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Browse the failure-mode index

11,312 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Safety, tolerability and biomarker results of bepranemab in participants with progressive supranuclear palsy: a randomised, multicentre, double-blind, placebo-controlled, phase 1b trial.

Höglinger G, Vandenberghe W, Woitalla D et al. · 2026 · BMJ neurology open

Background Preclinical evidence suggests targeting the mid-region of tau as a viable therapeutic strategy in diseases such as progressive supranuclear palsy (PSP): a rare, fatal, neurodegenerative tauopathy with no currently approved…

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Negative / Null Result ReportMedicine

Drugs targeting novel pathways in pulmonary arterial hypertension.

Sitbon O, Boucly A, Weatherald J et al. · 2025 · The European respiratory journal

Over the past three decades, several drugs have been developed to target three major dysfunctional pathways in pulmonary arterial hypertension (PAH), including the prostacyclin, endothelin and nitric oxide pathways. Despite these advances,…

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Negative / Null Result ReportMedicine

Family satisfaction with intensive care and preexisting family and patient characteristics: equivalence analysis of cross-sectional surveys.

Riguzzi M, Verweij L, Naef R · 2025 · Intensive & critical care nursing

Objectives This study aims to demonstrate that family satisfaction with intensive care and decision-making is independent of sociodemographic family member and patient characteristics and the patient outcomes of mortality and length of…

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Negative / Null Result ReportMedicine

Effect of an educational antimicrobial stewardship programme on antibiotic prescriptions' appropriateness in three medical units of a large university hospital: an interrupted time series analysis.

Giovannenze F, Del Vecchio P, Frondizi F et al. · 2025 · The Journal of hospital infection

Background Antimicrobial stewardship (AMS) programmes aim to enhance antibiotic prescription quality, reduce antibiotic use, and combat multi-drug-resistant pathogens. However, the optimal AMS intervention for different clinical settings…

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Negative / Null Result ReportOpen accessMedicine

Tremor Recurrence in MR-Guided Focused Ultrasound Thalamotomy for Essential Tremor: DBS vs. Re-lesion.

Walker-Pizarro N, Chan JL, Yu J et al. · 2026 · Tremor and other hyperkinetic movements (New York, N.Y.)

Clinical vignette A 59-year-old man with essential tremor (ET) and bilateral symptoms initially underwent left thalamic MRI-guided focused ultrasound (MRgFUS) at an outside institution to address tremor in the right upper extremity.…

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Negative / Null Result ReportOpen accessMedicine

Effect of Ultrasound-Guided Lateral Infraclavicular Brachial Plexus Block With Lidocaine or Ropivacaine for Closed Reduction of Distal Radius Fractures: A Randomized Controlled Noninferiority Trial.

Steensbæk MT, Yousef S, Bahuet AR et al. · 2026 · Acta anaesthesiologica Scandinavica

Background Closed reduction of distal radius fractures is painful, and current analgesic strategies may be inadequate. Ultrasound-guided lateral infraclavicular brachial plexus block may offer complete analgesia and muscle relaxation,…

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Negative / Null Result ReportOpen accessMedicine

Feasibility of an Isolated Kidney Perfusion Model for Postmortem Interval Estimation in a Rabbit Model: A Pilot Study.

Temürkol R, Güler H, Kaya A et al. · 2026 · Diagnostics (Basel, Switzerland)

Background: The estimation of the postmortem interval (PMI) remains a complex challenge in forensic medicine. While macroscopic, biochemical, and molecular methods are well-documented, postmortem functional approaches at the organ level…

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Negative / Null Result ReportOpen accessMedicine

Concomitant Bladder Neck Incision in Patients with Posterior Urethral Valve and Blad-der Neck Hypertrophy: Short-term Outcomes of a Randomized Controlled Trial.

