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Browse the failure-mode index

11,412 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Risk of major bleeding events associated with concomitant use of selective serotonin reuptake inhibitors and anti-thrombotic drugs: a nationwide case-case-time-control study.

Kim S, Kim JH, Shin JY et al. · 2026 · Age and ageing

Background Depression is common in older adults, who are also at elevated risk of bleeding due to age-related physiological changes and comorbidities. Concerns have been raised regarding potential bleeding risk from concomitant use of…

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Negative / Null Result ReportOpen accessMedicine

Postoperative radiotherapy improves overall survival and was not associated with a statistically significant increase in cardiac-specific mortality in thymoma patients: a propensity score-matched analysis of the SEER database.

Wang R, Dai P, Deng X et al. · 2026 · Journal of thoracic disease

Background Thymoma is an uncommon cancer of the thymus and postoperative radiotherapy (PORT) is often considered for selected patients with high-risk or locally advanced thymoma after resection. The effect of PORT on overall survival (OS)…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of Differences in Imaging Findings on Stress-MRI in Throwing Athletes With and Without a History of Ulnar Collateral Ligament Reconstruction.

Patel M, Schwartz K, Schenk M et al. · 2026 · Orthopaedic journal of sports medicine

Background Ulnar collateral ligament (UCL) reconstruction (UCLR) of the elbow is common in throwing athletes and reliably allows return to play. The literature supports stress imaging of the elbow to evaluate the integrity of the UCL. The…

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Negative / Null Result ReportOpen accessMedicine

Impact of a Routine Third Trimester Ultrasound Policy on Obstetric, Neonatal and Service Delivery Outcomes in an Australian Tertiary Centre.

Kumar P, Gordon A, Fisher E et al. · 2026 · The Australian & New Zealand journal of obstetrics & gynaecology

Background Routine third trimester ultrasound scans have been introduced in several maternity centres to increase detection of fetal growth disorders and improve perinatal outcomes. Aims To assess changes in obstetric and neonatal outcomes…

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Negative / Null Result ReportOpen accessMedicine

Photobiomodulation at 830 nm with 5 J/cm<sup>2</sup> does not promote PI3K/AKT/mTOR signalling pathway activation in hyperglycemic wounded cells.

Kasowanjete P, Dhilip Kumar SS, Houreld N · 2026 · Lasers in medical science

The phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), mammalian target of rapamycin (mTOR) (PI3K/AKT/mTOR) pathway regulates cell survival, proliferation, and the synthesis of protein. Photobiomodulation (PBM) stimulates…

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Negative / Null Result ReportOpen accessMedicine

The effect of sodium bicarbonate mini-tablets in a carbohydrate hydrogel on prolonged high-intensity cycling performance and metabolism in acute normobaric hypoxia.

Shannon ES, Sparks SA, McNaughton LR et al. · 2026 · European journal of applied physiology

PURPOSE: Hydrogen cation (H+) accumulation is exacerbated in hypoxia. Sodium bicarbonate (NaHCO3) ingestion can reduce fatigue associated with high-intensity exercise performance by counteracting H+ ion accumulation. The present study…

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Negative / Null Result ReportOpen accessMedicine

Comparison of root coverage by injectable-platelet rich fibrin in thick and thin phenotypes: a parallel-armed, prospective, preliminary clinical study with up to 48 months of follow-up.

Ayyildiz BG, Terzioglu B, Eken S · 2026 · Journal of applied oral science : revista FOB

Objective This study aimed to compare the effectiveness of injectable platelet-rich fibrin (I-PRF) using a submucosal injection technique for creeping attachment in thin and thick phenotypes with gingival recession. Methodology The study…

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Negative / Null Result ReportMedicine

Female reproductive toxicity induced by nitrate in drinking water and the comparative ameliorative effects of ascorbic acid, curcumin and their combination.

Sharma M, Kaur N · 2026 · Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes

The reproductive toxicity of nitrate in juvenile and adult female rats, and its amelioration with ascorbic acid, curcumin or their combination, was studied. Rats were classified into five groups: control, nitrate, nitrate + ascorbic acid,…

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Negative / Null Result ReportOpen accessMedicine

National Football League (NFL) "Dynamic Kickoff" Rule Change: A Comparative Analysis of Concussion and Musculoskeletal Injury Incidence.

