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11,312 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

The tipping point: Friction and thigh length influence imminent falls from a tilting ski lift chair.

Talhelm J, Srivastava S, Ostrander J et al. · 2026 · Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine

Falls by subjects riding a ski lift while in transit are rare but can cause significant injury. Falls can occur at variable heights and can occur to small children to adults of both genders. The current study was designed to investigate…

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Negative / Null Result ReportOpen accessMedicine

The Geographical Variation of Colour Change in the Arabian Killifish (<i>Aphaniops dispar</i> Sensu Lato) From Freshwater and Marine Ecosystems.

Alfakih A, Nadeau NJ, Watt PJ · 2026 · Ecology and evolution

Widely distributed animals may exhibit substantial plastic physiological, morphological and behavioural responses to environmental changes. One such extraordinary form of plasticity is colour change, which varies substantially among most…

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Negative / Null Result ReportOpen accessMedicine

Relationship Between Pulmonary Thromboembolism, its Mortality and Seasonal, Meteorological Factors

Seda Beyhan Sağmen, Sevda Cömert, Nesrin Kıral et al. · 2019 · Southern Clinics of Istanbul Eurasia

INTRODUCTION[|]Seasonal and weather changes may affect the development of pulmonary embolism. The effects of seasonal and meteorological factors on mortality are controversial. We aimed to investigate the effects of seasons and meteorological data on patients with a low and high pulmonary embolism severity index and those with 30-day mortality. [¤]METHODS[|]Pulmonary embolism cases were included in our study. Daily pressure, humidity, temperature, and wind values were taken from the general online information by the Directorate of Meteorology. All cases were divided into the low-risk and high-

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Negative / Null Result ReportOpen accessMedicine

Low-dose oral pregabalin is not effective enough to control the acute post-thoracotomy pain

Swati Dogra , Altaf Hussain Mir , Suhail Sidiq et al. · 2025 · Asian Journal of Medical Sciences

Background: Acute post-thoracotomy pain (APTP) is severe and can lead to various respiratory complications if left untreated. Epidural (Ep) analgesia is the gold standard for APTP relief. Aims and Objectives: The aims and objectives of this study were to study the impact of low-dose oral pregabalin 75 mg on APTP. Materials and Methods: 100 patients were randomized into two groups (Group P and C). The Group P, study group received pregabalin 75 mg per oral preoperatively and for 2 days postoperatively. Group C received no medication. All the patients received thoracic Ep as a standard practice.

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Negative / Null Result ReportOpen accessMedicine

Obturator or "lateral" bypass in the management of infected vascular prostheses at the groin

Davidović Lazar B., Kuzmanović Ilija B., Kostić Dušan M. et al. · 2002 · Srpski Arhiv za Celokupno Lekarstvo

The infection of the previously implanted vascular graft at the groin, is associated with great mortality and morbidity rate [1]. The authors present a retrospective study in which they analyzed management of infected vascular prostheses at the groin, using obturator bypass in 26 cases, and "lateral" bypass in 15 cases. The indications for obturator bypass reconstructions included: 20 infections of aorto-femoral grafts, two infected pse udoaneurysms in the groin after RTA of the superficial femoral artery, and 4 infections of iliac-femoral grafts. The indications for lateral bypass reconstruct

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Negative / Null Result ReportOpen accessMedicine

RETROSPECTIVE OBSERVATIONAL STUDY ON THE INCIDENCE OF ORAL COMPLICATIONS IN PATIENTS WITH DIABETES MELLITUS

Alberta Simona Tinu, Doina Lucia Ghergic, Mirel Stoian et al. · 2018 · Romanian Journal of Stomatology

Objectives. We performed a retrospective observational analytical study to determine the incidence of complications in the oral cavity in a group of patients diagnosed with diabetes mellitus. Material and method. We have studied 68 diabetic patients, who have been referred to dental practices seeking specialized treatment. Patient data sheets were centralized, categorized, and statistically processed with IBM SPSS Statistics 22 and Microsoft Excel 2010 depending on: sex of patients, age, type of diabetes, time elapsed from diagnosis of diabetes, the environment of origin of the patients, the l

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Negative / Null Result ReportOpen accessMedicine

The Effectiveness of Immature Granulocyte Count for Predicting COVID-19 Severity and Poor Outcomes

Yunsur Çevik, Fatma Nur Karaarslan, Şeref Kerem Çorbacıoğlu et al. · 2022 · Eurasian Journal of Emergency Medicine

