Negative / Null Result ReportOpen accessMedicine
Yuan Lin, Fang Zhou, Xihui Wang et al. · 2023 · PeerJ
Purpose: To investigate the prognostic value of the index of cardio-electrophysiological balance (ICEB) and its association with major adverse cardiac events (MACE) and cardiovascular death in diabetic patients complicated with coronary heart disease. Methods: A total of 920 diabetic patients were enrolled in this longitudinal study. Participants were categorized into three groups based on their ICEB levels: normal ICEB, low ICEB, and high ICEB. The primary outcome was the occurrence of MACE, and secondary outcomes included cardiovascular death, coronary heart disease (CHD), heart failure (HF)
View details →Negative / Null Result ReportOpen accessMedicine
Sara R. Rashkin, Mario A. Cleves, Gary M. Shaw et al. · 2022 · American Journal of Medical Genetics Part A
Abstract Obstructive heart defects (OHDs) share common structural lesions in arteries and cardiac valves, accounting for ~25% of all congenital heart defects. OHDs are highly heritable, resulting from interplay among maternal exposures,…
View details →Negative / Null Result ReportOpen accessMedicine
Bijay Kumar Jha, Sanjay Varikuti, Chaitenya Verma et al. · 2023 · npj Vaccines
Human infection with the protozoan parasite Trypanosoma cruzi causes Chagas disease for which there are no prophylactic vaccines. Cyclophilin 19 is a secreted cis-trans peptidyl isomerase expressed in all life stages of Trypanosoma cruzi. This protein in the insect stage leads to the inactivation of insect anti-parasitic peptides and parasite transformation whereas in the intracellular amastigotes it participates in generating ROS promoting the growth of parasites. We have generated a parasite mutant with depleted expression of Cyp19 by removal of 2 of 3 genes encoding this protein using doubl
View details →Negative / Null Result ReportOpen accessMedicine
Abdullahi Ahmed Mohamed, Camilla Fuchs Andersen, Daniel Mølager Christensen et al. · 2025 · Cardiovascular Diabetology
BACKGROUND: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) increase haemoglobin and haematocrit levels, potentially causing secondary erythrocytosis-defined as a haemoglobin level above 16.5 g/dL in men and 16.0 g/dL in women-which is…
View details →Negative / Null Result ReportOpen accessMedicine
S. Lot Aronson, Bram Thijssen, Marta López‐Yurda et al. · 2025 · Nature Communications
While immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, their efficacy in high-grade serous ovarian cancer (HGSOC) remains limited. Some patients, however, achieve lasting responses, emphasizing the need to…
View details →Negative / Null Result ReportOpen accessMedicine
Sha Sha, Lina Ren, Xiaona Xing et al. · 2025 · Neural Regeneration Research
Alzheimer's disease, a devastating neurodegenerative disorder, is characterized by progressive cognitive decline, primarily due to amyloid-beta protein deposition and tau protein phosphorylation. Effectively reducing the cytotoxicity of…
View details →Negative / Null Result ReportMedicine
Maryam Karimi, Mazaher Khodabandehloo, Bahram Nikkhoo et al. · 2016 · PubMed
Background and Objective: Any role of human papillomavirus (HPV) in the development of breast cancer is conjectural. The aim of this study was to investigate possible links between HPV and breast cancer in women, Sanandaj, Iran. Methods:…
View details →Negative / Null Result ReportOpen accessMedicine
LI-HSIOU CHEN, Kuo-Liang Chiu, Te‐Chun Hsia et al. · 2020 · In Vivo
BACKGROUND/AIM: Matrix metalloproteinase 2 (MMP2) is reported to be overexpressed in asthma; however, its genotypic contribution to asthma is not well studied. Therefore, we examined the association of MMP2 genotypes with asthma risk among…
View details →Negative / Null Result ReportOpen accessMedicine
Iván Chérrez-Ojeda, Marcus Maurer, Miguel Félix et al. · 2021 · World Allergy Organization Journal
BackgroundFew studies have explored the association between obstructive sleep apnea (OSA) and chronic urticaria (CU). Our study aims to fill this gap by determining the frequency of the risk categories for OSA and how they might correlate…
View details →Negative / Null Result ReportMedicine
Tatar, Coşgun · 2026 · BMC oral health
BACKGROUND: Enamel pretreatment with a deproteinization agent enhances fissure sealant bonding. This in vitro study investigates the effect of surface preparation methods and thermal cycling on the shear bond strength of fissure sealants…
View details →Negative / Null Result ReportMedicine
Yu, Choy, Bian et al. · 2026 · International journal of molecular sciences
Repeated low-level red light (RLRL) has been reported to control myopia progression clinically. Given safety concerns with laser sources, light-emitting diodes (LED)-sourced red light represents a promising alternative. This study…
View details →Negative / Null Result ReportMedicine
Xu, Xiang, Wang et al. · 2026 · Toxics
Antibiotic resistance genes (ARGs) are becoming a global issue due to the emergence of superbugs. However, the impact of elevated CO 2 (eCO 2 ) on the soil antibiotic resistome remains largely unknown. Here, using a free-air CO 2…
View details →Negative / Null Result ReportMedicine
Qiu, Hu, Guo et al. · 2026 · Metabolism: clinical and experimental
Acute liver injury is a common precipitating factor in the progression of various liver diseases including liver failure, underscoring the urgent need to identify novel therapeutic targets. G-protein coupled receptors (GPCRs) are widely…
View details →Negative / Null Result ReportMedicine
Lin, Dong, Yang et al. · 2026 · Zhonghua xin xue guan bing za zhi
Objective: To investigate through stratified analyses based on complete blood count-derived inflammatory markers, the effects of tirofiban on in-hospital all-cause mortality and one-year composite endpoint events in patients with…
