transit are rare but can cause significant injury. Falls can occur at variable heights and can occur to small children to adults of both genders. The current study was designed to investigate…

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Negative / Null Result ReportOpen accessMedicine

The Geographical Variation of Colour Change in the Arabian Killifish (<i>Aphaniops dispar</i> Sensu Lato) From Freshwater and Marine Ecosystems.

Alfakih A, Nadeau NJ, Watt PJ · 2026 · Ecology and evolution

Widely distributed animals may exhibit substantial plastic physiological, morphological and behavioural responses to environmental changes. One such extraordinary form of plasticity is colour change, which varies substantially among most…

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Negative / Null Result ReportMedicine

The effect of the liquid motion bubbler timer soothing sensory toy on children's fear and anxiety levels during blood sampling: a randomized clinical trial.

Sariali̇oğlu A, Oluç T · 2026 · BMC psychology

Background Blood sampling is one of the invasive procedures in a hospital setting that can cause fear, anxiety, and stress in children. Aim The study aimed to determine the effect of the Liquid Motion Bubbler Timer Soothing Sensory Toy on…

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Negative / Null Result ReportOpen accessMedicine

An improved translational approach to studying persistence-strengthening effects of differential reinforcement of alternative behavior.

Layton KL, Edwards TL, Foster TM · 2026 · Journal of the experimental analysis of behavior

Translational research investigating traditional differential reinforcement of alternative behavior (DRA) suggests that such procedures increase the persistence of target behavior relative to when the alternative behavior is first…

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Negative / Null Result ReportOpen accessMedicine

Obturator or "lateral" bypass in the management of infected vascular prostheses at the groin

Davidović Lazar B., Kuzmanović Ilija B., Kostić Dušan M. et al. · 2002 · Srpski Arhiv za Celokupno Lekarstvo

The infection of the previously implanted vascular graft at the groin, is associated with great mortality and morbidity rate [1]. The authors present a retrospective study in which they analyzed management of infected vascular prostheses at the groin, using obturator bypass in 26 cases, and "lateral" bypass in 15 cases. The indications for obturator bypass reconstructions included: 20 infections of aorto-femoral grafts, two infected pse udoaneurysms in the groin after RTA of the superficial femoral artery, and 4 infections of iliac-femoral grafts. The indications for lateral bypass reconstruct

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Negative / Null Result ReportOpen accessMedicine

Origins of the obturator artery in Thai and Chinese

Damkoeng Purnindu · 2023 · Siriraj Medical Journal

Dissection of one-half of adult pelvis in 197 Thai and 44 Chinese cadavers disclosed that the obturator artery arose from the internal iliac and umbilical arteries in 34.9%, from the inferior gluteal artery in 10.4%, from the internal pudendal artery in 8.7%, from the superior gluteal - inferior gluteal trunk in 4.2%, from the inferior gluteal - internal pudendal trunk in 9.1%, from the inferior epigastric artery in 12.0%, from the external iliac artery in 1.2%, and from the superior gluteal and the inferior epigastric arteries in 0.4%. There were no statistically significant differences of fi

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