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Browse the failure-mode index

11,407 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Overcoming donor-specific anti-human leukocyte antigen antibodies with desensitisation in adult ex-vivo T-cell depleted haploidentical haematopoietic stem cell transplantation: a real-world analysis.

Tham, Linn, Koh et al. · 2026 · Transplantation and cellular therapy

The presence of anti-human leukocyte antigen (HLA) antibodies directed against donor HLA (HLA-DSA) in HLA-mismatched haematopoietic stem cell transplantation (HCT) can affect engraftment and transplant outcomes. Desensitisation treatment…

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Negative / Null Result ReportMedicine

Knowledge of oxygen therapy among healthcare professionals in non-intubated patients: a cross-sectional study in Somalia.

Duman Aydin, Küçükosman, Mohamed et al. · 2026 · BMC medical education

Although oxygen therapy (OT) is a fundamental and life-saving intervention in the management of hypoxemia, it may lead to serious complications when applied incorrectly or in an uncontrolled manner. The aim of this study is to evaluate the…

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Negative / Null Result ReportMedicine

ClassPass Memberships to Improve Well-Being Among Psychiatry Residents: A Pilot Randomized Controlled Trial.

Yang, Mueller, D'Andrea et al. · 2026 · Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry

Resident physicians experience high rates of depression, anxiety, burnout, and loneliness, yet few evidence-based interventions have been evaluated in this population. This randomized controlled pilot trial examined the feasibility,…

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Negative / Null Result ReportMedicine

vNOTES Pelvic Reconstruction and Presacral-Uterosacral Ligament Compound Suspension for Treatment of Multicompartment Pelvic Organ Prolapse: A Three-Year, Three-Arm, Open-Label, Randomized Controlled Trial.

Peng, Wang, Xiao et al. · 2026 · Journal of minimally invasive gynecology

To compare the effectiveness and safety of transvaginal natural orifice transluminal endoscopic surgery (vNOTES) pelvic reconstruction (PRC), vNOTES presacral-uterosacral ligament suspension (PULS), and sacrospinous ligament fixation…

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Negative / Null Result ReportMedicine

Material fracture/retention rates of occluso-proximal composite resin restorations with polyethylene fibers in primary molars: an interim randomized controlled trial.

Rocha, Dos Anjos, Pinho et al. · 2026 · Journal of dentistry

This 12-month, double-blind, parallel, randomized controlled trial compared the material fracture/retention rates of occluso-proximal direct composite resin restorations associated with polyethylene fiber (CR+PF; Ribbond®) with…

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Negative / Null Result ReportMedicine

Generative Artificial Intelligence for Orthognathic Planning: Patient-Specific 3-Dimensional Jaw Reference Forms Conditioned on the Cranial Base.

Kim, Yang, Kuang et al. · 2026 · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

Conventional cephalometry relies on measurements derived from a limited set of landmarks and population-based norms, which may not fully capture individual skeletal form. Although evaluated independently, many cephalometric variables…

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Negative / Null Result ReportMedicine

Using a hand-held pupillometer to quantify pupil constriction as part of the accommodation reflex.

Olson, Perera, Kamal et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Quantitative pupillometry (QP) provides a reliable measure of the pupillary light reflex. The pupil accommodation reflex (P-AR) occurs when there is a change in visual focus from near to far or from far to near. The ability to measure the…

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Negative / Null Result ReportMedicine

Clinical outcomes of endovascular treatment in patients with large ischemic strokes selected by non-contrast computed tomography within the extended time window.

Jiang, Zhu, Gan et al. · 2026 · European journal of radiology

This study aimed to investigate the effectiveness and safety of endovascular treatment (EVT) in patients with large ischemic strokes assessed by non-contrast CT (NCCT) within the extended time window. This study was a sub-analysis of a…

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Negative / Null Result ReportMedicine

Effect of a Multidimensional Digital Health Intervention on Quality of Life in Breast Cancer Survivors: A Randomized Controlled Trial.

Fuentes-Expósito, Frid, Muñoz-Mateu et al. · 2026 · JCO clinical cancer informatics

We evaluated whether offering access to a multicomponent mHealth app improves quality of life (QoL) and psychosocial outcomes among breast cancer survivors under pragmatic, nonprescriptive conditions. In this single-center, randomized,…

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Negative / Null Result ReportMedicine

7-mm-Diamater Versus 5-mm-Diameter Immediate Post-Extraction Implants in the Molar Region: 1-Year Results from a Multicenter Randomized Controlled Trial.

Esposito, Bocari, Cho et al. · 2026 · The International journal of oral & maxillofacial implants

This multicenter randomized controlled trial compared the clinical effectiveness of 7.0-mm wide-diameter implants with 5.0-mm conventional-diameter implants placed immediately after molar extraction. Thirty-nine patients needing a single…

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Negative / Null Result ReportMedicine

Effects of fermented Arundo donax juice on growth performance, immunocompetence, antioxidant capacity, and intestinal digestive enzyme activity in Arbor Acres broilers.

Li, Ma, Liu et al. · 2026 · Tropical animal health and production

In this study, we used lactic acid bacteria to ferment the byproduct of Arundo donax papermaking, Arundo donax juice (ADJ), to obtain fermented Arundo donax juice (FADJ). We aimed to investigate the effects of FADJ on the growth…

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Negative / Null Result ReportMedicine

Beyond peak wavelength: spectral bandwidth of blue and red-blue laser diodes modulates photosynthesis, canopy architecture, chlorophyll maintenance, and whole-plant growth.

Li, Sugita, Togawa et al. · 2026 · Frontiers in plant science

High planting densities in indoor horticulture often accelerate lower-leaf chlorophyll degradation, increasing trimming frequency, reducing effective photosynthetic area, and raising labor costs. While spectral composition has been widely…

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Negative / Null Result ReportMedicine

Deep and repetitive transcranial magnetic stimulation improves motor dysfunction after basal ganglia infarction: preliminary findings on efficacy and electrophysiological mechanisms.

Yang, Zhu, Chen et al. · 2026 · Frontiers in neuroscience

To observe the therapeutic effects of deep transcranial magnetic stimulation (dTMS) and repetitive transcranial magnetic stimulation (rTMS) on upper and lower limb motor dysfunction in patients with basal ganglia infarction, and to…

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Negative / Null Result ReportMedicine

Connective tissue graft with injectable platelet rich fibrin for treatment of RT1 gingival recession by tunnel technique: a randomized clinical and immunohistochemical study.

Mahmoud, Elrefaei, Shata et al. · 2026 · Frontiers in oral health

The literature regarding the use of injectable platelet- rich fibrin (i-PRF) for root coverage is scarce. Therefore, this RCT aimed to evaluate and compare the effect of using connective tissue graft (CTG) with and without i-PRF using the…

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Negative / Null Result ReportMedicine

Association of achieved LDL-C levels with global coagulability and clinical outcomes in patients with acute coronary syndrome receiving PCSK9 inhibitors: a prospective cohort study.

Fu, Yao, Zhang et al. · 2026 · Frontiers in cardiovascular medicine

The safety of achieving ultra-low low-density lipoprotein cholesterol (LDL-C) levels in acute coronary syndrome (ACS) patients on dual antiplatelet therapy (DAPT), particularly regarding global coagulability, specific platelet reactivity,…

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