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Browse the failure-mode index

11,310 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Changes in sulphur content, uptake, internal efficiency index, harvest index and N:S ratio in pea plants from the four-leaf stage to full maturity.

Wysokinski A, Wiśniewska-Kadżajan B, Łozak I · 2026 · BMC plant biology

Background Sulphur is an important macronutrient for legume plants because it influences the formation and functioning of root nodules, the activity of enzymes reducing molecular nitrogen to available forms for plants, the formation of…

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Negative / Null Result ReportMedicine

Clinical course of Graves' orbitopathy in children with newly diagnosed hyperthyroidism: a prospective observational study.

Tepe D, Deligozoglu D, Baskan C et al. · 2026 · Journal of pediatric endocrinology & metabolism : JPEM

Objectives Although Graves' orbitopathy (GO) in childhood is generally considered milder than in adults, data regarding its clinical course and relationship with thyroid autoimmunity remain limited. This study aimed to evaluate the…

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Negative / Null Result ReportMedicine

Phase III maintenance telerehabilitation in elderly patients with chronic heart failure and type 2 diabetes (TELEMECHRON study).

Scalvini S, Donati V, Zanelli E et al. · 2026 · European journal of internal medicine

Background Heart failure (HF) and type 2 diabetes (T2DM) are significant public health concerns. This study evaluated a 6-month home-based telemedicine program for older patients with combined HF and T2DM. The primary outcome was exercise…

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Negative / Null Result ReportMedicine

Real-world impact of artificial intelligence on adenoma detection: A cross-sectional study at a single center in Lima, Peru.

Guillen B, Zambrano-Huailla R, Chirinos JA · 2026 · Revista de gastroenterologia de Mexico (English)

Introduction The use of artificial intelligence (AI) in endoscopic studies has grown in recent years. The present study evaluates the performance of AI in detecting polyps and adenomas in daily clinical practice. Materials and methods A…

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Negative / Null Result ReportMedicine

A Follow-Up Study of the Supraaortic and Intracranial Vessels, Cerebrovascular Reactivity, Brain Vascular Lesions and Atrophy in Patients with Rheumatoid Arthritis.

Sas A, Jónyer D, Valikovics A et al. · 2026 · Journal of clinical medicine

Background/Objectives: Rheumatoid arthritis (RA) has been associated with accelerated atherosclerosis and cerebrovascular alterations. Our 2017 study compared 60 RA patients to healthy controls, assessing vascular, neurological, and…

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Negative / Null Result ReportMedicine

Thrombotic Outcomes Associated With Factor Eight Inhibitor Bypassing Activity Use in Neonatal and Infant Cardiac Surgery Including the Norwood Procedure: A Propensity Score‒Matched Analysis.

Houska N, McCaw N, Meneses EC et al. · 2026 · Journal of cardiothoracic and vascular anesthesia

Objectives To describe thrombotic outcomes associated with Factor Eight Inhibitor Bypassing Activity (FEIBA) exposure in neonates and infants undergoing cardiac surgery with cardiopulmonary bypass (CPB), including the Norwood procedure.…

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Negative / Null Result ReportMedicine

Comparison of pain perception and heart rate between Dentapen and Vibraject during local anesthesia administration in adult patients: a randomized clinical study.

Almuashi H, AbuMostafa A · 2026 · Quintessence international (Berlin, Germany : 1985)

Objective The management of pain in dental procedures is crucial, as local anesthetic injections may induce patient anxiety and discomfort. Various techniques including Vibraject and Dentapen have been devised to alleviate injection…

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Negative / Null Result ReportMedicine

Trends and regional inequalities in cerebrovascular disease mortality in Peru: An ecological time-series analysis, 2017-2025.

Veli-Quispe D, Urquizo-Prado S, Cesare-Ariza E et al. · 2026 · Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Background Cerebrovascular disease remains a leading cause of mortality worldwide. In Peru, evidence on recent mortality trends and regional disparities is limited. Objective To evaluate temporal trends and regional disparities in…

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Negative / Null Result ReportMedicine

Impact of Aflibercept Dosing Frequency on Retinal Nonperfusion Progression Assessed by Ultra-Widefield Angiography After Endolaserless Vitrectomy for Proliferative Diabetic Retinopathy-Related Vitreous Hemorrhage.

Qin LG, Camarda ND, Kasetty VM et al. · 2026 · Journal of vitreoretinal diseases

Purpose: To investigate the effect of intravitreal (IVT) aflibercept injection monotherapy on retinal ischemia in eyes with severe proliferative diabetic retinopathy (PDR) that underwent pars plana vitrectomy (PPV) without panretinal…

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Negative / Null Result ReportMedicine

Effect of dietary carrageenan supplementation on growth performance, digestive enzyme and antioxidant enzyme activity, immune gene expression, and capacity against S. agalactiae of Nile tilapia (Oreochromis niloticus).

