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Browse the failure-mode index

11,412 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Delayed orocecal transit in pediatric gut-brain interaction disorders: A comparative study using the lactulose breath test.

Devanarayana NM, Rajindrajith S, de Silva DGH et al. · 2025 · World journal of gastrointestinal pathophysiology

Background Functional abdominal pain disorders (FAPDs) are common gut-brain interaction disorders with unclear pathophysiology. While impaired gastrointestinal motility is thought to play a key role, small intestinal dysmotility remains…

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Negative / Null Result ReportOpen accessMedicine

Non-tobacco nicotine dependence is associated with increased complications following clavicle open reduction internal fixation.

Adio AA, Goyal RK, Skiena A et al. · 2026 · Archives of orthopaedic and trauma surgery

Background Tobacco dependence is well established to impair bone healing and increase postoperative complications. However, the independent effects of nicotine, separate from combustion-related factors, remain unclear. This study aimed to…

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Negative / Null Result ReportOpen accessMedicine

Effects of Defatted Black Soldier Fly (<i>Hermetia illucens</i>) Meal on the Performance, Digestibility and Blood Parameters of Weaned Piglets.

Parreiras M, Pinheiro V, Moreira O et al. · 2026 · Animals : an open access journal from MDPI

This study investigated the effects of different inclusion levels of defatted black soldier fly ( Hermetia illucens : BSF) larval meal on growth performance, haematological and biochemical blood parameters, and nutrient digestibility in…

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Negative / Null Result ReportOpen accessMedicine

Effect of different feed particle size on digestive tract morphology, digesta viscosity, nutrient retention, and blood biochemical parameters in slow-growing broiler chickens.

Novotný J, Čumplík L, Horáková L et al. · 2026 · Veterinary and animal science

The study evaluated the effect of feed particle size on health and performance indicators in slow-growing broiler chickens. Performance traits, digestive tract morphology, digesta viscosity, nutrient retention, and blood biochemical…

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Negative / Null Result ReportOpen accessMedicine

Culture medium influences detectability of antimicrobial effects of autologous platelet concentrates against anaerobic periodontal pathogens.

Jansen EE, Braun A, Jansen P et al. · 2026 · BMC oral health

Background Autologous platelet concentrates (PRP, PRF, i-PRF) represent blood-derived biomaterials that have been reported to exhibit antimicrobial activity against oral microorganisms in vitro. In diffusion-based assays, visualization of…

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Negative / Null Result ReportMedicine

Effects of lower limb joint manipulation on squat strength and ankle range of motion: a sham-controlled double-blind randomised cross-over trial.

Morley-Hart R, Losco B, Dempsey AR et al. · 2026 · Chiropractic & manual therapies

Background The back squat is a commonly prescribed exercise for developing lower body strength. The ability to squat can be affected by reduced ankle dorsiflexion range of motion (DF-ROM), leading to limited squat depth and dysfunctional…

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Negative / Null Result ReportOpen accessMedicine

Cerebroplacental Ratio in Monochorionic Diamniotic Twin Pregnancies with and Without Gestational Diabetes: A Longitudinal Cohort Study.

Yerlikaya-Schatten G, Adamovic M, Catic A et al. · 2026 · Journal of clinical medicine

Objective: To investigate whether gestational diabetes mellitus (GDM), including insulin-treated GDM, affects cerebroplacental ratio (CPR) values in monochorionic diamniotic (MCDA) twin pregnancies. Methods: This retrospective…

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Negative / Null Result ReportMedicine

Assessment of mandibular ramus dimensions in relation to lower third molar impaction in class II malocclusion: a comparative 2D and 3D CBCT evaluation.

AbuHarb H, Abusafia B, Fu X et al. · 2026 · BMC oral health

Background To assess the relationship between mandibular ramus morphology and lower third molar impaction among patients with Class II malocclusion using CBCT. Methods A retrospective study included 536 patients with Class II malocclusion,…

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Negative / Null Result ReportMedicine

Exploratory Study of Radiation Exposure between Image Intensifier-Equipped C-Arm and a Flat Panel Detector During Volar Plate Fixation of the Distal Radius.

Honda Y, Kaida E, Miyazaki Y et al. · 2026 · The journal of hand surgery Asian-Pacific volume

Background: To compare the amount of radiation exposure received by the surgeon during volar locking plate fixation for distal radius fractures using an image intensifier (II) and a flat panel detector (FPD). Methods: We included 40…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of the effects of different irrigation activation techniques on the surface roughness of dentin and blood clot in regenerative endodontic models.

