11,310 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Bendtsen AW, Lykkebirk L, Behrens CM et al. · 2026 · Ophthalmic epidemiology
Purpose To examine changes in macular ganglion cell layer (GCL) thickness over five years in a community-based birth cohort of children without ophthalmic disease. Methods This prospective study included 660 children without ophthalmic…
View details →Bandiaky ON, Volteau C, Bihan A et al. · 2026 · The International journal of prosthodontics
Purpose The aim of this study was to evaluate the effect of using the VirTeaSy Dental simulator in conjunction with a virtual reality headset on student performance in conventional fixed prosthodontics simulations. Material and methods The…
View details →Asano T, Uemura K, Higuchi R et al. · 2026 · Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs
Purpose Closed suction drainage has been used after total hip arthroplasty (THA) to prevent hematoma, muscle swelling, and complications, but its effectiveness remains controversial. This study evaluated the effects of drains on…
View details →Osawa Y, Funahashi H, Ido H et al. · 2026 · International orthopaedics
Background Recent advances in navigation systems have enabled more precise osteotomies. However, the clinical outcomes of navigation-assisted transtrochanteric rotational osteotomy (TRO) for osteonecrosis of the femoral head (ONFH) remain…
View details →Sarıyılmaz E, Sarıyılmaz Ö, Sessiz R et al. · 2026 · BMC oral health
Background This study aimed to compare the filling volume and surface area of Biodentine placed in mandibular molar isthmuses using three different compaction techniques (manual, ultrasonic, and sonic endomotor system). Materials and…
View details →Dong M, Liu Y, Wei C · 2026 · BMC surgery
Background To evaluate whether constrained acetabular liners (CAL) used in total hip arthroplasty (THA) reduce the risk of dislocation and related complications in patients with neuromuscular disorders and unstable comminuted femoral…
View details →Marchi MB, Al Harami A, Maher A et al. · 2026 · European journal of ophthalmology
PurposeTo compare the clinical outcomes of conventional photorefractive keratectomy (PRK) and transepithelial PRK (TransPRK) for the correction of myopic refractive errors.MethodsThis prospective, paired-eye comparative study included 48…
View details →Farhadi F, Ahmadpour F, Nezafati S et al. · 2026 · Aesthetic plastic surgery
Background and aim The nasal tip plays a central role in facial aesthetics, and achieving long-term tip stability is a key objective in rhinoplasty. This study compared postoperative tip stability between structural rhinoplasty using a…
View details →Chen X, Xie L, Li B · 2026 · Frontiers in microbiology
Objective Gut microbiota is closely associated with athletic performance, but differences between sport disciplines have rarely been reported. This study collected gut microbiota samples from athletes across different sport disciplines to…
View details →Bruno A, D'Antimi A · 2026 · Aesthetic plastic surgery
Introduction Surgical bleeding remains a key determinant of morbidity in abdominoplasty and lipoabdominoplasty. While hormonal fluctuations during the menstrual cycle have been linked to altered hemostasis in hormonally responsive tissues…
View details →Telles PYV, Oliveira VC, Geng Vivanco R et al. · 2026 · Scientific reports
To evaluate the antibiofilm activity of a chlorine-releasing solution (CRS) and its in vitro effects on enamel color stability, surface roughness, and microhardness. A mixed biofilm composed of Staphylococcus aureus, Candida albicans, and…
View details →Veraza JA, Martinez MA, Angulo P et al. · 2026 · Cureus
Background Intrathecal morphine remains a cornerstone of post-cesarean analgesia due to its prolonged spinal effect; however, its use is limited by dose-dependent adverse effects. Contemporary practice trends favor dose minimization, yet…
View details →Qaraghuli AM, Cagidiaco EF, Ferrari M · 2026 · Journal of functional biomaterials
Background: The application of veneer restorations over previously composite-restored anterior teeth presents significant clinical challenges, particularly in achieving optimal marginal sealing. Aim: This in vitro study aimed to evaluate…
View details →Tanaka T, Tomihari M, Hasegawa T · 2026 · Australian veterinary journal
Primary peritoneal tumours are uncommon and include mesothelioma and carcinoma. Mesothelioma identification is challenging, as there are no established rapid diagnostic methods. In the absence of a simple means of diagnosis, evaluation…
View details →Li Y, Chen C, Wang C · 2026 · Frontiers in gastroenterology (Lausanne, Switzerland)
Objective To investigate the perspectives and clinical practice patterns of inflammatory bowel disease (IBD) physicians regarding the use of 5-aminosalicylic acid (5-ASA) in Crohn's disease (CD). Methods A 21-item questionnaire was…
