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Browse the failure-mode index

11,407 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Amuc_1100 alleviates HFD-induced hepatic lipid accumulation via gut microbiota in zebrafish: insights from the role of intestinal 14-3-3β/α-A.

Ding, Lou, Liang et al. · 2026 · Journal of animal science and biotechnology

Amuc_1100, the most abundant outer membrane protein of Akkermansia muciniphila, alleviates high-fat diet (HFD)-induced hepatic lipid accumulation and modulates gut microbiota in fish; however, its mechanism and mediators remain unknown.…

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Negative / Null Result ReportMedicine

Diagnostic accuracy of tuning fork weber test and audiometric weber test in school-aged children with conductive hearing loss.

Peng, Nik Othman, Zakaria et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

While the application of tuning fork Weber (TFW) test in adult is well-documented, its accuracy in the paediatric population remains uncertain although conductive hearing loss is frequently identified in children. Similarly, the…

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Negative / Null Result ReportMedicine

Effect of build orientation, sintering schedule, and resin cement on the bond strength of additively manufactured zirconia to dentin.

Sabatini, Molinero-Mourelle, Limones et al. · 2026 · The Journal of prosthetic dentistry

Whether the manufacturing protocol (build orientation and sintering schedule) of additively manufactured (AM) zirconia impacts the bond strength compared with subtractively manufactured (SM) zirconia remains unclear. The purpose of this in…

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Negative / Null Result ReportMedicine

Effect of sleep quality on physical performance in the elderly.

Roy, Jahagirdar, Kumar et al. · 2026 · Journal of bodywork and movement therapies

Deteriorating physical performance with ageing increases the risk of falls, loss of independence, institutionalisation and mortality amongst elderly. Apart from multisystem body decline, poor quality sleep, being a common complaint amongst…

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Negative / Null Result ReportMedicine

Effect of Inulin-Type Fructans on Body Composition, Carbohydrate Metabolism and Energy Expenditure in Patients with Psoriasis: Results of INGUTSKIN Randomized Controlled Trial.

Bieglecka, Kęszycka, Czerwińska et al. · 2026 · Nutrients

Patients with psoriasis, a non-contagious, chronic, systemic inflammatory skin disease, often suffer from carbohydrate metabolism disorders, which can exacerbate systemic inflammation. This randomized, double-blind, placebo-controlled…

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Negative / Null Result ReportMedicine

Inhibitory Effects of Oxytocin on Jejunal Migrating Myoelectric Complex Activity in Fasted Rats: Role of Oxytocin and GLP-1 Receptors.

Balcı, Saltık, Aktemur et al. · 2026 · Life (Basel, Switzerland)

The migrating myoelectric complex (MMC) is the electrical basis of fasting small intestinal motility. Although oxytocin (OT) regulates gastrointestinal functions through oxytocin receptors (OTRs), its effect on jejunal MMC activity during…

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Negative / Null Result ReportMedicine

Refractive and Corneal Astigmatism After Implantation of a Supraciliary Drainage Device in Microinvasive Glaucoma Surgery.

Englisch CN, Wakili P, Langenbucher A et al. · 2026 · Journal of refractive surgery (Thorofare, N.J. : 1995)

Purpose To assess the short-term impact of stand-alone MINIject (iSTAR Medical SA) implantation on astigmatism in a single-center retrospective study. Methods Refractive and corneal astigmatism was investigated based on preoperative and…

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Negative / Null Result ReportOpen accessMedicine

Automatic monitoring of single-wall MAPSE by transesophageal echocardiography for tracking global left ventricular function irrespective of regional hypokinesia: a secondary analysis.

Yu J, Grude O, Berg EAR et al. · 2026 · Intensive care medicine experimental

Background Measuring mitral annular plane systolic excursion (MAPSE) serially in a single wall may be an effective method for monitoring global left ventricular (LV) function, especially when automated with a novel deep learning method…

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Negative / Null Result ReportMedicine

Impact of cannabis legalization on drug possession offences among people who experience incarceration in Ontario, Canada.

Butler A, Croxford R, Owusu-Bempah A et al. · 2026 · The International journal on drug policy

Background In October 2018, Canada legalized non-medical cannabis possession and use. While a stated objective of legalization was to prevent people from entering the criminal justice system for cannabis possession, we lack evidence about…

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Negative / Null Result ReportOpen accessMedicine

Within-Patient, Quasi-Experimental Clinical Trial to Assess the Immediate Effects of Paraffin Wax on Adult, Post-Burn Hypertrophic Scar.

