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Browse the failure-mode index

11,312 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Culture medium influences detectability of antimicrobial effects of autologous platelet concentrates against anaerobic periodontal pathogens.

Jansen EE, Braun A, Jansen P et al. · 2026 · BMC oral health

Background Autologous platelet concentrates (PRP, PRF, i-PRF) represent blood-derived biomaterials that have been reported to exhibit antimicrobial activity against oral microorganisms in vitro. In diffusion-based assays, visualization of…

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Negative / Null Result ReportMedicine

Effects of lower limb joint manipulation on squat strength and ankle range of motion: a sham-controlled double-blind randomised cross-over trial.

Morley-Hart R, Losco B, Dempsey AR et al. · 2026 · Chiropractic & manual therapies

Background The back squat is a commonly prescribed exercise for developing lower body strength. The ability to squat can be affected by reduced ankle dorsiflexion range of motion (DF-ROM), leading to limited squat depth and dysfunctional…

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Negative / Null Result ReportOpen accessMedicine

Cerebroplacental Ratio in Monochorionic Diamniotic Twin Pregnancies with and Without Gestational Diabetes: A Longitudinal Cohort Study.

Yerlikaya-Schatten G, Adamovic M, Catic A et al. · 2026 · Journal of clinical medicine

Objective: To investigate whether gestational diabetes mellitus (GDM), including insulin-treated GDM, affects cerebroplacental ratio (CPR) values in monochorionic diamniotic (MCDA) twin pregnancies. Methods: This retrospective…

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Negative / Null Result ReportMedicine

Assessment of mandibular ramus dimensions in relation to lower third molar impaction in class II malocclusion: a comparative 2D and 3D CBCT evaluation.

AbuHarb H, Abusafia B, Fu X et al. · 2026 · BMC oral health

Background To assess the relationship between mandibular ramus morphology and lower third molar impaction among patients with Class II malocclusion using CBCT. Methods A retrospective study included 536 patients with Class II malocclusion,…

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Negative / Null Result ReportMedicine

Exploratory Study of Radiation Exposure between Image Intensifier-Equipped C-Arm and a Flat Panel Detector During Volar Plate Fixation of the Distal Radius.

Honda Y, Kaida E, Miyazaki Y et al. · 2026 · The journal of hand surgery Asian-Pacific volume

Background: To compare the amount of radiation exposure received by the surgeon during volar locking plate fixation for distal radius fractures using an image intensifier (II) and a flat panel detector (FPD). Methods: We included 40…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of the effects of different irrigation activation techniques on the surface roughness of dentin and blood clot in regenerative endodontic models.

Bulak Yeliz S, Uğur Aydın Z · 2026 · Lasers in medical science

Regenerative endodontic treatment (RET) is a biologically based approach aiming to restore the pulp-dentin complex in immature permanent teeth with necrotic pulps. In this procedure, a blood clot is induced within the canal to serve as a…

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Negative / Null Result ReportOpen accessMedicine

Clinical Status and Salivary aMMP-8 Evaluation of 0.12% Chlorhexidine Versus MicroRepair<sup>®</sup> ABX Mouthwash in the Non-Surgical Management of Plaque-Induced Gingivitis: A Randomized Controlled Trial.

Scribante A, Pascadopoli M, Pellegrini M et al. · 2026 · Dentistry journal

Objectives : To compare the adjunctive efficacy of a MicroRepair ® mouthwash containing an antibacterial complex (ABX), composed of cetylpyridinium chloride, magnolol, and honokiol, with 0.12% chlorhexidine (CHX) in the management of…

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Negative / Null Result ReportOpen accessMedicine

Safety of flexible bronchoscopy in elderly patients.

Spiegel S, Hübner RH, Schürmann D et al. · 2026 · BMC pulmonary medicine

Background Flexible bronchoscopy is an indispensable tool in respiratory medicine. In the context of an aging society and increasing life expectancy, the number of elderly, often multimorbid patients is growing. This raises important…

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Negative / Null Result ReportOpen accessMedicine

Effect of conventional warm-up versus stretching warm-up on physical performance in children soccer players: a randomized crossover trial.

Hernandez-Martínez J, Cid-Calfucura I, Perez-Carcamo J et al. · 2026 · Frontiers in physiology

Introduction To evaluate the effects of the conventional warm-up (CC) compared to warm-ups that included static (SSC), dynamic (DSC), or ballistic (BSC) stretching on jump performance (CMJ, SJ, DJ), curve sprint speed, agility (ICODT), and…

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Negative / Null Result ReportOpen accessMedicine

Assessment of pain and post-injection induration in children: A comparative study of cold application, manual pressure, and shot blocker techniques.

Sasireka V, Bhuvaneswari G, Babu S · 2026 · Journal of education and health promotion

Background Intramuscular (IM) injections are widely used in pediatric care but often cause pain and distress. Effective management is essential to improve children's healthcare experiences. Non-pharmacological methods, including Cold…

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Negative / Null Result ReportOpen accessMedicine

Critical care ultrasound evaluation of snuffbox artery vascular tension: a prospective observational study between healthy volunteers and intensive care unit patients.

Qin Y, Zhu Y, Dai X et al. · 2026 · Frontiers in medicine

Background Systemic vascular resistance is conventionally assessed using invasive methods; the snuffbox artery resistance index (RI) is a superior non-invasive predictor of lactate clearance in septic shock patients to the perfusion index.…

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Negative / Null Result ReportMedicine

Comparing video-assisted and verbal explanations in Japanese hospital dentistry: patient evaluations in third molar extraction and medical-dental collaborative care.

