11,310 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Salimi Y, Namdarzadeh B, Aarani FD et al. · 2026 · Behavioural brain research
The gut-brain axis plays a key role in the bidirectional communication between the gastrointestinal system and the brain, with gut microbiota significantly influencing cognitive function. While synbiotic and probiotic interventions have…
View details →Sudhakar S, Mishra VK, Harikrishna S et al. · 2026 · Physical chemistry chemical physics : PCCP
Human PrimPol (hPrimPol) is the primase and polymerase enzyme involved in reinitiating DNA replication at stalled replication forks. The hPrimPol mutants are linked to multiple ophthalmoplegic conditions and mitochondriopathies. The WFYY…
View details →Sanmartino F, Rashid-López R, López-Sosa F et al. · 2026 · International journal of neural systems
Resting-state eye conditions modulate cortical oscillations, but their impact on subthalamic nucleus (STN) and cortico-STN dynamics in Parkinson's disease (PD) remains poorly understood. Here, we characterized electrophysiological changes…
View details →Mabkhot BA, Taha SEE, Kamel MH et al. · 2026 · BMC oral health
BACKGROUND: Subgingival crown margins have been linked to chronic gingival inflammation in pediatric patients. This clinical trial evaluated periodontal outcomes in first permanent molars that had undergone root canal therapy and were…
View details →Koper M, Jaworska K, Kopacz W et al. · 2026 · Kidney & blood pressure research
Hypertension contributes to renal dysfunction, partly through dysregulation of the renin-angiotensin system (RAS). Betaine, an osmolyte that helps maintain medullary osmotic gradients, has demonstrated renoprotective effects in models of…
View details →Wiel É, Menu H, Roger F et al. · 2026 · Anaesthesia, critical care & pain medicine
Background Endotracheal Intubation (ETI) inserts an endotracheal tube (ETT) inside the human trachea to allow a proper mechanical ventilation of the lungs. Practitioners insert the ETT through the human vocal cords following a…
View details →Yuan Y, Gao Y, Moen H et al. · 2026 · NPJ digital medicine
Digital phenotyping leverages continuous data from smartphones and wearable devices for real-time mental health monitoring, offering opportunities for early detection and personalized care in mood disorders by enabling clinicians to…
View details →Montasser ZM, Montasser MA · 2026 · BMC oral health
Objective To review the available evidence on temporomandibular joint morphological changes after orthodontic treatment with clear aligners, as assessed using CBCT scans. Materials and methods This review sought randomized clinical trials,…
View details →Singh Y, Lei Q, Dixit M et al. · 2026 · Medical care research and review : MCRR
Corporate employment of primary care physicians by hospitals and private equity-backed organizations has increased in recent years, raising concerns that the financial incentives of corporate employment will incentivize provision of…
View details →Karacaer C, Kaya G, Ergenc H et al. · 2026 · Pakistan journal of medical sciences
Objectives This study aimed to evaluate the prognostic significance of Cluster of Differentiation 4 (CD4+) and Cluster of Differentiation 8 (CD8+) T cell dynamics and cytokine profiles during the early stage of Coronavirus Disease 2019…
View details →Abassi W, Ouerghi N, Feki O et al. · 2026 · Clinics (Sao Paulo, Brazil)
Objective Obesity is a major independent risk factor for chronic kidney disease. High-Intensity Interval Training (HIIT) is recognized as an interesting therapeutic strategy in managing obesity and related disorders. However, there is…
View details →Oğuz F, Türk SK, Yavan MA · 2026 · Scientific reports
This controlled retrospective study aimed to evaluate the effects of maxillary protraction therapy on mandibular symphysis morphology. In this regard, 35 growing individuals with skeletal class III malocclusion due to maxillary…
View details →Dantsi F, Kypraiou A, Kouvelas N et al. · 2026 · Sports (Basel, Switzerland)
Most detraining research in swimming has focused on competitive athletes, whereas less is known about recreational university swimmers, a population commonly exposed to temporary interruptions in structured training. This study examined…
View details →Schuckit MA, Smith TL, Danko G et al. · 2026 · Alcohol, clinical & experimental research
Objectives The retrospective self-report of the effects of alcohol (SRE) questionnaire generates three scores reflecting drinking quantities required for effects: SRE-5 (first five times of drinking), SRE-3 (recent 3 months of drinking),…
View details →Jambor T, Goc Z, Tokarova K et al. · 2025 · Physiological research
The growing popularity of microgreens is due to several health-promoting effects. Current evidence suggests a reduction in the risk of cardiovascular and neurodegenerative diseases, or anti-carcinogenic and anti-inflammatory effects.…