Puga T, Haechten T, Cush C et al. · 2025 · Orthopaedic journal of sports medicine

Background Kickoffs in the National Football League (NFL) are historically one of the most dangerous plays during an NFL game, with high levels of injuries. In 2024, the NFL introduced new rules aimed at reducing injuries during kickoffs,…

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Negative / Null Result ReportMedicine

Multidimensional Predictors of Ranking-Based Competitive Success in National-Level Junior Tennis Players: Evidence for the Dominant Role of Physical Performance.

Géczi R, Géczi G, Tóth L · 2026 · Sports (Basel, Switzerland)

The aim of this study was to examine the relative contribution of physical performance, executive functions, and competitive anxiety to competitive success in junior tennis players. A total of 39 national-level junior athletes (20 males,…

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Negative / Null Result ReportMedicine

Assessment of the relationship between sustainable and healthy eating behaviours, acceptance of alternative protein sources (plant-based products, mushroom protein, algae, artificial meat, edible insects) and food neophobia in young adults.

Karahan Yılmaz S, Güldüren S · 2026 · Nutricion hospitalaria

Introduction Introduction: a growing world population, constraints on natural resources and changing nutritional preferences all point to the need to find an alternative to traditional animal protein sources however food neophobia can come…

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Negative / Null Result ReportMedicine

Haemoglobin threshold-based blood transfusion practices in patients following hip fracture surgery: a multicentre retrospective study.

Berube M, Bortman JM, Law AC et al. · 2026 · Hip international : the journal of clinical and experimental research on hip pathology and therapy

Background The optimal threshold to blood transfusion in patients after hip fracture surgery is unclear. This study leveraged regression discontinuity to quantify blood transfusion practices across haemoglobin thresholds of 7.0, 8.0, and…

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Negative / Null Result ReportMedicine

Expression of tardigrade extremotolerance-associated proteins improves recovery but not acute stress response of human microvascular endothelial cells.

Darch W, Soliman J, Higgins NC et al. · 2026 · Scientific reports

Vascular endothelial cells (VECs) play a critical role in tissue and organ homeostasis, wound healing, and immune function. VECs are commonly utilized for in vitro cell culture and in vivo tissue engineering applications which experience…

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Negative / Null Result ReportMedicine

Microsurgical Denervation of the Penis for Lifelong Premature Ejaculation: A Prospective Multicenter Study Evaluating Technique Modification and Early Clinical Outcomes.

Almekaty K, Alhefnawy M, Ismael A et al. · 2026 · Urology

Objective To prospectively assess the clinical outcomes and safety of microsurgical denervation of the penis (MSDP) for treatment of lifelong premature ejaculation (LPE); and to examine the impact of transitioning from partial to more…

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Negative / Null Result ReportMedicine

Dento-facial changes and oral health-related quality of life assessment in management of anterior crossbite in mixed dentition: a randomized clinical trial.

Salem AS, Albelasy NF, El-Bialy AA · 2026 · The Angle orthodontist

Objectives To compare the effectiveness of clear aligner (CA) vs removable inclined plane (RP) in improving the dentofacial changes and oral health-related quality of life (OHRQoL) in children with anterior crossbite in the mixed…

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Negative / Null Result ReportMedicine

Size Dependent Effects of Aluminum Oxide Particles on Tissue Accumulation and Antioxidant Enzyme Activities of Oreochromis niloticus.

Tuncsoy M, Tuncsoy B · 2026 · Bulletin of environmental contamination and toxicology

Aluminum (Al) is a widely occurring element in nature and is the most abundant element in the earth's crust after oxygen and silicon. In this study, metal accumulation levels in the gills, liver and muscle tissues and liver SOD, CAT and…

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Negative / Null Result ReportMedicine

Conversion Rates From Initial Consultation to Bariatric Surgery: A Single-Center Community Practice Experience.

McDonough W, Gevorkian J, Wong D et al. · 2026 · Surgical laparoscopy, endoscopy & percutaneous techniques

Background As part of the accreditation process for bariatric surgery, patients must go through a preoperative pathway. There will inevitably be patients who are seen in the clinic but never undergo surgery. This rate of attrition is…

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Negative / Null Result ReportOpen accessMedicine

Pemafibrate therapy increases serum zinc levels in patients with metabolic dysfunction-associated steatohepatitis: a prospective study.

Wakui N, Ogino Y, Nagumo H et al. · 2026 · BMC gastroenterology

Background Zinc deficiency is common in chronic liver disease and is closely associated with the progression of hepatic fibrosis and metabolic dysfunction. Although pemafibrate, a selective peroxisome proliferator-activated receptor alpha…

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