e-ISSN: Pending

Browse the failure-mode index

11,312 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Tolerability and effectiveness of definitive chemoradiotherapy in locally advanced lung cancer patients with combined pulmonary fibrosis and emphysema.

Fujimoto K, Kogo M, Kobayashi H et al. · 2026 · Cancer treatment and research communications

Background This study evaluated the efficacy and safety of definitive chemoradiotherapy (CRT) for lung cancer in patients with combined pulmonary fibrosis and emphysema (CPFE), focusing on radiation pneumonitis (RP). Materials and methods…

View details →
Negative / Null Result ReportMedicine

DNAemia Thresholds to Discontinue Antivirals in Preemptive Management for Cytomegalovirus Seropositive Recipients After Kidney Transplantation.

Miehrig AH, Foresto RD, Tedesco-Silva H et al. · 2026 · Transplantation

Background Treatment of cytomegalovirus (CMV) after kidney transplantation aims to achieve cessation of viral replication; however, the use of highly sensitive DNA assays creates uncertainty regarding the optimal DNAemia threshold for…

View details →
Negative / Null Result ReportMedicine

Patient factors outweigh procedure extent in infection risk after cervical disc arthroplasty.

Mastrokostas PG, Said M, Mastrokostas LE et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Purpose To determine the 90-day incidence of surgical site infection (SSI) after cervical disc arthroplasty (CDA), compare single versus multilevel procedures, and identify independent predictors of SSI. Methods We identified adult…

View details →
Negative / Null Result ReportMedicine

Adrenocorticotropin hormone regulates sphingosine-1-phosphate synthesis via cortisol in bovine adrenocortical cells.

Medina-Moctezuma ZB, Guzmán-Sánchez A, González-Aretia D et al. · 2026 · Biochemical and biophysical research communications

Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) stimulate the synthesis of sphingosine-1 phosphate (S1P) in Gs-coupled receptors dependent manner, enabling S1P to mediate specific bioactivities of FSH and LH. Because…

View details →
Negative / Null Result ReportMedicine

Do congenital heart diseases or chromosomal anomalies influence the surgical outcomes of esophagocoloplasty in esophageal atresia patients?

Tannuri ACA, Abe Takahasi BN, de Almeida Estrambk G et al. · 2026 · Journal of pediatric surgery

Background Esophageal atresia (EA) is frequently associated with congenital heart disease (CHD) and chromosomal anomalies, mainly Down syndrome (DS). While these conditions affect outcomes following primary repair, their specific impact on…

View details →
Negative / Null Result ReportMedicine

Application of quinoa oil emulsions in fresh goat cheese: effects on lipid profile, technological properties and microstructure.

Muñoz-Tebar N, Lucas-González R, Muñoz-Bas C et al. · 2026 · Food chemistry

This study investigates the use of quinoa oil emulsion as a novel plant-based ingredient to improve the nutritional quality of fresh goat cheese. Quinoa oil emulsions (3 and 6 g/L) were characterized and incorporated in fresh cheese. The…

View details →
Negative / Null Result ReportMedicine

GnRH Administration Increases Synchronisation of Ovulation in Mares.

Cui B, Liu Y, Wu X et al. · 2026 · Reproduction in domestic animals = Zuchthygiene

The objective of this study was to evaluate the effects of exogenous GnRH administration at the beginning of estrus synchronisation in mares during the spring transitional period. Estrus was synchronised using a progesterone releasing…

View details →
Negative / Null Result ReportMedicine

Physiologic, Psychological, Nutritional, and Rest-Activity Observations During 120 Days of Low-Tech Off-Grid Living in the Baja California Desert: A 2-Participant Field Case Study.

Mauvieux B, Montardy Q, Remilly M et al. · 2026 · Wilderness & environmental medicine

Off-grid low-tech living is increasingly proposed for arid environments, yet longitudinal field data documenting health, nutrition, and rest-activity organization under real-world conditions remain scarce. Our objective was to describe…

View details →
Negative / Null Result ReportMedicine

A description of self-selected treatments and self-reported improvement following treatment among post-9/11 veterans experiencing disruptive dizziness following a comprehensive traumatic brain injury evaluation.

Cheever K, Kalvesmaki A, Swan AA et al. · 2026 · Brain injury

Background This study aimed to explore what treatments were sought by post-9/11 Veterans with and without a formal diagnosis related to their long-term dizziness following completion of a Comprehensive Traumatic Brain Injury Evaluation…

View details →
Negative / Null Result ReportMedicine

Glyphosate exposure did not increase the risk of UVR-induced skin tumors in hairless mice.

Lerche CM, Granborg JR, Al-Chaer RN et al. · 2025 · Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

Glyphosate (GLY) is the most widely used pesticide in the world. Agricultural workers are exposed to GLY via ingestion and skin contact. GLY may generate epigenetic changes that might be carcinogenic. However, whether GLY is carcinogenic…

View details →
Negative / Null Result ReportMedicine

Do intraoperative calcar fractures increase early complications or revisions in short stem total hip arthroplasty? A propensity score matching study.

Suksathien Y, Suarjui J, Tippimanchai T et al. · 2026 · International orthopaedics

Purpose Intraoperative calcar fracture (IOCF) can compromise initial stability, leading to stem subsidence and instability. We aimed to compare 2-year complications and revision rates between patients who sustained IOCF and matched…

View details →
Negative / Null Result ReportMedicine

Perioperative risk factors predicting CSF leak and retethering following tethered cord release for complex spinal lipomas.

Chesney KM, McAbee JH, Balu A et al. · 2026 · Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

Purpose Tethered cord release (TCR) is typically well tolerated in children, but cerebrospinal fluid (CSF) leaks can occur postoperatively, with rates as high as 33%. The aim of this study was to determine perioperative risk factors…

View details →
Negative / Null Result ReportMedicine

Pregnancy outcomes of gestational diabetes mellitus treated before versus after 24 weeks: A comparison of Carpenter-Coustan and IADPSG criteria.

Gorsagun S, Pruksanusak N, Geater AF · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Objective To compare pregnancy outcomes between early and standard treatment of gestational diabetes mellitus (GDM) diagnosed using the Carpenter-Coustan criteria and to assess the impact of applying the International Association of…

View details →
Negative / Null Result ReportMedicine

Comparison of surgical safety among different comprehensive treatment models for adenocarcinoma of esophagogastric junction: a single-center cohort study.

Dai H, Wang Y, Shan F et al. · 2026 · BMC gastroenterology

Background Neoadjuvant chemotherapy (NAC) and neoadjuvant chemoradiotherapy (nCRT) are increasingly used to treat adenocarcinoma of the esophagogastric junction (AEG). However, there is insufficient clinical evidence to compare surgical…

View details →
Negative / Null Result ReportMedicine

The impact of coronary artery bypass grafting on the short- and long-term development and progression of diabetic retinopathy: A Danish national matched cohort study.

Maschoreck LG, Stokholm L, Pedersen FN et al. · 2026 · Acta ophthalmologica

Purpose Diabetic retinopathy (DR) is a frequent long-term complication of diabetes. While hemodynamic changes are known risk factors for DR, the effect of coronary artery bypass grafting (CABG) on the development of DR is poorly…

View details →