11,421 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Omerovic E, Råmunddal T, Jha S et al. · 2026 · European heart journal. Cardiovascular pharmacotherapy
Two contemporary randomized trials of β-blocker therapy after myocardial infarction (MI) reached apparently conflicting conclusions. REBOOT, conducted in Spain and Italy, found no reduction in death or major cardiovascular events among…
View details →Mittal H, Thattaruthody F, Akella M et al. · 2026 · Indian journal of ophthalmology
Abstract This experiment was designed to study the effect of mitomycin C (MMC) on conjunctival lymphatics and the lymphangiogenesis potential of synthetic retinoic acid (ec23) in rat eyes. This prospective animal experimental study…
View details →Royo M, Jiménez Á, Molina-Martin A et al. · 2026 · European journal of ophthalmology
PurposeTo analyze the amplitude of accommodation and its changes at a 6-month follow-up in healthy subjects implanted with an anterior chamber pIOL, assessing whether accommodative function is affected. Additionally, changes in visual…
View details →Temizel KA, Dursun P, Ikizoglu G · 2026 · Postepy dermatologii i alergologii
Introduction Chronic spontaneous urticaria (CSU) and urticarial vasculitis (UV) are chronic inflammatory skin disorders. Monoclonal anti-IgE therapy is widely approved for CSU and is increasingly investigated for its broader…
View details →Siqueira RC, Pinho TS, Brandao CC · 2026 · Cureus
Objective The objective of this study was to evaluate the short-term ocular safety, feasibility, and exploratory functional signals associated with intravitreal adalimumab (ADA) in patients with retinitis pigmentosa (RP). Methods This…
View details →Nelles D, Özkan N, Vogelhuber J et al. · 2026 · Heart and vessels
To assess the impact of functional tricuspid regurgitation (FTR) and transcatheter tricuspid valve repair (TTVR) on sympathetic nerve activity (SNA). Increased SNA is associated with adverse outcomes and reduced survival in patients with…
View details →Sun G, Lin W, Peng Y et al. · 2026 · BMC anesthesiology
Postoperative fatigue is a prevalent complication delaying early recovery after gynecological laparoscopic surgery, with no proven effective interventions. To investigate the effect of continuous intraoperative low-dose esketamine on…
View details →Ciccarelli G, Monaco E, Nasso V et al. · 2026 · Journal of experimental orthopaedics
Purpose The purpose of this study was to quantify return-to-play (RTP) time, post-operative performance and market-value trends after proximal hamstring repair in top-tier European league soccer players. It was hypothesized that surgery…
View details →Deruelle P, Arcieri F, Martineau R · 2026 · Gynecologie, obstetrique, fertilite & senologie
Background Hyperemesis gravidarum (HG) remains one of the most disabling complications of the first trimester, with a high risk of recurrence after a prior episode that weighs heavily on family planning and on patients' mental health.…
View details →Pak K, Yoon C, Sadda SR · 2026 · Eye (London, England)
Purpose To evaluate longitudinal change in hard exudate (HEs) volume over 5-years following anti-VEGF treatment for diabetic macular oedema (DMO). Methods This study was a post-hoc analysis of structural optical coherence tomography (OCT)…
View details →Kim HSW, Cha S, Choi JY et al. · 2026 · The Journal of craniofacial surgery
This study compared the upper airway dimensions following maxillomandibular advancement (MMA) surgery in adults with obstructive sleep apnea (OSA) with those of normal controls. Korean adult OSA patients who underwent conventional MMA…
View details →Haflidadottir S, Helgadottir FD, Sighvatsson MB · 2026 · Scandinavian journal of psychology
The global burden of infertility and its associated psychological distress is substantial, yet many individuals face barriers to accessing psychological support. A scalable, low-cost online intervention presents a promising solution. A…
View details →Leal Barbosa V, Westenhofen D, Scherdien Silva P et al. · 2026 · Lasers in medical science
Purpose To evaluate the efficacy of 8% arginine-based desensitizing toothpaste and photobiomodulation (PBM), used alone or in combination, in the treatment of dentin hypersensitivity (DH). Materials and methods This randomized,…
View details →van Lohuizen Q, Fransen SJ, Yiasemis G et al. · 2026 · European radiology
Objectives To determine whether AI-reconstructed prostate MRI at reduced acquisition times maintains prostate cancer (PCa) detection performance comparable to conventional scans. Materials and methods This multicenter, retrospective,…
View details →Akay T, Arslan RS · 2026 · Scientific reports
Patients with deep perianal abscess (DPA) and transsphincteric fistula typically require incision and drainage as emergency treatment. However, recurrent abscesses and fistulas are common. This study aimed to evaluate the impact of…