Bulak Yeliz S, Uğur Aydın Z · 2026 · Lasers in medical science

Regenerative endodontic treatment (RET) is a biologically based approach aiming to restore the pulp-dentin complex in immature permanent teeth with necrotic pulps. In this procedure, a blood clot is induced within the canal to serve as a…

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Negative / Null Result ReportOpen accessMedicine

Clinical Status and Salivary aMMP-8 Evaluation of 0.12% Chlorhexidine Versus MicroRepair<sup>®</sup> ABX Mouthwash in the Non-Surgical Management of Plaque-Induced Gingivitis: A Randomized Controlled Trial.

Scribante A, Pascadopoli M, Pellegrini M et al. · 2026 · Dentistry journal

Objectives : To compare the adjunctive efficacy of a MicroRepair ® mouthwash containing an antibacterial complex (ABX), composed of cetylpyridinium chloride, magnolol, and honokiol, with 0.12% chlorhexidine (CHX) in the management of…

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Negative / Null Result ReportOpen accessMedicine

Safety of flexible bronchoscopy in elderly patients.

Spiegel S, Hübner RH, Schürmann D et al. · 2026 · BMC pulmonary medicine

Background Flexible bronchoscopy is an indispensable tool in respiratory medicine. In the context of an aging society and increasing life expectancy, the number of elderly, often multimorbid patients is growing. This raises important…

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Negative / Null Result ReportOpen accessMedicine

Effect of conventional warm-up versus stretching warm-up on physical performance in children soccer players: a randomized crossover trial.

Hernandez-Martínez J, Cid-Calfucura I, Perez-Carcamo J et al. · 2026 · Frontiers in physiology

Introduction To evaluate the effects of the conventional warm-up (CC) compared to warm-ups that included static (SSC), dynamic (DSC), or ballistic (BSC) stretching on jump performance (CMJ, SJ, DJ), curve sprint speed, agility (ICODT), and…

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Negative / Null Result ReportOpen accessMedicine

Assessment of pain and post-injection induration in children: A comparative study of cold application, manual pressure, and shot blocker techniques.

Sasireka V, Bhuvaneswari G, Babu S · 2026 · Journal of education and health promotion

Background Intramuscular (IM) injections are widely used in pediatric care but often cause pain and distress. Effective management is essential to improve children's healthcare experiences. Non-pharmacological methods, including Cold…

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Negative / Null Result ReportOpen accessMedicine

Critical care ultrasound evaluation of snuffbox artery vascular tension: a prospective observational study between healthy volunteers and intensive care unit patients.

Qin Y, Zhu Y, Dai X et al. · 2026 · Frontiers in medicine

Background Systemic vascular resistance is conventionally assessed using invasive methods; the snuffbox artery resistance index (RI) is a superior non-invasive predictor of lactate clearance in septic shock patients to the perfusion index.…

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Negative / Null Result ReportMedicine

Comparing video-assisted and verbal explanations in Japanese hospital dentistry: patient evaluations in third molar extraction and medical-dental collaborative care.

Matsumoto K, Mitani I, Tsutsui T et al. · 2026 · BMC medical informatics and decision making

Background Video-assisted explanations may support standardized patient information delivery, but their role in hospital dentistry remains insufficiently evaluated. This study aimed to compare patient evaluations of video-assisted and…

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Negative / Null Result ReportOpen accessMedicine

Retinal microvascular alterations in children with amblyopia.

Al-Haddad C, Ibrahim H, Salameh N et al. · 2026 · PloS one

Purpose To investigate and compare retinal vascular changes, including superficial macular vessel density, foveal avascular zone, and the macular perfusion densities, in amblyopic, fellow, and control eyes using optical coherence…

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Negative / Null Result ReportMedicine

Validity of optical coherence tomography angiography in the differential diagnosis of papilledema and pseudopapilledema.

Cerdan-Hernandez E, Palencia-Herranz MJ, Barón M et al. · 2026 · Journal of optometry

Purpose To assess the value of optical coherence tomography angiography (OCTA) peripapillary retinal vascularization in differentiating papilledema from pseudopapilledema. Methods A cross-sectional study, prospective recruitment patients…

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Negative / Null Result ReportMedicine

Influence of X-ray beam angulation on the radiographic detection of implant-abutment interface misfits: A quantitative in vitro analysis.

Terzioglu H, Efeoglu S, Sarikaya CH et al. · 2026 · Journal of prosthodontics : official journal of the American College of Prosthodontists

Purpose This study evaluated the effect of periapical X-ray angulation on the diagnostic accuracy of detecting vertical misfits at the implant-abutment interface using Medentika Microcone dental implants (4.0 mm diameter, 11 mm length;…

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