Aim:The aim of this study was to examine the relationship between immature granulocyte (IG) counts and the severity of the disease and to evaluate the effectiveness of IG in predicting the poor outcomes in polymerase chain reaction-confirmed Coronavirus disease-2019 (COVID-19) cases.Materials and Methods:The study was conducted prospectively and observationally at the emergency department. Patients were divided into three groups according to the clinical severity indicators such as mild, moderate and severe. The IG level was measured from the whole blood samples taken at the admission to the e

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Negative / Null Result ReportOpen accessMedicine

Associations between CYP2C8 rs10509681 and rs11572080 gene polymorphisms and age-related macular degeneration

Rasa Liutkevičienė, Ramunė Sungailienė, Alvita Vilkevičiūtė et al. · 2017 · Acta Medica Lituanica

Background. Age-related macular degeneration (AMD) is the most common cause of irreversible visual loss in industrialized countries. Early symptoms of AMD include drusen and changes in retinal pigment epithelium. However, the etiology of AMD and drusen formation is not fully understood. Recent studies suggest that CYP2C8-related metabolic processes might play an important role in the development of AMD. The aim of our study is to investigate CYP2C8 rs10509681 and CYP2C8 rs11572080 genotype frequencies in patients with early AMD and to compare them with healthy controls. Materials and Methods.

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Negative / Null Result ReportOpen accessMedicine

Origins of the obturator artery in Thai and Chinese

Damkoeng Purnindu · 2023 · Siriraj Medical Journal

Dissection of one-half of adult pelvis in 197 Thai and 44 Chinese cadavers disclosed that the obturator artery arose from the internal iliac and umbilical arteries in 34.9%, from the inferior gluteal artery in 10.4%, from the internal pudendal artery in 8.7%, from the superior gluteal - inferior gluteal trunk in 4.2%, from the inferior gluteal - internal pudendal trunk in 9.1%, from the inferior epigastric artery in 12.0%, from the external iliac artery in 1.2%, and from the superior gluteal and the inferior epigastric arteries in 0.4%. There were no statistically significant differences of fi

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Negative / Null Result ReportOpen accessMedicine

Correlation of body mass index and orthostatic hypotension in patients with hypertension on ACE inhibitor monotherapy

Tasić Danijela, Kovačević Zorana, Mitrović Miroslav et al. · 2021 · Scripta Medica

Background/Aim: Orthostatic hypotension (OH) is considered to be a drop in the systolic and diastolic blood pressure (> 20 mmHg; > 10 mmHg) 3 minutes from postural changes. The objective of this study was to analyse the correlation of body mass index (BMI) and OH during the treatment with trandolapril, as a single-drug treatment of hypertension. Methods: The study involved 255 patients (average age 54.3 ± 11.7; 54.1 % men) with poorly regulated hypertension, who were given trandolapril as a single-drug treatment. The patients were divided into two groups regarding stage of hypertension: first-

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Negative / Null Result ReportOpen accessMedicine

Impact of an Online Gastrointestinal Symptom History Taker on Physician Documentation and Charting Time: Pragmatic Controlled Trial

Hall, Natalie J, Berry, Sameer K, Aguilar, Jack et al. · 2021 · JMIR Formative Research

BackgroundA potential benefit of electronic health records (EHRs) is that they could potentially save clinician time and improve documentation by auto-generating the history of present illness (HPI) in partnership with patients prior to the clinic visit. We developed an online patient portal called AEGIS (Automated Evaluation of Gastrointestinal [GI] Symptoms) that systematically collects patient GI symptom information and then transforms the data into a narrative HPI that is available for physicians to review in the EHR prior to seeing the patient. ObjectiveThis study aimed to compare whether

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Negative / Null Result ReportOpen accessMedicine

Is pomegranate peels infusion effective for disinfection of toothbrushes?

Priscila Lima de Luna FREIRE, Priscila Hernández CAMPOS, Fabíola Galbiatti CARVALHO et al. · Revista de Odontologia da UNESP

Abstract Introduction Methods of decontamination or sanitization of toothbrushes have been questioned. Objective This study assessed the effectiveness of pomegranate peels infusion as a disinfectant of toothbrushes against Streptococcus mutans. Material and method A sample of 16 schoolchildren aged between 7 and 9 years performed brushing 5 days/week, with a careful brushing once a day. After each day of brushing, the toothbrushes were washed and sprayed with one disinfectant solution. This procedure was repeated for 4 weeks using one of the different solutions per week: distilled water (G1; n

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Negative / Null Result ReportOpen accessMedicine

Availability of volunteer-led home-based care system and baseline factors as predictors of clinical outcomes in HIV-infected patients in rural Zambia.

