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Browse the failure-mode index

11,309 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Hot dogs for snakes: alternative method for feeding coral snakes (Micrurus corallinus) maintained at Butantan Institute.

Ribeiro, Stuginski, do Amaral E Luna et al. · 2026 · Toxicon : official journal of the International Society on Toxinology

Snakebites represent a significant public health concern in tropical and subtropical countries. In 2025, approximately 21,000 incidents of snakebites were reported in Brazil, with 1.7% attributed to coral snakes. Although the incidence of…

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Negative / Null Result ReportMedicine

Clinical outcome of fiber post and fiber-reinforced resin composite for the full crowns of anterior endodontically treated teeth: a 5-year randomized clinical trial.

Ferrari, Saracutu, Pontoriero et al. · 2026 · Journal of dentistry

To compare the outcome of short fiber reinforced composites, as a core material, with respect to conventional fiber post, for the reconstruction of anterior endodontically treated teeth (ETT), covered by a lithium disilicate crown.…

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Negative / Null Result ReportMedicine

Vitamin B 12 Availability and Interaction with Bacterium Mesorhizobium loti Affect Growth and Biochemical Composition of Mixotrophic Alga Euglena Gracilis.

Ghimire, Sohrabi, Zhou et al. · 2026 · Microbial ecology

Over 90% of the mixotrophic algae surveyed require vitamin B 12 (B 12 ), a micronutrient synthesized exclusively by certain prokaryotes. Bacteria-mediated B 12 supply presents an important but poorly understood control on physiology and…

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Negative / Null Result ReportMedicine

Bile duct segmental resection versus pancreaticoduodenectomy for middle-third extrahepatic cholangiocarcinoma: A propensity-matched, single-center retrospective analysis.

Park, Kim, Kim et al. · 2026 · Annals of hepato-biliary-pancreatic surgery

The optimal surgical approach for middle-third extrahepatic cholangiocarcinoma (MCC)-bile duct segmental resection (BDSR) or pancreaticoduodenectomy (PD)-remains controversial. This study aimed to compare the short- and long-term outcomes…

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Negative / Null Result ReportMedicine

[Study on the incidence of adverse reactions following single versus simultaneous administration of the domestic diphtheria, tetanus, and acellular pertussis combined vaccine after immunization schedule adjustment].

Shao, Feng, Yang et al. · 2026 · Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]

This study compared the incidence of adverse reactions following single versus simultaneous administration of the domestic diphtheria, tetanus and acellular pertussis combined vaccine (DTaP) after the immunization schedule adjustment in…

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Negative / Null Result ReportMedicine

Thyroid hormones and thyroid hormone sensitivity indices correlate with volumetric bone mineral density and vertebral fracture risk among the osteoporotic population in northern China.

Meicen, Wei, Yanai et al. · 2026 · Frontiers in endocrinology

Thyroid hormones play critical roles in regulating bone turnover and maintaining bone mass. However, the relationship among thyroid hormones, their sensitivity indices, bone mineral density (BMD) and fracture risk remained unclear in the…

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Negative / Null Result ReportMedicine

Timing for green prescription: comparing the immediate and cumulative effects of different duration horticultural therapy programs on college students' mental health.

Liu, Chen, Sun et al. · 2026 · Frontiers in psychology

Although the mental health benefits of horticultural therapy (HT) are well-established, the influence of intervention duration and the temporal dynamics of effects remain insufficiently explored, lacking evidence for optimal protocol…

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Negative / Null Result ReportMedicine

Risk Factors and Survival Analysis of Epstein-Barr Virus Infection After Pediatric Liver Transplantation.

Li, Li, Xie et al. · 2026 · Pediatrics international : official journal of the Japan Pediatric Society

To explore the risk factors affecting Epstein-Barr virus (EBV) infection after pediatric liver transplantation (PLT) and analyze the survival outcomes of EBV infection in PLT. A retrospective analysis was conducted on clinical data from…

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Negative / Null Result ReportMedicine

[Targeted muscle reinnervation for treatment of painful stump neuroma].

Xiong, Shali, Kadier et al. · 2026 · Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

To investigate the effectiveness of incorporating small gap anastomosis (SGA) and epineurial sheath tube (EST) sleeve coaptation into conventional targeted muscle reinnervation (TMR) for the treatment of post-amputation painful stump…

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Negative / Null Result ReportMedicine

[Comparative study on effectiveness of bioinductive patch-augmented arthroscopic rotator cuff repair].

