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Browse the failure-mode index

11,309 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Impact of hydrophobic ion pair type and self-nanoemulsifying drug delivery systems composition on the oral delivery of salmon calcitonin.

Al-Maghrabi, Müllertz, Rades · 2026 · Journal of controlled release : official journal of the Controlled Release Society

Salmon calcitonin (sCT) is a peptide with poor enzymatic stability and permeability, limiting its oral delivery. This study investigated how hydrophobic ion pair (HIP) type and self-nanoemulsifying drug delivery systems (SNEDDS)…

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Negative / Null Result ReportMedicine

A multicenter randomized controlled trial comparing metallic stents with 10- versus 14-mm diameter for distal biliary obstruction caused by unresectable pancreatic carcinoma.

Ishiwatari, Nakahara, Kawaguchi et al. · 2026 · Gastrointestinal endoscopy

Endoscopic retrograde cholangiopancreatography with metal stent (MS) placement is the standard treatment for biliary drainage in patients with unresectable pancreatic cancer. A 10-mm diameter MS is generally used; however, a larger stent…

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Negative / Null Result ReportMedicine

Prognostic markers, quality of life (QoL) and value of health (V-He) in advanced biliary cancers (ABC) treated with second-line active symptom control (ASC) alone or ASC with oxaliplatin-5-FU chemotherapy (ASC + FOLFOX) in the randomised phase III, multicentre, open-label ABC-06 clinical trial.

Lamarca, Palmer, Wasan et al. · 2026 · ESMO open

The ABC-06 trial established FOLFOX as the reference second-line regimen for patients diagnosed with advanced biliary tract cancer (ABC). Here we analysed the prognostic role of tumour markers carbohydrate antigen 19-9 (CA19-9),…

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Negative / Null Result ReportMedicine

Transition practices of patients with inflammatory bowel disease from pediatric to adult healthcare systems. Results from a national survey.

Leruste, Ley, Gottrand et al. · 2026 · Archives de pediatrie : organe officiel de la Societe francaise de pediatrie

Although recommendations for structured transition programs in adolescents with Inflammatory Bowel Diseases (IBD) have been published, few studies have addressed the implementation of transition in real-life settings at a national level.…

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Negative / Null Result ReportMedicine

Impact of testosterone therapy and hypogonadism on treatment outcomes in Peyronie's disease: a multicenter retrospective analysis of collagenase clostridium histolyticum therapy.

Hernandez, Walia, Coady et al. · 2026 · The journal of sexual medicine

Peyronie's disease (PD) is an acquired connective tissue disorder characterized by fibrous plaque formation within the penile tunica albuginea that may be influenced by androgen status. To evaluate whether baseline testosterone levels and…

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Negative / Null Result ReportMedicine

An Internet-Based Mindfulness- and Compassion-Based Intercare Program for Reducing Parental Burnout: Randomized Controlled Trial.

Villalón López, Escaffi-Schwarz · 2026 · Journal of medical Internet research

Parental burnout is an underrecognized syndrome characterized by emotional exhaustion, detachment from children, and reduced parental efficacy. It is associated with sleep disturbance, addictive behaviors, suicidal ideation, and increased…

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Negative / Null Result ReportMedicine

Pancreatitis in Familial Dysautonomia Patients.

Benson, Cohen, Peskin et al. · 2026 · Digestive diseases (Basel, Switzerland)

Introduction Familial Dysautonomia (FD) is characterized by abnormal function of autonomic and sensory nervous systems. Gastrointestinal (GI) symptoms are extremely prevalent in FD patients, but the impact of FD on the pancreas is less…

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Negative / Null Result ReportMedicine

The Impact of Glucagon-Like Peptide 1 Receptor Agonists Versus Diabetes Mellitus on Endoscopic Procedures: A Case-Control Study From a Large Tertiary Care Health System.

Bahdi, Bachu, Aldzhyan et al. · 2026 · Journal of clinical gastroenterology

While glucagon-like peptide 1 receptor agonists (GLP1-RAs) increase the risk of gastric food retention (GFR) and inadequate bowel preparation (IBP), the confounding role of diabetes mellitus is still questioned. Here, we compare the…

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Negative / Null Result ReportMedicine

Symptom burden and outcomes among patients with early-onset versus average-onset neuroendocrine neoplasms.

Baskar, Patel, Rose et al. · 2026 · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

The incidence of neuroendocrine neoplasms (NENs) is rising, particularly among younger patients, but data comparing early-onset (EO-NENs) and average-onset (AO-NENs) remain limited. Using the National Inpatient Sample (2016-2020), we…

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Negative / Null Result ReportMedicine

Minimally invasive stabilisation of anterior pelvic ring injuries through anterior infix versus percutaneous anterior retrograde pubic screw: a prospective comparative cohort study.

Goda El-Hamalawy, Abdelmoneim, Al-Sayed et al. · 2026 · Archives of orthopaedic and trauma surgery

Management of unstable anterior pelvic ring fractures has shifted toward minimally invasive fixation techniques. This prospective randomized cohort study compares anterior subcutaneous internal fixator with percutaneous retrograde pubic…

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Negative / Null Result ReportMedicine

Scavenging of Reactive Carbonyl Species by Dihydromyricetin and Its Thermal Degradation Products Through Consumption of Hot-Brewed and Cold-Brewed Vine Tea.

Wang, Wang, Zhang et al. · 2026 · Journal of agricultural and food chemistry

Reactive carbonyl species (RCS) are highly reactive molecules linked to chronic diseases. Dihydromyricetin (DMY), a high-activity RCS scavenger, exhibited MGO- and ACR-scavenging rates of 70.1% (0.5 h) and 70.3% (2 h) at 37 °C,…

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Negative / Null Result ReportMedicine

Multi-omics analysis reveals Parabacteroides distasonis and Kineothrix alysoides as potential key bacterial species associated with anemia in sows.

Sun, Chen, Yang et al. · 2026 · Journal of animal science and biotechnology

Sow anemia has been reported to be associated with reduced reproductive performance. Additionally, anemia may alter gut microbiota composition. However, the gut microbiota and metabolic signatures specifically linked to sow anemia status…

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Negative / Null Result ReportMedicine

Effect of visual disruption on the lower limb kinematic and kinetic characteristics in athletes after anterior cruciate ligament reconstruction.

Yu, Yu, Sun et al. · 2026 · Frontiers in bioengineering and biotechnology

Proprioceptive deficits following anterior cruciate ligament (ACL) injury increase reliance on visual input in athletes after ACL reconstruction (ACLR). Visual disruption may therefore alter movement patterns and increase re-injury risk.…

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