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11,309 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

The associations of long-term physical activity in adulthood with later biological ageing and all-cause mortality – a prospective twin study

Anna Kankaanpää, Asko Tolvanen, Laura Joensuu et al. · 2025 · European Journal of Epidemiology

OBJECTIVES: The association between leisure-time physical activity (LTPA) and a lower risk of mortality is susceptible to bias from multiple sources. We investigated the potential of biological ageing to mediate the association between long-term LTPA and mortality and whether the methods used to account for reverse causality affect the interpretation of this association. METHODS: Study participants were twins from the older Finnish Twin Cohort (n = 22,750; 18-50 years at baseline). LTPA was assessed using questionnaires in 1975, 1981 and 1990. The mortality follow-up lasted until 2020 and biol

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Negative / Null Result ReportOpen accessMedicine

SHAP-based interpretable machine learning for injury risk prediction in university football players: a multi-dimensional data analysis approach

Jiacheng Ma, Shengrui Liu, Yuting Pei · 2025 · Scientific Reports

Sports injury prediction is crucial for university football player health, yet existing research predominantly focuses on professional athletes and lacks interpretability. Using the Kaggle "University Football Injury Prediction Dataset"…

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Negative / Null Result ReportOpen accessMedicine

Effects of regular exercise on neutrophil functions, oxidative stress parameters and antibody responses against 4-hydroxy-2-nonenal adducts in middle aged humans

Soichiro Sasaki, Takayuki Matsuura, Rei Takahashi et al. · 2026 · PubMed

Regular exercise has recognized health benefits, partly because it reportedly lowers the levels of the oxidation products of proteins and DNA at rest, in contrast with the effect of acute exercise. However, when we compared oxidative…

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Negative / Null Result ReportOpen accessMedicine

Coffee and Tea Intake, Dementia Risk, and Cognitive Function

Yu Zhang, Yuxi Liu, Yanping Li et al. · 2026 · JAMA

Importance: Evidence linking coffee and tea to cognitive health remains inconclusive, and most studies fail to differentiate caffeinated from decaffeinated coffee. Objective: To investigate associations of coffee and tea intake with…

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Negative / Null Result ReportOpen accessMedicine

Feasibility of two levels of protein intake in patients with colorectal cancer: findings from the Protein Recommendation to Increase Muscle (PRIMe) randomized controlled pilot trial

Katherine L. Ford, Michael B. Sawyer, Sunita Ghosh et al. · 2024 · ESMO Open

•Patients were able to increase and sustain dietary protein intake from preintervention levels.•Over one-half of patients in the 2.0 g/kg/day group maintained or gained MM with a 12-week targeted nutrition intervention.•This work…

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Negative / Null Result ReportOpen accessMedicine

Relationship between central autonomic effective connectivity and heart rate variability: A Resting-state fMRI dynamic causal modeling study

Liangsuo Ma, Larry Keen, Joel L. Steinberg et al. · 2024 · NeuroImage

• Resting- state fMRI data were acquired from 34 healthy participants. • Effective connectivities (ECs) associated with HRV and heart rate were investigated. • Regression DCM and ICA were used to identify most relevant network nodes. • ECs…

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Negative / Null Result ReportMedicine

The effects of prehospital TXA on mortality and neurologic outcomes in patients with traumatic intracranial hemorrhage: A subgroup analysis from the prehospital TXA for TBI trial

Susan Rowell, Eric N. Meier, Tatiana Hoyos Gomez et al. · 2024 · The Journal of Trauma: Injury, Infection, and Critical Care

BACKGROUND: In the prehospital tranexamic acid (TXA) for traumatic brain injury (TBI) trial, TXA administered within 2 hours of injury in the out-of-hospital setting did not reduce mortality in all patients with moderate/severe traumatic…

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Negative / Null Result ReportOpen accessMedicine

Efficacy, public health impact and optimal use of the Takeda dengue vaccine

Bethan Cracknell Daniels, Neil M. Ferguson, Ilaria Dorigatti · 2025 · Nature Medicine

Dengue is the most common arboviral infection, causing substantial morbidity and mortality globally. The licensing of Qdenga, a second-generation vaccine developed by Takeda Pharmaceuticals, is therefore timely, but the potential public health impact of vaccination across transmission settings needs to be evaluated. To address this, we characterized Qdenga's efficacy profile using mathematical models calibrated to published clinical trial data and estimated the public health impact of routine vaccine use. We find that efficacy against both virologically confirmed dengue and hospitalization dep

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Negative / Null Result ReportOpen accessMedicine

Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus

Elisa Alonso‐Perez, Marian Suarez-Gestal, Manuel Calaza et al. · 2014 · Arthritis Research & Therapy