View details →Mor H, Şar H, Arslan T et al. · 2026 · BMC sports science, medicine & rehabilitation
Background The FIFA 11 + Kids (FIFA 11+) warm-up program is effective for injury prevention and to enhance sports performance, including vertical jump (VJ), sprint, balance, and agility. However, no previous study has examined the acute…
View details →Garrido LM, Duarte MA, Martins MP et al. · 2026 · General dentistry
This in vitro study aimed to compare the effects of conventional and ultrasonic root canal preparation on the adhesion of glass fiber posts to root canal dentin. A total of 20 human maxillary central incisors were instrumented and then…
View details →Reder SR, Hardt J, Brockmann MA et al. · 2026 · PNAS nexus
The aim of this present study was to investigate the multifactorial determinants of recovery outcomes in cerebral aneurysm patients by identifying subgroups based on clinical and psychological factors. A cross-sectional approach was used (…
View details →Devanarayana NM, Rajindrajith S, de Silva DGH et al. · 2025 · World journal of gastrointestinal pathophysiology
Background Functional abdominal pain disorders (FAPDs) are common gut-brain interaction disorders with unclear pathophysiology. While impaired gastrointestinal motility is thought to play a key role, small intestinal dysmotility remains…
View details →Giudice GC, Beckermann KE, Siqueira Do Amaral P et al. · 2025 · JAMA oncology
Importance Immune checkpoint inhibitors have transformed the treatment landscape for metastatic renal cell carcinoma; however, the failure of first-line therapeutic strategies remains a considerable challenge. Currently, clinicians face…
View details →Adio AA, Goyal RK, Skiena A et al. · 2026 · Archives of orthopaedic and trauma surgery
Background Tobacco dependence is well established to impair bone healing and increase postoperative complications. However, the independent effects of nicotine, separate from combustion-related factors, remain unclear. This study aimed to…
View details →Ruiz G, Moyano J, Alcaraz I et al. · 2026 · Dentistry journal
Background/Objectives : Changes in the mechanical behavior of orthodontic archwires during clinical use are not fully understood, particularly when different bracket systems are employed. Self-ligating (SL) brackets have gained…
View details →Delgado Álvarez S, Méndez Sánchez R, Polo Ferrero L et al. · 2026 · Cureus
Introduction Achilles tendinopathy (AT) is characterized by pain, inflammation, and functional limitations. It is also the most common cause of pain located at the back of the calcaneus. The Achilles tendon is among the most vulnerable…
View details →Li J, Shi Y, Meng H et al. · 2026 · BMC nephrology
Background The gut-kidney axis is critical in acute kidney injury (AKI) pathophysiology, but its specific characteristics in intensive care unit (ICU) patients remain unclear. This study aimed to investigate compositional and functional…
View details →Parreiras M, Pinheiro V, Moreira O et al. · 2026 · Animals : an open access journal from MDPI
This study investigated the effects of different inclusion levels of defatted black soldier fly ( Hermetia illucens : BSF) larval meal on growth performance, haematological and biochemical blood parameters, and nutrient digestibility in…
View details →Gan Q, Ma W, Liu L et al. · 2026 · Clinical and experimental reproductive medicine
Objective This study investigated whether changes in embryonic morphological scores can predict pregnancy outcomes to support optimal blastocyst selection. Methods This retrospective dual-center study analyzed 1,492 single blastocyst…
View details →Novotný J, Čumplík L, Horáková L et al. · 2026 · Veterinary and animal science
The study evaluated the effect of feed particle size on health and performance indicators in slow-growing broiler chickens. Performance traits, digestive tract morphology, digesta viscosity, nutrient retention, and blood biochemical…
View details →Einfeldt AK, Tücking L, Savov P et al. · 2026 · Scientific reports
The current literature remains inconclusive about whether kinematic alignment (KA) is superior to mechanical alignment (MA) in total knee arthroplasty (TKA). Therefore, this randomized controlled trial sought to provide further…
View details →Jansen EE, Braun A, Jansen P et al. · 2026 · BMC oral health
Background Autologous platelet concentrates (PRP, PRF, i-PRF) represent blood-derived biomaterials that have been reported to exhibit antimicrobial activity against oral microorganisms in vitro. In diffusion-based assays, visualization of…
View details →Morley-Hart R, Losco B, Dempsey AR et al. · 2026 · Chiropractic & manual therapies
Background The back squat is a commonly prescribed exercise for developing lower body strength. The ability to squat can be affected by reduced ankle dorsiflexion range of motion (DF-ROM), leading to limited squat depth and dysfunctional…
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