View details →Puls HT, Lindberg DM, Noelke C et al. · 2026 · Academic pediatrics
Objective To determine whether community advantage moderated rates of hospital encounters for child physical abuse during the COVID-19 pandemic. Methods This was a population-based retrospective study of 12 states during 2019 to 2021. The…
View details →Fuchs S, Majer M, Ma Y et al. · 2026 · Pflugers Archiv : European journal of physiology
Diabetic nephropathy (DN) is characterized by a decline in renal function resulting from hyperglycaemia and is often requiring dialysis or renal transplantation. Yet, the signalling events causing DN and the effective treatment options are…
View details →Noell SE, Colville EC, Marshall A et al. · 2026 · FEMS microbiology ecology
The Bratina Island meltwater ponds (McMurdo Ice Shelf, Antarctica) host complex microbial communities in the form of benthic microbial mats. These ponds are long-lasting but can experience significant alterations in physicochemistry on an…
View details →Jahanian Najafabadi A, Rastegari A, Imani H et al. · 2026 · Acta psychologica
The plasticity of body representation in response to tool use is a dynamic process that evolves across the lifespan. Research has shown that tools can become integrated into the body representation, effectively being treated as extensions…
View details →Chowdhury M, Bustamante AV · 2026 · Health affairs (Project Hope)
Lawfully present noncitizen immigrants face persistent coverage gaps due to federal restrictions on Medicaid eligibility, including the five-year bar under the 1996 Personal Responsibility and Work Opportunity Reconciliation Act, and…
View details →Yakasai AM, Maharaj SS, Danazumi MS · 2026 · American journal of physical medicine & rehabilitation
Objective This study evaluated the efficacy of endurance exercise on balance impairment and gait disturbance among individuals living with Human Immunodeficiency Virus (HIV)-related distal symmetrical polyneuropathy (DSPN). Design This was…
View details →Srinivasan VV, Ravikumar A, Ostrin LA · 2026 · Eye & contact lens
Purpose To determine the effects of contact lens-induced full-field and peripheral-field myopic defocus on choroid thickness and variation with time of day in young adults. Methods In this prospective, randomized, crossover study, 16…
View details →Echizen T, Yusu S, Chiba U et al. · 2026 · Physical therapy research
Objectives This study aimed to compare the effects of repetitive peripheral magnetic stimulation (rPMS) and neuromuscular electrical stimulation (NMES) on hemodynamics and obtain basic data to verify the safety of rPMS in healthy adults.…
View details →Esen Baris M, Guclu A, Guven S et al. · 2026 · BMC ophthalmology
Background Phenylephrine is widely used for pharmacological mydriasis in routine ophthalmic practice. While its vascular and pupillary effects are well established, its influence on anterior segment structures and intraocular inflammatory…
View details →Dobsikova R, Marsalek P, Velisek J et al. · 2026 · Veterinarni medicina
This study assessed the effect of a 24-hour bath with praziquantel (2 and 4 mg/l) on grass carp ( Ctenopharyngodon idella ) by monitoring the haematological parameters, plasma biochemical profile, and oxidative stress indices. Fish were…
View details →Di̇ncer M, Canturk N, Dagalp R et al. · 2026 · Forensic science international
A signature is writing and/or signs that contain the signatory's personal characteristics and are used to indicate that people accept the authenticity of the formal and private transactions made by themselves in their daily lives and…
View details →Koyama K, Hosono S · 2026 · Journal of strength and conditioning research
Abstract Koyama, K and Hosono, S. Comparison of the effects of barefoot and shod training on foot structure, muscle strength, and sensory function. J Strength Cond Res 40(5): 566-575, 2026-The aim of this study was to compare the effects…
View details →Bicici Ulusahin S, Celik C, Abut CZ et al. · 2026 · Health care for women international
Primary dysmenorrhea (PD) is a prevalent condition in young women, characterized by menstrual pain, sleep disturbances, and reduced physical activity. Yoga has been suggested as a non-pharmacological intervention. We examined the effects…
View details →Kim J, Han E · 2026 · Disability and health journal
Background Households including a member with disabilities carry greater caregiving burdens than those without, increasing the likelihood of economic and emotional imbalances. Objectives Using Korea Welfare Panel Study (KOWEPS) waves 1-19,…
View details →Blasco-Giner C, Salanova M, Meneghel I · 2026 · The Journal of general psychology
This study draws on the Conservation of Resources Theory to examine two objectives: (1) whether consideration of future consequences (CFC) moderates the relationship between psychological capital (PsyCap) and innovative work behavior…
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