INTRODUCTION: We aimed to replicate a recent study which showed higher genetic risk load at 15 loci in men than in women with systemic lupus erythematosus (SLE). This difference was very significant, and it was interpreted as indicating that men require more genetic susceptibility than women to develop SLE. METHODS: Nineteen SLE-associated loci (thirteen of which are shared with the previous study) were analyzed in 1,457 SLE patients and 1,728 healthy controls of European ancestry. Genetic risk load was calculated as sex-specific sum genetic risk scores (GRS(s)). RESULTS: Our results did not r

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Negative / Null Result ReportOpen accessMedicine

Cancer cachexia: molecular basis and therapeutic advances

Yuting Tan, Rui Xue, Yuwei Pan et al. · 2026 · Signal Transduction and Targeted Therapy

The dynamic interplay between neoplastic cells and the host has been increasingly recognized as important players in the pathogenesis of cancer cachexia, a syndrome affecting ~50-80% of cancer patients with various incidences of different types of malignancies. Despite its prevalence, a comprehensive understanding of cancer cachexia progression, with a holistic view at the cross-organismal, cellular and molecular levels, remains elusive. In this review, we undertake an in-depth exploration of the relevant target organs and their regulatory roles in cancer cachexia, with a particular focus on m

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Negative / Null Result ReportOpen accessMedicine

Safety of Avacopan for the Treatment of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: Combined Data From Three Clinical Trials

Peter A. Merkel, Michael George, Huibin Yue et al. · 2025 · ACR Open Rheumatology

OBJECTIVE: This study aimed to report the safety of avacopan, an oral selective complement C5a receptor antagonist, using pooled data from clinical trials in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis…

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Negative / Null Result ReportOpen accessMedicine

Lingual Lymph Node Metastases as a Prognostic Factor in Oral Squamous Cell Carcinoma—A Retrospective Multicenter Study

Masahiro Kikuchi, Hiroyuki Harada, Ryo Asato et al. · 2021 · Medicina

Backgrounds and Objectives: The epidemiology and prognostic role of lingual lymph node (LLN) metastasis in patients with oral squamous cell carcinoma (OSCC) remain unclear. Here, we aimed to analyze the clinicopathological features, risk factors, and prognostic role of LLN metastasis in patients with OSCC. Materials and Methods: In total, 945 patients with OSCC were retrospectively analyzed. Clinicopathological features were compared between patients with and without LLN metastasis. The risk factors of LLN metastasis and its effects on survival outcomes were evaluated using multi-variate analy

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Negative / Null Result ReportOpen accessMedicine

Sensitivity of the UK Clinical Practice Research Datalink to Detect Neurodevelopmental Effects of Medicine Exposure in Utero: Comparative Analysis of an Antiepileptic Drug-Exposed Cohort

Rachel Charlton, Anita McGrogan, Julia Snowball et al. · 2017 · Drug Safety

Electronic healthcare data have several advantages over prospective observational studies, but the sensitivity of data on neurodevelopmental outcomes and its comparability with data generated through other methodologies is unknown. The…

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Negative / Null Result ReportMedicine

Replication of a predictive model for youth ADHD in an independent sample from a developing country

Cezar H. Lorenzi, Douglas Teixeira Leffa, Rodrigo A. Bressan et al. · 2022 · Journal of Child Psychology and Psychiatry

BACKGROUND: Very few predictive models in Psychiatry had their performance validated in independent external samples. A previously developed multivariable demographic model for attention-deficit/hyperactivity disorder (ADHD) accurately…

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Negative / Null Result ReportOpen accessMedicine

Characterization of a Novel Tanay Virus Isolated From Anopheles sinensis Mosquitoes in Yunnan, China

Lu Zhao, Caroline Mwaliko, Evans Atoni et al. · 2019 · Frontiers in Microbiology

Globally, mosquitoes are known to be competent vectors to various arboviruses that cause serious and debilitating diseases to humans and animals. Conversely, mosquitoes harbor a wide array of insect specific viruses (ISVs) that are generally neglected. Extensive characterization of these ISVs is important in understanding their persistence infection effect on host behavior and arbovirus transmission. Herein, we report first time isolation of Tanay virus (TANAV) isolate YN15_103_01 in Anopheles sinensis mosquitoes from Yunnan Province, China. Phylogenetically, the isolate’s nucleotide identity

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Negative / Null Result ReportOpen accessMedicine

Evaluating deep learning methods in detecting and segmenting different sizes of brain metastases on 3D post-contrast T1-weighted images

Youngjin Yoo, Pascal Ceccaldi, Siqi Liu et al. · 2021 · Journal of Medical Imaging

Purpose: We investigate the impact of various deep-learning-based methods for detecting and segmenting metastases with different lesion volume sizes on 3D brain MR images. Approach: A 2.5D U-Net and a 3D U-Net were selected. We also…

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Negative / Null Result ReportOpen accessMedicine

