11,312 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Almutairi M, Mousa I, Alqahtani R et al. · 2026 · Scientific reports
Single-shade composite restorations can adapt to the tooth structure, improve esthetics, and reduce reliance on shade selection. The objective of this study was to assess the effect of four different children's beverages on the color…
View details →DuPaul GJ, Kern L, Dever BV et al. · 2026 · Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
Objective Behavioral parent training is a first-line psychosocial intervention for young children with Attention-Deficit/Hyperactivity Disorder. Traditional face-to-face delivery is limited by access to therapists, feasibility, and/or…
View details →Wen B, Wu X, Ma X et al. · 2026 · Frontiers in immunology
The therapeutic strategy for Idiopathic Pulmonary Fibrosis (IPF) has undergone a fundamental transformation over recent decades. Combination therapy with glucocorticoids and immunosuppressants, particularly the "triple therapy" regimen…
View details →Sukmarova ZN, Simonenko VB · 2025 · Kardiologiia
Despite significant advances in pharmacological, interventional, and surgical treatments for cardiovascular diseases (CVDs) in recent decades, it appeared that the effectiveness of standard treatments has reached a ceiling, and growing…
View details →Zhou J, Jiang X, Liu Q et al. · 2026 · Cancer metastasis reviews
Efforts to translate advances in immunology into anti-cancer immunotherapies have progressed rapidly in recent years. Six antibodies acting on programmed death ligand 1 or programmed death 1 pathways were approved in 75 cancer indications…
View details →Kakaletsis N, Ntaios G · 2025 · Polish archives of internal medicine
Embolic stroke of undetermined source (ESUS) represents up to one‑sixth of ischemic strokes, and is associated with an annual recurrence risk of 4%-5% despite contemporary secondary prevention. The hypothesis that oral anticoagulation…
View details →Gweon TG, Kim SJ, Myung DS et al. · 2026 · Gastrointestinal endoscopy
Background and aims Insufficient submucosal lifting because of pretreatment with forceps biopsy frequently complicates endoscopic treatment of rectal neuroendocrine tumors (NETs) and potentially affects procedural outcomes. Despite…
View details →Xu H · 2026 · Nutrition & metabolism
BACKGROUND: Epidemiological data consistently associate low vitamin D status with elevated cardiovascular risk, yet causal mechanisms remain contested. METHODS: This review synthesized evidence through a protocol-guided approach, with…
View details →Horsburgh CR Jr, Jenkins HE, Kendall EA et al. · 2026 · IJTLD open
Background Active screening for TB may help address the global TB burden, but the optimal screening strategies are not defined. We have reviewed the effectiveness of community-wide active screening programmes to assess the characteristics…
View details →Stasinos I, Voulgaris T, Kouimtsidis IA et al. · 2026 · World journal of gastrointestinal pharmacology and therapeutics
Background Risk of post colonoscopy colorectal cancer is related to adenoma miss rate (AMR) during colonoscopy. Artificial intelligence (AI) and Endocuff Vision are tools both used to increase adenoma detection rate (ADR). Aim To assess…
View details →Lengyel B, Armos R, Bojtor B et al. · 2025 · Pharmaceuticals (Basel, Switzerland)
Vitamin D is well established for its skeletal effects, being a cornerstone of several endocrine disorders. In recent years, it has come under investigation as a potential disease-modifying drug in several endocrine disorders through its…
View details →Sadoul M, Balança B, Dailler F et al. · 2025 · Neurosurgical review
Aneurysmal subarachnoid hemorrhage (aSAH) is associated with significant morbidity, particularly related to delayed cerebral ischemia (DCI). Hyponatremia, defined as a serum sodium level < 135 mmol/l, is a common complication of aSAH and…
View details →Klinghammer K, Graeven U, Ivanyi P et al. · 2026 · Oncology research and treatment
Introduction Elderly, frail, or cisplatin-ineligible patients with recurrent or metastatic squamous cell carcinoma of the head and neck (R/M HNSCC) have a poor prognosis. To date, no standard of care has been defined for this population.…
View details →Ge Y, Wang X, Zhang Y et al. · 2026 · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
Objectives This study aims to assess the efficacy of total hysterectomy versus radical hysterectomy in the treatment of gastric-type endocervical adenocarcinoma (GEA). Methods Patients diagnosed with GEA from 2001 to 2021 were derived from…
View details →Bakakos A, Sotiropoulou Z, Anagnostopoulos N et al. · 2025 · Respiratory medicine
Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality around the globe. Its main characteristics are persistent respiratory symptoms and progressive airflow limitation, both of which are driven by…
View details →Bellamy D, Vickery K · 2026 · Infection, disease & health