Sun, Yao, Gu et al. · 2026 · Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

To evaluate the effectiveness of using a bioinductive patch on tendon healing, functional recovery, and safety in arthroscopic rotator cuff repair. A non-concurrent controlled study with prospective enrollment of the intervention group and…

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Negative / Null Result ReportMedicine

[Effectiveness analysis of single-incision treatment for adjacent two-segmental lumbar disc herniation using uni-portal non-coaxial spinal endoscopic surgery].

He, Li, Xiao et al. · 2026 · Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

To investigate the feasibility and effectiveness of uni-portal non-coaxial spinal endoscopic surgery (UNSES) via a single incision for the treatment of adjacent two-segmental lumbar disc herniation (LDH). A retrospective analysis was…

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Negative / Null Result ReportMedicine

Effect of ammonia-free silver fluoride and silver diammine fluoride on immediate microshear bond strength of resin-modified glass ionomer to demineralised primary tooth dentine.

Abedinzade Zare, Vafadar, Behroozibakhsh et al. · 2026 · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

This study aimed to compare the effect of water-based ammonia-free silver fluoride (SF) and silver diammine fluoride (SDF) on the microshear bond strength (MSBS) of resin-modified glass ionomer (RMGIC) to artificially demineralised primary…

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Negative / Null Result ReportMedicine

Biologically enhanced anterior cruciate ligament reconstruction: Platelet-rich plasma or bone marrow aspirate concentrate does not lead to better clinical or radiological outcomes-A randomized controlled trial of 175 cases with 2 years of follow-up.

Mokhtar, Gawish, Abdelgawad et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

To compare the clinical and radiological outcomes of anterior cruciate ligament reconstruction (ACLR) augmented with platelet-rich plasma (PRP) (1) or bone marrow aspirate concentrate (BMAC) (2) against a control group undergoing standard…

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Negative / Null Result ReportMedicine

Impact of central adiposity on the heart rate and calorie estimation accuracy of diverse smartwatches and the resulting subjective exercise experience.

Lertyongphati, Udomkhwamsuk, Amornrungrojanakul et al. · 2026 · Frontiers in sports and active living

In light of the growing global trend toward health awareness, wearable technologies like smartwatches have become essential for monitoring physiological indicators such as heart rate (HR). However, their utility faces two critical…

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Negative / Null Result ReportMedicine

Transcervical carotid artery stenting compared to transfemoral carotid artery stenting and carotid endarterectomy: perioperative and short-term results from a single center.

Jin, Ni, Huang et al. · 2026 · Frontiers in cardiovascular medicine

Carotid artery stenosis is a major cause of ischemic stroke. Various revascularization strategies exist, including Carotid Endarterectomy (CEA), Transfemoral Carotid Artery Stenting (TF-CAS), and Transcervical Carotid Artery Stenting…

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Negative / Null Result ReportMedicine

Accuracy of Visual Inspection of Thickened Liquids: Implications for Multidisciplinary Dysphagia Management and Clinical Nutrition.

Fong, Kwan · 2026 · Journal of human nutrition and dietetics : the official journal of the British Dietetic Association

To evaluate the accuracy of visually estimating thickened liquid volume via video-observed conditions and to determine whether clinical experience or thickener composition influences judgement reliability. A cross-sectional online survey…

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Negative / Null Result ReportMedicine

The relationship between appetite hormones and body mass index in children with intoxication type metabolic diseases.

Koç, Konyalıgil, Özen Yeşil et al. · 2026 · Orphanet journal of rare diseases

The aim of this study is to comparatively examine the effects of appetite loss and insufficient energy intake, which trigger poor metabolic control parameters, on appetite hormones and body mass index in children with intoxication-type…

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Negative / Null Result ReportMedicine

The Effect of the Temporal Position of a Gap on Its Automatic Detection.

Omidvar, Campbell, Alain et al. · 2026 · The European journal of neuroscience

The presentation of a rarely occurring auditory stimulus that contains a silent interval (or gap) among a sequence of frequently occurring stimuli that do not contain a gap can elicit a negative-going event-related potential known as the…

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Negative / Null Result ReportMedicine

Prognosis of ER-positive, HER2-negative postmenopausal early breast cancer patients based on response to neoadjuvant endocrine therapy and multigene assay results: findings from the NEOS trial.

Iwata, Masuda, Yamamoto et al. · 2026 · Breast cancer (Tokyo, Japan)

We previously reported the 21-gene Oncotype DX® assay results from TransNEOS in patients enrolled in the phase 3 NEOS trial. However, the association between assay results and long-term prognosis has remained unclear. Of the 296…

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