ELghareeb A, Dawaba M, Eldeeb M et al. · 2026 · International braz j urol : official journal of the Brazilian Society of Urology

Introduction Concomitant bladder neck incision (BNI) with posterior urethral valve ablation (VA) was proposed to mitigate the long-term sequela of posterior urethral valve (PUV) and reduce the reoperation rates. This study aimed to…

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Negative / Null Result ReportMedicine

Dose-Escalated Stereotactic Versus Conventional Radiotherapy for Painful Bone Metastases (ROBOMET): A Multicenter, Patient-Blinded Randomized Clinical Trial.

Mercier C, Billiet C, Ost P et al. · 2025 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Purpose To test whether dose-escalated single fraction (SF) stereotactic body radiotherapy (SBRT) of 20 Gy to painful bone metastases is superior to conventional SF three-dimensional (3D) conformal radiotherapy (RT) to a standard dose of 8…

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Negative / Null Result ReportMedicine

Infants with bronchiolitis with high-flow nasal cannula in the paediatric ward. Is there a role for the ROXi (respiratory rate-oxygenation index) in predicting failure of high-flow nasal cannula?

Le Pallec C, Cerasuolo D, Cauvin JC et al. · 2025 · European journal of pediatrics

The respiratory rate-oxygenation index (ROXi) has been shown to be a reliable tool for predicting the risk of high-flow nasal cannula (HFNC) failure in adult patients with lower respiratory tract infections. However, the usefulness of the…

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Negative / Null Result ReportMedicine

Hyperbaric Treatment of Air or Gas Embolism: Current Recommendations.

Moon RE, Mitchell SJ · 2025 · Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc

Gas can enter arteries (arterial gas embolism) due to alveolar-capillary disruption (caused by pulmonary overpressurization, e.g. breath-hold ascent by divers), veins (venous gas embolism, VGE) as a result of tissue bubble formation due to…

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Negative / Null Result ReportOpen accessMedicine

No survival benefit is associated with pelvic and para-aortic lymphadenectomy in lymph node-negative early-stage endometrioid endometrial cancer.

Yalcin Y, Yalcin SE, Demir BC et al. · 2026 · BMC surgery

OBJECTIVE: The therapeutic role of lymphadenectomy in endometrial cancer remains controversial. Although systematic pelvic and para-aortic lymphadenectomy (PPLND) has been suggested to improve survival in certain patients, randomized…

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Negative / Null Result ReportOpen accessMedicine

Adjuvant therapy for renal cell carcinoma: lessons from past failures and new opportunities in the era of immune checkpoint inhibition.

Liu Z, Cong X, Liu Z et al. · 2026 · Frontiers in immunology

Renal cell carcinoma (RCC) has historically posed a significant therapeutic challenge in the adjuvant setting. Although surgical resection remains the cornerstone of curative-intent treatment for localized disease, a substantial proportion…

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Negative / Null Result ReportMedicine

Hypofractionated Versus Single-Session Radiosurgery to Preserve Hearing in Patients Affected by Sporadic Vestibular Schwannoma: The ACOUNEU Randomized Clinical Trial.

Marchetti M, Pinzi V, Gemma M et al. · 2025 · International journal of radiation oncology, biology, physics

Purpose During the last decades, in addition to tumor control, hearing preservation has become an important priority in the treatment of vestibular schwannoma (VS). Given that the potential advantages of hypofractionated radiosurgery (hRS)…

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Negative / Null Result ReportMedicine

Can visual acceleration evoke a sensation of tilt?

Harris LR, Jörges B, Bury N et al. · 2025 · Experimental brain research

Under the microgravity of the International Space Station, many of the normal processes that determine the perceptual upright on Earth are disrupted. For example, somatosensory cues are absent and an applied physical linear acceleration…

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Negative / Null Result ReportOpen accessMedicine

External cold and vibration with BUZZY versus topical anesthetic gel for pain and anxiety associated with infiltrative anesthesia in pediatric dentistry: a double-blinded, split-mouth, randomized, controlled trial.

Faghihian R, Tofighi MM, Ziaei S et al. · 2025 · European oral research

Purpose A way to reduce the pain of injection is applying of external cold or vibrations with BUZZY, along with spinal cord gate control systems. We aimed to evaluate the effectiveness of this method in reducing children's pain and anxiety…

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