Matsumoto K, Mitani I, Tsutsui T et al. · 2026 · BMC medical informatics and decision making

Background Video-assisted explanations may support standardized patient information delivery, but their role in hospital dentistry remains insufficiently evaluated. This study aimed to compare patient evaluations of video-assisted and…

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Negative / Null Result ReportOpen accessMedicine

Retinal microvascular alterations in children with amblyopia.

Al-Haddad C, Ibrahim H, Salameh N et al. · 2026 · PloS one

Purpose To investigate and compare retinal vascular changes, including superficial macular vessel density, foveal avascular zone, and the macular perfusion densities, in amblyopic, fellow, and control eyes using optical coherence…

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Negative / Null Result ReportMedicine

Validity of optical coherence tomography angiography in the differential diagnosis of papilledema and pseudopapilledema.

Cerdan-Hernandez E, Palencia-Herranz MJ, Barón M et al. · 2026 · Journal of optometry

Purpose To assess the value of optical coherence tomography angiography (OCTA) peripapillary retinal vascularization in differentiating papilledema from pseudopapilledema. Methods A cross-sectional study, prospective recruitment patients…

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Negative / Null Result ReportMedicine

Influence of X-ray beam angulation on the radiographic detection of implant-abutment interface misfits: A quantitative in vitro analysis.

Terzioglu H, Efeoglu S, Sarikaya CH et al. · 2026 · Journal of prosthodontics : official journal of the American College of Prosthodontists

Purpose This study evaluated the effect of periapical X-ray angulation on the diagnostic accuracy of detecting vertical misfits at the implant-abutment interface using Medentika Microcone dental implants (4.0 mm diameter, 11 mm length;…

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Negative / Null Result ReportOpen accessMedicine

Effects of dietary chitin supplementation on body weight, haematology and serum biochemistry, fecal scores and gut microbiota of captive pangolins.

Wang X, Xie C, Zheng R et al. · 2026 · Animal microbiome

Termites are a natural component of the diet of Malayan pangolins, whereas artificial diets used under captive conditions may differ substantially from wild prey in structure and composition, particularly in chitin content. This study…

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Negative / Null Result ReportOpen accessMedicine

Transspinal direct current stimulation as targeted therapy to increase motor neuron output and restore inhibition in human spinal cord injury.

Sayed Ahmad AM, Knikou M · 2026 · Frontiers in neurology

Introduction In this clinical trial, we evaluated changes in the output of motoneurons and spinal inhibitory mechanisms across multiple spinal segments before and after a series of transspinal direct current stimulation (tsDCS) sessions in…

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Negative / Null Result ReportOpen accessMedicine

Preclinical Analysis of Sex-Specific Differences in the Angiogenic and Inflammatory Tissue Response to Surgical Sutures.

Wrublewsky S, Weigl J, Bickelmann C et al. · 2026 · Journal of functional biomaterials

Surgical sutures are widely used biomaterials in clinical practice. Like all other biomaterials, they induce a foreign body response after implantation that involves inflammation and angiogenesis. Although it is well known that these…

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Negative / Null Result ReportOpen accessMedicine

N95 filtering facepiece respirator fit assessment outcomes by gender, age, race, and facial hair in a community population sample.

Bagheri Hosseinabadi M, Yu M, Petersen A et al. · 2026 · Annals of work exposures and health

The necessity for respiratory protection has increased due to global threats such as pandemics, industrial accidents, and extreme weather events. The effectiveness of N95 filtering facepiece respirators depends on how well they fit the…

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Negative / Null Result ReportMedicine

Comparable survival over an extended follow-up after on-pump versus off-pump coronary artery bypass grafting: a propensity score-matched cohort.

Pikkujämsä A, Rinne P, Wistbacka JO et al. · 2026 · BMC cardiovascular disorders

Background Long-term survival following off-pump coronary artery bypass grafting (OPCAB) compared with conventional on-pump coronary artery bypass grafting (ONCAB) remains uncertain. Randomised trials and meta-analyses up to 5-10 years…

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Negative / Null Result ReportMedicine

Impact of music intervention on endoscopic retrograde cholangiopancreatography patients' pain, anxiety, and vital signs: a randomized controlled trial.

Çakır E, Ciğerci Y, Yılmaz S · 2026 · Scientific reports

This study aimed to evaluate the effects of a music intervention on anxiety, pain, and vital signs in patients undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP). This randomized controlled trial included 70 patients who…

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Negative / Null Result ReportMedicine

Automated Rigo Classification: An Innovative Artificial Intelligence System.

Schmidt N, Johnson G, Nencka A et al. · 2026 · Studies in health technology and informatics

Although there is variation in clinicians' application of the Rigo classification system (RCS) to adolescent idiopathic scoliosis, no artificial intelligence (AI) models have been developed to standardize the RCS specifically. This study…

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Negative / Null Result ReportMedicine

Mid-term clinical outcomes of mobile-bearing UKA: a retrospective study on the influence of patellofemoral joint disease, lower limb alignment, and implant positioning.

Chen M, Zhang C, Fan Z et al. · 2026 · BMC musculoskeletal disorders

Background Unicompartmental knee arthroplasty (UKA) has become an effective treatment for medial compartment osteoarthritis of the knee. However, its use in patients who also have patellofemoral joint osteoarthritis (PFOA) before surgery…

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