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11,407 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

A Significant Effect of Pemafibrate on Hepatic Steatosis and Fibrosis Indexes in Patients With Hypertriglyceridemia

Hisayuki Katsuyama, Hidekatsu Yanai, Hiroki Adachi et al. · 2023 · Gastroenterology Research

Background: We previously reported that the selective peroxisome proliferator-activated receptor alpha modulator, pemafibrate, significantly reduced serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and…

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Negative / Null Result ReportOpen accessMedicine

An exploratory study to evaluate visual function endpoints in non-advanced age-related macular degeneration

Divya Narayanan, John David Rodriguez, Garrick Wallstrom et al. · 2020 · BMC Ophthalmology

BACKGROUND: To prevent irreversible vision loss in age-related macular degeneration (AMD), it is critical to detect retinal dysfunction before permanent structural loss occurs. In the current study we evaluated a series of visual function tests to identify potential endpoints to detect visual dysfunction in non-advanced AMD. METHODS: A series of visual function tests were performed on 23 non-advanced AMD subjects (AREDS grade 1-4 on simplified scale) and 34 age-matched normals (AREDS grade 0). Tests included some commonly used endpoints such as ETDRS visual acuity (VA), low luminance (LL) 2.0N

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Negative / Null Result ReportOpen accessMedicine

Emergent immunotherapy approaches for brain metastases

Jianbo Wang, Hussein A. Tawbi · 2021 · Neuro-Oncology Advances

Brain metastases from solid tumors are increasing in incidence, especially as outcomes of systemic therapies continue to extend patients' overall survival. The long-held notion that the brain is an immune sanctuary has now been largely…

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Negative / Null Result ReportOpen accessMedicine

Does gender have a significant effect on normal nerve conduction studies values?

Kawthar Al-Salmi, Farook S Wali, Ahmed Sameer Nadeem et al. · 2019 · Journal of Neurology & Stroke

Background: nerve conduction study (NCS) is a neurophysiologic medical diagnostic test used commonly to evaluate the function of the peripheral nerves. It is an extension to the clinical examination and extremely useful to diagnose and…

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Negative / Null Result ReportOpen accessMedicine

The Binary Model of Chronic Diseases Applied to COVID-19

Zeev Elkoshi · 2021 · Frontiers in Immunology

A binary model for the classification of chronic diseases has formerly been proposed. The model classifies chronic diseases as “high Treg” or “low Treg” diseases according to the extent of regulatory T cells (Treg) activity (frequency or function) observed. The present paper applies this model to severe acute respiratory syndrome coronavirus 2 (SARS - CoV - 2) infection. The model correctly predicts the efficacy or inefficacy of several immune-modulating drugs in the treatment of severe coronavirus disease 2019 (COVID-19) disease. It also correctly predicts the class of pathogens mostly associ

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Negative / Null Result ReportOpen accessMedicine

Antineoplastic Drug Synergy of Artesunate with Navitoclax in Models of High-Grade Serous Ovarian Cancer

J. Robert McCorkle, Rebecca Ahn, Connie D. Cao et al. · 2024 · Cancers

) known as artemisinins. Artesunate has traditionally been used as a frontline treatment for severe malaria but has also demonstrated antineoplastic activity against various malignancies, including ovarian cancer. Data suggest that artesunate exacerbates cellular oxidative stress, triggering apoptosis. In the current study, we investigated the ability of navitoclax, an inhibitor of the antiapoptotic Bcl-2 protein family, to enhance artesunate efficacy in ovarian cancer cells. Artesunate and navitoclax both demonstrated antiproliferative effects on 2D and 3D ovarian cancer cell models as single

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Negative / Null Result ReportOpen accessMedicine

Vaccines targeting the primary amino acid sequence and conformational epitope of amyloid‐β had distinct effects on neuropathology and cognitive deficits in EAE/AD mice

Xiaolin Yu, Jie Zhu, Xiang‐meng Liu et al. · 2020 · British Journal of Pharmacology

BACKGROUND AND PURPOSE: Immunotherapeutic intervention is one of the most promising strategies for the prevention and treatment of Alzheimer's disease (AD). Although they showed great success in AD mouse models, the clinical trials of many…

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Negative / Null Result ReportOpen accessMedicine

Systemic Therapies for HER2-Positive Advanced Breast Cancer

Vasileios Angelis, Alicia Okines · 2023 · Cancers

Despite recent advances, HER2-positive advanced breast cancer (ABC) remains a largely incurable disease, with resistance to conventional anti-HER2 drugs ultimately unavoidable for all but a small minority of patients who achieve an enduring remission and possibly cure. Over the past two decades, significant advances in our understanding of the underlying molecular mechanisms of HER2-driven oncogenesis have translated into pharmaceutical advances, with the developing of increasingly sophisticated therapies directed against HER2. These include novel, more potent selective HER2 tyrosine kinase in

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Negative / Null Result ReportOpen accessMedicine

