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11,421 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Metagenomic Insights into Gut Microbiota Alterations Following <i>Dendrobium huoshanense</i> Water Extract Intervention in Streptozotocin-Induced Type 1 Diabetic Rats.

Xu HJ, Liu QL, Zhang YF et al. · 2026 · International journal of molecular sciences

Dendrobium huoshanense water extract (DHWE) exhibits hypoglycemic effects in streptozotocin-induced type 1 diabetic (STZ-T1D) rats. However, its regulatory impact on the gut microbiota of T1D rats remains largely unclear. In this study,…

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Negative / Null Result ReportMedicine

The impact of postoperative calcaneocuboid joint articular surface gap and step on long-term outcomes in surgically treated calcaneal fractures: a brief report.

Sayyed-Hosseinian SH, Samadi S, Yazdi P et al. · 2026 · BMC musculoskeletal disorders

Background Calcaneal fractures, the most common tarsal fractures, often result in significant long-term disability and impose substantial healthcare burdens. Surgical intervention aims to restore hindfoot anatomy, but the role of…

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Negative / Null Result ReportMedicine

Effects of Combined Lipid-Based Nutrient Supplements and Malaria Preventive Treatment during Pregnancy on Malaria, Maternal Nutrition, and Birth Outcomes: A Scoping Review.

Parikh P, Zeilani M, Pieret A et al. · 2026 · Nutrition reviews

Malaria and malnutrition adversely affect maternal and neonatal health in Sub-Saharan Africa. While intermittent preventive treatment of malaria in pregnancy (IPTp) is widely used to reduce malaria incidence, the potential additional…

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Negative / Null Result ReportMedicine

Incidence of periprocedural myocardial injury and clinical outcomes after rotational atherectomy vs. intravascular lithotripsy.

Emori H, Shiono Y, Yamanobe H et al. · 2026 · International journal of cardiology

Background Intravascular lithotripsy (IVL) and rotational atherectomy (RA) are established plaque-modifying strategies for heavily calcified coronary lesions. Despite their different mechanisms, the incidence of significant periprocedural…

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Negative / Null Result ReportMedicine

Moderate Dietary <i>Lactobacillus acidophilus</i> Supplementation Enhances Mid-Growth Nutrient Utilization and Shifts Intestinal <i>Lactobacillus</i> and <i>Escherichia coli</i> Counts in Yellow-Feathered Broilers.

Yushanaji B, Zhang X, Tian T et al. · 2026 · Animals : an open access journal from MDPI

This study tested the hypothesis that dietary L. acidophilus would improve nutrient utilization in yellow-feathered broilers mainly through intestinal changes rather than a consistent increase in growth performance. A total of 195…

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Negative / Null Result ReportMedicine

Mitochondrial dysfunction in schizophrenia and its modulation by atypical antipsychotic drugs: A randomized controlled trial.

Shaju A, Mishra BR, Mohapatra D et al. · 2026 · Journal of psychopharmacology (Oxford, England)

BackgroundRecent evidence increasingly links schizophrenia to mitochondrial dysfunction, implicating altered mitochondrial respiratory and metabolic processes in its pathophysiology. Preclinical data suggest that atypical antipsychotics…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of Changes in the Iridocorneal Angle and Anterior Segment Parameters Following Selective Laser Trabeculoplasty in Pseudoexfoliation Glaucoma.

Yıldırım Erdal BD, Bayraktar S · 2026 · Turkish journal of ophthalmology

Objectives To investigate the effects of selective laser trabeculoplasty (SLT) on the iridocorneal angle, anterior chamber, and iris in patients with pseudoexfoliation glaucoma (PEXG) and to evaluate the relationship between these…

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Negative / Null Result ReportMedicine

Effects of exercise mode and intensity on retinal microvascular structure and function in heart failure patients with preserved ejection fraction: a pilot exercise intervention trial.

Streese L, Ritter ET, Schoch R et al. · 2026 · Journal of vascular research

Purpose We aimed to investigate the effect of different exercise modes on retinal microvascular endothelial function in patients with HF with preserved ejection fraction (HFpEF). Methods Twenty-eight patients were randomly allocated to…

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Negative / Null Result ReportMedicine

Postoperative Mobility After Partial Semitendinosus Tendon Harvesting in Pelvic Organ Prolapse Surgery: Results of a Prospective Observational Study.

Hornemann A, Bosserhoff M, Coltan L et al. · 2026 · International urogynecology journal

Introduction and hypothesis This study investigates the postoperative mobility following partial semitendinosus tendon harvesting performed during pelvic organ prolapse (POP) repair using the Hornemann Tendon Transplantation (HoTT®)…

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Negative / Null Result ReportOpen accessMedicine

Assessment of changes in lung aeration and diaphragmatic function using ultrasonography in laparoscopic abdominal surgery: a prospective observational study.

Sethi D, Prajapati S, Garg G · 2026 · Anesthesia and pain medicine

Background A few studies investigating the perioperative use of lung ultrasound (LUS) have shown loss of lung aeration with decline in diaphragmatic function after general anesthesia. We aimed to measure changes in lung aeration and…

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Negative / Null Result ReportMedicine

Precision, least significant change and validity of body composition estimates from bioelectrical impedance analysis, 3D-optical scanning, and dual X-ray absorptiometry.

Oliver CJ, Del Vecchio L, Climstein M et al. · 2026 · Clinical nutrition ESPEN

Background Accurate assessment of body composition beyond BMI is necessary in clinical care. Bioelectrical impedance analysis (BIA) and 3D scanning (3DS) are practical two-compartment (2C) methods estimating % body fat (%BF), fat mass…

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Negative / Null Result ReportMedicine

Real-world outcomes of naïve, early switch and late switch eyes treated with dexamethasone intravitreal implant for retinal vein occlusion.

Diego-Navarro O, Copete S, Moreno-Martínez A et al. · 2026 · European journal of ophthalmology

PurposeTo evaluate functional and anatomical outcomes after intravitreal dexamethasone implant (DEXI) in macular edema secondary to retinal vein occlusion (ME-RVO), comparing treatment-naïve eyes with early-switch (ES) and late-switch (LS)…

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Negative / Null Result ReportMedicine

Incremental peritoneal dialysis with days off vs standard-dose peritoneal dialysis: a propensity-matched study (PD holiday).

Parapiboon W, Pattanapongpaibool A, Sanprasert S · 2026 · International urology and nephrology

Purpose The benefits of incremental peritoneal dialysis (IPD) with days off remain controversial. This study aimed to compare the survival rate between IPD with days off and standard-dose peritoneal dialysis (PD). Methods Participants who…

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Negative / Null Result ReportOpen accessMedicine

Machine learning for patient selection in corticosteroid decision making in knee osteoarthritis: A feasibility model.

Musbahi O, Pouris K, Hadjixenophontos S et al. · 2025 · World journal of methodology

Background Relieving pain is central to the early management of knee osteoarthritis, with a plethora of pharmacological agents licensed for this purpose. Intra-articular corticosteroid injections are a widely used option, albeit with…

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Negative / Null Result ReportMedicine

Comparison of the Effects of Different Routes of Hysterectomy With Salpingectomy Procedures on the Ovarian Reserve, Ovarian Doppler, and Sexual Function Parameters.

Aytekin AM, Ulusoy HE, Efe MA et al. · 2026 · The journal of obstetrics and gynaecology research

Objective To evaluate the impact of bilateral salpingectomy added to hysterectomy performed via different surgical routes on ovarian reserve, ovarian stromal blood flow, and sexual function in premenopausal women. Methods This prospective…

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