Negative / Null Result ReportOpen accessMedicine
A. Giordano, Cristina Romero-Mascarell, Begoña González-Suárez et al. · 2025 · Digestive Diseases and Sciences
The integration of artificial intelligence (AI) into capsule endoscopy is transforming gastrointestinal diagnostics by enhancing lesion detection and optimizing reading efficiency. This review focuses on the clinical applications of…
View details →Negative / Null Result ReportMedicine
Wen Sun, Pan Zhang, Miaomiao Hu et al. · 2025 · Radiology
= .39). Conclusion In patients with VBAO admitted with an NIHSS score of 10 or less, early EVT (DPT ≤ 120 minutes) combined with BMM outperformed BMM alone, whereas late EVT (DPT > 120 minutes) combined with BMM did not outperform BMM…
View details →Negative / Null Result ReportOpen accessMedicine
Pinar Sargin, Mark F. Roethle, Shuang Jia et al. · 2022 · Gut Microbes
The increasing incidence of Type 1 diabetes has coincided with the emergence of the low-fiber, high-gluten Western diet and other environmental factors linked to dysbiosis. Since Lactiplantibacillus plantarum 299 v (Lp299v) supplementation improves gut barrier function and reduces systemic inflammation, we studied its effects in spontaneously diabetic DRlyp/lyp rats provided a normal cereal diet (ND) or a gluten-free hydrolyzed casein diet (HCD). All rats provided ND developed diabetes (62.5±7.7 days); combining ND with Lp299v did not improve survival. Diabetes was delayed by HCD (72.2±9.4 day
View details →Negative / Null Result ReportOpen accessMedicine
L. Liang, Weidong Wang · 2026 · Frontiers in Immunology
Mutant p53(Mtp53) not only loses its canonical tumor-suppressive functions but also acquires oncogenic gain-of-function properties, positioning it as a central orchestrator in reshaping the tumor immune microenvironment. This review systematically delineates how Mtp53 actively establishes and sustains an immunosuppressive niche through multiple interconnected mechanisms, including chronic inflammation, immune cell dysfunction, reprogramming of cancer-associated fibroblasts, metabolic dysregulation, epigenetic hijacking, and potentially aberrant liquid–liquid phase separation, thereby promoting
View details →Negative / Null Result ReportOpen accessMedicine
I Gede Nyoman Mindra Jaya, Yudhie Andriyana, Bertho Tantular et al. · 2025 · Sustainability
Accurate dengue forecasting is essential for sustainable public health planning, especially in tropical regions where the disease remains a persistent threat. This study evaluates the predictive performance of seven modeling approaches—Seasonal Autoregressive Integrated Moving Average (SARIMA), Extreme Gradient Boosting (XGBoost), Recurrent Neural Network (RNN), Long Short-Term Memory (LSTM), Bidirectional LSTM (BiLSTM), Convolutional LSTM (CNN–LSTM), and a Bayesian spatiotemporal model—using monthly dengue incidence data from 2009 to 2023 in Bandung City, Indonesia. Model performance was asse
View details →Negative / Null Result ReportOpen accessMedicine
Anna Morena D’Alise, Jason Willis, Fahriye Duzagac et al. · 2026 · Nature Medicine
Cancer interception is a preventative approach aiming to reduce cancer incidence by targeting precancers and early-stage cancers. Lynch syndrome (LS) is a prevalent hereditary cancer syndrome affecting ~1 in 300 individuals, with an…
View details →Negative / Null Result ReportOpen accessMedicine
Linjie Luo, Yan Wang, Tuyen Bui et al. · 2026 · Nature Communications
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy are the standard first-line treatment for hormone receptor-positive, HER2−negative (HR+/HER2−) metastatic breast cancer, but resistance inevitably develops.…
View details →Negative / Null Result ReportOpen accessMedicine
Jacopo Conti, Nicholas Geremia, Stefano Di Bella et al. · 2025 · European Journal of Clinical Microbiology & Infectious Diseases
PURPOSE: To describe the epidemiology, diagnosis, microbiological findings, clinical features, and outcomes of infectious spondylodiscitis (IS). METHODS: Retrospective analysis of 98 IS patients (2010-2023 - Trieste Hospital). Clinical, radiological, and microbiological data analysed, multivariate logistic regression assessed risk factors for poor outcomes. RESULTS: The incidence of IS was 3 cases per 100,000 inhabitants per year. Pyogenic infections accounted for 54% of cases, tuberculosis for 10%, while 35% remained of unknown etiology. Back pain (79%) and fever (72%) were the most common sy
View details →Negative / Null Result ReportOpen accessMedicine
Shabnam Santos, Ivonne Salinas, Nicolás Almeida et al. · 2025 · Engineering Microbiology
ABSTRACT Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disorder characterized by debilitating motor and non-motor symptoms. Its etiology is multifactorial, with no single definitive cause identified, although aging…
View details →Negative / Null Result ReportOpen accessMedicine
Kevin Damman, Dirk J. van Veldhuisen, Johann Bauersachs et al. · 2026 · JAMA
Importance: Digitalis glycosides may be used as additional therapy in patients with heart failure with mildly reduced ejection fraction (HFmrEF) or HF with reduced EF (HFrEF). Objective: To assess the effect of digitalis glycosides on…