Polaprezinc for prevention of oral mucositis in patients receiving chemotherapy followed by hematopoietic stem cell transplantation: A multi‐institutional randomized controlled trial

Junichi Kitagawa, Ryo Kobayashi, Yasuyuki Nagata et al. · 2020 · International Journal of Cancer

Oral mucositis is a common and distressing complication in patients receiving high-dose chemotherapy followed by hematopoietic stem cell transplantation (HSCT). We reported previously in a single-center retrospective analysis that…

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Negative / Null Result ReportOpen accessMedicine

Microstructural White Matter Characteristics in Parkinson's Disease With Depression: A Diffusion Tensor Imaging Replication Study

Colleen Lacey, Lisa Ohlhauser, Jodie R. Gawryluk · 2019 · Frontiers in Neurology

Background Clarifying the neuropathology of depression as a symptom of Parkinson's disease (PD) has been the goal of recent neuroimaging studies; however, results have been conflicting and lack replication. The purpose of the current study was to replicate recent methods that have used diffusion tensor imaging (DTI) to compare individuals with PD with and without depression and to extend previous findings to allow for a better understanding of the results. Methods Thirty-seven participants with de novo PD were retrieved from the Parkinson's Progression Marker's Initiative (PPMI) and were separ

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Negative / Null Result ReportOpen accessMedicine

Correlation of Objective Endpoints and Subjective Patient-Reported Outcomes in NAFLD Treatment with Essential Phospholipids: Real-World Data Based on Pooled Analysis of Observational Studies

В. Т. Ивашкин, М. V. Maevskaya, Е. Н. Широкова et al. · 2021 · Drugs - Real World Outcomes

While no “gold-standard” pharmacotherapy for nonalcoholic fatty liver disease (NAFLD) is yet established, essential phospholipids (EPLs) are reported to decrease steatosis and improve laboratory parameters. This analysis evaluated…

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Negative / Null Result ReportMedicine

Results of the Kigali Imbereheza Project: A 2-Arm Individually Randomized Trial of TI-CBT Enhanced to Address ART Adherence and Mental Health for Rwandan Youth Living With HIV

Geri R. Donenberg, Jessica Fitts, Charles Ingabire et al. · 2022 · JAIDS Journal of Acquired Immune Deficiency Syndromes

Background: Adolescents living with HIV have elevated mental distress and suboptimal antiretroviral therapy (ART) adherence. Setting: Two urban clinics in Kigali, Rwanda. Methods: A 2-arm individual randomized controlled trial compared…

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Negative / Null Result ReportMedicine

In situcell–matrix mechanics in tendon fascicles and seeded collagen gels: implications for the multiscale design of biomaterials

Neil A. Duncan, Sabina B. Bruehlmann, Christopher Hunter et al. · 2012 · Computer Methods in Biomechanics & Biomedical Engineering

Designing biomaterials to mimic and function within the complex mechanobiological conditions of connective tissues requires a detailed understanding of the micromechanical environment of the cell. The objective of our study was to measure…

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Negative / Null Result ReportOpen accessMedicine

Phase II clinical trial of sequential treatment with systemic chemotherapy and intraperitoneal paclitaxel for gastric and gastroesophageal junction peritoneal carcinomatosis - STOPGAP trial

Maheswari Senthil, Farshid Dayyani · 2023 · BMC Cancer

BACKGROUND: Studies from Asia indicate that normothermic intraperitoneal chemotherapy (NIPEC) may confer survival benefit in patients with gastric peritoneal carcinomatosis (PC). However, data regarding this approach is lacking in western population. The current STOPGAP trial is intended to assess 1-year progression-free survival benefit of sequential systemic chemotherapy and paclitaxel NIPEC in patients with gastric/ gastroesophageal junction (GEJ) adenocarcinoma PC. METHODS: This is a prospective, single center, single arm, phase II investigator-initiated clinical trial. Patients with histo

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Negative / Null Result ReportOpen accessMedicine

Validating genetic markers of response to recombinant human growth hormone in children with growth hormone deficiency and Turner syndrome: the PREDICT validation study

Adam Stevens, Philip Murray, Jérôme Wojcik et al. · 2016 · European Journal of Endocrinology

OBJECTIVE: Single-nucleotide polymorphisms (SNPs) associated with the response to recombinant human growth hormone (r-hGH) have previously been identified in growth hormone deficiency (GHD) and Turner syndrome (TS) children in the PREDICT long-term follow-up (LTFU) study (Nbib699855). Here, we describe the PREDICT validation (VAL) study (Nbib1419249), which aimed to confirm these genetic associations. DESIGN AND METHODS: Children with GHD (n = 293) or TS (n = 132) were recruited retrospectively from 29 sites in nine countries. All children had completed 1 year of r-hGH therapy. 48 SNPs previou

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