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Browse the failure-mode index

11,407 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Virtual Reality Glasses vs Conventional Behavior Management Techniques for Anxiety and Pain Control in 6-10-year-old Children: A Randomized Controlled Trial.

Rathee, Bhardwaj, Gupta et al. · 2026 · International journal of clinical pediatric dentistry

Anxiety and pain often lead to a challenging situation in a dental clinic. This study aimed to compare the efficacy of virtual reality (VR) glasses to conventional techniques for anxiety control in children. Jio Dive VR glasses (passive)…

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Negative / Null Result ReportMedicine

Quantitative Analysis of the Intracellular Efficacy of Conventional Antileishmanial Drugs Against Leishmania tropica : A Translational Approach Using the THP-1 Macrophage-Amastigote Model.

Yıldırım, Aksoy, Özbilgin · 2026 · Turkiye parazitolojii dergisi

This study aimed to quantitatively assess the intracellular susceptibility of Leishmania tropica ( L. tropica ) to conventional antileishmanial drugs using the parasite rescue and transformation assay (PRTA), which involves controlled…

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Negative / Null Result ReportMedicine

A Comparative Analysis of the Hinotori and da Vinci Robotic Systems in Total Hysterectomy for Benign Uterine Gynecological Diseases Using Propensity Score Matching.

Torii, Oshima, Aoki et al. · 2026 · Asian journal of endoscopic surgery

The hinotori surgical robot system, the first Japanese-made robotic-assisted surgical system to receive Japanese regulatory approval in 2020, is now being applied clinically in gynecology. This study aimed to comprehensively compare the…

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Negative / Null Result ReportMedicine

Clinical and radiological outcomes of unilateral biportal endoscopy and percutaneous endoscopic interlaminar discectomy for highly downward-migrated lumbar disc herniation: a retrospective study.

Liu, Zhang, Zhang et al. · 2026 · BMC surgery

To compare the clinical efficacy and safety of unilateral biportal endoscopy (UBE) versus percutaneous endoscopic interlaminar discectomy (PEID) in the treatment of highly downward-migrated lumbar disc herniation (HDM-LDH). A retrospective…

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Negative / Null Result ReportMedicine

Modeling the Effects of Gravity and Patient Positioning on Stone Migration During Ureteroscopy with Laser Lithotripsy in a Physics-Based Simulator.

Velasquez Ospina, Gordon, Ojalvo et al. · 2026 · Urologia internationalis

Introduction Residual lower pole fragments are a common limitation of ureteroscopy, yet the optimal patient positioning to minimize stone migration remains undefined. This study aimed to evaluate the impact of Trendelenburg (HeadTilt) and…

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Negative / Null Result ReportMedicine

Proton FLASH preserves neurocognition across delivery techniques: implications for clinical translation in pediatric brain tumors.

Miles, Sforza, Tan et al. · 2026 · bioRxiv : the preprint server for biology

Radiation therapy is integral to the curative treatment of childhood brain tumors but contributes to late neurocognitive impairment in survivors. FLASH (ultra-high dose rate, >40Gy/s) reduces normal-tissue toxicity in preclinical models,…

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Negative / Null Result ReportMedicine

Middle Eastern male ACL-deficient patients exhibit steeper posterior tibial slope than European counterparts: A cross-cultural matched cohort study.

Romandini, AlKhelaifi, Macchiarola et al. · 2026 · Journal of experimental orthopaedics

The posterior tibial slope (PTS) is a key anatomical factor influencing anterior cruciate ligament (ACL) stability. Steeper slopes have been associated with increased anterior tibial translation (ATT) and a higher risk of graft failure…

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Negative / Null Result ReportMedicine

Prognostic value of hematological ratios in sepsis: A prospective observational study of neutrophil-to-lymphocyte, platelet-to-lymphocyte, and monocyte-to-lymphocyte ratios.

Deokate, Acharya, Patil et al. · 2026 · International journal of critical illness and injury science

Early identification of high-risk sepsis patients remains a clinical priority. Hematological ratios such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) have emerged as…

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Negative / Null Result ReportMedicine

Nanostructure and Collagen-Stimulating Activity of Cationic Pentapeptide Lipopeptides.

de Mello, Castelletto, Seitsonen et al. · 2026 · Journal of peptide science : an official publication of the European Peptide Society

The self-assembly in aqueous solutions, cytocompatibility, and collagen production of lipopeptide C 16 -KTTKS and a variant with arginine substitution for lysine, C 16 -RTTRS, are investigated. C 16 -KTTKS is known commercially as Matrixyl…

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Negative / Null Result ReportMedicine

Efficacy of Nurse-Led WIKAP Intervention on Hypoglycemia Coping Confidence and Outcomes in Adolescents with Type 1 Diabetes Mellitus: A Quasi-Experimental Study in Zhijiang, China.

Xiao, Zheng, Guo et al. · 2026 · Patient preference and adherence

Hypoglycemia is a frequent and burdensome complication in adolescents with type 1 diabetes mellitus (T1DM). Despite its high prevalence, structured interventions targeting hypoglycemia coping confidence remain scarce, especially in China.…

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Negative / Null Result ReportMedicine

The effectiveness of a cognitive behavioural therapy for insomnia based intervention to improve sleep quality in nursing home residents, a cluster randomised controlled trial.

Lahaye, Haegdorens, Franck et al. · 2026 · European geriatric medicine

To evaluate the effectiveness of a structured, team-delivered intervention based on cognitive behavioural therapy for insomnia (CBT-I) on sleep and related outcomes in nursing home residents. A cluster randomised controlled trial with…

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Negative / Null Result ReportMedicine

Occurrence of acrylamide and 4-methylimidazole in roasted and ground coffee and the effect of L-asparaginase treatment of green coffee on their levels.

da Costa, Ramirez, de Carvalho et al. · 2026 · Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment

Acrylamide and 4-methylimidazole (4-MEI) are heat-induced contaminants formed during coffee roasting, raising concerns due to their potential toxicological effects. Considering the limited information about the occurrence of these…

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Negative / Null Result ReportMedicine

The cortisol awakening response (CAR) of elite athletes is elevated before a competition, but no interaction with sport type.

Jiménez, Lopez-Lluch, Barón-López et al. · 2026 · Psychoneuroendocrinology

The cortisol awakening response (CAR) is thought to represent an anticipatory mechanism to prepare for upcoming demands. In sport, competition increases in the CAR have been reported, although findings remain inconsistent. A study on…

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