Background In accordance with AS5369:2023, disinfection processes need to undergo routine performance qualification (PQ) as part of in-field validation. Automated high-level disinfection (HLD) devices therefore need to undergo PQ.…
View details →Yang Q, Li J, Ding L et al. · 2026 · Cancer management and research
Background Growing research findings highlight the potential of inflammatory markers measured after surgery as prognostic indicators for survival outcomes in rectal carcinoma patients. However, their precise clinical significance remains…
View details →Wong A, Cheah K, Papathanakos G et al. · 2026 · Anaesthesiology intensive therapy
Introduction Fluid management in critically ill patients relies on clinical assessment, fluid balance calculations and, increasingly, point-of-care ultrasound. However, the rela-tionships between these assessment modalities remain poorly…
View details →Xu T, Grubbs JB, Kraus SW · 2025 · Addictive behaviors
As sports betting legalization expands across the United States, understanding its effects on problem gambling remains crucial for evidence-based policy development. This longitudinal study tracked 112 American sports bettors over two…
View details →Ke TM, Lin T, Chow WH et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Introduction Neoadjuvant chemoradiotherapy (nCRT) followed by surgery is the standard treatment for esophageal cancer, but the role of adjuvant chemotherapy remains unclear. This study investigates the survival benefits of adjuvant…
View details →Schneble CA, Miltenberg B, Jurgensmeier K et al. · 2025 · The American journal of sports medicine
Background Arthrofibrosis is seen in 1.7% to 38% of patients after anterior cruciate ligament reconstruction (ACLR) and has been associated with worse postoperative patient-reported outcomes. There are limited data regarding the optimal…
View details →Rowland S, Brummel K, Aatre R et al. · 2026 · Case reports in medicine
Familial dysbetalipoproteinemia (FDB) is a lipid disorder characterized by defective clearance of triglyceride-rich lipoprotein remnants. Definitive diagnosis has relied on genetic markers, lipid profiles, and specialized lipid assays…
View details →Chakraborty S, Gagnon H, McNamara TP et al. · 2026 · IEEE transactions on visualization and computer graphics
Multi-user virtual reality (VR) systems support multiple locomotion methods, but coordination may be challenging when partners use different methods. We studied dyads navigating a shared virtual maze using symmetric (same) or asymmetric…
View details →Roy S, Gupta N, Bharti SJ et al. · 2026 · Journal of anaesthesiology, clinical pharmacology
Background and aims Managing acute postsurgical pain following midline exploratory laparotomy in colorectal cancer patients involves various approaches, such as central neuraxial blockade, patient-controlled intravenous analgesia with…
View details →Singh N, Petrakis I, Pittman B et al. · 2025 · Journal of psychopharmacology (Oxford, England)
Background There is growing interest in developing pharmacological agents to reverse alcohol (ethanol) intoxication, akin to naloxone for opioids. GABAergic modulation offers a potential pathway for reversing alcohol effects, specifically…
View details →Li ZY, Peng SY, Li FL et al. · 2026 · World journal of clinical oncology
Pancreatic ductal adenocarcinoma remains largely refractory to current immunotherapies due to a profoundly immunosuppressive tumor microenvironment dominated by regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), and…
View details →Huang L, He J · 2025 · World journal of clinical oncology
Background Human epidermal growth factor receptor 2 (HER2) plays pivotal roles in cellular proliferation, survival, and differentiation of several malignancies. Upper tract urothelial carcinoma (UTUC) is a relatively rare malignancy. The…
View details →Anzures G, Mildort M, Valenzuela KPM · 2026 · Developmental psychobiology
Despite the early emergence of differences in processing own- and other-race faces, examinations of the corresponding neural correlates prior to adulthood remain limited. The present study examined 5- to 10-year-olds' and adults' P100 and…
View details →Trube J, Sabina M, Khanani A et al. · 2025 · American heart journal plus : cardiology research and practice
Introduction Inflammation is a key risk factor in cardiovascular diseases, such as atherosclerosis, and has been linked to increased mortality following myocardial infarction. While inflammation promotes tissue repair, sustained…
View details →Zacharia GS, Ashraf MH, Sosa F et al. · 2025 · World journal of gastrointestinal pharmacology and therapeutics
Metabolic dysfunction-associated steatotic liver disease (MASLD), recognized as the most prevalent liver disease worldwide and a leading cause of liver transplantation, is closely associated with type 2 diabetes, cardiovascular disease,…
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