View details →Negative / Null Result ReportMedicine
Faria, Megía-Palma, Whiting et al. · 2026 · Journal of thermal biology
Parasites have the potential to disrupt and induce changes in thermoregulation and behaviour in ectotherm hosts, possibly with deleterious effects. In a previous study, the lizard Podarcis lusitanicus (Lacertidae), when infected with blood…
View details →Negative / Null Result ReportMedicine
Elrys, Müller, Ali et al. · 2026 · Journal of environmental management
Soil nitrogen (N) turnover regulates plant nutrient availability and potential N loss, yet how microbial communities, anthropogenic activities, and climate-change factors are associated with its global patterns remains poorly synthesized.…
View details →Negative / Null Result ReportMedicine
Caldana M, Rusconi E · 2026 · Cortex; a journal devoted to the study of the nervous system and behavior
Olfaction is an archaic sense but its central mechanisms are lesser known than those of other senses. Here we address a possible link between olfactory stimuli and mental spatial representations. Although olfactory percepts are not…
View details →Negative / Null Result ReportMedicine
Aydemir HB · 2024 · Parasitology research
Invertebrate mitogenomes are generally fixed with formal 37 genes: 13 PCGs encoded subunits of OXPHOS, 2 ribosomal RNA (rRNA) functional in the translation of these PCGs and 22 transfer RNA (tRNA) genes. The order of these genes varies…
View details →Negative / Null Result ReportMedicine
Nice, Storer, Fisher et al. · 2026 · Environmental toxicology and chemistry
Due to recent advances in green energy initiatives in response to climate change impacts, lithium exploration and production are rapidly increasing, with concomitant elevated lithium in discharges to waterways. However, lithium toxicity to…
View details →Negative / Null Result ReportMedicine
Gou, He, Zhuo · 2026 · Frontiers in medicine
To investigate the effect and safety of astragalus injection at Neiguan (PC6) for chronic heart failure (CHF; HF) with qi-deficiency and blood-stasis syndrome, and its effect on the renin-angiotensin-aldosterone system (RAAS). A…
View details →Negative / Null Result ReportMedicine
Özel, Efiloğlu, Cim et al. · 2026 · Neurourology and urodynamics
This study aimed to evaluate the association between gestational diabetes mellitus and urinary incontinence during pregnancy, including symptom subtype, symptom severity, and incontinence-related quality of life. This cross-sectional study…
View details →Negative / Null Result ReportMedicine
van Driel, Swartjes, Lemmens et al. · 2026 · The British journal of surgery
Colorectal cancer (CRC) incidence is rising, consequentially traditional follow-up care models are increasingly unsustainable. Patient-led, home-based follow-up (PHFU) may offer a promising alternative to reduce hospital visits while…
View details →Negative / Null Result ReportMedicine
Tham, Linn, Koh et al. · 2026 · Transplantation and cellular therapy
The presence of anti-human leukocyte antigen (HLA) antibodies directed against donor HLA (HLA-DSA) in HLA-mismatched haematopoietic stem cell transplantation (HCT) can affect engraftment and transplant outcomes. Desensitisation treatment…
View details →Negative / Null Result ReportMedicine
Ni, Adams, Momenaei et al. · 2026 · Ophthalmology. Retina
To assess the effect of prophylactic treatment of lattice degeneration on retinal break and rhegmatogenous retinal detachment (RRD) risk in fellow eyes of patients with bilateral lattice degeneration treated for retinal break(s) without RD…
View details →Negative / Null Result ReportMedicine
Okada, Tominaga, Iwakura et al. · 2026 · Resuscitation
Out-of-hospital cardiac arrest (OHCA) is a public health concern. Whether conventional cardiopulmonary resuscitation (CPR) with rescue breathing may improve outcomes compared with compression-only or no CPR in suffocation-related OHCA is…
View details →Negative / Null Result ReportMedicine
AlDhafeeri, AlMugeiren · 2026 · Quintessence international (Berlin, Germany : 1985)
The use of lasers in dental implant procedures raises questions regarding the preservation of keratinized tissues and implant outcomes. This study aimed to compare the clinical effects (pain and impression time) and soft tissue healing…
View details →Negative / Null Result ReportMedicine
Ruan, Wu, Liao et al. · 2026 · Journal of neuroengineering and rehabilitation
Functional constipation (FCon) involves central nervous system dysregulation, particularly in brain regions responsible for visceral sensation, emotional processing, and autonomic control. Using functional near-infrared spectroscopy…
View details →Negative / Null Result ReportMedicine
Duman Aydin, Küçükosman, Mohamed et al. · 2026 · BMC medical education
Although oxygen therapy (OT) is a fundamental and life-saving intervention in the management of hypoxemia, it may lead to serious complications when applied incorrectly or in an uncontrolled manner. The aim of this study is to evaluate the…
View details →Negative / Null Result ReportMedicine
Zhou, Cao, You et al. · 2026 · BMC oral health
Photogrammetry technique may provide a promising approach compared to conventional techniques for multiple implants. However, the accuracy of photogrammetric technique for implant-supported fixed complete dentures in clinical scenarios…
View details →Negative / Null Result ReportMedicine
Yang, Mueller, D'Andrea et al. · 2026 · Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry
Resident physicians experience high rates of depression, anxiety, burnout, and loneliness, yet few evidence-based interventions have been evaluated in this population. This randomized controlled pilot trial examined the feasibility,…
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