View details →Verhulst E, Ten Broek R, Bislenghi G et al. · 2026 · Techniques in coloproctology
Postoperative intraabdominal adhesions remain one of the most common and clinically significant complications following abdominal and pelvic surgery. Adhesions contribute to adhesive small bowel obstruction (aSBO), chronic abdominal pain,…
View details →Ichie K, Asomugha A, Okafor I · 2026 · BMC neuroscience
Background Parkinson's disease (PD) is a progressive neurodegenerative disorder strongly associated with dopaminergic neuronal degeneration and alpha-synuclein pathology. Paraquat (PQ) has been implicated in Parkinsonian neurodegeneration;…
View details →Somerville E, Bollinger RM, Haxton M et al. · 2026 · OTJR : occupation, participation and health
Interventions to address polypharmacy and improve adherence are insufficient for community-dwelling older adults. To examine the feasibility, acceptability, and preliminary efficacy of a tailored medication management intervention (TIMM)…
View details →Hsieh YC, Lu WY, Chen YL et al. · 2026 · BMC ophthalmology
Background Selective laser trabeculoplasty (SLT) is a widely accepted treatment for primary open-angle glaucoma (POAG), but its role in primary angle-closure glaucoma (PACG) remains less defined. This study aimed to evaluate the short-term…
View details →Verbo A, Verbo I · 2026 · Langenbeck's archives of surgery
Background Enhanced Recovery After Surgery (ERAS) protocols are widely implemented in colorectal surgery to improve postoperative recovery and reduce hospital stay. However, their impact on postoperative morbidity in elderly and clinically…
View details →Maiorca C, Tramontano D, Di Costanzo A et al. · 2026 · Internal and emergency medicine
Residual cardiovascular risk persists in many patients despite optimal control of established factors such as low-density lipoprotein cholesterol (LDL-C), blood pressure and glycaemia. Mounting evidence indicates that hypertriglyceridemia…
View details →Osorio Oliveros AV, Velasco Jaramillo JA, Alejo-Martínez H et al. · 2026 · Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
Purpose To implement a continuous improvement cycle aimed at identifying and reducing radiation exposure incidents in patients undergoing PET-CT scans. Methods A comparative quasi-experimental study was conducted within a nuclear medicine…
View details →Schalch TO, Ando-Suguimoto ES, Ferreira BS et al. · 2026 · Clinical oral investigations
Objectives The aim of this study was to compare the effectiveness of two antimicrobial photodynamic therapy (aPDT) protocols using different methylene blue formulations in the treatment of initial pericoronitis. The research question was…
View details →Scampoli A, Governatori L, Solimeo A et al. · 2026 · Retina (Philadelphia, Pa.)
Purpose To evaluate whether baseline glycosylated hemoglobin (HbA1C) levels play a predictive role in faricimab loading phase outcomes. In addition, the authors assessed the efficacy of faricimab loading phase for diabetic macular edema…
View details →Pajina B, Leurcharusmee P · 2026 · Minerva anestesiologica
Background The anterior quadratus lumborum (QL) block provides effective post-cesarean delivery analgesia, but the optimal local anesthetic (LA) volume remains unknown. This is critical for balancing efficacy and safety in pregnant…
View details →Koubek CT, Aghaee MA · 2026 · Journal of economic entomology
Lygus hesperus Knight (Hemiptera: Miridae) is a major pest of California strawberries, where feeding injury from nymphs and adults leads to fruit deformation and economic losses. Management relies heavily on insecticides, with supplemental…
View details →Li Z, Li X, Yang B et al. · 2026 · Frontiers in oncology
Background Multidisciplinary team (MDT) care is widely advocated for soft tissue sarcoma (STS), yet real-world evidence in high-grade disease remains limited and subject to confounding. We investigated whether pre-treatment MDT care was…
View details →Shah M, Burshtein J, Zakria D et al. · 2026 · Journal of drugs in dermatology : JDD
Background Mineral sunscreens are increasingly favorable among consumers. However, mineral sunscreens typically cause a white cast that can impact consumer selection and application. Objective This study measured the whitening effect of…
View details →Wei W, Shi Y, Hu Q · 2026 · Cirugia y cirujanos
Objectives This study aimed to evaluate and compare the effects of prolonged daily wear of a surgical mask (SM) versus a KN95 respirator on tear film stability in healthcare workers. Methods Forty-eight healthcare workers (96 eyes) were…
View details →Hamersma S, McFarlane M · 2026 · The Milbank quarterly
Policy Points Reimposing work requirements for the Supplemental Nutrition Assistance Program-by removing temporary, location-based waivers-causes a decline in food assistance participation among childless women. This loss of nutritional…
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