e-ISSN: Pending

Browse the failure-mode index

11,310 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

The Effects of Geranylgeraniol Supplementation on Testosterone in Middle-Aged Healthy Adults: An 18-Week, Single-Group Crossover Placebo-Controlled Trial.

Jurgelewicz M, D'Adamo CR, Malaya CA · 2026 · Integrative medicine (Encinitas, Calif.)

Background Geranylgeraniol (GG) is a naturally occurring isoprenoid that is involved in steroid hormone synthesis, the endogenous production of coenzyme Q10 (CoQ10), healthy muscle function, bone metabolism, and cellular energy production.…

View details →
Negative / Null Result ReportMedicine

Barriers, facilitators and promising interventions for reducing sedentary behaviour during and after stroke rehabilitation - A scoping review.

Te Lindert L, van Meijeren-Pont W, Meesters J et al. · 2026 · Disability and rehabilitation

Purpose Reducing sedentary behaviour (SB) in stroke rehabilitation is essential, yet effects of most interventions remain limited. This review used the Behaviour Change Wheel to identify: (1) barriers and facilitators for reducing SB of…

View details →
Negative / Null Result ReportMedicine

SlROP4 negatively regulates drought tolerance in tomato.

Cheng C, Li M, Sun B et al. · 2026 · Plant science : an international journal of experimental plant biology

Rho-like GTPases of plants (ROPs) regulate diverse cellular processes, but their roles in tomato drought responses are largely unknown. In this study, nine ROP genes were identified in tomato (Solanum lycopersicum). Among them, SlROP4, the…

View details →
Negative / Null Result ReportOpen accessMedicine

Effects of Phenolic-Rich Extra Virgin Olive Oil and Prebiotics on Sarcopenia in Older Adults: FOOP-Sarc Project.

Besora-Moreno M, Jiménez-Ten Hoevel C, Queral J et al. · 2026 · Journal of cachexia, sarcopenia and muscle

Background Management of sarcopenia by nutritional and lifestyle interventions is a challenge. The aim is to assess the effectiveness of a phenolic-rich extra virgin olive oil (EVOO), alone or combined with a prebiotic (PREB)…

View details →
Negative / Null Result ReportOpen accessMedicine

Lumbar Plexus Block

Yao PY, Hendrix JM · 2026

The concept of a regional anesthesia technique that provides neural blockade of the entire lumbar plexus, a lumbar plexus block, dates back nearly 50 years. The first description of such a block by Winnie et al in 1973 was an “inguinal…

View details →
Negative / Null Result ReportOpen accessMedicine

Features and trends of marine heat waves and marine cold spells along the Western Iberian Coast from four decades of satellite data.

Biguino B, Haigh ID, Dias JM et al. · 2025 · Scientific reports

Marine Heat Waves (MHWs) have been the focus of numerous studies due to the dramatic consequences they can have on coastal systems. However, Marine Cold Spells (MCSs) can also have harmful effects on the environment while play an important…

View details →
Negative / Null Result ReportMedicine

Inclusion of high-pressure-treated grape pomace to modulate barbecued Frankfurter sausages: insights into oxidation and PAH generation during barbecuing.

Andrés AI, Martín-Mateos MJ, D'Arrigo M et al. · 2026 · Food chemistry

This study evaluated the effects of high hydrostatic pressure (HHP)-treated white (WGP) and red grape pomace (RGP) on oxidative stability, volatile compounds, and polycyclic aromatic hydrocarbons (PAHs) in barbecued Frankfurter sausages.…

View details →
Negative / Null Result ReportOpen accessMedicine

Investigating cycle-to-cycle variation and the impact of endometrial injury through differential gene expression analysis.

Teh WT, Chung J, Donoghue JF et al. · 2026 · Human reproduction (Oxford, England)

Study question Does endometrial gene expression change across consecutive cycles and after endometrial injury? Summary answer Although paired endometrial samples collected from the same woman across two consecutive cycles show greater…

View details →
Negative / Null Result ReportMedicine

Effect of Tai Chi vs. Strength Training on Body Composition, Physical Performance, and Well-Being in Community-Dwelling Older Mexican Women.

Flores-Bello C, Correa-Muñoz E, Sánchez-Rodríguez MA et al. · 2026 · Healthcare (Basel, Switzerland)

Background/Objectives : Tai Chi (TC) practice has been shown to positively affect the physical, psychological, and cognitive health of older adults. However, discrepancies persist regarding its effectiveness compared to strength training…

View details →
Negative / Null Result ReportMedicine

Pharmacokinetics, pharmacodynamics, and radiomitigative efficacy of IEPA in a non-human primate model of acute radiation syndrome.

