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Browse the failure-mode index

11,310 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Evaluation of physicomechanical and optical properties of bioactive glass (BAG)-filled resin composites: an <i>in vitro</i> study.

de Santana YVS, Vasconcelos EEM, de Melo Monteiro GQ et al. · 2026 · Biomaterial investigations in dentistry

Objective To evaluate the behavior of bioactive glass (BAG)-filled resin composites (Beautifil II / Shofu-BR and Beautifil Flow Plus / Shofu-BF) compared with conventional resin composites (Filtek Z350 XT / Solventum-ZR and Filtek Supreme…

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Negative / Null Result ReportMedicine

Comparison of functional outcomes between medialized and lateralized reverse shoulder prostheses in acute proximal humerus fractures.

Delgado-Flores L, Pérez-Abad M, Di Felice Ardente P et al. · 2026 · Journal of orthopaedic surgery and research

Hypothesis/background Reverse shoulder arthroplasty (RSA) is increasingly used for complex proximal humerus fractures (PHFs). Although lateralized designs have demonstrated advantages in elective indications, their role in acute PHFs…

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Negative / Null Result ReportMedicine

Analysis of Contrast-enhanced CT Radiation Dose in Children.

Wang F, Sheng J, Zhang G et al. · 2026 · Health physics

Reducing radiation exposure in pediatric imaging is a key focus globally, and it is necessary to establish diagnostic reference levels (DRLs) for contrast-enhanced computed tomography (CT) in children. This study assesses typical radiation…

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Negative / Null Result ReportMedicine

Investigation of the effectiveness of different suture materials used in impacted mandibular third molar extractions on wound healing and clinical features.

Ömezli MM, Torul D, Doğanay Z · 2026 · Quintessence international (Berlin, Germany : 1985)

Purpose The aim of this study was to explore the physical and clinical efficacy of different suture materials used following impacted third molar surgery. Patients and methods This retrospective study included patients who underwent…

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Negative / Null Result ReportOpen accessMedicine

Metabolic profiles show few differences in serum amino acid, one-carbon, and fatty acid compounds in dogs fed a plant-based ("vegan") or meat-based diet.

Dodd SAS, Adolphe JL, Shoveller AK et al. · 2025 · Frontiers in veterinary science

Introduction Dogs are omnivores, not herbivores, and yet entirely plant-based diets are formulated to meet their current known nutrient recommendations. However, little is known about the metabolic effects of feeding diets containing no…

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Negative / Null Result ReportMedicine

Comparison of first trimester complete blood count parameters in missed abortion and healthy pregnant women: a retrospective case-control study.

Tural E, Coşkun ADE, Demi̇r D et al. · 2026 · BMC pregnancy and childbirth

Background The aim of our study is to compare the markers and parameters obtained from complete blood count between patients diagnosed with missed abortion in the first trimester and a healthy pregnant control group. Materials and methods…

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Negative / Null Result ReportOpen accessMedicine

Physiological and growth responses to replacing corn gluten with corn fermented protein in diets for juvenile European sea bass: growth performance, intestinal morphology and fillet quality.

Yılmaz E, Güler M, Midilli S et al. · 2026 · Fish physiology and biochemistry

This study evaluated the effects of replacing corn gluten with corn fermented protein in the diets of European sea bass (Dicentrarchus labrax) juveniles (25.9 ± 0.2 g) during a 60-day feeding trial. Four experimental diets were prepared by…

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Negative / Null Result ReportMedicine

Neuromuscular and Subjective Recovery Responses to Day and Night Fixtures During Congested and Noncongested Microcycles in Professional Soccer Players.

Mukandi I, Turner A, Bishop C et al. · 2026 · Journal of strength and conditioning research

Abstract Mukandi, I, Turner, A, Bishop, C, Beato, M. Neuromuscular and subjective recovery responses to day and night fixtures during congested and noncongested microcycles in professional soccer players. J Strength Cond Res XX(X):…

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Negative / Null Result ReportMedicine

More pronounced effects of the extent of discectomy over the extent of laminectomy on postoperative biomechanics and clinical outcomes in unilateral biportal endoscopy for lumbar disc herniation.

Wang F, Wang T, Lu G et al. · 2026 · Journal of orthopaedic surgery and research

Background Unilateral biportal endoscopy (UBE) can be performed to treat lumbar disc herniation (LDH). Nevertheless, the postoperative clinical outcomes and spinal biomechanical implications following partial discectomy and laminectomy,…

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Negative / Null Result ReportOpen accessMedicine

Radiofrequency Fields at 2.45 GHz Reprogram Mitochondria-Lysosome Crosstalk and Modulate the Survival/Death of Macrophages Exposed to LPS and/or the SARS-CoV-2 Spike Protein.