Christopher B Estopinal, Janneke H van Dijk, Stanley Sitali et al. · 2012 · PLoS ONE

Background We assessed the impact of home-based care (HBC) for HIV+ patients, comparing outcomes between two groups of Zambians receiving antiretroviral therapy (ART) who lived in villages with and without HBC teams. Methods We conducted a retrospective cohort study using medical charts from Macha Mission Hospital, a hospital providing HIV care in Zambia's rural Southern Province. Date of birth, date of ART initiation, place of residence, sex, body mass index (BMI), CD4+ cell count, and hemoglobin (Hgb) were abstracted. Logistic regression was used to test our hypothesis that HBC was associate

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Negative / Null Result ReportOpen accessMedicine

Challenges and strategies in the soluble expression of CTA1-(S14P5)4-DD and CTA1-(S21P2)4-DD fusion proteins as candidates for COVID-19 intranasal vaccines.

Simson Tarigan, Gita Sekarmila, Apas et al. · 2024 · PLoS ONE

Developing intranasal vaccines against pandemics and devastating airborne infectious diseases is imperative. The superiority of intranasal vaccines over injectable systemic vaccines is evident, but developing effective intranasal vaccines presents significant challenges. Fusing a protein antigen with the catalytic domain of cholera toxin (CTA1) and the two-domain D of staphylococcal protein A (DD) has significant potential for intranasal vaccines. In this study, we constructed two fusion proteins containing CTA1, tandem repeat linear epitopes of the SARS-CoV-2 spike protein (S14P5 or S21P2), a

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Negative / Null Result ReportMedicine

Statins May Not Reduce Reoperation Rates in Chronic Subdural Hematoma, Regardless of the Use of Antithrombotic Medication.

Klein J, Carl B, Schackert G · 2026 · Journal of neurological surgery. Part A, Central European neurosurgery

Objective Various studies have shown a beneficial effect of statins in patients with chronic subdural hematoma (cSDH) who do not require surgery. In surgical cohorts, however, the results of statin treatment in cSDH have been inconsistent,…

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Negative / Null Result ReportMedicine

Determination of the First Aid Knowledge Level of Teachers Working in Special Education and Rehabilitation Centers Regarding Tooth Avulsion.

Yabaş ŞM, Gümüşboğa ZŞ · 2026 · Dental traumatology : official publication of International Association for Dental Traumatology

Aim Tooth avulsion is among the traumatic dental injuries that require immediate intervention during childhood, and children are often with teachers or parents at the time of such incidents. This situation highlights the need to evaluate…

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Negative / Null Result ReportMedicine

Nociception-guided opioid administration within multimodal analgesia for laparoscopic endometriosis surgery: a randomized controlled trial.

Buis HT, Berger-Estilita J, Zirngast S et al. · 2026 · Journal of clinical monitoring and computing

Women with endometriosis are at increased risk of severe postoperative pain due to nociceptive sensitization. While multimodal analgesia reduces opioid use, the added value of objective nociception monitoring remains unclear. This study…

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Negative / Null Result ReportMedicine

Influence of Cavity Design, Bonding-Banding Sequence, and Thermomechanical Loading on the Marginal Adaptation of Class II Resin Composite Restorations.

Ismail HS, Ali AI, Soliman HAN · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]

Objective To evaluate whether differences exist in marginal adaptation among beveled and non-beveled cavity designs, different bonding-banding sequences, and before and after thermomechanical loading. Methods Forty molars received…

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Negative / Null Result ReportOpen accessMedicine

Intravascular Imaging for Facilitated Coronary Interventions in DES Era.

Zeren G, Bakır EO, Tufaro V et al. · 2026 · Journal of cardiovascular development and disease

Intravascular imaging (IVI) was introduced 35 years ago to assess coronary artery pathology and plaque vulnerability. However, from its first applications it became apparent that it can also be useful in percutaneous coronary intervention…

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Negative / Null Result ReportMedicine

Artificial Liver Support.

Kim HK, Huang DT, Al-Khafaji A · 2026 · Journal of intensive care medicine

Acute liver failure (ALF) and acute-on-chronic liver failure (ACLF) both have high mortality rates without liver transplantation. Artificial liver support systems may benefit patients with liver failure, serving as a bridge to…

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Negative / Null Result ReportMedicine

Employing Comics Storytelling to Promote Climate Change Mitigation: An Experimental Study Grounded on the Situational Theory of Public.

Guo Y, Wei D, Xu S et al. · 2026 · Risk analysis : an official publication of the Society for Risk Analysis

This study examines the potential of comics as an infotainment strategy for engaging the public in climate change mitigation from the perspective of the situational theory of public. A 2 × 2 × 2 factorial experiment (N = 320) was conducted…

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