11,310 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Bhavya ML, Bayati M, Poojary MM et al. · 2026 · Food chemistry
Ultrasound (US) processing is a promising food technology to improve protein solubility, reduce particle size, and modify functional properties. However, concerns exist regarding US-induced protein oxidation due to reactive oxygen species…
View details →Wolinsky D, Blaine S, Strickland JC et al. · 2026 · Journal of cannabis research
Background This Phase I randomized controlled trial aimed to assess the safety and tolerability of cannabidiol (CBD) and alcohol co-administration among moderate alcohol consumers in acute laboratory and chronic outpatient settings.…
View details →Celik C, Celik MS · 2026 · Cutaneous and ocular toxicology
Background and objective Acne vulgaris is a chronic inflammatory skin disease frequently treated with systemic agents such as isotretinoin and doxycycline. Although these treatments are known to modulate inflammatory pathways, their…
View details →Qasim MSA, Kang P, Evans B et al. · 2026 · Contact lens & anterior eye : the journal of the British Contact Lens Association
Purpose To investigate the utility of in vivo confocal microscopy (IVCM) combined with standardized image grading for identifying early morphological changes in the central corneal and superior limbal basal epithelial cells during…
View details →Alenezi BM, Khoyratty F, Biswas S et al. · 2026 · Translational vision science & technology
Purpose To investigate the effect of corneal cross-linking (CXL) on corneal curvature and thickness in two different keratoconic populations, one based in the Middle East (Saudi Arabia) and one in Europe (UK), and to explore whether age…
View details →Zhuang SR, Leong PY, Chiang HP et al. · 2026 · Nutrients
Objective This study aimed to evaluate the effects of 12 weeks of Astragalus membranaceus saponins (AMS) supplementation on functional performance, knee joint mobility, self-reported outcomes, and biomarkers of inflammation and cartilage…
View details →Kniha K, Scholz K, Kohnert E et al. · 2026 · Scientific reports
To evaluate the effect of the implant material-either titanium or zirconia-on the development of bacterial deposits. In this one-year prospective split-mouth study, 20 patients with an edentulous lower jaw were treated with two zirconia…
View details →Ormsbee LT, Akhavan NS, Munoz J et al. · 2026 · Nutrients
Background/Objectives : Approximately 53.4 million U.S. adults aged 50 or older have low bone mass, yet male bone health remains under-researched. This study evaluated the effects of one year of prune supplementation on bone health in…
View details →Sangermani M, Desiati I, Quattrini N et al. · 2026 · Scientific reports
Reanalysing previously collected samples to address new research questions offers a time-efficient alternative to initiating new cohort studies. However, concerns remain regarding the stability of the faecal microbiome following repeated…
View details →Karahan M, Uluçam E · 2026 · Work (Reading, Mass.)
BackgroundSleep deprivation, common among physicians working long shifts, affects sensory integration, motor coordination, and cognitive performance. While its impact on cognitive and motor skills is well-documented, its effect on gait…
View details →Perović A, Juričić G, Bratičević MN et al. · 2026 · Medicine and science in sports and exercise
Purpose During scuba diving, breathing under elevated pressure leads to hyperoxia, which may induce oxidative stress and erythrocyte damage. Hyperoxia may also influence erythropoietin (EPO) production, a phenomenon referred to as the…
View details →Dobariya A, Patel R, Patel M · 2026 · European journal of hospital pharmacy : science and practice
Objective The study aimed to analyse the physicochemical stability and compatibility of ceftriaxone sodium (CEF) (2mg/mL) with pantoprazole sodium (PAN) (0.08mg/mL) and ondansetron hydrochloride (OND) (0.008mg/mL) in different infusion…
View details →Amiri D, Hellmann PH, Thyssen JP et al. · 2026 · JAMA dermatology
Importance Increased intraocular pressure (IOP) is a known adverse effect of corticosteroid use and may lead to corticosteroid-induced glaucoma. However, clinical evidence on the impact of topical corticosteroids (TCS) on IOP is limited.…
View details →Nechemya Y, Shames J · 2026 · Harefuah
Introduction Background: Chronic pain syndrome is a common disease with major economic costs. The aim of this study is to examine the effect of outpatient multidisciplinary pain rehabilitation on the utilization of medical services in…
View details →Nemes A, Ambrus N, Szili-Török T et al. · 2026 · Journal of clinical medicine
Introduction : The left ventricular (LV) function can be characterized by the spatial displacement of the aortic valve annulus (AVA), represented by the AVA plane systolic excursion (AAPSE). AAPSE, measured using 3DSTE, has been shown to…