Wesolowski R, Asang C, Eibl M et al. · 2026 · International journal of radiation biology

Purpose The acute radiation syndrome (ARS) represents a significant public health threat following nuclear exposure, with limited available medical countermeasures (MCMs). Imidazolyl ethanamide pentandioic acid (IEPA), a novel orally…

View details →
Negative / Null Result ReportMedicine

[Translated article] Is one year follow-up sufficient to assess functional outcomes after rotator cuff repair?

Pasqualini I, Lucero Viviani N, Turan O et al. · 2026 · Revista espanola de cirugia ortopedica y traumatologia

Background Arthroscopic rotator cuff repair (ARCR) traditionally requires a 2-year follow-up to report results. However, most of the recovery occurs within the first year. The aim of this study was to determine if there are clinically…

View details →
Negative / Null Result ReportOpen accessMedicine

IL-18 and MIG increase one year after transition to dolutegravir-based dual therapy despite sustained viral suppression.

Pérez-González A, Alonso-Domínguez J, Martínez-Barros I et al. · 2026 · Frontiers in immunology

Introduction Modern antiretroviral treatment allowed a significant improvement in the life expectancy of people with HIV (PWH), exhibiting robust and sustained efficacy with scarce toxicities, both in two-drug regimens (2DRs) and…

View details →
Negative / Null Result ReportMedicine

Condylar Positional Changes Following Manual Proximal Segment Positioning During Bilateral Sagittal Split Ramus Osteotomy: A Cephalometric Study.

Tanrısever NC, Gökalp H · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Maintenance of condylar position during bilateral sagittal split ramus osteotomy (BSSRO) is important for preserving temporomandibular joint biomechanics and skeletal stability. During surgery, loss of muscle…

View details →
Negative / Null Result ReportMedicine

Efficacy of nonablative radiofrequency on sexual function in postmenopausal women: a randomized clinical trial.

Quezada-Bascuñán C, Ferri-Morales A, Martínez-Vizcaíno V et al. · 2026 · Menopause (New York, N.Y.)

Objective To evaluate the efficacy of nonablative capacitive-resistive monopolar radiofrequency on sexual function and vaginal health in postmenopausal women with genitourinary syndrome of menopause. Methods This was a single-blind,…

View details →
Negative / Null Result ReportOpen accessMedicine

Effect of <i>Bacillus coagulans</i> DSM 32016 (TechnoSpore<sup>®</sup>) Supplementation on Growth Performance and Selected Blood Parameters and Serum Urea in Weaning Danube White Pigs.

Eneva K, Yordanova G, Petrova M et al. · 2026 · Life (Basel, Switzerland)

The present study evaluated the effects of dietary supplementation with Bacillus coagulans DSM 32016 on growth performance, hematological and biochemical parameters, and nitrogen metabolism in weaned Danube White pigs reared under standard…

View details →
Negative / Null Result ReportOpen accessMedicine

Salivary responses to an experimental activation of the HPA axis in pigs: Effects of ACTH on analytes related to stress, immune system, inflammation, redox status and metabolism.

Botía M, Cerón JJ, Martínez-Subiela S et al. · 2026 · Veterinary and animal science

Non-invasive biomarkers are essential for assessing stress and welfare. Saliva is a suitable sample type because it can reflect endocrine, immune, inflammatory and redox responses without causing stress from handling. This study examined…

View details →
Negative / Null Result ReportMedicine

No evidence for depletion of circulating lymphocyte populations in primary brain tumor patients receiving radiotherapy alone.

Beekman C, Morita S, Neibart S et al. · 2026 · International journal of radiation oncology, biology, physics

Purpose To investigate the impact of radiotherapy (RT) for brain tumors on circulating lymphocyte populations and understand this from a dosimetric perspective. Methods This prospective study enrolled primary brain tumor patients treated…

View details →
Negative / Null Result ReportMedicine

Comparison of the Effects of Incubator and Radiant Environments on Physiological Criteria and Pain-Stress Levels during Heel Lance in Neonates in the Neonatal Intensive Care Unit: A Randomized Controlled Trial.

Gürsu S, Saydam BK, Kalkanlı O · 2026 · Saudi medical journal

Objectives To compare the effects of incubator and radiant heat on physiological criteria and pain-stress levels during heel prick procedures in newborns in the neonatal intensive care unit (NICU). Methods This randomized controlled…

View details →