Bellali YA, Jetté S, Delisle M et al. · 2026 · Journal of burn care & research : official publication of the American Burn Association

Paraffin wax is applied to scar tissue for its proposed benefits of increasing skin pliability and relieving pain. However, limited studies have objectively assessed hypertrophic scar (HSc) response. This study examined immediate HSc…

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Negative / Null Result ReportMedicine

Comparative study of the tumor-infiltrating lymphocytes before and after neoadjuvant chemoimmunotherapy in esophageal squamous cell carcinoma.

Xu Y, Wang H, Wang N et al. · 2026 · Journal of cardiothoracic surgery

Background OBJECTIVE: To explore changes of tumor-infiltrating lymphocytes and the relationship with therapeutic effect before and after neoadjuvant chemoimmunotherapy in patients with esophageal squamous cell carcinoma(ESCC). Method This…

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Negative / Null Result ReportMedicine

Association Between Local Anesthetic Volume-Dose Combinations and Optic Nerve Sheath Diameter as an Indirect Marker of Intracranial Pressure During Ultrasound-Guided Supraclavicular Brachial Plexus Block: A Randomized Trial.

Çopur İ, Erbay RH, İlhan S et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : This prospective, randomized study aimed to evaluate the effects of different local anesthetic (LA) volume-dose combinations administered during supraclavicular brachial plexus block (SCBPB), a widely used…

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Negative / Null Result ReportMedicine

Dual Glucagon and GLP-1 Receptor Agonist Survodutide Improves Biomarkers of Beta-Cell Function and Insulin Sensitivity in People With Type 2 Diabetes or Living With Overweight/Obesity.

Ekinci EI, Maldonado SG, Unseld A et al. · 2026 · Diabetes, obesity & metabolism

Aims This post hoc analysis evaluated the effect of survodutide on beta-cell function, insulin sensitivity, and glucose biomarkers in two phase 2 trial populations. Materials and methods Trial 1404-0002 randomised 413 participants with…

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Negative / Null Result ReportMedicine

Comparison of the effect of internet-based and in-person cognitive behavioral therapy on the fear of childbirth in primiparous pregnant women: a randomized controlled trial.

Piri K, Gholamzadeh Jofreh M, Haghighizadeh MH et al. · 2026 · BMC psychology

Introduction Fear of childbirth (FOC) is a significant factor contributing to requests for elective cesarean sections. This study aimed to compare the effectiveness of internet-based cognitive behavioral therapy (ICBT) versus in-person…

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Negative / Null Result ReportMedicine

Providing insight in resilience and recovery by using fatigability and its development over time in older adults after hip fracture surgery.

Dijksterhuis J, Hurmuz MZM, van Dartel D et al. · 2026 · European geriatric medicine

Purpose Older hip fracture patients are often frail, complicating their recovery trajectories. Insight into patients' resilience may help in getting more understanding of their predicted recovery and adjusting their treatment plan…

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Negative / Null Result ReportMedicine

Learning and deskilling effects of artificial intelligence in colonoscopy among endoscopists with different levels of experience: a pragmatic, prospective trial.

Pedersen TA, Mori Y, Botteri E et al. · 2026 · Endoscopy

Background The effect of computer-aided detection (CADe) on performance of endoscopists with different experience levels is not well understood. This study assessed whether CADe use promotes learning or deskilling. Methods We performed a…

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Negative / Null Result ReportMedicine

Evaluation of preoperative screw planning and X-ray simulation for iliosacral and transsacral screw placement.

Hoskens S, Bamps K, Herteleer M · 2026 · European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

Objectives The percutaneous placement of iliosacral (IS) and transsacral (TS) screws has become a standard practice for the treatment of pelvic fractures. Due to the complex sacral anatomy, accurate screw placement is essential to avoid…

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Negative / Null Result ReportMedicine

Effects of Dietary Conjugated Linoleic Acid on the Growth Performance of Fattening Broiler Duck and the Properties of Its Dry-Cured Products.

Feng J, Li S, Li X et al. · 2026 · Journal of agricultural and food chemistry

The effects of dietary supplementation with conjugated linoleic acid (CLA) on broiler duck growth performance and the quality of dry-cured products were investigated. Ten days preslaughter with the supplementation of 2 mL/d CLA was more…

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