Ramachandran I, Rajesh AT, Elumalai P · 2026 · Fish physiology and biochemistry

The current study aimed to ascertain the growth, antioxidant capacity, intestinal architecture, digestive enzyme activity, and disease resistance of S. agalactiae of Nile tilapia (Oreochromis niloticus) fed a diet enriched with…

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Negative / Null Result ReportMedicine

Risk of major bleeding events associated with concomitant use of selective serotonin reuptake inhibitors and anti-thrombotic drugs: a nationwide case-case-time-control study.

Kim S, Kim JH, Shin JY et al. · 2026 · Age and ageing

Background Depression is common in older adults, who are also at elevated risk of bleeding due to age-related physiological changes and comorbidities. Concerns have been raised regarding potential bleeding risk from concomitant use of…

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Negative / Null Result ReportOpen accessMedicine

Postoperative radiotherapy improves overall survival and was not associated with a statistically significant increase in cardiac-specific mortality in thymoma patients: a propensity score-matched analysis of the SEER database.

Wang R, Dai P, Deng X et al. · 2026 · Journal of thoracic disease

Background Thymoma is an uncommon cancer of the thymus and postoperative radiotherapy (PORT) is often considered for selected patients with high-risk or locally advanced thymoma after resection. The effect of PORT on overall survival (OS)…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of Differences in Imaging Findings on Stress-MRI in Throwing Athletes With and Without a History of Ulnar Collateral Ligament Reconstruction.

Patel M, Schwartz K, Schenk M et al. · 2026 · Orthopaedic journal of sports medicine

Background Ulnar collateral ligament (UCL) reconstruction (UCLR) of the elbow is common in throwing athletes and reliably allows return to play. The literature supports stress imaging of the elbow to evaluate the integrity of the UCL. The…

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Negative / Null Result ReportOpen accessMedicine

Impact of a Routine Third Trimester Ultrasound Policy on Obstetric, Neonatal and Service Delivery Outcomes in an Australian Tertiary Centre.

Kumar P, Gordon A, Fisher E et al. · 2026 · The Australian & New Zealand journal of obstetrics & gynaecology

Background Routine third trimester ultrasound scans have been introduced in several maternity centres to increase detection of fetal growth disorders and improve perinatal outcomes. Aims To assess changes in obstetric and neonatal outcomes…

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Negative / Null Result ReportOpen accessMedicine

Photobiomodulation at 830 nm with 5 J/cm<sup>2</sup> does not promote PI3K/AKT/mTOR signalling pathway activation in hyperglycemic wounded cells.

Kasowanjete P, Dhilip Kumar SS, Houreld N · 2026 · Lasers in medical science

The phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), mammalian target of rapamycin (mTOR) (PI3K/AKT/mTOR) pathway regulates cell survival, proliferation, and the synthesis of protein. Photobiomodulation (PBM) stimulates…

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Negative / Null Result ReportOpen accessMedicine

The effect of sodium bicarbonate mini-tablets in a carbohydrate hydrogel on prolonged high-intensity cycling performance and metabolism in acute normobaric hypoxia.

Shannon ES, Sparks SA, McNaughton LR et al. · 2026 · European journal of applied physiology

PURPOSE: Hydrogen cation (H+) accumulation is exacerbated in hypoxia. Sodium bicarbonate (NaHCO3) ingestion can reduce fatigue associated with high-intensity exercise performance by counteracting H+ ion accumulation. The present study…

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Negative / Null Result ReportOpen accessMedicine

Comparison of root coverage by injectable-platelet rich fibrin in thick and thin phenotypes: a parallel-armed, prospective, preliminary clinical study with up to 48 months of follow-up.

Ayyildiz BG, Terzioglu B, Eken S · 2026 · Journal of applied oral science : revista FOB

Objective This study aimed to compare the effectiveness of injectable platelet-rich fibrin (I-PRF) using a submucosal injection technique for creeping attachment in thin and thick phenotypes with gingival recession. Methodology The study…

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Negative / Null Result ReportMedicine

Female reproductive toxicity induced by nitrate in drinking water and the comparative ameliorative effects of ascorbic acid, curcumin and their combination.

Sharma M, Kaur N · 2026 · Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes

The reproductive toxicity of nitrate in juvenile and adult female rats, and its amelioration with ascorbic acid, curcumin or their combination, was studied. Rats were classified into five groups: control, nitrate, nitrate + ascorbic acid,…

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Negative / Null Result ReportOpen accessMedicine

National Football League (NFL) "Dynamic Kickoff" Rule Change: A Comparative Analysis of Concussion and Musculoskeletal Injury Incidence.

Puga T, Haechten T, Cush C et al. · 2025 · Orthopaedic journal of sports medicine

Background Kickoffs in the National Football League (NFL) are historically one of the most dangerous plays during an NFL game, with high levels of injuries. In 2024, the NFL introduced new rules aimed at reducing injuries during kickoffs,…

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