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Browse the failure-mode index

11,309 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Modeling the Effects of Gravity and Patient Positioning on Stone Migration During Ureteroscopy with Laser Lithotripsy in a Physics-Based Simulator.

Velasquez Ospina, Gordon, Ojalvo et al. · 2026 · Urologia internationalis

Introduction Residual lower pole fragments are a common limitation of ureteroscopy, yet the optimal patient positioning to minimize stone migration remains undefined. This study aimed to evaluate the impact of Trendelenburg (HeadTilt) and…

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Negative / Null Result ReportMedicine

Proton FLASH preserves neurocognition across delivery techniques: implications for clinical translation in pediatric brain tumors.

Miles, Sforza, Tan et al. · 2026 · bioRxiv : the preprint server for biology

Radiation therapy is integral to the curative treatment of childhood brain tumors but contributes to late neurocognitive impairment in survivors. FLASH (ultra-high dose rate, >40Gy/s) reduces normal-tissue toxicity in preclinical models,…

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Negative / Null Result ReportMedicine

Middle Eastern male ACL-deficient patients exhibit steeper posterior tibial slope than European counterparts: A cross-cultural matched cohort study.

Romandini, AlKhelaifi, Macchiarola et al. · 2026 · Journal of experimental orthopaedics

The posterior tibial slope (PTS) is a key anatomical factor influencing anterior cruciate ligament (ACL) stability. Steeper slopes have been associated with increased anterior tibial translation (ATT) and a higher risk of graft failure…

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Negative / Null Result ReportMedicine

Prognostic value of hematological ratios in sepsis: A prospective observational study of neutrophil-to-lymphocyte, platelet-to-lymphocyte, and monocyte-to-lymphocyte ratios.

Deokate, Acharya, Patil et al. · 2026 · International journal of critical illness and injury science

Early identification of high-risk sepsis patients remains a clinical priority. Hematological ratios such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) have emerged as…

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Negative / Null Result ReportMedicine

Nanostructure and Collagen-Stimulating Activity of Cationic Pentapeptide Lipopeptides.

de Mello, Castelletto, Seitsonen et al. · 2026 · Journal of peptide science : an official publication of the European Peptide Society

The self-assembly in aqueous solutions, cytocompatibility, and collagen production of lipopeptide C 16 -KTTKS and a variant with arginine substitution for lysine, C 16 -RTTRS, are investigated. C 16 -KTTKS is known commercially as Matrixyl…

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Negative / Null Result ReportMedicine

Efficacy of Nurse-Led WIKAP Intervention on Hypoglycemia Coping Confidence and Outcomes in Adolescents with Type 1 Diabetes Mellitus: A Quasi-Experimental Study in Zhijiang, China.

Xiao, Zheng, Guo et al. · 2026 · Patient preference and adherence

Hypoglycemia is a frequent and burdensome complication in adolescents with type 1 diabetes mellitus (T1DM). Despite its high prevalence, structured interventions targeting hypoglycemia coping confidence remain scarce, especially in China.…

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Negative / Null Result ReportMedicine

The effectiveness of a cognitive behavioural therapy for insomnia based intervention to improve sleep quality in nursing home residents, a cluster randomised controlled trial.

Lahaye, Haegdorens, Franck et al. · 2026 · European geriatric medicine

To evaluate the effectiveness of a structured, team-delivered intervention based on cognitive behavioural therapy for insomnia (CBT-I) on sleep and related outcomes in nursing home residents. A cluster randomised controlled trial with…

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Negative / Null Result ReportMedicine

Occurrence of acrylamide and 4-methylimidazole in roasted and ground coffee and the effect of L-asparaginase treatment of green coffee on their levels.

da Costa, Ramirez, de Carvalho et al. · 2026 · Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment

Acrylamide and 4-methylimidazole (4-MEI) are heat-induced contaminants formed during coffee roasting, raising concerns due to their potential toxicological effects. Considering the limited information about the occurrence of these…

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Negative / Null Result ReportMedicine

The cortisol awakening response (CAR) of elite athletes is elevated before a competition, but no interaction with sport type.

Jiménez, Lopez-Lluch, Barón-López et al. · 2026 · Psychoneuroendocrinology

The cortisol awakening response (CAR) is thought to represent an anticipatory mechanism to prepare for upcoming demands. In sport, competition increases in the CAR have been reported, although findings remain inconsistent. A study on…

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Negative / Null Result ReportMedicine

Exploring an integrated group psychotherapy-exercise program for multiple sclerosis: a non-randomized pilot study.

Abelovska, Malinova, Sucha et al. · 2026 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

This pilot study evaluated "Your Health Belongs to You," a six-week group intervention combining psychotherapy and exercise to improve quality of life, emotional health, and symptom management in individuals with Multiple Sclerosis (MS),…

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Negative / Null Result ReportMedicine

Effects, Acceptability, and Use of a Dynamically Tailored Mobile What Do You Drink Intervention to Reduce Excessive Drinking Among Adolescents and Young Adults in the Netherlands: Randomized Controlled Trial.

van Keulen, Voogt, Kleinjan et al. · 2026 · JMIR mHealth and uHealth

Excessive alcohol consumption among adolescents and young adults is a serious health problem. Dynamically tailored interventions could reduce their excessive drinking. We therefore developed "What Do You Drink" (WDYD), a 17-week…

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Negative / Null Result ReportMedicine

Comparison of Submental Muscle Activation and Tongue Pressure of Tongue Hold, Effortful Swallow and Mendelsohn Maneuvers in Different Gravitational Positions.

Cengiz, Yıldırım, Yaşaroğlu et al. · 2026 · Dysphagia

This study aimed to investigate the effects of Tongue Hold Maneuver (THM), Mendelsohn Maneuver (MM), and Effortful Swallow Maneuver (ESM) performed under different gravitational positions (90° sitting, 45° sitting, supine, and…

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Negative / Null Result ReportMedicine

Improving ricotta cheese shelf life using saffron petal extract double nanoemulsions stabilized by plant proteins and Lepidium sativum L. gum.

Bakhshalipoor, Bolandi, Nahidi et al. · 2026 · Scientific reports

This study evaluated the effects of double nanoemulsions of saffron petal extract (DN-SPE), stabilized with soybean (SPI) and pea protein isolates (PPI), alone or combined with Lepidium sativum L. seed gum (LSG) (SL or PL), on the quality…

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Negative / Null Result ReportMedicine

Cholinesterase activity determines the action potential-dependent increase in glycine receptor-mediated inhibitory synaptic transmission in the substantia gelatinosa of the spinal trigeminal nucleus of the rat.

Kawamura, Masaki, Kato · 2026 · Journal of pharmacological sciences

Acetylcholine-mediated modulation of pain-associated behaviors has been progressively well described. The mechanisms of cholinergic antinociception have been reported to involve the activation of nAChRs or mAChRs modulating GABAergic…

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