Sueiro-Benavides RA, Leiro-Vidal JM, Rodríguez-González JA et al. · 2026 · International journal of molecular sciences

The redox mechanisms of RAW 264.7 macrophages exposed to 2.45 GHz RF-EMF at subthermal specific absorption rates and to lipopolysaccharide (LPS) and/or the SARS-CoV-2 spike protein (CSP) were investigated. To this end, cellular responses…

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Negative / Null Result ReportOpen accessMedicine

Toxicological Relevance of Biogenic Amines in Honey: Dietary Exposure and Integrated Risk Indicators in Algerian and Moroccan Honeys.

Bruno F, Bruschetta G, Miller A et al. · 2026 · Foods (Basel, Switzerland)

Biogenic amines are nitrogenous compounds that may occur in foods through plant metabolism, bee enzymatic activity, or microbial decarboxylation. This study evaluated biogenic amines content in monofloral honeys from Algeria and Morocco,…

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Negative / Null Result ReportMedicine

[Analysis of the prevalence characteristics and trends of allergen-specific IgE levels in a children's hospital in Wuhan City from 2019 to 2024].

Liu YH, Du Q, Zhang MR et al. · 2026 · Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]

Objective: To investigate the changes in the positive rate of specific immunoglobulin E (sIgE) for inhalant and ingestive allergens in children at a certain children's hospital in Wuhan City from 2019 to 2024, and to analyze the…

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Negative / Null Result ReportMedicine

Local Delivery of Tranexamic Acid and Dexamethasone via Piezoelectric Irrigationin Rhinoplasty: A Prospective Double-Blind Comparative Study of Early Postoperative Morbidities.

Gunay G, Ece M, Beloglu Tonyali Y et al. · 2026 · The Journal of craniofacial surgery

This study aimed to evaluate the effects of adding tranexamic acid (TXA) and dexamethasone to the irrigation solution of a piezoelectric device during open rhinoplasty on postoperative periorbital edema, ecchymosis, and pain. In this…

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Negative / Null Result ReportOpen accessMedicine

Microscopic and computational analysis of the stomach, duodenum, and liver of rats with induced hyperprolactinemia treated with exogenous melatonin.

da Silva JV, da Silva RC, Ferreira RGDS et al. · 2026 · Frontiers in veterinary science

Introduction This study evaluated the effects of exogenous melatonin (MEL) on morphological and computational alterations in the stomach, duodenum, and liver of hyperprolactinemic rats. Methods Twenty-four animals were divided into three…

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Negative / Null Result ReportMedicine

The application of internal ring closure in laparoscopic transabdominal preperitoneal (TAPP) repair for large indirect inguinal hernias: a retrospective study of 162 cases.

Liu M, Shen X · 2026 · Langenbeck's archives of surgery

Purpose Patients with primary unilateral indirect inguinal hernias and large internal inguinal rings have a higher incidence of seroma formation following laparoscopic transabdominal preperitoneal (TAPP) hernia repair. This study aims to…

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Negative / Null Result ReportMedicine

Acetabular cup orientation differs across surgical approaches in primary total hip arthroplasty: a retrospective analysis.

Chimeno-Pigrau C, Fernández-Valencia JA, Alías A et al. · 2026 · International orthopaedics

Purpose Accurate acetabular cup positioning is crucial in primary total hip arthroplasty (THA), as malposition is associated with instability and early failure. We hypothesized that acetabular cup orientation may differ according to the…

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Negative / Null Result ReportOpen accessMedicine

Psychostimulant effects on motor and cognitive function in adults attention deficit hyperactivity disorder.

Cundari M, Kanold L, Bergwall D et al. · 2026 · The international journal of neuropsychopharmacology

Objectives This study aims to compare the performance on motor and cognitive functions of adult patients with attention deficit hyperactivity disorder (ADHD) with or without psychostimulant medication and controls. A secondary objective is…

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Negative / Null Result ReportMedicine

Obstetric and perinatal outcomes in twin pregnancies conceived through assisted reproduction: A retrospective cohort study.

Izbizky GH, Sevillano G, Abramor RM et al. · 2026 · Archivos argentinos de pediatria

Introduction. Multiple pregnancies are more frequently associated with adverse maternal and neonatal outcomes. The incidence of multiple pregnancies has increased with the use of assisted reproductive technologies (ART): they account for…

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