View details →Ozden H · 2026 · Open life sciences
Perfluorooctanoic acid (PFOA) is widely utilized perfluoroalkyl substance (PFAS) in various industrial and household applications, known for its persistence in the environment. Due to the limited toxicity data for PFOA in edible vegetable…
View details →Kathpalia A, Vlachos I, Hlinka J et al. · 2026 · Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Objective Finding indicators of early response to antidepressant treatment in EEG signals recorded from patients suffering from major depressive disorder. Methods Functional brain connectivity networks based on weighted imaginary coherence…
View details →Putos J, Atkinson HF, Walton DM · 2026 · Osteoarthritis and cartilage open
Objectives The acute response of lumbar intervertebral discs (IVD) to spinal rotation mobilization (SRM) is poorly understood. We evaluated sustained morphological changes in lumbar IVDs following a rotation mobilization commonly used to…
View details →Ajiki H, Tanaka M · 2026 · Journal of imaging
Even when an object's color is accurately reproduced in a colorimetrically reproduced image (CRI), the perceived material appearance does not necessarily match that of the original object. This mismatch remains a challenge for faithfully…
View details →Uysal A, Soslu R, Soslu R · 2026 · Journal of strength and conditioning research
Abstract Uysal, A and Soslu, R. Acute and long-term effects of spinning-based high-intensity interval training on inducible nitric oxide synthase: a randomized controlled trial. J Strength Cond Res XX(X): 000-000, 2026-This study…
View details →Ravenda S, Gerra MC, Barbetti M et al. · 2026 · Psychoneuroendocrinology
MicroRNAs (miRNAs) have attracted great interest as potential biomarkers in several research domains, including acute and chronic stress conditions. While most of these studies focused on circulating blood miRNA levels, the investigation…
View details →Lojek NM, Bostanci N, Henrique Borges P et al. · 2026 · Radiation research
Proton radiation is known to have detrimental neurological effects, but there is limited scientific understanding of these effects at the cellular and tissue levels. We leveraged our 3D in vitro cortical tissue model alongside 2D cortical…
View details →Hu JC, Kapadia SN, Zhang H et al. · 2026 · JAMA health forum
Importance Buprenorphine is the most commonly prescribed medication for opioid use disorder, but rates of retention in treatment remain low. Prior authorization (PA) has been identified as a barrier to the administration of buprenorphine,…
View details →Saud MA, Khamees Abed S, Shahooth MA et al. · 2026 · F1000Research
Background While ivermectin is a common antiparasitic drug used in veterinary medicine, the effects of repeated administration at therapeutic doses have not been well studied. Of particular interest is the impact of ivermectin on…
View details →Zainuddin MS, Pamidi N, Azman AS et al. · 2026 · Redox report : communications in free radical research
Alzheimer's disease (AD) is a major global neurodegenerative disorder associated with high morbidity and mortality, yet current treatments remain largely symptomatic and ineffective in halting neurodegeneration. Growing evidence links…
View details →Fukui S, Sumiyoshi R, Koga T et al. · 2026 · Drug discoveries & therapeutics
Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disease characterized by systemic inflammation. Although IL-6 receptor blockade with tocilizumab is an established treatment, Janus kinase (JAK) inhibition may…
View details →Garabet W, Beckamp KH, Shabes P et al. · 2026 · VASA. Zeitschrift fur Gefasskrankheiten
Background: Supervised Exercise Therapy (SET) improves walking performance in patients with peripheral arterial disease (PAD) and intermittent claudication, yet implementation and adherence remain inconsistent. This study evaluated…
View details →Mobasseri M, Vahabie AH, Jafari G et al. · 2026 · Brain imaging and behavior
Behavioral contagion is defined as the tendency of individuals to conform with others' behavior after observing them. Despite the important role that behavioral contagion plays in societies, its brain mechanism is still not fully…
View details →Ptak A, Stefańska M · 2026 · Journal of clinical medicine
Background: The objective of this study was to assess the tension of selected postural muscles during the jaw-sucking movement in four body positions (standing position, all-fours position, lying on front, lying on the side). Material and…
View details →Guo C, Geng A, Wang Q et al. · 2026 · Journal of integrative neuroscience
Background The cortex and cerebellum have a closely connected closed-loop circuit. Intermittent theta burst stimulation (iTBS) targeting the cerebellum has shown promise in improving balance function and inducing neuroplasticity. This…
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