Effect of the index of cardiac electrophysiological balance on major adverse cardiovascular events in patients with diabetes complicated with coronary heart disease

Yuan Lin, Fang Zhou, Xihui Wang et al. · 2023 · PeerJ

Purpose: To investigate the prognostic value of the index of cardio-electrophysiological balance (ICEB) and its association with major adverse cardiac events (MACE) and cardiovascular death in diabetic patients complicated with coronary heart disease. Methods: A total of 920 diabetic patients were enrolled in this longitudinal study. Participants were categorized into three groups based on their ICEB levels: normal ICEB, low ICEB, and high ICEB. The primary outcome was the occurrence of MACE, and secondary outcomes included cardiovascular death, coronary heart disease (CHD), heart failure (HF)

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Negative / Null Result ReportOpen accessMedicine

A genome‐wide association study of obstructive heart defects among participants in the National Birth Defects Prevention Study

Sara R. Rashkin, Mario A. Cleves, Gary M. Shaw et al. · 2022 · American Journal of Medical Genetics Part A

Abstract Obstructive heart defects (OHDs) share common structural lesions in arteries and cardiac valves, accounting for ~25% of all congenital heart defects. OHDs are highly heritable, resulting from interplay among maternal exposures,…

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Negative / Null Result ReportOpen accessMedicine

Immunization with a Trypanosoma cruzi cyclophilin-19 deletion mutant protects against acute Chagas disease in mice

Bijay Kumar Jha, Sanjay Varikuti, Chaitenya Verma et al. · 2023 · npj Vaccines

Human infection with the protozoan parasite Trypanosoma cruzi causes Chagas disease for which there are no prophylactic vaccines. Cyclophilin 19 is a secreted cis-trans peptidyl isomerase expressed in all life stages of Trypanosoma cruzi. This protein in the insect stage leads to the inactivation of insect anti-parasitic peptides and parasite transformation whereas in the intracellular amastigotes it participates in generating ROS promoting the growth of parasites. We have generated a parasite mutant with depleted expression of Cyp19 by removal of 2 of 3 genes encoding this protein using doubl

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Negative / Null Result ReportOpen accessMedicine

Erythrocytosis incidence and thromboembolic risk in heart failure with reduced ejection fraction treated with SGLT2 inhibitors: a nationwide register-based cohort study

Abdullahi Ahmed Mohamed, Camilla Fuchs Andersen, Daniel Mølager Christensen et al. · 2025 · Cardiovascular Diabetology

BACKGROUND: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) increase haemoglobin and haematocrit levels, potentially causing secondary erythrocytosis-defined as a haemoglobin level above 16.5 g/dL in men and 16.0 g/dL in women-which is…

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Negative / Null Result ReportMedicine

[Impact of tirofiban on outcomes in STEMI patients across different levels of inflammation: a stratified analysis based on complete blood count-derived inflammatory markers].

Lin, Dong, Yang et al. · 2026 · Zhonghua xin xue guan bing za zhi

Objective: To investigate through stratified analyses based on complete blood count-derived inflammatory markers, the effects of tirofiban on in-hospital all-cause mortality and one-year composite endpoint events in patients with…

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Negative / Null Result ReportMedicine

Olfactory notes in the mind space: A registered report.

Caldana M, Rusconi E · 2026 · Cortex; a journal devoted to the study of the nervous system and behavior

Olfaction is an archaic sense but its central mechanisms are lesser known than those of other senses. Here we address a possible link between olfactory stimuli and mental spatial representations. Although olfactory percepts are not…

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Negative / Null Result ReportMedicine

Toxicity assessment of green energy by-product, lithium, using a novel suite of eight Australian aquatic-species tests from a Global Biodiversity Hotspot.

Nice, Storer, Fisher et al. · 2026 · Environmental toxicology and chemistry

Due to recent advances in green energy initiatives in response to climate change impacts, lithium exploration and production are rapidly increasing, with concomitant elevated lithium in discharges to waterways. However, lithium toxicity to…

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Negative / Null Result ReportMedicine

Effect and safety of Neiguan acupoint injection with astragalus injection for chronic heart failure with qi-deficiency and blood-stasis syndrome: a randomized controlled trial.

Gou, He, Zhuo · 2026 · Frontiers in medicine

To investigate the effect and safety of astragalus injection at Neiguan (PC6) for chronic heart failure (CHF; HF) with qi-deficiency and blood-stasis syndrome, and its effect on the renin-angiotensin-aldosterone system (RAAS). A…

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Negative / Null Result ReportMedicine

Does Gestational Diabetes Increase Urinary Incontinence During Pregnancy? A Cross-Sectional Study of Symptom Patterns and Incontinence-Related Quality of Life.

Özel, Efiloğlu, Cim et al. · 2026 · Neurourology and urodynamics

This study aimed to evaluate the association between gestational diabetes mellitus and urinary incontinence during pregnancy, including symptom subtype, symptom severity, and incontinence-related quality of life. This cross-sectional study…

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