View details →Negative / Null Result ReportOpen accessMedicine
Jimmy Chun Yu Louie · 2026 · Critical Reviews in Food Science and Nutrition
The Nova food classification system has become highly influential in nutritional epidemiology, linking negative health outcomes to "ultra-processed foods" based on industrial formulation. It assumes that products made with substances and…
View details →Negative / Null Result ReportOpen accessMedicine
Yuanbing Jiang, Wenyue Zheng, Zengjie Xia et al. · 2026 · Proceedings of the National Academy of Sciences
Phosphorylated-tau 217 (pTau217) is currently the most promising blood-based biomarker for accurately detecting Alzheimer’s disease (AD) pathology. However, interference from peripheral tau species in the kidneys or peripheral nerves can…
View details →Negative / Null Result ReportOpen accessMedicine
Y. Kanemitsu, Yasuhiro Shimizu, Junki Mizusawa et al. · 2026 · Journal of Clinical Oncology
JCOG0603 demonstrated improved disease-free survival (DFS) with adjuvant mFOLFOX6 after hepatectomy compared with hepatectomy alone in colorectal liver-only metastasis (CRLM), but the overall survival (OS) data were immature. Here, we…
View details →Negative / Null Result ReportOpen accessMedicine
Megan L. Uhelski, Mandee K. Schaub, Felipe Espinosa et al. · 2026 · Pain
ABSTRACT: Nonselective antagonists of voltage-gated sodium channels (VGSCs) provide effective local analgesia, but systemic administration is fraught with unwanted cardiovascular and central nervous system toxicity. The development of…
View details →Negative / Null Result ReportOpen accessMedicine
Florian Kahles, Andreas L. Birkenfeld, Nikolaus Marx · 2026 · Journal of Clinical Investigation
The incretin hormone glucagon-like peptide-1 (GLP-1) exerts potent effects on glucose metabolism, prompting the development of therapeutic strategies that enhance activity of the GLP-1 receptor (GLP-1R) pathway. Inhibitors of dipeptidyl peptidase 4 (DPP-4) prolong the half-life of endogenous GLP-1 and typically achieve reductions in HbA1c of 0.5%-0.8%. However, large-scale cardiovascular (CV) outcomes trials (CVOTs) with DPP-4 inhibitors demonstrated CV safety but did not show a reduction in CV events. A second incretin-based therapeutic approach was the development of GLP-1R agonists (GLP-1RA
View details →Negative / Null Result ReportOpen accessMedicine
Youying Mao, Weidong Shen, Jiayao Shen et al. · 2025 · Kidney International Reports
Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease and approximately 40% of patients with SLE progress to lupus nephritis (LN). The treatment of refractory SLE and LN remains challenging. This clinical study aimed to…
View details →Negative / Null Result ReportOpen accessMedicine
Jean‐Christophe Marine, Osnat Bartok, Shira Sagie et al. · 2026 · Cell
Intratumor heterogeneity (ITH) encompasses genetic, epigenetic, transcriptional, proteomic, and immunopeptidomic diversity. Beyond genetic heterogeneity, it is increasingly clear that non-mutational heterogeneity and plasticity generate…
View details →Negative / Null Result ReportOpen accessMedicine
Lyduine Eisa Collij, Gemma Salvadó, Kanta Horie et al. · 2026 · Nature Communications
To efficiently implement plasma and cerebrospinal fluid (CSF) biomarkers for staging and prognosis of Alzheimer disease (AD), we must understand their dynamics across disease progression. We analyzed participants from the Swedish BioFINDER-2 study with mass spectrometry measurements of plasma and CSF tau species, including eMTBR-tau243/MTBR-tau243 and phosphorylation occupancies (%p-tau). Disease duration was estimated using Aβ-PET and tau-PET with the SILA algorithm. Bootstrapped LOESS models showed that %p-tau217 changes earliest, increasing just before Aβ-PET positivity. Other p-tau species
View details →Negative / Null Result ReportOpen accessMedicine
Bilal A. Siddiqui, Sumit K. Subudhi, Padmanee Sharma · 2022 · Cell Reports Medicine
The addition of atezolizumab (anti-PD-L1) to enzalutamide (androgen receptor antagonist) did not prolong survival in metastatic prostate cancer.1Powles T. Yuen K.C. Gillessen S. Kadel 3rd, E.E. Rathkopf D. Matsubara N. Drake C.G. Fizazi K.…
View details →Negative / Null Result ReportOpen accessMedicine
Marta Młodawska, Anna Zmelonek-Znamirowska, Grzegorz Świercz et al. · 2026 · Journal of Clinical Medicine
Background and Objectives: Placenta accreta spectrum (PAS) complicating placenta praevia is associated with increased maternal morbidity; however, neonatal respiratory burden may be underappreciated. We compared neonatal outcomes between pregnancies complicated by placenta praevia with and without histopathologically confirmed PAS, with additional adjustment of respiratory outcomes for gestational age at delivery. Materials and Methods: We conducted a retrospective single-centre cohort study (n = 82). Based on placental histopathology, women were classified as PAS (n = 37; accreta/increta/perc
View details →Negative / Null Result ReportOpen accessMedicine
Ashley I. Martinez, Sarah C. MacDonald, Sruthi Adimadhyam et al. · 2026 · JAMA Network Open
