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Browse the failure-mode index

11,309 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Effects of sex, residential area, and age on the seasonality of insomnia-related symptoms: a detailed re-analysis of the longitudinal data of Japanese community residents.

Kizuki, Kaneko, Taniguchi et al. · 2026 · Sleep and biological rhythms

We previously found that seasonal changes in sleep duration were affected by sex, residential area, and age in Japanese community residents. This study aimed to determine whether these factors also affect the seasonality of…

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Negative / Null Result ReportMedicine

Treatment of Persisting Symptoms after Concussion with Repetitive Transcranial Magnetic Stimulation: A Double-Blinded, Randomized, Controlled Trial.

Campbell, Wilson, Du Plessis et al. · 2026 · Journal of neurotrauma

Following a mild traumatic brain injury (mTBI), up to 30% of individuals will experience persisting symptoms beyond 3 months. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neuromodulation technique that has shown…

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Negative / Null Result ReportMedicine

Opioid Toxicity Following Concomitant Use of Macrolide Antibiotics with Fentanyl, Hydromorphone, or Oxycodone: A Population-Based Study.

Antoniou, Yang, Juurlink et al. · 2026 · Clinical pharmacology and therapeutics

Fentanyl, hydromorphone, and oxycodone are metabolized by cytochrome P450 3A4 (CYP3A4). Co-administration with CYP3A4-inhibiting macrolides (clarithromycin or erythromycin) may increase opioid concentrations and overdose risk, but the…

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Negative / Null Result ReportMedicine

Cerebellar Volumes Are Smaller in Veterans with PTSD and a History of Mild Traumatic Brain Injury, but Not Mild Traumatic Brain Injury Alone.

Huggins, Martinez, Baird et al. · 2026 · Journal of neurotrauma

Mild traumatic brain injury (mTBI), a common health burden among combat veterans, has been associated with alterations in brain structure. Moreover, post-traumatic stress disorder (PTSD), frequently comorbid with mTBI, is linked to smaller…

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Negative / Null Result ReportMedicine

Microbial-chemical synergy in the immobilization of cadmium in contaminated floodplain soils: A field-mesocosm assessment of Sporosarcina pasteurii and SiO₂ nanoparticles.

Han, Wang, Shang et al. · 2026 · Journal of hazardous materials

Cadmium (Cd) accumulation in river floodplains is threatening grain safety and agro-ecosystem sustainability. We conducted a 10-month field-mesocosm experiment to evaluate the effectiveness, side effects and underlying mechanisms of three…

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Negative / Null Result ReportMedicine

Multimodal perioperative monitoring of intracranial pressure surrogates and cerebral oxygenation during laparoscopic surgery: implications for early cognitive outcomes.

Aba O, Yalçın Sezen G, Ersoy Karka O · 2026 · BMC anesthesiology

Purpose This study aimed to evaluate perioperative changes in optic nerve sheath diameter (ONSD) and regional cerebral oxygen saturation (rSO₂) using noninvasive monitoring techniques during laparoscopic abdominal surgery, and to assess…

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Negative / Null Result ReportMedicine

Clinical Implications of ChatGPT-assisted Multimodal Pre-operative Assessment in Elderly Pertrochanteric Fracture Patients: An Exploratory Study.

Noda, Takahara, Hayashi et al. · 2026 · Journal of orthopaedic case reports

Given the high mortality associated with femoral trochanteric fractures, reliable pre-operative estimation of post-operative death risk is essential. Commonly used scoring systems demonstrate only moderate predictive ability, largely…

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Negative / Null Result ReportMedicine

Parental oral health knowledge and sociodemographic influences in children aged 2-12 years: a cross-sectional study in Valencia, Spain.

Borrell-García, Mestanza-Tocto, Boo-Gordillo et al. · 2026 · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

The present study aimed to assess parental knowledge of paediatric oral health among parents and guardians of children aged 2-12 years in Valencia, Spain, and to analyse its association with key sociodemographic variables. A…

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Negative / Null Result ReportMedicine

Quality of life and gender identity in females with congenital adrenal hyperplasia after genital restoration surgery: A single-center experience.

Heidtmann, Umbreit, Eckoldt · 2026 · Journal of pediatric urology

Legislation restricting surgical interventions in children with differences of sex development (DSD) has intensified debate about female genital restoration surgery (FGRS) in patients with congenital adrenal hyperplasia (CAH). Long-term…

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Negative / Null Result ReportOpen accessMedicine

Voir La Vie Sans Rose-Colored Glasses.

Paap K, Majoubi J · 2025 · Experimental psychology

In a recent article, Ellen Bialystok argued that bilingual experience enhances nonverbal cognition, that its effects are continuous rather than categorical, and that selective attention is the key mechanism underlying cognitive changes in…

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