Importance: Respiratory syncytial virus (RSV) is a leading cause of infant hospitalizations. In August 2023, the US Food and Drug Administration approved a bivalent RSV prefusion F subunit-based vaccine (RSVpreF) for maternal immunization…
View details →Negative / Null Result ReportOpen accessMedicine
Grzegorz K. Jakubiak, Natalia Pawlas, Monika Starzak et al. · 2026 · Vascular Health and Risk Management
Purpose: The purpose of this study was to analyze the relationship between resting high-sensitive serum cardiac troponin T concentration (hs-cTnT), D-dimer, and N-terminal pro–B-type natriuretic peptide (NT-proBNP), measured outside the…
View details →Negative / Null Result ReportOpen accessMedicine
Suli Yu, Zhen Pang, Hong Fang et al. · 2026 · Molecular Biomedicine
Ferroptosis, a regulated cell death modality driven by iron accumulation and lipid peroxidation, has emerged as a pivotal pathophysiological mechanism across a broad spectrum of cardiovascular diseases (CVDs), which remain the leading cause of global mortality. Although robust preclinical evidence indicates that modulation of ferroptosis attenuates myocardial and vascular injury, clinical translation is constrained by incomplete understanding of context-specific roles, the paucity of validated biomarkers, and the absence of targeted therapeutics with acceptable safety profiles. In this Review,
View details →Negative / Null Result ReportOpen accessMedicine
Mónika Fekete, Tamás Jarecsny, Andrea Ceglédi et al. · 2025 · Nutrients
Background: Neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease, are among the leading causes of disability and mortality worldwide. Dietary patterns have emerged as modifiable risk factors that may influence disease onset and progression. The Mediterranean diet (MedDiet), rich in fruits, vegetables, whole grains, legumes, fish, and extra virgin olive oil, has been consistently associated with better cognitive outcomes and reduced risk of neurodegeneration. Aim: This narrative review summarizes current evidence on the role of the MedDiet in slowing the progression
View details →Negative / Null Result ReportOpen accessMedicine
Cristina Migliore, Elisabetta Fenocchio, Silvia Giordano et al. · 2025 · Cancer Treatment Reviews
Gastric cancer (GC) is the third leading cause of cancer-related mortality worldwide, and is associated with a very poor prognosis, largely due to its aggressive nature and, typically, late-stage diagnosis. Molecular classifications proposed one decade ago have provided valuable insights into the disease's heterogeneity and paved the way for clinical trials of tailored treatments. However, most of these trials have failed, often due to inadequate patient selection, lack of reliable biomarkers of response/resistance, or for the high level of inter- and intra-tumor heterogeneity characterizing t
View details →Negative / Null Result ReportOpen accessMedicine
Steffen Tiedt, Alejandro Bustamante, Alan Cameron et al. · 2026 · The Lancet Neurology
The complexity and incomplete understanding of the pathophysiology of stroke poses substantial challenges to personalised medicine and the development of novel therapies, as reflected in the neutral results of many randomised trials. Current clinical algorithms lack the precision to diagnose stroke before hospital admission, predict disease progression and recovery, or assess recurrence risk. Biomarkers are urgently needed, yet the absence of a robust evidence base hinders their clinical translation. To lay the groundwork for addressing this knowledge gap, an international multidisciplinary pa
View details →Negative / Null Result ReportOpen accessMedicine
T. Nguyen, Tam Dao, Ha Thu Nguyen et al. · 2026 · Endocrinology and Metabolism
Sarcopenia is a progressive, age-related condition characterized by the loss of skeletal muscle mass, strength, and function, which increases the risk of falls, frailty, and loss of independence. Despite growing recognition and its…
View details →Negative / Null Result ReportOpen accessMedicine
Eleanor Quek, Neve Horn, Salman Siddiqui · 2025 · ImmunoTargets and Therapy
Asthma represents a profoundly heterogeneous syndrome underpinned by multiple, distinct and overlapping immunopathological mechanisms. Nevertheless, prevailing management algorithms continue to adopt a largely uniform, stepwise approach in…
View details →Negative / Null Result ReportOpen accessMedicine
Dinh Van Trung, Bui Thi Huong Giang, Đang Quoc Tuan et al. · 2025 · Scientific Reports
Electrical impedance tomography (EIT)-guided positive end-expiratory pressure (PEEP) titration may optimize ventilation and reduce ventilator-induced lung injury in acute respiratory distress syndrome (ARDS). We compared EIT-guided PEEP…
View details →Negative / Null Result ReportMedicine
Maximilian Stahl, Amer M. Zeidan · 2025 · Blood
ABSTRACT: Aside from allogeneic transplantation, the current standard-of-care approach for higher-risk myelodysplastic syndromes/neoplasms (HR-MDS) remains monotherapy with a hypomethylating agent (HMA), including azacitidine, decitabine,…
View details →